Displaying publications 41 - 60 of 816 in total

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  1. Alpha-asarone attenuates depression-like behavior in nicotine-withdrawn mice: Evidence for the modulation of hippocampal pCREB levels during nicotine-withdrawal
    Chellian R, Pandy V, Mohamed Z
    Eur J Pharmacol, 2018 Jan 05;818:10-16.
    PMID: 29042206 DOI: 10.1016/j.ejphar.2017.10.025
    In the present study, the effect α-asarone on nicotine withdrawal-induced depression-like behavior in mice was investigated. In this study, mice were exposed to drinking water or nicotine solution (10-200µg/ml) as a source of drinking for forty days. During this period, daily fluid consumption, food intake and body weight were recorded. The serum cotinine level was estimated before nicotine withdrawal. Naïve mice or nicotine-withdrawn mice were treated with α-asarone (5, 10 and 20mg/kg, i.p.) or bupropion (10mg/kg, i.p.) for eight consecutive days and the forced swim test (FST) or locomotor activity test was conducted. In addition, the effect of α-asarone or bupropion on the hippocampal pCREB, CREB and BDNF levels during nicotine-withdrawal were measured. Results indicated that α-asarone (5, 10 and 20mg/kg, i.p.) or bupropion (10mg/kg, i.p.) pretreatment did not significantly alter the immobility time in the FST or spontaneous locomotor activity in naïve mice. However, the immobility time of nicotine-withdrawn mice was significantly attenuated with α-asarone (5, 10 and 20mg/kg, i.p.) or bupropion (10mg/kg, i.p.) pretreatment in the FST. Besides, α-asarone (5, 10 and 20mg/kg, i.p.) or bupropion (10mg/kg, i.p.) pretreatment significantly attenuated the hippocampal pCREB levels in nicotine-withdrawn mice. Overall, the present results indicate that α-asarone treatment attenuated the depression-like behavior through the modulation of hippocampal pCREB levels during nicotine-withdrawal in mice.
    Matched MeSH terms: Body Weight/drug effects
  2. Fulltext An Experimental Evaluation of Adaptogenic Potential of Standardized Epipremnum Aureum Leaf Extract
    Das SK, Sengupta P, Mustapha MS, Sarker MMR
    J Pharm Bioallied Sci, 2017 Apr-Jun;9(2):88-93.
    PMID: 28717330 DOI: 10.4103/0975-7406.183227
    BACKGROUND: Stress is a normal part of everyday life but chronic stress can lead to a variety of stress-related illnesses including hypertension, anxiety, and depression. In the present investigation, standardized leaf extract of Epipremnumaureum was evaluated for its anti-stress potential.

    MATERIALS AND METHODS: For the evaluation of anti-stress activity, groups of mice (n = 6) were subjected to forced swim stress and anoxic stress tolerance test in mice 1h after daily treatment of E.aureumextract. Diazepam (5 mg/kg) was taken as a reference standard. Urinary vanillylmandelic acid (VMA) and ascorbic acid were selected as noninvasive biomarkers to assess the anti-stress activity and plasma cortisol, blood ascorbic acid, and weight of adrenal were measured. The 24 h urinary excretion of VMA and ascorbic acid were determined by spectrophotometric methods in all groups under normal and stressed conditions. The hematological parameters (neutrophils, lymphocytes, and eosinophils) were also determined.

    RESULTS: Administration of E.aureumat doses of 400 and 600 mg/kg wasfound to be effective in inhibiting the stress induced urinary biochemical changes in a dose-dependent manner. Treatment with E. aureum extract prevents the rise in blood ascorbic acid and plasma cortisol. Moreover, the extract prevented the increase in weight of adrenal gland also significantly increased the anoxia stress tolerance time. Dose-dependent significant reduction in white blood cell count was observed in anoxic stress tolerance test as compared to stressed group.

    CONCLUSION: Hence, the present study provides scientific support for the positiveadaptogenic effect of E. aureum extract.
    Matched MeSH terms: Body Weight
  3. An age-independent anthropometric index of nutritional status
    Dugdale AE
    Am J Clin Nutr, 1971 Feb;24(2):174-6.
