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Fulltext Iatrogenic (‘clinician-induced’) damage incurred by human sperm during infertility treatment: postgraduate research and collaborative developments between the universities of Malaya and Oxford

Yelumalai, S., Jones, C., Coward, K.

JUMMEC, 2013;16(2):1-6.
MyJurnal

Assisted Reproductive Technology (ART) is a suite of laboratory techniques designed to rescue infertile phenotypes. While ART has led to the birth of 5 million ART babies worldwide, success rates rarely exceed 40%. One potential factor for this could be iatrogenic (‘clinician-induced’) damage to critical sperm proteins, such as phospholipase C zeta (PLCζ) and protamine, which are fundamental for oocyte activation and sperm DNA integrity, respectively. This report describes how we have begun to investigate the adverse effects of ART techniques upon these key sperm proteins. We also describe the pathway taken by Miss Suseela Yelumalai to acquire a scholarship from the Malaysian Government and her postgraduate experience at the University of Oxford. We introduce the facilities and learning opportunities available at the Institute of Reproductive Sciences (IRS) which houses Dr Kevin Coward’s research laboratory, and finally, highlight the potential for collaborative development between the Universities of Oxford and Malaya.

Matched MeSH terms: Iatrogenic Disease
Fulltext Gaining insight into patients’ experience of adherence to hypertensive treatment

Lee, K., Yunus, M., Loong, Y. Y., Shamsuddin, A., Zubaidah, J., Rosna, A. R.

Malaysian Journal of Medicine and Health Sciences, 2010;6(2):43-50.
MyJurnal

Hypertension is one of the major risk factors for coronary heart disease and the most important factor for cerebrovascular diseases. Adherence to treatment is a fundamental pre-requisite for therapeutic benefit in hypertensive patients. Adherence is a complex behavioural process that is strongly influenced by the way in which patients live, as well as the psychological and social support system.
Aim: To understand and conceptualize the experience of people on long-term antihypertensive treatment Method: Qualitative analysis using semi-structured interviews with ten hypertensive patients from the medical clinic of Kuala Lumpur General Hospital.
Results: Although the participants were aware of having high blood pressure they declined receiving any treatment at the early stage of the disease. Fear of death and disease complications are reinforcements for participants to adhere to medication. They perceived the label of “hypertension” will affect their self-identity and social role. Positive thinking regarding medication assists participants to adhere to treatment. Conversely, participants who perceived medication negatively also adhere to a medication regime, as adherence behaviour satisfies the family. Participants justified modifying their regimen or taking Complementary and Alternative Medicine (CAM) as they believe know the their body best. However, participants wished to obtain more information regarding hypertension and its treatment from the doctors.
Conclusion: In finding the fine balance between stepping in and holding back treatment and care, health professionals need to know their clients in context. This balance can only be achieved by establishing processes of negotiation within an ongoing therapeutic relationship.

Study site: medical clinic of Kuala Lumpur General Hospital.

Matched MeSH terms: Coronary Artery Disease
Fulltext Why metabonomics?

Yap, Ivan K.S.

International e-Journal of Science, Medicine & Education, 2011;5(1):17-26.
MyJurnal

Metabonomics can be used to quantitatively measure dynamic biochemical responses of living organisms to physiological or pathological stimuli. A range of analytical tools such as high-resolution nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) combined with multivariate statistical analysis can be employed to create comprehensive metabolic signatures of biological samples including urine, plasma, faecal water and tissue extracts. These metabolic signatures can reflect the physiological or pathological condition of the organism and indicate imbalances in the homeostatic regulation of tissues and extracellular fluids. This technology has been employed in a diverse range of application areas including investigation of disease mechanisms, diagnosis/prognosis of pathologies, nutritional interventions and drug toxicity. Metabolic profiling is becoming increasingly important in identifying biomarkers of disease progression and drug intervention, and can provide additional information to support or aid the interpretation of genomic and proteomic data. With the new generation of postgenomic technologies, the paradigm in many biological fields has shifted to either top down systems biology approaches, aiming to achieve a general understanding of the global and integrated response of an organism or to bottom up modelling of specific pathways and networks using a priori knowledge based on mining large bodies of literature. Whilst metabolic profiling lends itself to either approach, using it in an exploratory and hypothesis generating capacity clearly allows new mechanisms to be uncovered.

