Displaying publications 561 - 580 of 2311 in total

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  1. Lee B, Ibrahim SA, Zhang T
    JMIR Mhealth Uhealth, 2021 Nov 11;9(11):e32093.
    PMID: 34748515 DOI: 10.2196/32093
    BACKGROUND: The COVID-19 pandemic increased attention to digital tools to support governmental public health policies in East and South-East Asia. Mobile apps related to the COVID-19 pandemic continue to emerge and evolve with a wide variety of characteristics and functions. However, there is a paucity of studies evaluating such apps in this region, with most of the available studies conducted in the early days of the pandemic.

    OBJECTIVE: This study aimed to examine free apps developed or supported by governments in the East and South-East Asian region and highlight their key characteristics and functions. We also sought to interpret how the release dates of these apps were related to the commencement dates of other COVID-19 public health policies.

    METHODS: We systematically searched for apps in Apple App Store and Google Play Store and analyzed the contents of eligible apps. Mobile apps released or updated with COVID-19-related functions between March 1 and May 7, 2021, in Singapore, Taiwan, South Korea, China (mainland), Japan, Thailand, Hong Kong, Vietnam, Malaysia, Indonesia, and the Philippines were included. The CoronaNet Research Project database was also examined to determine the timeline of public health policy commencement dates in relation to the release dates of the included apps. We assessed each app's official website, media reports, and literature through content analysis. Descriptive statistics were used to summarize relevant information gathered from the mobile apps using RStudio.

    RESULTS: Of the 1943 mobile apps initially identified, 46 were eligible, with almost 70% of the apps being intended for the general public. Most apps were from Vietnam (n=9, 20%), followed by Malaysia, Singapore, and Thailand (n=6 each, 13%). Of note, most apps for quarantine monitoring (n=6, 13%) were mandatory for the target users or a population subset. The most common function was health monitoring (32/46, 70%), followed by raising public health awareness (19/46, 41%) through education and information dissemination. Other functions included monitoring quarantine (12/46, 26%), providing health resources (12/46, 26%). COVID-19 vaccination management functions began to appear in parallel with vaccine rollout (7/46, 15%). Regarding the timing of the introduction of mobile solutions, the majority of mobile apps emerged close to the commencement dates of other public health policies in the early stages of the pandemic between March and April 2020.

    CONCLUSIONS: In East and South-East Asia, most governments used mobile health apps as adjuncts to public health measures for tracking COVID-19 cases and delivering credible information. In addition, these apps have evolved by expanding their functions for COVID-19 vaccination.

    Matched MeSH terms: China
  2. Yan M, Yu Y, Li S, Zhang P, Yu J
    J Med Internet Res, 2024 Oct 31;26:e59142.
    PMID: 39481094 DOI: 10.2196/59142
    BACKGROUND: Diabetes poses a significant public health challenge in China and globally, with the number of patients expected to reach 592 million by 2035, notably in Asia. In China alone, an estimated 140 million individuals are living with diabetes, and a significant portion is nonadherent to medications, underscoring the urgency of effective management strategies. Recognizing the necessity of early and comprehensive management for newly diagnosed patients with type 2 diabetes, this study leverages an online teach-back method and "Internet + Nursing" platform based on King's Theory of Goal Attainment. The approach aims to enhance glycemic control and reduce fear and misconceptions about the disease, addressing both the educational and emotional needs of the patients.

    OBJECTIVE: The primary aim of this study was to assess the effectiveness of King's Goal Attainment Theory in the management of newly diagnosed patients with type 2 diabetes. This research sought to develop a collaborative model for blood glucose management, integrating the expertise and roles of physicians, nurses, and patients. The model is designed to enhance the synergy in health care provision, ensuring a comprehensive approach to diabetes management.

