MyMedR

Non-syndromic craniosynostosis treated by frontal orbital advancement: A case report

Khoo KW, Arman Zaharil MS, Mohd Ali MZ

Med J Malaysia, 2018 12;73(6):423-424.

Craniosynostosis is a premature pathologic fusion of one or more cranial vault sutures leading to abnormally-shaped skull. It can occur in isolated event (non-syndromic), or it can occur in conjunction with other anomalies in welldefined patterns (syndromic). The diagnosis rests on clinical examination and confirmation is generally on the computed tomography scan. The need for surgery is both for cosmetic and functional reasons. Here we describe a case of nonsyndromic craniosynostosis that was treated with frontal orbital advancement (FOA). The potential benefits of FOA need to be carefully weighed against the potential complications when deciding for any surgical intervention.

Matched MeSH terms: Humans

Fulltext Willingness to pay for outpatient services user fees: Malaysian community perspective

Syed Mohamed Al Junid, Azimatun Noor Aizuddin

Jurnal Sains Kesihatan Malaysia, 2018;16(1):145-153.

MyJurnal

Health care services are not often accessible and available for all people in one country due to multiple reasons such as the geographical barrier, affordability, etc. The aim of this study was to analyse willingness to pay (WTP) for healthcare services user fees among Malaysian population and determine its’ influencing factors. Structured interviews were conducted involving 774 households in 4 states represents Peninsular Malaysia. Validated questionnaires with open ended, followed by bidding games were applied to elicit maximum amount of WTP. The study was analysed descriptively and with multivariate regression method to adjust for potential confounding factors. More than half of respondents WTP more than current fee for the government clinic outpatient registration fee with mean MYR3.76 (SD2.71). Majority of respondents not WTP more than usual for private clinic simple outpatient treatment charges with the mean MYR38.76 (SD5.45). Factors that were found to have significant associations with WTP for both government and private clinic were income and having health insurance. Community willing to pay for healthcare services user fees and charges but at certain amount. The healthcare services user fees and charges can be increased up to community WTP level to avoid from catastrophic expenditure.

Matched MeSH terms: Humans

Transit Time Flowmeter Graft Flow Measurement in an Arrested Heart

Hashim SA

Heart Lung Circ, 2019 02;28(2):e3.

PMID: 30654949 DOI: 10.1016/j.hlc.2018.04.288

Matched MeSH terms: Humans

Fulltext Effects of a school-based substance use prevention program on students in Malaysia

Tan, Renee H.J., Yee, Anne, Ahmad Hatim Sulaiman, Mas Ayu Said, Mahmoud Danaee, Chang, Lua Ahai

JUMMEC, 2018;21(1):40-46.

MyJurnal

Background: The rise in substance-use-related problems among Malaysian adolescents called for a study to
assess the efficacy of an anti-drug educational program to improve the knowledge, attitude and perception
(KAP) of Malaysian students regarding substance use.
Methods: This study involved 573 students from four Malaysian Chinese schools in Malacca. Each student
filled out a Likert-scale mandarin translated questionnaire (KAP-C) on substance use ( Pre-test). Following an
educational program on substance use, the KAP-C questionnaire was given again to the students, immediately
following the program (PT 1), and after a month (PT 2) and two months (PT3) of the programme.
Results: The students showed improvement in knowledge of the types of substance use in PT 1 (p

Matched MeSH terms: Humans

Fulltext A study of monkey malaria, and its experimental transmission to man

Knowles R, Gupta BMD

Ind Med Gaz, 1932 Jun;67(6):301-320.

PMID: 29010910

This is the first report of new Plasmodium species (later known as P. knowlesi, after its discoverer) in a long-tailed macaque (Macaca fascicularis) imported to India from Singapore.

Matched MeSH terms: Humans

Fulltext Could melatonin be used in COVID-19 patients with laryngopharyngeal reflux disease?

Kow CS, Hasan SS

J Med Virol, 2021 01;93(1):92-93.

