Displaying publications 21 - 40 of 97 in total

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  1. The physicochemical properties of geraniin, a potential antihyperglycemic agent
    Elendran S, Wang LW, Prankerd R, Palanisamy UD
    Pharm Biol, 2015;53(12):1719-26.
    PMID: 25853977 DOI: 10.3109/13880209.2014.1003356
    Natural products play a vital role in the discovery of leads for novel pharmacologically active drugs. Geraniin (GE) was identified as the major compound in the rind of Nephelium lappaceum L. (Sapindaceae), while ellagic and gallic acids have been shown to be its main metabolites. GE and its metabolites possess a range of bioactive properties including being an anti-infective, anticarcinogenic, antihyperglycemic, and antihypertensive.
    Matched MeSH terms: Hydrolyzable Tannins/isolation & purification; Hydrolyzable Tannins/chemistry*
  2. Fulltext Antifungal Activity of Aqueous Extracts of Some Dominant Algerian Medicinal Plants
    Salhi N, Mohammed Saghir SA, Terzi V, Brahmi I, Ghedairi N, Bissati S
    Biomed Res Int, 2017;2017:7526291.
    PMID: 29226147 DOI: 10.1155/2017/7526291
    Aim: This study investigated the antifungal properties of aqueous extracts obtained from indigenous plants that grow spontaneously in the Northern Sahara of Algeria. The activities of these plants in controlling two fungal species that belong to Fusarium genus were evaluated in an in vitro assay.

    Materials and Methods: Fresh aerial parts of four plant species (Artemisia herba alba, Cotula cinerea, Asphodelus tenuifolius, and Euphorbia guyoniana) were collected for the preparation of aqueous extracts. Two levels of dilution (10% and 20%) of the pure extracts were evaluated against Fusarium graminearum and Fusarium sporotrichioides.

    Results: The results of this study revealed that the A. herba alba, C. cinerea, A. tenuifolius, and E. guyoniana aqueous extracts are effective at both concentrations of 10% and 20% for the Fusarium mycelia growth inhibition. In particular, A. tenuifolius extract is effective against F. graminearum, whereas F. sporotrichioides mycelium growth is strongly affected by the E. guyoniana 20% extract. The phytochemical characterization of the compositions of the aqueous extracts has revealed that the presence of some chemical compounds (tannins, flavonoids, saponins, steroids, and alkaloids) is likely to be responsible for the antifungal activities sought.

    Conclusion: The antifungal properties of A. herba alba, C. cinerea, A. tenuifolius, and E. guyoniana make these plants of potential interest for the control of fungi affecting both wheat yield and safety.