    METHODS: In this study conducted at Changzhou Traditional Chinese Medicine Hospital between January 2022 and February 2023, eligible patients were randomized into a control group or an online feedback group. The control group received standard care, while the online feedback group participated in a King's Theory of Goal Attainment-based online teach-back program, enhanced by "Internet + Nursing" strategies. This included an interactive platform for goal planning, video content sharing, comprehension assessment, misconception correction, and patient-driven recaps of disease information. Health monitoring was facilitated through the "Internet + Nursing" platform. The study focused on comparing changes in glucose metabolism and emotional disorder symptoms between the groups to evaluate the intervention's effectiveness.

    RESULTS: Following a 24-week intervention, we observed significant differences in key metrics between the online feedback group and the control group, each comprising 60 participants. The online feedback group demonstrated significant reductions in fasting plasma glucose, 2-hour postprandial glucose, and hemoglobin A1c (P

    Matched MeSH terms: China
  3. Gu X, Hassan NC, Sulaiman T, Wei Z, Dong J
    PLoS One, 2024;19(11):e0313405.
    PMID: 39561125 DOI: 10.1371/journal.pone.0313405
    Internet access for adolescents is becoming more prevalent around the world. Although video game playing has been verified to be negatively related to adolescent academic achievement, the mechanisms underlying this relationship are also unknown. Using a nationally representative sample of adolescents from the China Education Panel Survey (2014-2015), this study aims to explore the parallel mediation roles of self-educational expectation and learning attitude in the link between video game playing and academic achievement, and whether the direct and indirect effects are moderated by parent-child relationship. The results indicate that video game playing in adolescents is both directly and indirectly related to their academic achievement, and self-educational expectation and learning attitude partially mediate this association. Moreover, the results reveal that parent-child relationship moderates the direct association between video game playing and academic achievement as well as the indirect association of video game playing on academic achievement via self-educational expectation, respectively. By showing empirical evidence for the usefulness of social cognitive theory to adolescents' academics in the Internet Age, our research provides a supplement to existing literature.
    Matched MeSH terms: China
  4. Bourtsalas ACT, Yepes IM, Tian Y
    J Environ Manage, 2023 Oct 15;344:118604.
    PMID: 37459814 DOI: 10.1016/j.jenvman.2023.118604
    This study analyzes the regional implications of China's 2017 import ban on plastic waste by examining U.S. census data. A statistically significant decrease in total U.S. plastic waste exports was found, dropping from about 1.4 million tons to 0.6 million tons in the post-ban period. California remained the top exporter, throughout both pre- and post-ban periods, while South Carolina exhibited the highest per capita exports. Malaysia emerged as the largest importer of U.S. plastic waste, followed by Vietnam, Indonesia, and Thailand. The ban also led to a change in the composition of the exported plastic waste. Ethylene polymers increased from 32.6% of total exports in the pre-ban period to 46.9% in the post-ban period. Other plastics (vinyl chloride polymers, styrene polymers, and for plastics not elsewhere specified or included) decreased from 67.4% of total exports in the pre-ban period to 53.1% in the post-ban period. Moreover, we found that exporting plastic waste has significant environmental and human health impacts. For example, the Global Warming Potential (GWP) decreased from 20 million tons CO2-eq in the scenario where 100% of plastics are exported, or 25 million tons exported from the U.S. since 2002, to -11.1 million tons CO2-eq in the scenario where 100% of plastics are treated domestically. Transportation exacerbates these impacts for exported waste scenarios, increasing to 5.4 million tons CO2-eq when plastics are exported by ship while decreasing to 0.9 million tons CO2-eq for domestic treatment. Although exporting plastic waste is initially cost-effective, our study highlights that investing in domestic waste management can yield significant long-term benefits, considering the environmental and public health impacts. Therefore, it is crucial to prioritize context-specific solutions to address the challenges of the evolving global plastic waste landscape.
    Matched MeSH terms: China
  5. Kang J, Peng R, Feng J, Wei J, Li Z, Huang F, et al.
    BMJ Open, 2023 Sep 06;13(9):e075030.
    PMID: 37673450 DOI: 10.1136/bmjopen-2023-075030
    OBJECTIVE: To evaluate the health systems efficiency in China and Association of Southeast Asian Nations (ASEAN) countries from 2015 to 2020.