    PMID: 5545844 DOI: 10.1093/ajcn/24.2.174
    Matched MeSH terms: Body Weight
  4. Fulltext An assessment of dietary intake, food avoidance and food beliefs in patients with ulcerative colitis of different disease status
    Shafiee NH, Manaf ZA, Mokhtar NM, Raja Ali RA
    Intest Res, 2020 Oct;18(4):447-458.
    PMID: 32475103 DOI: 10.5217/ir.2019.00042
    BACKGROUND/AIMS: Ulcerative colitis (UC) is a chronic, relapsing and remitting inflammation of the gastrointestinal tract. Little is known about the link between dietary intake, food avoidance, and beliefs among UC patients of different disease severity. Therefore, this study aimed to assess the dietary intake, food avoidance, and beliefs among active and inactive UC patients.

    METHODS: A cross-sectional study was conducted among UC patients from a tertiary medical center in Kuala Lumpur, Malaysia. Demographic, anthropometric, dietary intake, food avoidance and beliefs were assessed. Disease activity of UC patients was evaluated using the Powell Tuck Index.

    RESULTS: UC patients were recruited (64.1% inactive UC and 35.9% active UC). As compared to inactive UC patients, active UC patients were likely to lose weight (75.0% vs. 0%), possess certain food beliefs (95.7% vs. 39.0%), and frequently practiced dietary avoidance (95.7% vs. 43.9%). The dietary intake among inactive UC patients was higher than active UC patients. However, neither of them met the standard nutrients recommendation for protein, calcium, iron, folate, zinc, vitamin D, vitamin B12, and vitamin E.

    CONCLUSIONS: Active UC patients had poorer dietary intake, were more prone to practicing food avoidance and exhibited certain food beliefs as compared to inactive UC patients. Both macro- and micronutrients intakes were inadequate regardless of patient's disease status. These findings emphasized the importance for patients to be provided with the nutrition-related knowledge as part of strategies to avoid nutritional inadequacies.

    Matched MeSH terms: Body Weight
  5. Fulltext An evaluation of eating behavior, psychosocial status and body mass index among adolescents in Malaysia
    Zuraida, A.S., Mohammad Basri, R., Ho, C.E.
    Malaysian Journal of Psychiatry, 2013;22(2):10-18.
    MyJurnal
    Objective: This study is an attempt to produce an abbreviated Malay version of Weight and Lifestyle Inventory (MWALI), as well as to examine the psychometric properties of the eating behavior which formed part of MWALI. Methods: The MWALI was translated ‘forward–backward’ from English to Malay and then administered to 135 adolescents. The factor construct of the 24-item eating behavior and the relationships between factor scores and demographic profile, dysphoria, global self-esteem and body mass index (BMI) were examined. Results: The exploratory factor analysis yielded five factors: Negative Emotion, Poor Impulse Control, Social Cues, Snacking and Early Meals in relation to over-eating. All the factors were significantly and positively correlated with BMI. Internal consistency and test-retest reliability of the eating behavior were satisfactory. Conclusion: MWALI is appropriate for assessing eating behavior among overweight and obese adolescents in the primary care setting in Malaysia.
    Matched MeSH terms: Body Weight
  6. Fulltext An introduction to the My Body is Fit and Fabulous at home (MyBFF@home): a community-based weight loss intervention study among Malaysian housewives
    Mohamad Nor NS, Ambak R, Aris T
    BMC Womens Health, 2018 07 19;18(Suppl 1):107.
    PMID: 30066634 DOI: 10.1186/s12905-018-0589-x
    BACKGROUND: The national prevalence of overweight and obesity in Malaysia has been increasing in the past 10 years and many efforts have been implemented by the Malaysian government to combat obesity problem among the Malaysian population. The aim of this paper was to describe the background of the My Body is Fit and Fabulous at home (MyBFF@home) study (Phase II).