    Matched MeSH terms: Tannins/pharmacology; Tannins/chemistry
  3. Permeability of the ellagitannin geraniin and its metabolites in a human colon adenocarcinoma Caco-2 cell culture model
    Elendran S, Muniyandy S, Lee WW, Palanisamy UD
    Food Funct, 2019 Feb 20;10(2):602-615.
    PMID: 30566155 DOI: 10.1039/c8fo01927d
    Ellagitannins, found abundantly in berries, pomegranates, walnuts and almonds, have been increasingly investigated for their health benefits. Geraniin (GE), an ellagitannin, found predominantly in herbal plants, as well has been shown to exhibit a number of biological activities. Like many hydrolysable tannins, geraniin is water-soluble and readily undergoes hydrolysis in the presence of hot water, weak acids and weak bases to yield several metabolites including corilagin (CO), ellagic acid (EA) and gallic acid (GA). There are numerous studies on the pharmacological effectiveness of GE, CO and GA. However, the intestinal permeability of GE and CO has never been investigated before. Caco-2 cell transport assay was utilized to evaluate the in vitro permeability of GE and its metabolites. GE, CO and EA were found to have no apparent permeability (Papp) while GA displayed a Papp value of 31.3 ± 1.1 × 10-6 cm s-1. Mass balance studies showed a loss of geraniin and its metabolites during transport. Chemical stability studies in the transport buffers revealed that GE and CO were hydrolyzed in the HBSS buffers. Experiments using lysed cells revealed that GE and its metabolites were metabolized during transport. Absorption and desorption studies confirmed the accumulation of EA inside the cells. The above results indicate that the compounds have poor oral absorption. To consider these compounds or their natural extracts as oral nutraceutical candidates, formulation strategies are mandatory.
    Matched MeSH terms: Hydrolyzable Tannins/metabolism*; Hydrolyzable Tannins/chemistry
  4. New cyanogenic and alkyl glycoside constituents from Phyllagathis rotundifolia
    Ling SK, Tanaka T, Kouno I
    J Nat Prod, 2002 Feb;65(2):131-5.
    PMID: 11858743
    Methanolic extracts of the leaves, stems, and roots of Phyllagathis rotundifolia collected in Malaysia yielded seven galloylated cyanogenic glucosides based on prunasin, with six of these being new compounds, prunasin 2',6'-di-O-gallate (3), prunasin 3',6'-di-O-gallate (4), prunasin 4',6'-di-O-gallate (5), prunasin 2',3',6'-tri-O-gallate (6), prunasin 3',4',6'-tri-O-gallate (7), and prunasin 2',3',4',6'-tetra-O-gallate (8). Also obtained was a new alkyl glycoside, oct-1-en-3-yl alpha-arabinofuranosyl-(1-->6)-beta-glucopyranoside (9). For compounds 3-8, the galloyl groups were individually linked to the sugar moieties via ester bonds. All new structures were established on the basis of NMR and MS spectroscopic studies. In addition, prunasin (1), gallic acid and its methyl ester, beta-glucogallin, 3,6-di-O-galloyl-D-glucose, 1,2,3,6-tetra-O-galloyl-beta-D-glucose, strictinin, 6-O-galloyl-2,3-O-(S)-hexahydroxydiphenoyl-D-glucose, praecoxin B, and pterocarinin C were isolated and identified. The isolation of 1 and its galloyl derivatives (3-8) from a Melastomataceous plant are described for the first time.
    Matched MeSH terms: Tannins/isolation & purification; Tannins/chemistry
  5. Fulltext Phytochemical constituents, nutritional values, phenolics, flavonols, flavonoids, antioxidant and cytotoxicity studies on Phaleria macrocarpa (Scheff.) Boerl fruits
    Lay MM, Karsani SA, Mohajer S, Abd Malek SN