    DESIGN: Health efficiency analysis using data envelopment analysis (DEA) and stochastic frontier approach analysis.

    SETTING: Health systems in China and ASEAN countries.

    METHODS: DEA-Malmquist model and SFA model were used to analyse the health system efficiency among China and ASEAN countries, and the Tobit regression model was employed to analyse the factors affecting the efficiency of health system among these countries.

    RESULTS: In 2020, the average technical efficiency, pure technical efficiency and scale efficiency of China and 10 ASEAN countries' health systems were 0.700, 1 and 0.701, respectively. The average total factor productivity (TFP) index of the health systems in 11 countries from 2015 to 2020 was 0.962, with a decrease of 1.4%, among which the average technical efficiency index was 1.016, and the average technical progress efficiency index was 0.947. In the past 6 years, the TFP index of the health system in Malaysia was higher than 1, while the TFP index of other countries was lower than 1. The cost efficiency among China and ASEAN countries was relatively high and stable. The per capita gross domestic product (current US$) and the urban population have significant effects on the efficiency of health systems.

    CONCLUSIONS: Health systems inefficiency is existing in China and the majority ASEAN countries. However, the lower/middle-income countries outperformed high-income countries. Technical efficiency is the key to improve the TFP of health systems. It is suggested that China and ASEAN countries should enhance scale efficiency, accelerate technological progress and strengthen regional health cooperation according to their respective situations.