PMID: 32519764 DOI: 10.1002/jmv.26150

Matched MeSH terms: Humans

Fulltext The EMPOWER-SUSTAIN e-Health Intervention to improve patient activation and self-management behaviours among individuals with metabolic syndrome in primary care: study protocol for a pilot randomised controlled trial

Daud MH, Ramli AS, Abdul-Razak S, Isa MR, Yusoff FH, Baharudin N, et al.

Trials, 2020 Apr 05;21(1):311.

PMID: 32248825 DOI: 10.1186/s13063-020-04237-x

BACKGROUND: Epidemiological studies conducted in various parts of the world have clearly demonstrated that metabolic syndrome (MetS) is an increasing global health problem, not only in Western societies but also in Asian populations. Web-based and mobile phone-based self-management applications have been proven to be effective in improving self-management behaviour of patients with MetS components (i.e., diabetes or hypertension). However, evidence is lacking in terms of their effectiveness specifically for patients with MetS. The aim of this pilot study is to evaluate the feasibility and potential effectiveness of the EMPOWER-SUSTAIN Self-Management e-Health Intervention in improving activation and self-management behaviours among patients with MetS. This paper presents the study protocol.

METHODS: A pilot randomised controlled trial will be conducted in a university primary care clinic. A total of 232 patients aged 18-60 years with MetS will be recruited; 116 will be randomised to receive the EMPOWER-SUSTAIN intervention for 6 months, and another 116 patients will continue with usual care. The EMPOWER-SUSTAIN intervention is a multifaceted chronic disease management strategy based on the Chronic Care Model and persuasive technology theory. It consists of training primary care physicians, nurses and patients to use the EMPOWER-SUSTAIN web-based self-management mobile app, strengthening the patient-physician relationship and reinforcing the use of relevant clinical practice guidelines to guide management and prescribing. The primary outcome is the mean change in patient activation score using the Patient Activation Measure short form Malay version (PAM-13-M) questionnaire. The secondary outcomes include the changes in waist circumference, body mass index, blood pressure, patient physical activity level, eating behaviour, perception of chronic illness care, satisfaction with patient-physician interaction, and perceived absolute 10-year cardiovascular disease risk. Feasibility of implementing the intervention will be evaluated. This includes acceptability of the intervention, estimating the likely rate of participant recruitment and retention, appropriateness of the outcome measures, calculation of sample size, and the intervention's potential effectiveness.

CONCLUSION: To our knowledge, this is the first study in Malaysia that aims to determine the feasibility of a multifaceted e-health intervention, as well as to indicate more useful aspects of this intervention for further exploration in a larger trial.

TRIAL REGISTRATION: ClinicalTrials.gov, NCT04120779. Registered on 9 October 2019, protocol version 1.

Matched MeSH terms: Humans

Fulltext Can Building "Artificially Intelligent Cities" Safeguard Humanity from Natural Disasters, Pandemics, and Other Catastrophes? An Urban Scholar's Perspective

Yigitcanlar T, Butler L, Windle E, Desouza KC, Mehmood R, Corchado JM

Sensors (Basel), 2020 May 25;20(10).

PMID: 32466175 DOI: 10.3390/s20102988

In recent years, artificial intelligence (AI) has started to manifest itself at an unprecedented pace. With highly sophisticated capabilities, AI has the potential to dramatically change our cities and societies. Despite its growing importance, the urban and social implications of AI are still an understudied area. In order to contribute to the ongoing efforts to address this research gap, this paper introduces the notion of an artificially intelligent city as the potential successor of the popular smart city brand-where the smartness of a city has come to be strongly associated with the use of viable technological solutions, including AI. The study explores whether building artificially intelligent cities can safeguard humanity from natural disasters, pandemics, and other catastrophes. All of the statements in this viewpoint are based on a thorough review of the current status of AI literature, research, developments, trends, and applications. This paper generates insights and identifies prospective research questions by charting the evolution of AI and the potential impacts of the systematic adoption of AI in cities and societies. The generated insights inform urban policymakers, managers, and planners on how to ensure the correct uptake of AI in our cities, and the identified critical questions offer scholars directions for prospective research and development.