    BMC Complement Altern Med, 2014;14:152.
    PMID: 24885709 DOI: 10.1186/1472-6882-14-152
    The edible fruits of Phaleria macrocarpa (Scheff.) Boerl are widely used in traditional medicine in Indonesia. It is used to treat a variety of medical conditions such as - cancer, diabetes mellitus, allergies, liver and heart diseases, kidney failure, blood diseases, high blood pressure, stroke, various skin diseases, itching, aches, and flu. Therefore, it is of great interest to determine the biochemical and cytotoxic properties of the fruit extracts.
    Matched MeSH terms: Tannins/analysis; Tannins/pharmacology
  6. Inhibitive behaviour of corrosion of aluminium alloy in NaCl by mangrove tannin
    Solhan Yahya, Afidah Abdul Rahim, Affaizza Mohd Shah, Rohana Adnan
    Sains Malaysiana, 2011;40.
    Anticorrosion potential of mangrove tannins on aluminium alloys AA6061 in NaCl solution has been studied using potentiodynamic polarisation method and scanning electron microscopy (SEM). The study was carried out in different pH of corrosive medium in the absence and presence of various concentrations of tannin. The corrosion inhibition behaviour of the mangrove tannin on AA6061 aluminium alloy corrosion was found to be dependant on the pH of NaCl solution. Our results showed that the inhibition efficiency increased with increasing tannins concentration in chloride solution at pH 6. Treatment of aluminium alloy 6061 with all concentrations of mangrove tannins reduced the current density, thus decreased the corrosion rate. Tannins behaved as mixed inhibitors at pH 6 and reduction in current density predominantly affected in cathodic reaction. Meanwhile, at pH 12, addition of tannins shifted the corrosion potential to more cathodic potentials and a passivating effect was observed in anodic potentials. SEM studies have shown that the addition of tannins in chloride solution at pH 12 reduced the surface degradation and the formation of pits.
    Matched MeSH terms: Tannins
  7. Anti-nociceptive effect of caralluma edulis on peripheral and central pain pathways
    Firdoos S, Khan AU, Ali F
    Sains Malaysiana, 2017;46:1859-1863.
    The purpose of the present research was to evaluate the phytochemical content and analgesic effect of Caralluma edulis
    (Ce.Cr). Established methods were used for phytochemical analysis of plant. The anti-nociceptic activity of Ce.Cr was
    scrutinized using acetic acid-induced writhings, tail immersion and hot plate methods. Ce.Cr was tested positive for the
    presence of therapeutically active metabolites such as alkaloids, flavonoids, glycosides, phenol, tannins, terpenoids and
    saponins. Ce.Cr at the dose of 10, 30 and 100 mg/kg inhibited acetic acid-induced abdominal writhes and increase the
    latency time to thermal stimuli in both tail immersion and hot plate tests, similar to standard drug. These results showed
    that the ethanolic extract of Caralluma edulis possesses anti-nociceptive property.
    Matched MeSH terms: Tannins
  8. Fulltext Pressurized hot water extraction of hydrosable tannins from Phyllanthus tenellus Roxb
    Mohd Jusoh NH, Subki A, Yeap SK, Yap KC, Jaganath IB
    BMC Chem, 2019 Dec;13(1):134.
    PMID: 31891160 DOI: 10.1186/s13065-019-0653-0
    Background: Safety, environmental and economic setbacks are driving industries to find greener approaches to extract bioactive compounds from natural resources. Pressurized hot water extraction (PHWE) is among the solvent free and efficient methods for extracting bioactive compounds.