    Matched MeSH terms: China
  6. Li Z, Zhang F, Shi J, Chan NW, Tan ML, Kung HT, et al.
    Mar Pollut Bull, 2023 Nov;196:115653.
    PMID: 37879130 DOI: 10.1016/j.marpolbul.2023.115653
    Chromophoric dissolved organic matter (CDOM) occupies a critical part in biogeochemistry and energy flux of aquatic ecosystems. CDOM research spans in many fields, including chemistry, marine environment, biomass cycling, physics, hydrology, and climate change. In recent years, a series of remarkable research milestone have been achieved. On the basis of reviewing the research process of CDOM, combined with a bibliometric analysis, this study aims to provide a comprehensive review of the development and applications of remote sensing in monitoring CDOM from 2003 to 2022. The findings show that remote sensing data plays an important role in CDOM research as proven with the increasing number of publications since 2003, particularly in China and the United States. Primary research areas have gradually changed from studying absorption and fluorescence properties to optimization of remote sensing inversion models in recent years. Since the composition of oceanic and freshwater bodies differs significantly, it is important to choose the appropriate inversion method for different types of water body. At present, the monitoring of CDOM mainly relies on a single sensor, but the fusion of images from different sensors can be considered a major research direction due to the complex characteristics of CDOM. Therefore, in the future, the characteristics of CDOM will be studied in depth inn combination with multi-source data and other application models, where inversion algorithms will be optimized, inversion algorithms with low dependence on measured data will be developed, and a transportable inversion model will be built to break the regional limitations of the model and to promote the development of CDOM research in a deeper and more comprehensive direction.
    Matched MeSH terms: China
  7. Chen CF, He HY, Tong YX, Chen XL
    Sci Rep, 2024 Jan 23;14(1):1944.
    PMID: 38253608 DOI: 10.1038/s41598-024-52158-5
    To analyze the public opinion related to the employment situation, a combined approach is proposed to study the valuable ideas from social media. Firstly, the popularity of public opinion was analyzed according to the time series from a statistical point of view. Secondly, the feature extraction was carried out on the public opinion information, and the thematic analysis of the employment environment was carried out based on the Latent Dirichlet Allocation model. Thirdly, the Bert model was used to analyze the sentiment classification and trend of the employment-related public opinion data. Finally, the employment public opinion texts in different regions were studied based on the spatial sequence popularity analysis, keyword difference analysis. A case study in China is conducted to verify the effectiveness of proposed combined approach. Results shown that the popularity of employment public opinion reached the highest level in March 2022. Public opinions towards employment situation are negative. There is a specific relationship between the popularity of employment public opinion in different provinces.
    Matched MeSH terms: China
  8. Li X, Zhang F, Shi J, Chan NW, Cai Y, Cheng C, et al.
    Environ Sci Pollut Res Int, 2024 Feb;31(6):9333-9346.
    PMID: 38191729 DOI: 10.1007/s11356-023-31702-2
    As an inland dryland lake basin, the rivers and lakes within the Lake Bosten basin provide scarce but valuable water resources for a fragile environment and play a vital role in the development and sustainability of the local societies. Based on the Google Earth Engine (GEE) platform, combined with the geographic information system (GIS) and remote sensing (RS) technology, we used the index WI2019 to extract and analyze the water body area changes of the Bosten Lake basin from 2000 to 2021 when the threshold value is -0.25 and the slope mask is 8°. The driving factors of water body area changes were also analyzed using the partial least squares-structural equation model (PLS-SEM). The result shows that in the last 20 years, the area of water bodies in the Bosten Lake basin generally fluctuated during the dry, wet, and permanent seasons, with a decreasing trend from 2000 to 2015 and an increasing trend between 2015 and 2019 followed by a steadily decreasing trend afterward. The main driver of the change in wet season water bodies in the Bosten Lake basin is the climatic factors, with anthropogenic factors having a greater influence on the water body area of dry season and permanent season than that of wet season. Our study achieved an accurate and convenient extraction of water body area and drivers, providing up-to-date information to fully understand the spatial and temporal variation of surface water body area and its drivers in the basin, which can be used to effectively manage water resources.
    Matched MeSH terms: China
  9. Xu H, Zhang F, Li W, Shi J, Johnson BA, Tan ML
    Environ Monit Assess, 2023 Dec 27;196(1):94.
    PMID: 38150164 DOI: 10.1007/s10661-023-12249-8
    This study analyzed the spatial-temporal change pattern and underlying factors in production-living-ecological space (PLES) of Nanchong City, China, over the past 20 years using historical land use data (2000, 2010, 2020). A land use transfer matrix was calculated from the historical land use maps, and spatial analysis was conducted to analyze changes in the land use dynamics degree, standard deviation ellipse, and center of gravity. The results showed that there was a rapid spatial evolution of the PLES in Nanchong from 2000 to 2010, followed by a stabilization in the second decade. The transfer of ecological-production space occurred mainly in the Jialing and Yilong River basins, while the reduction of production space and the increase of living space were most prominent in the intersection of three districts (Shunqing, Jialing, and Gaoping districts). The return of production-ecological space was observed in the south and northeast of Yingshan, and there was little notable transfer of other types. The distribution of production space in Nanchong evolved in a north-south to east-west trend, with the center of gravity moving from Yilong to Peng'an County. The living space and production space expanded in a north-south direction, and the center of gravity position was in Nanbu, indicating a more balanced growth or decrease in the last 20 years. The changes in the spatial-temporal pattern of PLES in Nanchong were attributed to the intertwined factors of national policies, economic development, population growth, and the natural environment. This study introduced a novel approach towards rational planning of land resources in Nanchong, which may facilitate more sustainable urban planning and development.
    Matched MeSH terms: China
  10. Kurniawan TA, Liang X, Goh HH, Dzarfan Othman MH, Anouzla A, Al-Hazmi HE, et al.
    J Environ Manage, 2024 Feb;351:119879.
    PMID: 38157574 DOI: 10.1016/j.jenvman.2023.119879
    In recent years, food waste has been a global concern that contributes to climate change. To deal with the rising impacts of climate change, in Hong Kong, food waste is converted into electricity in the framework of low-carbon approach. This work provides an overview of the conversion of food waste into electricity to achieve carbon neutrality. The production of methane and electricity from waste-to-energy (WTE) conversion are determined. Potential income from its sale and environmental benefits are also assessed quantitatively and qualitatively. It was found that the electricity generation from the food waste could reach 4.33 × 109 kWh annually, avoiding equivalent electricity charge worth USD 3.46 × 109 annually (based on US' 8/kWh). An equivalent CO2 mitigation of 9.9 × 108 kg annually was attained. The revenue from its electricity sale in market was USD 1.44×109 in the 1st year and USD 4.24 ×109 in the 15th year, respectively, according to the projected CH4 and electricity generation. The modelling study indicated that the electricity production is 0.8 kWh/kg of landfilled waste. The food waste could produce electricity as low as US' 8 per kW ∙ h. In spite of its promising results, there are techno-economic bottlenecks in commercial scale production and its application at comparable costs to conventional fossil fuels. Issues such as high GHG emissions and high production costs have been determined to be resolved later. Overall, this work not only leads to GHG avoidance, but also diversifies energy supply in providing power for homes in the future.