    DISCUSSION: The MyBFF@home (Phase II) was a quasi-experimental study and it was conducted among overweight and obese housewives living in the urban areas in Malaysia. In this phase, the study involved a weight loss intervention phase (6 months) and a weight loss maintenance phase (6 months). The intervention group received a standard weight loss intervention package and the control group received group seminars related to women's health. Measurements of weight, height, waist circumference, body composition, fasting blood lipids, dietary intake, physical activity, health literacy, body pain and quality of life were conducted during the study. Overweight and obese housewives from 14 People's Housing/Home Project (PHP) in Federal Territory of Kuala Lumpur (Klang Valley) were selected as control and intervention group (N = 328). Majority of the participants (76.1%) were from the low socioeconomic group. Data were analysed and presented according to the specific objectives and the needs for the particular topic in the present supplement report.

    CONCLUSION: MyBFF@home is the first and the largest community-based weight loss intervention study which was conducted among overweight and obese housewives in Malaysia. Findings of the study could be used by the policy makers and the researchers to enhance the obesity intervention programme among female adults in Malaysia.

    Matched MeSH terms: Body Weight/physiology*
  7. Fulltext An investigation of links between metabolic rate and feed efficiency in European sea bass Dicentrarchus labrax
    Rodde C, de Verdal H, Vandeputte M, Allal F, Nati J, Besson M, et al.
    J Anim Sci, 2021 Jun 01;99(6).
    PMID: 33966070 DOI: 10.1093/jas/skab152
    Feed efficiency (FE) is the amount of body weight gain for a given feed intake. Improving FE through selective breeding is key for sustainable finfish aquaculture but its evaluation at individual level is technically challenging. We therefore investigated whether individual routine metabolic rate (RMR) was a predictor of individual FE in the European sea bass Dicentrarchus labrax, a major species in European mariculture. The European sea bass has three genetically distinct populations across its geographical range, namely Atlantic (AT), West Mediterranean (WM), and East Mediterranean (EM). We compared FE and RMR of fish from these three populations at 18 or 24 °C. We held 200 fish (62 AT, 66 WM, and 72 EM) in individual aquaria and fed them from ad libitum down to fasting. FI was assessed for an ad libitum feeding rate and for a fixed restricted ration (1% of metabolic body weight·day-1, with metabolic body weight = body weight0.8). After being refed 12 wk in a common tank, individual RMR was measured over 36 h by intermittent flow respirometry. There was a significant effect of temperature whereby fish at 18 °C had greater mean FE (P < 0.05) and lower RMR (P < 0.001). There was also a significant effect of population, where AT fish had lower FE (P < 0.05) and greater RMR (P < 0.001) than WM and EM, at both temperatures. Despite these differences in temperature and population means, individual FE and RMR were not significantly correlated (P > 0.05). Therefore, although the results provide evidence of an association between metabolic rate and FE, RMR was not a predictor of individual FE, for reasons that require further investigation.
    Matched MeSH terms: Body Weight
  8. Fulltext Animal leptospirosis in Malaya: 3. Incidence in rats by sex, weight and age
    Gordon Smith CE, Turner LH, Harrison JL, Broom JC
    Bull World Health Organ, 1961;24(6):807-16.
    PMID: 20604093
    In previous papers it has been demonstrated that ground-dwelling rats are the principal reservoir of leptospirosis in Malaya. The present paper considers the distribution of infection by sex and weight in the ten principal rat species. There appears to be a general tendency for females to be infected more frequently than males, but significant differences were demonstrated only in R. sabanus (more than three times as many females as males infected) and R. whiteheadi. In Malaya, where seasonal changes are minimal, weights can be used as a good index of age in rats. In rat species with a low incidence of infection the incidence appeared to rise steadily with age. In species with a medium incidence the infection rate rose at first with age, fell in the 6-8-month age-group, and then rose again. In high-incidence species the rate rose rapidly from the second month.There appear to be three types of enzootic infection; (1) intensive transmission of a single serogroup in a crowded population of rats of a single species (transmission probably being through urinary contamination of damp soil); (2) low-intensity transmission of several serogroups among ground-rats frequenting wet places (probably with urinary transmission); and (3) low-intensity transmission of several serogroups among ground-rats in dry places (the transmission may be venereal).