Matched MeSH terms: Disease Progression
Fulltext Care demands-related concerns and perceived service needs of families of people with mental illness in the community

Saloma, P., Chan, K.G., Ong, M.F.

Malaysian Journal of Psychiatry, 2014;23(1):17-26.
MyJurnal

Owing to reduced inpatient stays, people with mental illness (PMI) were often discharged from the hospital in ‘acute’ conditions. During this transition period of fragility, the relocation of care from hospital to home has tremendous impact on every aspect of a family’s life as they need to face a challenging task of caring especially when they are ‘not ready’ and ‘ignorant’ about the chronicity and severity of the illness. Furthermore, where economic and psychological support is concerned, those who are undertaking this task may require significant professional guidance. Aims: This study examines the experiences of 100 families in caring for people with mental illness in the community. Methods: Qualitative interviews were conducted in their homes within three Malaysian states of Sabah, Sarawak and Johor in year 2013. Results: Three themes emerged from the findings of ‘care demands related concerns’ of these families. These include theme (1): care provision related concerns of families which were related to the needs of people with mental illness for continuing care provision, their non-compliance with medication and relapse, altered sleep pattern, limited self-care ability, behavioral problems and also social isolation. Theme (2): perceived availability of resources of service provision/support which were related to activities planned for the families before the discharge of the people with mental illness and theme (3): family members perceived service needs whereby they informed of their needs such as continual health care through home visit, provision of financial aid, job coach service, centre for care provision of PMI and rehabilitative programs.

Matched MeSH terms: Chronic Disease
Fulltext Health screening for older people—what are the current recommendations?

Sazlina SG

Malays Fam Physician, 2015;10(1):2-10.
PMID: 26425289 MyJurnal

The world population of older people is on the rise with improved health services. With longevity, older people are at increased risk of chronic non-communicable diseases (NCDs), which are also leading causes of death among older people. Screening through case finding in primary care would allow early identification of NCDs and its risk factors, which could lead to the reduction of related complications as well as mortality. However, direct evidence for screening older people is lacking and the decision to screen for diseases should be made based on comorbidity, functional status and life expectancy, and has to be individualised.

Matched MeSH terms: Chronic Disease
Helminth parasites from the Old World leaf monkey Presbytis from West Malaysia

Palmieri JR, Krishnasamy M, Sullivan JT

Southeast Asian J. Trop. Med. Public Health, 1977 Sep;8(3):409.
PMID: 415371
Matched MeSH terms: Disease Models, Animal
Recurrence of influenza with A2-Hong Kong-68 within two months

Kamath S, Omar M, Wah LT

Med J Malaya, 1970 Dec;25(2):123-7.
PMID: 4251133
Matched MeSH terms: Chronic Disease
Mosquito breeding in the Kuching area, Sarawak, with special reference to the epidemiology of dengue fever

Surtees G

J Med Entomol, 1970 Apr;7(2):273-6.
PMID: 5425695
Matched MeSH terms: Disease Reservoirs
Cycles of jungle malaria in West Malaysia

Warren M, Cheong WH, Fredericks HK, Coatney GR

Am J Trop Med Hyg, 1970 May;19(3):383-93.
PMID: 4392806
Matched MeSH terms: Disease Vectors
Cercaria of Trichobilharzia brevis Basch, 1966 in Djakarta as a possible cause of schistosome dermatitis

Margono SS

Med J Malaya, 1968 Jun;23(4):306-12.
PMID: 4235595
Matched MeSH terms: Disease Vectors
The role of infectious disease impact in informing decision-making for animal health management in aquaculture systems in Bangladesh

Garza M, Mohan CV, Rahman M, Wieland B, Häsler B

Prev Vet Med, 2019 Jun 01;167:202-213.
PMID: 29625785 DOI: 10.1016/j.prevetmed.2018.03.004