Matched MeSH terms: Humans

Fulltext Modern Trends and Applications of Intelligent Methods in Biomedical Signal and Image Processing

Kubicek J, Penhaker M, Krejcar O, Selamat A

Sensors (Basel), 2021 Jan 27;21(3).

PMID: 33513910 DOI: 10.3390/s21030847

There are various modern systems for the measurement and consequent acquisition of valuable patient's records in the form of medical signals and images, which are supposed to be processed to provide significant information about the state of biological tissues [...].

Matched MeSH terms: Humans

Fulltext Healthcare Professional in the Loop (HPIL): Classification of Standard and Oral Cancer-Causing Anomalous Regions of Oral Cavity Using Textural Analysis Technique in Autofluorescence Imaging

Awais M, Ghayvat H, Krishnan Pandarathodiyil A, Nabillah Ghani WM, Ramanathan A, Pandya S, et al.

Sensors (Basel), 2020 Oct 12;20(20).

PMID: 33053886 DOI: 10.3390/s20205780

Oral mucosal lesions (OML) and oral potentially malignant disorders (OPMDs) have been identified as having the potential to transform into oral squamous cell carcinoma (OSCC). This research focuses on the human-in-the-loop-system named Healthcare Professionals in the Loop (HPIL) to support diagnosis through an advanced machine learning procedure. HPIL is a novel system approach based on the textural pattern of OML and OPMDs (anomalous regions) to differentiate them from standard regions of the oral cavity by using autofluorescence imaging. An innovative method based on pre-processing, e.g., the Deriche-Canny edge detector and circular Hough transform (CHT); a post-processing textural analysis approach using the gray-level co-occurrence matrix (GLCM); and a feature selection algorithm (linear discriminant analysis (LDA)), followed by k-nearest neighbor (KNN) to classify OPMDs and the standard region, is proposed in this paper. The accuracy, sensitivity, and specificity in differentiating between standard and anomalous regions of the oral cavity are 83%, 85%, and 84%, respectively. The performance evaluation was plotted through the receiver operating characteristics of periodontist diagnosis with the HPIL system and without the system. This method of classifying OML and OPMD areas may help the dental specialist to identify anomalous regions for performing their biopsies more efficiently to predict the histological diagnosis of epithelial dysplasia.

Matched MeSH terms: Humans

Fulltext Ultrasensitive and Highly Selective Graphene-Based Field-Effect Transistor Biosensor for Anti-Diuretic Hormone Detection

Selvarajan RS, Rahim RA, Majlis BY, Gopinath SCB, Hamzah AA

Sensors (Basel), 2020 May 06;20(9).

PMID: 32384631 DOI: 10.3390/s20092642

Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from the failure of the kidney to respond to the anti-diuretic hormone (ADH). This will lead to excessive water loss from the body in the form of urine. The kidney, therefore, has a crucial role in maintaining water balance and it is vital to restore this function in an artificial kidney. Herein, an ultrasensitive and highly selective aptameric graphene-based field-effect transistor (GFET) sensor for ADH detection was developed by directly immobilizing ADH-specific aptamer on a surface-modified suspended graphene channel. This direct immobilization of aptamer on the graphene surface is an attempt to mimic the functionality of collecting tube V 2 receptors in the ADH biosensor. This aptamer was then used as a probe to capture ADH peptide at the sensing area which leads to changes in the concentration of charge carriers in the graphene channel. The biosensor shows a significant increment in the relative change of current ratio from 5.76 to 22.60 with the increase of ADH concentration ranging from 10 ag/mL to 1 pg/mL. The ADH biosensor thus exhibits a sensitivity of 50.00 µA· ( g / mL ) - 1 with a limit of detection as low as 3.55 ag/mL. In specificity analysis, the ADH biosensor demonstrated a higher current value which is 338.64 µA for ADH-spiked in phosphate-buffered saline (PBS) and 557.89 µA for ADH-spiked in human serum in comparison with other biomolecules tested. This experimental evidence shows that the ADH biosensor is ultrasensitive and highly selective towards ADH in PBS buffer and ADH-spiked in human serum.