    Matched MeSH terms: Body Weight
  9. Fulltext Anorexia nervosa with comorbid borderline personality disorder, major depression and homosexuality in a young Malay man: a case report
    Osman Che Bakar, Ainsah Omar
    ASEAN Journal of Psychiatry, 2008;9(2):126-128.
    MyJurnal
    We aimed to report the first case of anorexia nervosa in a young Malaysian Malay homosexual man with underlying borderline personality disorder and major depression. Patient and parents were interviewed. The Structured Clinical Interview for DSM IV was used to generate Axis-I diagnosis. The Hamilton Depressive Rating Scale was used to assess the severity of depression. His parents had marital discord. His father was overinvolved. Regarding anorexia nervosa, he had 163 cm height, 46kg weight and a body mass index (BMI) of 17 kg/m2. His four limbs had multiple scratch marks. Laboratory test results showed anemia, leukocytosis and hypoalbuminemia. Family pathology, borderline personality disorder and homosexuality could be the risk factors of anorexia nervosa in this patient.
    Matched MeSH terms: Body Weight
  10. Fulltext Anthropometric Measurements and Body Composition of English and Malaysian Footballers
    Malays J Nutr, 1999;5(1):-.
    MyJurnal
    This comparative study was conducted to determine the anthropometric measurements and body composition of football teams in the UK and Malaysia. A total of 32 footballers from two teams were studied. The teams were the St Mary’s University team (UK) and the Selangor Reserved League team. The height and body weight of the subjects were measured using SECA digital balance with height attachment. Skinfold thickness measurements were taken using Harpenden skinfold callipers at four sites (biceps, triceps, subscapular and suprailiac) and the VO2 max of the subjects was estimated by participation in a multi-stage 20m shuttle-run test. The UK team were significantly heavier (p
    Matched MeSH terms: Body Weight
  11. Anthropometric and growth assessment of children receiving renal replacement therapy in Malaysia
    Karupaiah T, Chooi CH, Lim YN, Morad Z
    J Ren Nutr, 2002 Apr;12(2):113-21.
    PMID: 11953925
    To report on the anthropometric and growth status of children receiving renal replacement therapy (RRT) in Malaysia.
    Matched MeSH terms: Body Weight/physiology
  12. Anthropometric and physiological profiles of sepak takraw players
    Jawis MN, Singh R, Singh HJ, Yassin MN
    Br J Sports Med, 2005 Nov;39(11):825-9; discussion 825-9.
    PMID: 16244191
    OBJECTIVES: Anthropometric and physiological profiles of national sepak takraw players were determined.
    METHODS: Thirty nine players, specialising in the three playing positions (tekong/server, feeder, and killer/spiker) were divided into three age categories of under 15 (U15), under 18 (U18), and under 23 (U23) years of age. Height, weight, percent body fat (%bf), maximum oxygen consumption (Vo(2max)), range of motion (ROM), back and leg strength, and heart rate, for the estimation of oxygen consumption during matches, were recorded. Statistical analysis was performed using one way ANOVA for independent measurements and data are presented as mean+/-standard deviation.
    RESULTS: The U23 players were significantly taller and heavier with significantly better ROM of the neck, trunk, and ankle joints and back and leg strength than the U15 players. No significant difference was found in %bf between the three age categories. Mean maximum heart rate during exercise was significantly higher in the U15 group when compared to the U18 and U23 groups (p<0.05). Mean Vo2max was similar between the three groups. Estimated oxygen consumption during matches was 69.1%, 68.5%, and 56.4% of Vo2max in the killer, tekong, and the feeder groups, respectively.
    CONCLUSIONS: The mean height, body weight, and cardiopulmonary capacities of the players were within the Malaysian population norms, but were somewhat lower than those of players of other court games from other countries. %bf was also lower in these players. This study provides the much needed anthropometric and physiological data of sepak takraw players for further development of this sport.
    Matched MeSH terms: Body Weight/physiology
  13. Fulltext Anthropometric and reproductive factors among newly- diagnosed breast cancer patients and healthy women: a case-control study
    Zunura'in Z, Almardhiyah AR, Gan SH, Arifin WN, Sirajudeen K, Bhavaraju V, et al.
    Asian Pac J Cancer Prev, 2016;17(9):4439-4444.