The aquaculture sector in Bangladesh is an important employer and a significant source of foreign exchange. In addition, it contributes significantly to food security due to the role of fish in peoples' diets, the most important source of protein and micronutrients. However, infectious diseases represent an important barrier to sector development due to economic losses and vulnerability of smallholders. The aim of this study was to gain an overview of the impact of infectious diseases in the aquaculture sector, and to assess the usefulness and use of impact studies in decision making for animal health management and biosecurity governance in Bangladesh. A review of scientific and grey literature on infectious disease impact in different aquaculture systems was conducted and their methodologies and findings summarised. Subsequently, interviews with 28 stakeholders from the private and public sector were conducted to enquire about decision-making structures in animal health management. The data were analysed using the framework method to allow the development of themes, by using the information, experiences and opinions inductively obtained from interviewees, deductively through the reviewed literature. Results showed a substantial socio-economic impact of infectious diseases. The numerous stakeholders involved in the decision-making process explained that key barriers to effective aquaculture health management were insufficient resources to investigate and tackle infectious aquatic animal diseases, a dearth of legislation and capacity for disease surveillance, a reliance on reactive response, and a lack of impact and evidence-based approaches for prioritising problem-solving, commonly based on anecdotal evidence. Furthermore, communication among the multiple stakeholders involved was reported to be weak. This complex situation requires a multi-level response, which should span from strengthening the knowledge of farmers and professionals in the field to the improvement of surveillance and diagnostic systems. Improved systems along with evidence on disease impact could inform the prioritisation of diseases and resource allocation for disease control in Bangladesh. Further, this evidence needs to be used to advise decisions to have a true value, for which establishing and strengthening communication pathways and processes is critical to make systematic use of the information and improve animal health management. In the light of future threats to Bangladesh such as climate change, increasing population density and demand for animal source foods, it is crucial to strengthen animal health management systems to reduce livelihoods vulnerability, food insecurity and the likelihood of disease emergence.

Matched MeSH terms: Communicable Disease Control
Fulltext Precontoured Clavicular Locking Plate with Broad Lateral End: A Newly Designed Plate for Lateral Third Clavicle Fractures

Kapil-Mani KC, Acharya P, Arun S

Malays Orthop J, 2018 Mar;12(1):15-20.
PMID: 29725507 DOI: 10.5704/MOJ.1803.003

Introduction: Various treatment modalities are available but no consensus has been reached for optimal treatment of lateral third clavicle fractures. Precontoured locking plates with broad lateral end for multiple screws fixation is a newly designed plate for lateral third clavicle fractures. The objective of our study was to analyse the functional outcomes as well as complications of this technique in a significant number of cases with long follow-up duration. Materials and Methods: Forty-six patients with distal third clavicle fractures were treated by precontoured clavicular locking plate with broad lateral end. Functional outcomes were assessed on the basis of Constant-Murley Shoulder Outcome Score and University of California, Los Angeles (UCLA) Shoulder Rating Score, active shoulder range of motion, time for fracture union and coraco-clavicular distance. Results: The mean Constant-Murley score was 92.56±4.47 (range: 79-98) for injured side and 96.22±2.23 (range: 90-100) for normal side with p-Value 0.56. Mean coraco-clavicular distance at final follow-up was 10.52±1.13 mm (range 9.7 to 11.7 mm) in injured side and 10.25±0.98 mm (range 9.6 to 11.2 mm) in normal side. Mean UCLA Shoulder Rating Score was 32.55±2.12 (range: 27-34) for injured side and 33.46±1.88 (range: 31- 35) on normal side with p value 0.58. No major complications that necessitated revision of surgery occurred in our study. Conclusion: This newly designed plate seemed extremely useful in successful union of lateral third clavicle fractures, with reduced rate of complications like fixation failures, iatrogenic rotator cuff injury, AC joint osteoarthritis and sub-acromial bursitis, with good functional outcomes.

Matched MeSH terms: Iatrogenic Disease
Fulltext Association between HLA-B* 15:02 and carbamazepine induced severe cutaneous adverse drug reactions in Myanmar

Amy Hui-Ping Khor, Lim, Kheng-Seang, Tan, Chong-Tin, Seinn Mya Mya Aye, Yan Lynn Aung, Yin Minn Aye, et al.