Matched MeSH terms: Humans

Impact of the Journal of Chemical Information and Modeling Special Issue on Women in Computational Chemistry

Mazzolari A, Nunes-Alves A, Wahab HA, Amaro RE, Cournia Z, Merz KM

J Chem Inf Model, 2020 07 27;60(7):3328-3330.

PMID: 32623887 DOI: 10.1021/acs.jcim.0c00636

In this Viewpoint, we provide a commentary on the impact of the Journal of Chemical Information and Modeling Special Issue on Women in Computational Chemistry published in May 2019 and the feedback we received.

Matched MeSH terms: Humans

Fulltext The use of dgDocSPACE in personal file management: a case study at Majlis Perbandaran Port Dickson (MPPD)

Rafidah Kamarudin, Azura Abd Jamil @ Kamarudzzaman, Albakri Mohammad, Norlis Osman, Zaidatulhusna Mohd Isnani

Jurnal Inovasi Malaysia, 2020;3(2):26-41.

MyJurnal

Hari Bertemu Pelanggan (HBP) is an essential event of the Port Dickson Municipal Council (MPPD) which is held twice a year for staff to review their Personal Files. The problem faced by the staff at the Human Resource Department (JPSM) MPPD is to handle staff Personal Files from the file room to the HBP location during the event. Risks such as loss and damage of Personal Files and the high cost in transferring staff Personal Files lead to the development of innovation known as dgDocSPACE. The implementation of the innovation has successfully reduced the operating cost, increased productivity, shortened time for reviewing Personal Files and increased customer satisfaction.

Matched MeSH terms: Humans

Fulltext Sri Petaling COVID-19 cluster in Malaysia: challenges and the mitigation strategies

Safuan S, Edinur HA

Acta Biomed, 2020 11 10;91(4):e2020154.

PMID: 33525245 DOI: 10.23750/abm.v91i4.10345

.

Matched MeSH terms: Humans

Fulltext A young man with chronic dry cough

Shalihin SE, Osman IF, Harun Z, Mukhali HB, Gnathimin B

Malays Fam Physician, 2020;15(1):68-70.

PMID: 32284811 MyJurnal

In primary care, chest X-rays are commonly performed to assess patients presenting with a prolonged
cough. However, the extent to which the flms are accurately interpreted depends on the skill of the
doctors. Doctors with insufcient experience may miss an exact diagnosis when evaluating a flm,
especially in patients with nonspecifc symptoms, such as in the case discussed in this paper.
( Copied from article ).

Matched MeSH terms: Humans

Safeguarding human health in the Anthropocene epoch: report of The Rockefeller Foundation-Lancet Commission on planetary health

Whitmee S, Haines A, Beyrer C, Boltz F, Capon AG, de Souza Dias BF, et al.

Lancet, 2015 Nov 14;386(10007):1973-2028.

PMID: 26188744 DOI: 10.1016/S0140-6736(15)60901-1

Matched MeSH terms: Humans

True Median Cleft Lip-15 Years of Review and Prevalence

Hamzan MI, Sulaiman WAW

Cleft Palate Craniofac J, 2020 08;57(8):1051-1054.

PMID: 32476501 DOI: 10.1177/1055665620926346

OBJECTIVES: The author presents 4 cases and attempts to analyze the prevalence of true median cleft lip (MCL) in one center. Embryology, associated anomalies, and surgical treatment are discussed.

DESIGN: A retrospective descriptive study.

SETTING: Hospital Universiti Sains Malaysia.

PARTICIPANTS: All patients with congenital facial cleft deformities from 2005 to 2019 were retrieved from the Plastic Surgery OR Registry. All characteristics in interest were individually tabulated and evaluated. Four cases were reviewed and discussed.

OUTCOME: Prevalence of true MCL.

RESULTS: Out of the 494 patients included in the study, only 4 (0.81%) were affected with a median cleft, and the prevalence of true median cleft was hence determined to be 3 (0.61%) among the cleft population.

CONCLUSION: The prevalence of the true MCL is rare which makes it hard to categorize these clefts, and the surgical protocol needs to be established for the definitive treatment.