    Matched MeSH terms: China
  11. Owen JR, Kemp D, Lechner AM, Ang Li Ern M, Lèbre É, Mudd GM, et al.
    J Environ Manage, 2024 Feb;351:119691.
    PMID: 38064991 DOI: 10.1016/j.jenvman.2023.119691
    Matched MeSH terms: China
  12. Huang L, Zhu Y, Liu H, Wang Y, Allen DT, Chel Gee Ooi M, et al.
    Environ Int, 2023 Jan;171:107710.
    PMID: 36566719 DOI: 10.1016/j.envint.2022.107710
    In recent years, ozone pollution in China has been shown to increase in frequency and persistence despite the concentrations of fine particulate matter (PM2.5) decreasing steadily. Open crop straw burning (OCSB) activities are extensive in China and emit large amounts of trace gases during a short period that could lead to elevated ozone concentrations. This study addresses the impacts of OCSB emissions on ground-level ozone concentration and the associated health impact in China. Total VOCs and NOx emissions from OCSB in 2018 were 798.8 Gg and 80.6 Gg, respectively, with high emissions in Northeast China (31.7%) and North China (23.7%). Based on simulations conducted for 2018, OCSB emissions are estimated to contribute up to 0.95 µg/m3 increase in annual averaged maximum daily 8-hour (MDA8) ozone and up to 1.35 µg/m3 for the ozone season average. The significant impact of OCSB emissions on ozone is mainly characterized by localized and episodic (e.g., daily) changes in ozone concentration, up to 20 µg/m3 in North China and Yangtze River Delta region and even more in Northeast China during the burning season. With the implementation of straw burning bans, VOCs and NOx emissions from OCSB dropped substantially by 46.9%, particularly over YRD (76%) and North China (60%). Consequently, reduced OCSB emissions result in an overall decrease in annual averaged MDA8 ozone, and reductions in monthly MDA8 ozone could be over 10 µg/m3 in North China. The number of avoided premature death due to reduced OCSB emissions (considering both PM2.5 and ozone) is estimated to be 6120 (95% Confidence Interval: 5320-6800), with most health benefits gained over east and central China. Our results illustrate the effectiveness of straw burning bans in reducing ozone concentrations at annual and national scales and the substantial ozone impacts from OCSB events at localized and episodic scales.
    Matched MeSH terms: China
  13. Zhao J, Wang C, Ibrahim H, Chen Y
    PLoS One, 2024;19(8):e0309099.
    PMID: 39163358 DOI: 10.1371/journal.pone.0309099
    The use of digital technology by banks and other financial institutions to facilitate financial inclusion is referred to as digital financial inclusion. This fusion of digital finance and traditional banking methods has the potential to impact banks' operational effectiveness. This study uses the panel effects model to examine the link between digital financial inclusion and bank performance in 30 Chinese provinces from 2012 to 2021. This research uses kernel density estimation to examine the spatial-temporal growth patterns of both variables. The mediator variable in examining how digital financial inclusion affects bank performance is risk-taking. Finally, the paper analyses the regional heterogeneity of the impact. It presents the following conclusions: (1) In China, digital financial inclusion and bank performance have constantly increased, with noticeable regional variances in their development levels. This regional inequality has widened gradually since 2018, yet it has not resulted in polarization. (2) The significant positive correlation between digital inclusive finance and banking performance indicates that banking performance tends to increase with the enhancement of digital inclusive finance. (3) Digital financial inclusion impacts bank performance, with risk-taking as a moderator. The spread of digital financial inclusion services enhances banks' willingness to take risks, enhancing overall efficiency. (4) Digital financial inclusion boosts bank performance in the Northwest, South, North, and East regions while lightly inhibiting it in the Central region. Based on the findings, this study makes bank and government suggestions.
    Matched MeSH terms: China
  14. Chen X, Keong CY, Mei X, Lan J
    PMID: 24508891 DOI: 10.1016/j.saa.2014.01.048
    Spaceflight represents a complex environmental condition. Space mutagenesis breeding has achieved and marked certain results over the years. This method was employed in our previous studies in order to obtain improved germplasm of Isatis indigotica. This study is to determine the chemical changes in I. indigotica seeds carried after Chinese first spaceship (Shenzhou I). Fourier transform infrared (FTIR), second derivative and two-dimensional infrared (2DIR) correlation spectroscopy were used in analysis. Not much differences between the two spectra were found except the peaks in the range of 1500-1200 cm(-)(1) which was about 7 cm(-)(1) different and indicated the absorption could be initialed from different bonds. SP4 showed different derivative compared with C4 in the second derivative spectra of 1200-800 cm(-)(1). The stronger signal of 2DIR in SP4 indicated the protein content of the seed was changed after spaceflight. It is concluded that spaceflight provided an extreme condition that caused changes of chemical properties in I. indigotica.
    Matched MeSH terms: China
  15. Abdullah JM, Wan Ismail WFN, Mohamad I, Ab Razak A, Harun A, Musa KI, et al.
    Malays J Med Sci, 2020 Mar;27(2):1-9.
    PMID: 32308536 DOI: 10.21315/mjms2020.27.2.1
    When the first report of COVID-19 appeared in December 2019 from Wuhan, China, the world unknowingly perceived this as another flu-like illness. Many were surprised at the extreme steps that China had subsequently taken to seal Wuhan from the rest of the world. However, by February 2020, the SARS-CoV-2 virus, which causes COVID-19, had spread so quickly across the globe that the World Health Organization officially declared COVID-19 a pandemic. COVID-19 is not the first pandemic the world has seen, so what makes it so unique in Malaysia, is discussed to avoid a future coronacoma.
    Matched MeSH terms: China
  16. Yu S, Fan D, Ge M, Chen Z
    PLoS One, 2024;19(12):e0314242.
    PMID: 39680565 DOI: 10.1371/journal.pone.0314242
    The article examines the spatial distribution characteristics and influencing factors of traditional Tibetan "Bengke" residential architecture in Luhuo County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province. The study utilizes spatial statistical methods, including Average Nearest Neighbor Analysis, Getis-Ord Gi*, and Kernel Density Estimation, to identify significant clustering patterns of Bengke architecture. Spatial autocorrelation was tested using Moran's Index, with results indicating no significant spatial autocorrelation, suggesting that the distribution mechanisms are complex and influenced by multiple factors. Additionally, exploratory data analysis (EDA), the Analytic Hierarchy Process (AHP), and regression methods such as Lasso and Elastic Net were used to identify and validate key factors influencing the distribution of these buildings. The analysis reveals that road density, population density, economic development quality, and industrial structure are the most significant factors. The study also highlights that these factors vary in impact between high-density and low-density areas, depending on the regional environment. These findings offer a comprehensive understanding of the spatial patterns of Bengke architecture and provide valuable insights for the preservation and sustainable development of this cultural heritage.
    Matched MeSH terms: China
  17. Wang C, Yuan Y, Ji X
    BMC Public Health, 2024 Sep 09;24(1):2451.
    PMID: 39252015 DOI: 10.1186/s12889-024-20001-1
    OBJECTIVE: The university period is a critical stage of personal development, and improving the physical fitness of university students is crucial to their academic performance, quality of life, and future. However, in recent years, the physical fitness level of Chinese university students has shown a decreasing trend. This study aimed to investigate the effects of a blended learning model on the physical fitness of Chinese university students through a 16-week intervention.