Neurology Asia, 2017;22(3):283-285.
MyJurnal

Genetic predisposition to carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and toxic
epidermal necrolysis (TEN) had been reported in several Southeast Asian populations, but not in
Myanmar. Previous studies had so far reported more than 70% of CBZ-induced SJS/TEN cases
positive for HLA-B*15:02 allele.1-4 Myanmar, as the second largest country in Southeast Asia with a
population of 54.5 million, has high HLA-B*15:02 carrier frequency in its general population (27.3-
49.1%).5,6 We investigated the association of HLA-B alleles and CBZ-induced SJS/TEN in Myanmar
population. HLA-B*15:02 was detected in 3/3 (100%) of cases and 6/53 (11.3%) of tolerant controls,
and HLA-B*15:02 is significantly associated with CBZ-SJS/TEN in Myanmar population (OR 51.2,
95% CI 2.36-1106.95, p=0.003). (Copied from article)

Matched MeSH terms: Genetic Predisposition to Disease
Fulltext The natural history of optic neuritis in Asian patients: an observational cohort study

Seah, B.H.A., Tow, S.L.C., Ong, K.C.B. Ong, Yang, C.C., Tsai, C.P., Lee, K.H., et al.

Neurology Asia, 2017;22(4):341-348.
MyJurnal

Optic neuritis, which may be a precursor to multiple sclerosis (MS), is an uncommon disease in
Asian patients. The Asian Collaborative Longitudinal Optic Neuritis Epidemiology (ACLONE) is
an observational cohort study that assessed the risk of recurrent optic neuritis and/or progression
of further neurologic events, either MS or neuromyelitis optica (NMO) in Asian patients with firstever
optic neuritis. Secondary aims were to study the presenting characteristics and visual outcome,
and to identify risk factors for development of either MS or NMO. A total of 112 patients (25 men
and 87 women) aged from 12 to 61 years were recruited from Singapore, Taiwan, South Korea and
Malaysia. Of these, 94 (84%) had unilateral optic neuritis, with the right eye involved in 45 patients
and the left eye in 49 patients and the remaining 18 (16%) had bilateral optic neuritis. Follow up
data was available for 104 patients, and patients were followed for a median duration of 25.9 months.
Of these patients, 6 patients were adjudicated to have reached the primary endpoint (composite of
MS/NMO and optic neuritis): 3 patients with recurrent optic neuritis also subsequently experienced
neurologic symptoms, and 3 patients without recurrent eye involvement had neurologic symptoms.
Only one patient was considered to have prototypical MS, the other 5 were diagnosed with NMO,
all with subsequent antibody confirmation. Optic neuritis in Asian patients has significantly different
presenting characteristics from the classic description. However, in the majority of the patients it is
usually a benign disease, with good visual outcome and no further events.

Matched MeSH terms: Disease Progression
A computed tomographic analysis of frontal recess cells in association with the development of frontal sinusitis

Johari HH, Mohamad I, Sachlin IS, Aziz ME, Mey TY, Ramli RR

Auris Nasus Larynx, 2018 Dec;45(6):1183-1190.
PMID: 29880289 DOI: 10.1016/j.anl.2018.04.010

OBJECTIVE: This study was done to determine frontal recess anatomy cell variations and its association with frontal sinusitis. The incidence of frontal recess cells in the population, the presence of frontal recess cell variations in chronic rhinosinusitis and non-chronic rhinosinusitis and the association of frontal recess cell variation in the development of frontal sinusitis were also assessed.
METHODS: This was an observational, retrospective cross-sectional study of computed tomography (CT) scan of paranasal sinus that had been performed on patients in Hospital Universiti Sains Malaysia and Hospital Sultanah Bahiyah done from January 2009 until December 2016. The presence of frontal recess cells variation was compared with other populations.
RESULTS: A total of 312 sides from 156 patients' CT scan images were analyzed. Left and right sinuses were considered individually. A total of 63 sides showed evidence of frontal sinusitis, 37 were male and 26 were female, whereas 249 sides were clear from frontal sinus disease. It was not much difference in mean age for frontal sinusitis patient (46.51±14.00) and patients without frontal sinusitis (48.73±16.44). The percentage was almost equal for CRS and non-CRS groups regardless of side and gender. In our study, the frontal recess cell such as agger nasi cell was found in almost all patients 98.1%, frontal ethmoidal cell type 1, type 2, type 3 and type 4 comprised of 28.8%, 31.1%, 14.4% and 0% respectively. Whereas, suprabullar cell can be seen in 40.3%, supraorbital ethmoid cells 16.7%, frontal bullar cell 33.0% and inter-frontal sinus septal cells 10.8%. There was a statistically significant association between the presence of frontal bullar cell and the development of frontal sinusitis (p value<0.001).
CONCLUSION: The frontal recess cells variation in Malaysian subjects were almost similar to those reported in other Asian populations such as Japanese, Taiwanese, Chinese and Korean. Our study found that frontal bullar cells had a significant association with the development of frontal sinusitis than other frontal recess cells. The understanding of the frontal recess anatomical structures was very important as this would lead to a successful treatment of CRS and at the same time it helped the surgeon to have a better plan of endoscopic sinus surgery to prevent the disease recurrence and surgical complication.