    PMID: 27797258
    The objective of this case-control study was to determine anthropometric and reproductive factors associated with the development of breast cancer among women. Fifty-six newly diagnosed breast cancer patients were recruited from the Oncology Clinic, Universiti Sains Malaysia (USM), and 56 healthy female hospital employees were recruited as controls. Socio-demographic and reproductive data were obtained using a standard questionnaire. Anthropometric factors (body weight, height, body fat percentage, visceral fat and waist and hip circumference) were assessed. A high waist circumference (adjusted OR= 1.04, [95% CI: 1.00, 1.09]) and being more than 30 years of age at rst full-term pregnancy (adjusted OR=3.77, [95% CI: 1.10, 12.90]) were predictors of breast cancer development. The results of this study indicate that weight and reproductive health management should be emphasized for breast cancer prevention in Malaysia.

    Study site: Oncology clinic, Hospital Universiti Sains Malaysia (HUSM)
    Matched MeSH terms: Body Weight/physiology
  14. Fulltext Anthropometric correlates of motor performance among Malaysian university athletes
    Saidon Amri, Aris Fazil Ujang, Mohd Rozilee Wazir Norjali Wazir, Ahmad Naim Ismail
    Movement Health & Exercise, 2012;1(1):75-92.
    MyJurnal
    The purpose of this study was to investigate the relationship between anthropometric and motor performance and to determine the contribution of combined anthropometric dimensions on motor performance. A total of 225 male (n = 138) and female (n = 87) Malaysian university athletes aged
    between 18 and 28 years (M = 22.1, SD = 1.8) from 18 different team related sports and individual sports participated in this study. The subjects underwent anthropometric measurements (height, weight, BMI,% body fat, waist-hip ratio) and motor performance tests (grip strength - GS, back
    strength - BS, 7 level sit-up - SU7, 10m sprint - S10, 30m sprint - S30, sit and reach - SR, trunk extension test - TE, SEMO agility test - SEMO, vertical jump - VJ, standing long jump - SLJ, reaction time (audio) - RTa, reaction time (visual) - RTv, bleep test - Bleep, leg strength - LS, stork test– ST, and push-ups - PU). Descriptive analysis showed that anthropometric and performance difference between sports reflected the needs and requirements of the sports. Multivariate Analysis of Covariance (MANCOVA) and multiple regression analysis showed that height, weight, BMI, % body fat, waist-hip ratio contributed positively or negatively on specific components of motor performance. Among male athletes, all anthropometric were found to be a significant contributor to strength, vertical jump, cardiovascular endurance, while among females, only % body fat and WHR contributed significantly to abdominal strength, vertical jump and trunk extension. Findings of the study suggested that anthropometric characteristics that contributed to motor performance should provide a scientific rationale in selecting and training of athletes.
    Matched MeSH terms: Body Weight
  15. Fulltext Anthropometric measures and birth date distribution of student athletes in selected Malaysian state sports schools
    Ong, Kuan Boon, Hishamuddin Ahmad, Sanmuganathan Jegathesan, Lee, Ai Choo
    Jurnal Sains Sukan & Pendidikan Jasmani, 2015;4(1):17-24.
    MyJurnal
    Anthropometric measurements are widely used to determine body composition, size and weight, and proportions of the human body, especially in children. Our aim was to identify common physical characteristics of student athletes in selected Malaysia states sports schools. The ensuing analysis aimed to provide these states sports school athletes with a competitive advantage. Participants (n=317) were from student-athletes, aged between 13-14y and 15-16y staying in their school’s dormitory. These student-athletes comprise of 181 males (13-14y, n=138; 15-16y, n=43) and 136 females (13-14y, n=84; 15-16y, n=52). All subjects were measured on 26 anthropometric dimensions using measurements of four skin folds, six direct lengths, seven segment girths, six segment breadths, plus body mass, stretch stature and sitting height. The results showed significantly differences (p
    Matched MeSH terms: Body Weight
  16. Anthropometric status and resting metabolic rate in users of the areca nut and smokers of tobacco in rural Sarawak
    Strickland SS, Duffield AE
    Ann Hum Biol, 1997 Sep-Oct;24(5):453-74.