    METHODS: A total of 78 first-year students from a public university in Henan Province were recruited for this study via a cluster randomized controlled trial (CRCT) design. The participants were divided into an experimental group (blended learning) and a control group (traditional learning). The intervention lasted for 16 weeks, and physical fitness indices such as body mass index (BMI), lung capacity, sit and reach, pull-ups/sit-ups, standing long jumps, 50-meter runs, and 1000/800-meter runs were measured before and after the intervention. Statistical analyses were conducted via generalized estimating equation (GEE) modeling, with the significance level set at P 

    Matched MeSH terms: China
  18. Jingya B, Ye H, Jing W, Xi H, Tao H
    ScientificWorldJournal, 2013;2013:180863.
    PMID: 24453807 DOI: 10.1155/2013/180863
    To fully analyze and compare BMI among Han, Tibetan, and Uygur university students, to discuss the differences in their physical properties and physical health, and thus to provide some theoretical suggestions for the improvement of students' physical health.
    Matched MeSH terms: China/ethnology; China/epidemiology
  19. Venketasubramanian N, Tan LC, Sahadevan S, Chin JJ, Krishnamoorthy ES, Hong CY, et al.
    Stroke, 2005 Mar;36(3):551-6.
    PMID: 15692124
    Stroke prevalence data among mixed Asian populations are lacking. Prevalence rates of stroke were studied among Singaporeans aged > or =50 years of Chinese, Malay, and Indian origin.
    Matched MeSH terms: China/ethnology; China/epidemiology
  20. Tan MS, Cheah PL, Chin AV, Looi LM, Chang SW
    PeerJ, 2024;12:e17643.
    PMID: 39035156 DOI: 10.7717/peerj.17643
    BACKGROUND: Alzheimer's disease (AD) is the most common type of dementia that affects the elderly population. Lately, blood-based proteomics have been intensively sought in the discovery of AD biomarkers studies due to the capability to link external environmental factors with the development of AD. Demographic differences have been shown to affect the expression of the proteins in different populations which play a vital role in the degeneration of cognitive function.