Matched MeSH terms: Chronic Disease
Fulltext Pyrethroid resistance status of Aedes (Stegomyia) aegypti (Linneaus) from dengue endemic areas in Peninsular Malaysia

Rosilawati, R., Lee, H.L., Nazni, W.A., Nurulhusna, A.H., Roziah, A., Khairul Asuad, M., et al.

International Medical Journal Malaysia, 2017;16(2):73-78.
MyJurnal

Vector control is still the principal method to control dengue and chemical insecticides, especially the
pyrethroids such as permethrin are the forerunners of mosquito control agent. Intensive and extensive use
of pyrethroids often result in resistance, thereby hampering control efforts. The present study was
conducted to evaluate the susceptible status of Aedes aegypti, the primary vector of dengue against
permethrin. A nationwide mosquito sampling via ovitrapping was conducted in 12 dengue hotspots across 5
states in Peninsular Malaysia. Field collected Aedes eggs were hatched and reared until L3 larval and further
identified it species. Adult F0 Aedes aegypti were reared until F1 progeny and the female were used in
adult assay, performed according to World Health Organization (WHO) protocol as to determine the
resistance level. The laboratory strain maintained for more than 1000 generations that were susceptible to
permethrin served as the control strain. Evaluation of resistance ratio was assessed by comparing the
knockdown rate with laboratory susceptible strain. In this present study, 70% ofAe. aegypti population from
dengue hotspots was highly resistance to permethrin. The study clearly demonstrated that widespread of
permethrin resistant Ae. aegypti in Malaysian mosquito’s population, indicating the need of implementing
an efficient pyrethroid resistance management.

Matched MeSH terms: Disease Vectors
Fulltext Viral Determinants and Vector Competence of Zika Virus Transmission

Tham HW, Balasubramaniam V, Ooi MK, Chew MF

Front Microbiol, 2018;9:1040.
PMID: 29875751 DOI: 10.3389/fmicb.2018.01040

Zika virus (ZIKV) has emerged as a new global health threat. Since its first discovery in Zika forest in Uganda, this virus has been isolated from several mosquito species, including Aedes aegypti and Aedes albopictus. The geographical distribution of these mosquito species across tropical and subtropical regions has led to several outbreaks, including the recent pandemic in Brazil, followed by the Pacific islands and other areas of North and South America. This has gained attention of the scientific community to elucidate the epidemiology and transmission of ZIKV. Despite its strong attention on clinical aspects for healthcare professionals, the relationships between ZIKV and its principal vectors, A. aegypti and A. albopictus, have not gained substantial interest in the scientific research community. As such, this review aims to summarize the current knowledge on ZIKV tropism and some important mechanisms which may be employed by the virus for effective strategies on viral survival in mosquitoes. In addition, this review identifies the areas of research that should be placed attention to, for which to be exploited for novel mosquito control strategies.

Matched MeSH terms: Disease Outbreaks
Fulltext 27 years of benthic and coral community dynamics on turbid, highly urbanised reefs off Singapore

Guest JR, Tun K, Low J, Vergés A, Marzinelli EM, Campbell AH, et al.