    Experimental: In this study, the suitability of PHWE for extracting bioactive compounds such as phenolics, hydrolysable tannins and flavonoids from Phyllanthus tenellus was investigated by UPLC-qTOF-MS.

    Results: Solvent properties of water are significantly increased through imposing temperature at 121 °C and pressure at 15 p.s.i. Pressurized hot water extraction obtained 991-folds higher hydrolysable tannins than methanol extraction.

    Conclusion: The extraction yields of hydrolysable tannins with PHWE was almost double of absolute methanol extraction.

    Matched MeSH terms: Hydrolyzable Tannins
  9. Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation
    Jalil J, Attiq A, Hui CC, Yao LJ, Zakaria NA
    Inflammopharmacology, 2020 Oct;28(5):1195-1218.
    PMID: 32617790 DOI: 10.1007/s10787-020-00734-2
    The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternatives in this scenario. Genus Uvaria is a part of Annonaceae family, while the majority of its species are widely distributed in tropical rain forest regions of South East Asia. Uvaria species have been used extensively used as traditional medicine for treating all sorts of inflammatory diseases including catarrhal inflammation, rheumatism, acute allergic reactions, hemorrhoids, inflammatory liver disease and inflamed joints. Phytochemical analysis of Uvaria species has revealed flavones, flavonoids, tannins, saponins, polyoxygenated cyclohexene and phenolic compounds as major phyto-constituents. This review is an attempt to highlight the anti-inflammatory activity of Uvaria species by conducting a critical appraisal of the published literature. The ethnopharmacological relevance of Uvaria species in the light of toxicological studies is also discussed herein. An extensive and relevant literature on anti-inflammatory activity of Uvaria species was collected from available books, journals and electronic databases including PubMed, ScienceDirect, Scopus, Proquest and Ovid. Extracts and isolates of Uvaria species exhibited significant anti-inflammatory activity through various mechanisms of action. 6,7-di-O-Methyl-baicalein, flexuvarol B, chrysin, (-)-zeylenol, 6-hydroxy-5,7-dimethoxy-flavone, and pinocembrin were the most potent anti-inflammatory compounds with comparable IC50 with positive controls. Therefore, it is suggested that further research should be carried out to determine the pharmacokinetics, pharmacodynamics and toxicity of these therapeutically significant compounds, to convert the pre-clinical results into clinical data for drug development and design.
    Matched MeSH terms: Tannins
  10. Fulltext Potential of Malaysian Cherry Leaves (Muntingia calabura) as an Antioxidant Agent
    Noor Hidayah Pungot, Nurul Auni Zainal Abidin, Nur Syafiqah Atikah Nazaharuddin
    Science Letters, 2020;14(2):103-109.
    MyJurnal
    Muntingia calabura has a high phytochemical content, especially the phenolic group that can act as antioxidant. In Malaysia country, this M. calabura also known as ‘kerukup siam’ or ‘Ceri Kampung’ and it belongs to Muntingiaceae family. This research was conducted to determine the potential of antioxidant activity application of cherry leaves (M. calabura) from various solvent extracts (methanol, ethyl acetate, and n-hexane). The phytochemical contents was screening by using the established standard procedure. Total phenolic content (TPC) was determined according to the Folin-Ciocalteau colorimetric method, while the antioxidant activity was carried out using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging assay. Phytochemical screening on the leaves part methanolic extracts revealed that the presence of various biochemicals like flavonoids, phenols, steroids, triterpenes, tannins, reducing sugars, and saponins except the alkaloids. Among the three extracts, the methanol leaf extract gave the highest content of phenolics (8.20 mg GAE/g extract). Analyses of antioxidant activity with DPPH method showed that cherry leaf methanolic extracts produced high antioxidant activity with IC50 value of 167.70 g/mL. The present study confirms that the presence of various phytochemicals which shows good antioxidant activity of M. calabura leaves. Therefore, it has the potential as a therapeutic antioxidant agent and can be used in cosmeceutical and food products.