Matched MeSH terms: Humans

Gemcitabine and vinorelbine treatment in cutaneous T-cell lymphoma in four patients

Affandi AM, Blumetti TP, Wells J, Hertzberg M, Fernandez-Peñas P

Australas J Dermatol, 2015 Nov;56(4):294-7.

PMID: 25496219 DOI: 10.1111/ajd.12270

Treatment options for advanced stage cutaneous T-cell lymphoma (CTCL) are limited by the their efficacy and side-effects profile. Gemcitabine, a pyrimidine analogue, has been reported to be efficacious in CTCL. Most of the studies published used gemcitabine as a single agent in treating advanced CTCL. Our small case series demonstrated that a combination of gemcitabine and vinorelbine induced partial remission in all four patients with refractory or advanced CTCL, although the effects were not sustained for a long duration (2-6 months). Two patients had neutropenia and one had acute hepatitis, requiring discontinuation of treatment.

Matched MeSH terms: Humans

Fulltext Enhancing attendance and student exam score based on mobile attendance application

Nurhafizah Ahmad, Siti Asmah Mohamed, Ahmad Zia Ul-Saufie, Hasfazilah Ahmat, Fadzilawani Astifar Alias

ESTEEM Academic Journal, 2020;16(1):38-46.

MyJurnal

In today’s digital era, it is possible to use the latest technology to improve student attendance and performance. The purpose of the present study is to determine the relationship between absenteeism and academic performance among Calculus students, as well as to measure the impact of class absence on the student’s final exam scores. Based on this, the use of appropriate
strategy was employed, which is the mobile attendance application to reduce absenteeism among students in higher educational institution. The selection of sample was based on cluster sampling, involving the selection of 87 repeater students. The data collected were analyzed using quartile
regression and independent sample t-test. The result of the findings revealed that the class absence has an impact on the student’s final exam scores. This is because, if the student was absences by 1 class, the final exam score is expected to decrease on average by 1.89%. Hence, findings show that the percentage of absences for the students with manual attendance was higher
than the percentage of absences for the students with mobile attendance application. The application can help to reduce absenteeism by reminding students about recent attendance records.

Matched MeSH terms: Humans

Prevalence and predictors of resistant hypertension in Southeast Asia [Abstract SSA 03-2]

Chia YC

J Hypertens, 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e4-e5.

PMID: 27753807

Conference abstract:
Hypertension is the leading cause of mortality worldwide. It is highly prevalent throughout the world. Even in regions liike South-East Asia (SEA) which has been perceived to be less prone to cardiovascular diseases, the prevalence of hypertension has been reported to be around 35% (1). Awareness and control of hypertension in SEA is also low, both being less than 50% each (2).Control of hypertension is an interplay between patients, doctors and system factors. One of the reasons for poor control of hypertension is resistant hypertension. Resistant hypertension is defined as blood presure that remains above goal despite being on three concurrent anti-hypertensive medications preferbaly one of which is a diuretic (3).True resistant hypertension should be differiented from secondary hypertension and pseudo-resistant hypertension. Resistant hypertension is almost always multi-factorial in aetiology. The exact prevalence of resistant hypertenion even in developed countries is not known It has been estimated that it is as high as 20-30% in clinical trial patients (4)Not many studies about resistant hypertension have been done in SEA but one done in an outpatient clinic in Thailand found it to be 7.82% Another study also done in a primary care clinc in Malaysia on 1217 patients with hypertension found the prevalence of resistant hypertension to be 8.8%. (6) Here it was found that the presence of chronic kidney disease was more likely to be associated with resistant hypertension (odds ratio [OR] 2.89, 95% confidence interval [CI] 1.56-5.35). Other factors like increasing age, female gender, presence of diabetes, obesity and left ventricular hypertrophyage which have been found to be predictors of resistant hypertension in other studies in the west were not seen in this study. There are various reasons for these findingsBut whatever the factors are that are associated with uncontrolled hypertension, the task is to sort out true resistant hypertension from pseudo-resistant hypertension and secondary casues of hypertension which may be treatable. A concerted effort is needed to reduce the BP in resistant hypertension. Failure to do so would mean a substantal increase in CV risk for the patient.

Matched MeSH terms: Humans

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