    METHOD: In this study, a proteomic study focused on Malaysian Chinese and Malay prospects was conducted. Differentially expressed proteins (DEPs) in AD patients and normal controls for Chinese and Malays were identified. Functional enrichment analysis was conducted to further interpret the biological functions and pathways of the DEPs. In addition, a survey investigating behavioural practices among Chinese and Malay participants was conducted to support the results from the proteomic analysis.

    RESULT: The variation of dysregulated proteins identified in Chinese and Malay samples suggested the disparities of pathways involved in this pathological condition for each respective ethnicity. Functional enrichment analysis supported this assumption in understanding the protein-protein interactions of the identified protein signatures and indicate that differentially expressed proteins identified from the Chinese group were significantly enriched with the functional terms related to Aβ/tau protein-related processes, oxidative stress and inflammation whereas neuroinflammation was associated with the Malay group. Besides that, a significant difference in sweet drinks/food intake habits between these two groups implies a relationship between sugar levels and the dysregulation of protein APOA4 in the Malay group. Additional meta-analysis further supported the dysregulation of proteins TF, AHSG, A1BG, APOA4 and C4A among AD groups.

    CONCLUSION: These findings serve as a preliminary understanding in the molecular and demographic studies of AD in a multi-ethnic population.

    Matched MeSH terms: China/ethnology; China/epidemiology
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