    Matched MeSH terms: Tannins
  11. Fulltext Effect of germination on total phenolic, tannin and phytic acid contents in soy bean and peanut
    Megat Rusydi, M.R., Azrina, A.
    International Food Research Journal, 2012;19(2):673-677.
    MyJurnal
    Legume is a plant in the family of Fabacae or Leguminosae that rich in protein, carbohydrate, dietary fibre, and minerals. Germination of legume causes some important changes in the biochemical and a nutritional characteristic of the legumes that may be beneficial to human’s health and nutritional status. This study was carried out to determine the effect of germination on total phenolic, tannin and phytic acid contents of soy beans and peanut. The process of germination was carried out by soaking legumes in water for 6 hours, followed by germinating them in wet muslin cloth for 48 hours. After germination, samples were dried and stored in refrigerator before analysis. Total phenolic, tannin and phytic acid were determined spectrophotometrically. Total phenolic contents were decreased significantly (p
    Matched MeSH terms: Tannins
  12. Pomegranate peel-derived punicalagin: Ultrasonic-assisted extraction, purification, and its α-glucosidase inhibitory mechanism
    Liu Y, Kong KW, Wu DT, Liu HY, Li HB, Zhang JR, et al.
    Food Chem, 2022 Apr 16;374:131635.
    PMID: 34823934 DOI: 10.1016/j.foodchem.2021.131635
    The pomegranate peel is a by-product of pomegranate fruit rich in polyphenols. In this study, pomegranate peel polyphenols were explored using LC-MS/MS, and punicalagin was the most abundant compound. The highest yield (505.89 ± 1.73 mg/g DW) of punicalagin was obtained by ultrasonic-assisted extraction (UAE) with the ethanol concentration of 53%, sample-to-liquid ratio of 1:25 w/v, ultrasonic power of 757 W, and extraction time of 25 min. Punicalagin was further purified by the macroporous resin D101 and prep-HPLC, reaching the purity of 92.15%. The purified punicalagin had the IC50 of 82 ± 0.02 µg/mL against α-glucosidase, similar to the punicalagin standard with IC50 of 58 ± 0.014 µg/mL, both exhibiting a mixed inhibitory mechanism. Molecular docking further revealed that a steric hindrance with the intermolecular energy of -7.99 kcal/mol was formed between punicalagin and α-glucosidase. Overall, pomegranate peel is a promising source of punicalagin to develop anti-diabetic functional foods.
    Matched MeSH terms: Hydrolyzable Tannins
  13. Sustainable approach in phlorotannin recovery from macroalgae
    Chia SR, Show PL, Phang SM, Ling TC, Ong HC
    J Biosci Bioeng, 2018 Aug;126(2):220-225.
    PMID: 29673988 DOI: 10.1016/j.jbiosc.2018.02.015
    In this present study, alcohol/salt liquid biphasic system was used to extract phlorotannin from brown macroalgae. Liquid biphasic system is a new green technology that integrated with various processes into one-step, by concentrating, separating and purifying the bioproduct in a unit operation. The solvent used is non-toxic and there is potential for solvent recovery which is beneficial to the environment. Phlorotannin is a bioactive compound that has gained much attention due to its health beneficial effect. Therefore, the isolation of phlorotannin is lucrative as it contains various biological activities that are capable to be utilised into food and pharmaceutical application. By using 2-propanol/ammonium sulphate system, the highest recovery of phlorotannin was 76.1% and 91.67% with purification factor of 2.49 and 1.59 from Padina australis and Sargassum binderi, respectively. A recycling study was performed and the salt phase of system was recycled where maximum salt recovery of 41.04% and 72.39% could be obtained from systems containing P. australis and S. binderi, respectively. Similar recovery of phlorotannin was observed after performing two cycles of the system, this concludes that the system has good recyclability and eco-friendly.
    Matched MeSH terms: Tannins/isolation & purification*