    PMID: 9300122
    The areca nut is chewed by many of the world's population, mainly in South and Southeast Asia. Anthropometric data for 458 Sarawaki adults aged over 24 years, measured both in 1990 and in 1996, were examined in relation to use of tobacco and areca nut. Compared to non-smokers, smoking men were significantly taller and slightly (not significantly) thinner in both years, while smoking women were thinner in 1990 and slightly (not significantly) thinner in 1996. In both sexes there was an increase in the mean and range of body mass index (BMI, W/H2) over the 6-year interval. Smoking women showed a significantly smaller increment in BMI after allowing for areca nut use, which was associated with a similar trend, and this finding depended on including areca use in the model. The trend for men was similar. Possible effects of areca use could reflect variation in 'affluence' or conservatism, or appetite suppression. However, resting metabolic rate in 54 men and 70 women aged 24-60 years was associated with areca use. This association appeared to be mediated by the maximum room temperature of the 24 h preceding measurement. In women, a significant curvilinear association of RMR with maximum temperature was found in users of areca nut but not in non-users. In men, RMR was 7% higher (p < 0.05) in users of areca nut than in non-users, after allowing for age, height, weight, the sum of four skinfold thicknesses, and haemoglobin, but the association with maximum temperature was similar in both groups. It is speculated that constituents of areca nut modulate thermoregulatory pathways, resulting in prolonged temperature-dependent and hyperthermic heat production in this population; that males are more responsive to this effect than females; and that by this mechanism, and possibly also through centrally mediated effects on appetite for food, areca use could contribute to long-term variation in energy balance represented by change in BMI.
    Matched MeSH terms: Body Weight*
  17. Fulltext Anthropometry and body composition status during Ramadan among higher institution learning centre staffs with different body weight status
    Rohin MA, Rozano N, Abd Hadi N, Mat Nor MN, Abdullah S, Dandinasivara Venkateshaiah M
    ScientificWorldJournal, 2013;2013:308041.
    PMID: 24311975 DOI: 10.1155/2013/308041
    This study was done to observe the anthropometry and body composition changes before, during, and after the holy month of Ramadan. This study was carried out on 46 staff from one of the local universities, which comprised of 14 males and 32 females ranging in age from 25 to 40 years old. There were four sessions done to complete this study, namely, a week before Ramadan (T1), 1st week of Ramadan (T2), 3rd week of Ramadan (T3), and a month after Ramadan (T4). All subjects were assessed according to weight, body circumference, and body composition status. It was found that subjects with different weight status showed a significant reduction in weight (P < 0.01) but no significant reduction in body fat percentage (P < 0.05). The findings suggest that weight reduction does not promise a reduction in body fat. Changes in neck circumference were only found in normal subjects. Hence, it can be said that overweight and obese subjects showed no changes in anthropometry status during Ramadan. No changes in body composition were reported in all three weight groups except for trunk body fat. In conclusion, normal subjects showed significant changes in various anthropometry parameters, but overweight and obese subjects showed no obvious difference.
    Matched MeSH terms: Body Weight/physiology*
  18. Fulltext Anthropometry measurements to determine nutritional status among cerebral palsy children: a scoping review
    Mahnon Suria Mokhy, Rosita Jamaluddin, Abd Rasyid Ismail, Woan Yie Siah, Norhasmah Sulaiman, Siti Nur ‘Asyura Adznam, et al.
    Malaysian Journal of Medicine and Health Sciences, 2020;16(106):213-218.
    MyJurnal
    This article aimed to review the available anthropometry measurements used in the assessment of nutritional sta- tus among Cerebral Palsy (CP) children. Searched journals were from Medline, PubMed and Ovid published from 2015 to 2018. The search identified 443 articles, and eight studies met the criteria. Anthropometric measurements included weight, height, recumbent length, knee height, tibia length, Dual-energy X-ray absorptiometry (DXA), Bio- electrical impedance (BIA), Mid arm circumference (MUAC) subscapular skinfold (SFT), Triceps skinfold (TSF) and prediction equations. Body fat composition can be obtained by DXA, BIA, skinfold measurement, and also prediction equation. The predictive equation is the most reported method to determine nutritional status among CP. This review found that TSF and SFT are more accurate to determine body fat percentage when using together with the predictive equation. Besides, predictive equations using segmental length are reliable in estimating the height and can be used to evaluate the nutritional status using the specific CP growth chart.