Sci Rep, 2016 11 08;6:36260.
PMID: 27824083 DOI: 10.1038/srep36260

Coral cover on reefs is declining globally due to coastal development, overfishing and climate change. Reefs isolated from direct human influence can recover from natural acute disturbances, but little is known about long term recovery of reefs experiencing chronic human disturbances. Here we investigate responses to acute bleaching disturbances on turbid reefs off Singapore, at two depths over a period of 27 years. Coral cover declined and there were marked changes in coral and benthic community structure during the first decade of monitoring at both depths. At shallower reef crest sites (3-4 m), benthic community structure recovered towards pre-disturbance states within a decade. In contrast, there was a net decline in coral cover and continuing shifts in community structure at deeper reef slope sites (6-7 m). There was no evidence of phase shifts to macroalgal dominance but coral habitats at deeper sites were replaced by unstable substrata such as fine sediments and rubble. The persistence of coral dominance at chronically disturbed shallow sites is likely due to an abundance of coral taxa which are tolerant to environmental stress. In addition, high turbidity may interact antagonistically with other disturbances to reduce the impact of thermal stress and limit macroalgal growth rates.

Matched MeSH terms: Disease Resistance
Fulltext Incorporation of Pleurotus Sajor-caju powder in cinnamon biscuit: Study on nutritional, physical, colour and sensorial properties

Wan Amir Nizam, W.A., Ng, S.H., Wan Rosli, W.I.

International Food Research Journal, 2017;24(6):2442-2450.
MyJurnal

Discovery of novel dietary fibre (DF)-rich food ingredient is of great interest to meet the rising consumer demand for healthy food. Intake of DF-enriched food has been positively associated with a decreased risk of chronic diseases. Pleurotus sajor-caju (PSC), one of the prominent edible mushrooms widely cultivated in Malaysia, is useful for its culinary and medicinal purpose. This study aimed to determine the nutritional, physical, colour and sensorial properties of cinnamon biscuit formulated with PSC powder as partial replacement (0, 4, 8 and 12%) for wheat flour. Results indicated that elevated incorporation levels of PSC powder significantly (P

Matched MeSH terms: Chronic Disease
Fulltext The association between physical fitness with successful ageing and risk of cognitive impairment among Malaysian older adults

Huijin, Lau, Nor Fadilah Rajab, Arimi Fitri Mat Ludin, Suzana Shahar

Jurnal Sains Kesihatan Malaysia, 2015;15(22):97-102.
MyJurnal

The expansion of ageing population has gained much public attention on the importance of healthy and successful ageing,
which is absence of major chronic diseases, preserved physiological and cognitive functioning and active engagement
with life. Previous studies have found there was a significant correlation between physical fitness with cognition. However,
the relationship between physical fitness with successful and unsuccessful cognitive ageing groups are very limited. This
study was aimed to identify the significant physical fitness components that contribute in reducing risk of cognitive decline
represented as different cognitive ageing groups. A total of 300 community-based elderly aged 60 and above from the
states of Selangor, Perak and Kelantan were recruited using multistage random sampling method in this cross-sectional
study. Cognitive function of subjects was categorized into three groups, namely Mild Cognitive Impairment (MCI) (n
= 100), Usual Ageing (UA) (n = 100) and Successful Ageing (SA) (n = 100) based on defined criteria. Senior Fitness
Tests included 2-minute step, handgrip strength, chair stand, chair sit-and-reach, 8 foot up-and-go and back scratch
were measured to determine the cardiorespiratory fitness; muscle strength; agility and flexibility of subjects. SA group
had significantly better performance than non-SA groups in all fitness components, except for chair sit-and-reach. After
controlling for age, gender, education years and smoking status, handgrip strength and chair stand tests were associated
with a reduced risk of MCI by 7% [OR: 0.93, 95% C.I: 0.88-0.99, p < 0.05] and 15% [OR: 0.85, 95% C.I: 0.75-0.95, p <
0.01], respectively. These findings suggest that older adults with higher upper and lower body muscular strength could
serve as protective factors for cognitive impairment. Further research is warranted to evaluate the mechanism of physical
and cognitive decline such as Motoric Cognitive Risk Syndrome (MCR) in more detailed for the purpose for promoting
healthy and successful ageing.

Matched MeSH terms: Chronic Disease

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