  14. Texturized mung bean protein as a sustainable food source: techno-functionality, anti-nutrient properties, in vivo protein quality and toxicity
    Brishti FH, Chay SY, Muhammad K, Rashedi Ismail-Fitry M, Zarei M, Saari N
    Food Funct, 2020 Oct 21;11(10):8918-8930.
    PMID: 32996964 DOI: 10.1039/d0fo01463j
    Mung bean is gaining attention as a sustainable and economic source of plant protein. The current study evaluates the techno-functionality, anti-nutrient properties, in vivo protein quality and toxicity of texturized mung bean protein (TMBP) produced under optimized conditions. Our work successfully produces TMBP with improved techno-functionalities that are crucial for meat-based food applications, credited to retained juiciness and fat-binding ability. Alkaline extraction and extrusion significantly reduce trypsin inhibitor, phytic acid and tannin content in TMBP. An in vivo study using Sprague-Dawley rats reveals the good protein quality of TMBP, with a true protein digestibility of 99.26% resembling casein (99.36%, control protein), a net protein utilization of 63.99% and a biological value of 64.46%. The good protein quality, increased lean muscle mass along with reduced cholesterol and triglyceride secures TMBP's potential as a Protein meal replacer and dietary suplement. Non-toxicity of TMBP is confirmed by normal serum biochemical parameters and healthy organs, ascertaining the safety of alkaline extraction. The current study elucidates the production of TMBP with improved techno-functionalities (for meat-based food applications), reduced anti-nutritional factors and high quality (for weight-watchers and malnourished individuals).
    Matched MeSH terms: Tannins/analysis
  15. Fulltext Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer
    Ganesan T, Sinniah A, Chik Z, Alshawsh MA
    Nutrients, 2020 Aug 13;12(8).
    PMID: 32823596 DOI: 10.3390/nu12082430
    Punicalagin (PU), a polyphenol extracted from pomegranate (Punica granatum) husk is proven to have anti-cancer effects on different types of cancer including colorectal cancer (CRC). Its role in modulating endogenous protein as a means of eliciting its anti-cancer effects, however, has not been explored to date. Hence, this study aimed to investigate the role of PU in modulating the interplay between apoptosis and autophagy by regulating Annexin A1 (Anx-A1) expression in HCT 116 colorectal adenocarcinoma cells. In the study, selective cytotoxicity, pro-apoptotic, autophagic and Anx-A1 downregulating properties of PU were shown which indicate therapeutic potential that this polyphenol has against CRC. Autophagy flux analysis via flow cytometry showed significant autophagosomes degradation in treated cells, proving the involvement of autophagy. Proteome profiling of 35 different proteins in the presence and absence of Anx-A1 antagonists in PU-treated cells demonstrated a complex interplay that happens between apoptosis and autophagy that suggests the possible simultaneous induction and inhibition of these two cell death mechanisms by PU. Overall, this study suggests that PU induces autophagy while maintaining basal level of apoptosis as the main mechanisms of cytotoxicity via the modulation of Anx-A1 expression in HCT 116 cells, and thus has a promising translational potential.
    Matched MeSH terms: Hydrolyzable Tannins/pharmacology*
  16. Pleiotropic ameliorative effects of ellagitannin geraniin against metabolic syndrome induced by high-fat diet in rats
    Cheng HS, Goh BH, Phang SCW, Amanullah MM, Ton SH, Palanisamy UD, et al.
    Nutrition, 2020 08 12;79-80:110973.
    PMID: 32916379 DOI: 10.1016/j.nut.2020.110973
    OBJECTIVES: Metabolic syndrome (MetS), a multiplex risk factor for cardiovascular disease and type 2 diabetes, is increasingly prevalent worldwide. Ellagitannin geraniin, a polyphenol found in the rind of rambutan (Nephelium lappaceum), has demonstrated therapeutic effects against metabolism dysfunction. The aim of this study was to characterize the metabolic effects and possible mechanism of geraniin in rats with MetS induced by a high-fat diet (HFD).

    METHODS: MetS was induced in Sprague Dawley rats on an HFD, followed by a daily oral gavage of geraniin (25 mg/kg) for 4 wk. The outcomes of geraniin-treated rats were compared with those of untreated rats on either a control diet or an HFD and with rats with MetS treated with metformin on a daily basis (200 mg/kg).

    RESULTS: The supplementation of geraniin ameliorated multiple metabolic abnormalities caused by HFD, including hypertension, impaired glucose and lipid metabolism, ectopic fat deposition in the visceral fat and liver, and disturbed antioxidant mechanism and inflammatory response. The benefits conferred by geraniin were comparable to metformin. Transcriptomic analysis revealed a profound influence of geraniin on the hepatic expression profiles. The lipid and steroid metabolic processes that were aberrantly activated by HFD were suppressed by geraniin. Based on the differential transcriptomes, geraniin also exerted a significant modulatory effect on the expression of mitochondrial genes, potentially influencing the mitochondrial activity and leading to the observed beneficial effects.

    CONCLUSION: Geraniin supplementation mitigated metabolic anomalies of MetS in rats, making it an attractive drug candidate for further investigation.

    Matched MeSH terms: Hydrolyzable Tannins/pharmacology
  17. Gambir, "Gambir Sarawak" and toad venom
    Lim WJ, Yap AT, Mangudi M, Hu CY, Yeo CY, Eyo ZW, et al.
    Drug Test Anal, 2017 Mar;9(3):491-499.
    PMID: 27367276 DOI: 10.1002/dta.2034
    Matched MeSH terms: Tannins/analysis
  18. A tannin-based agent for coagulation and flocculation of municipal wastewater: Chemical composition, performance assessment compared to Polyaluminum chloride, and application in a pilot plant
    Hameed YT, Idris A, Hussain SA, Abdullah N
    J Environ Manage, 2016 Dec 15;184(Pt 3):494-503.
    PMID: 27789092 DOI: 10.1016/j.jenvman.2016.10.033
    Chemical composition and flocculation efficiency were investigated for a commercially produced tannin - based coagulant and flocculant (Tanfloc). The results of Fourier Transform Infrared Spectroscopy (FTIR) and Energy Dispersive Spectroscopy (EDX) confirmed what claimed about the chemical composition of Tanfloc. For moderate polluted municipal wastewater investigated in both jar test and pilot plant, Tanfloc showed high turbidity removal efficiency of approximately 90%, while removal efficiencies of BOD5 and COD were around 60%. According to floc size distribution, Tanfloc was able to show distinct performance compared to Polyaluminum chloride (PAC). While 90% of flocs produced by Tanfloc were smaller than 144 micron, they were smaller than 96 micron for PAC. Practically, zeta potential measurement showed the cationic nature of Tanfloc and suggested coincidence of charge neutralization and another flocculation mechanism (bridging or patch flocculation). Sludge Volumetric Index (SVI) measurements were in agreement with the numbers found in the literature, and they were less than 160 mL/g. Calcium cation as flocculation aid showed significant improvement of flocculation efficiency compared to other cations. Finally Tanfloc showed competing performance compared to PAC in terms of turbidity, BOD5 and COD removal, floc size and sludge characteristics.
    Matched MeSH terms: Tannins/chemistry*
  19. Fulltext Tropical plant extracts as potential antihyperglycemic agents
    Manaharan T, Palanisamy UD, Ming CH
    Molecules, 2012;17(5):5915-23.
    PMID: 22609782 DOI: 10.3390/molecules17055915
    Preliminary investigations on 14 plant extracts (obtained by ethanolic and aqueous extraction) identified those having high antioxidant and a significant total phenolic content. Antihyperglycemic, α-amylase and α-glucosidase inhibition activities were also observed. A correlation between the antihyperglycemic activity, total phenolic content and antioxidant (DPPH scavenging) activity was established. To further substantiate these findings, the possibility of tannins binding non-specifically to enzymes and thus contributing to the antihyperglycemic activity was also investigated. Our study clearly indicated that the antihyperglycemic activity observed in the plant extracts was indeed not due to non-specific tannin absorption.
    Matched MeSH terms: Tannins/metabolism
  20. Evaluating belinjau (Gnetum gnemon L.) seed flour quality as a base for development of novel food products and food formulations
    Bhat R, binti Yahya N
    Food Chem, 2014 Aug 1;156:42-9.
    PMID: 24629936 DOI: 10.1016/j.foodchem.2014.01.063
    Belinjau (Gnetum gnemon L.) seed flour was evaluated for nutritional composition, antioxidant activity and functional properties. Seed flour was found to be rich in protein (19.0g/100g), crude fibre (8.66g/100g), carbohydrates (64.1%), total dietary fibre (14.5%) and encompassed adequate amounts of essential amino acids, fatty acids and minerals. Antioxidant compounds such as total phenols (15.1 and 12.6mgGAE/100g), tannins (35.6 and 16.1mgCE/100g) and flavonoids (709 and 81.6mgCEQ/100g) were higher in ethanolic extracts over aqueous extracts, respectively. Inhibition of DPPH was high in ethanol extracts (48.9%) compared to aqueous extracts (19.7%), whereas aqueous extracts showed a higher FRAP value compared to ethanol extracts (0.98 and 0.61mmolFe(II)/100g, respectively). Results on functional properties revealed acceptable water and oil absorption capacities (5.51 and 1.98g/g, respectively), emulsion capacity and stability (15.3% and 6.90%, respectively), and foaming capacity (5.78%). FTIR spectral analysis showed seed flour to encompass major functional groups such as: amines, amides, amino acids, polysaccharides, carboxylic acids, esters and lipids. As belinjau seed flour possesses a rich nutraceutical value, it has high potential to be used as a basic raw material to develop new low cost nutritious functional foods.
    Matched MeSH terms: Tannins/analysis
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