    Matched MeSH terms: Body Weight
  19. Fulltext Anti-Obesity Attributes; UHPLC-QTOF-MS/MS-Based Metabolite Profiling and Molecular Docking Insights of Taraxacum officinale
    Aabideen ZU, Mumtaz MW, Akhtar MT, Mukhtar H, Raza SA, Touqeer T, et al.
    Molecules, 2020 Oct 26;25(21).
    PMID: 33114490 DOI: 10.3390/molecules25214935
    The naturopathic treatment of obesity is a matter of keen interest to develop efficient natural pharmacological routes for disease management with low or negligible toxicity and side effects. For this purpose, optimized ultrasonicated hydroethanolic extracts of Taraxacum officinale were evaluated for antiobesity attributes. The 2,2-diphenyl-1-picrylhydrazyl method was adopted to evaluate antioxidant potential. Porcine pancreatic lipase inhibitory assay was conducted to assess the in vitro antiobesity property. Ultra-high performance chromatography equipped with a mass spectrometer was utilized to profile the secondary metabolites in the most potent extract. The 60% ethanolic extract exhibited highest extract yield (25.05 ± 0.07%), total phenolic contents (123.42 ± 0.007 mg GAE/g DE), total flavonoid contents (55.81 ± 0.004 RE/g DE), DPPH-radical-scavenging activity (IC50 = 81.05 ± 0.96 µg/mL) and pancreatic lipase inhibitory properties (IC50 = 146.49 ± 4.24 µg/mL). The targeted metabolite fingerprinting highlighted the presence of high-value secondary metabolites. Molecular-binding energies computed by docking tool revealed the possible contribution towards pancreatic lipase inhibitory properties of secondary metabolites including myricetin, isomangiferin, icariside B4, kaempferol and luteolin derivatives when compared to the standard drug orlistat. In vivo investigations revealed a positive impact on the lipid profile and obesity biomarkers of obese mice. The study presents Taraxacum officinale as a potent source of functional bioactive ingredients to impart new insights into the existing pool of knowledge of naturopathic approaches towards obesity management.
    Matched MeSH terms: Body Weight/drug effects
  20. Fulltext Anti-Obesity Effects of Melastoma malabathricum var Alba Linn in Rats Fed with a High-Fat Diet
    Karupiah S, Ismail Z
    AAPS PharmSciTech, 2015 Jun;16(3):548-53.
    PMID: 25374344 DOI: 10.1208/s12249-014-0245-1
    Obesity is one of the major public health problems worldwide and it is generally associated with many diseases. Although synthetic drugs are available for the treatment of obesity, herbal remedies may provide safe, natural, and cost-effective alternative to synthetic drugs. One example of such drugs is Melastoma malabathricum var Alba Linn (MM). Although several studies have been reported for the pharmacological activities of MM, there is no report on the anti-obesity effect of MM. The aim of the present study is to evaluate the anti-obesity potential of methanolic extract of MM. The anti-obesity effect of MM on rats fed with a high-fat diet was investigated through determination of the changes in body weight, fat weight, organ weights, and blood biochemicals. The animals in this study were divided into three groups: a normal group with a standard diet (N), a control group fed with high-fat diet (C), and a MM treatment group fed with high-fat (HFD + MM) diet for 8 weeks. There was no significant difference in the amount of food intake between control and HFD + MM treatments. These results also suggest that MM does not induce a dislike for the diet due to its smell or taste. The study shows that MM significantly prevented increases in body weight, cholesterol, LDL, HDL, and total lipids that resulted from the high-fat diet. MM also decreased the epididymal fat (E-fat) and retroperitoneal fat (R-fat) weights and phospholipid concentrations induced by the high-fat diet. On the basis of these findings, it was concluded that MM had anti-obesity effects by suppressing body weight gain and abdominal fat formation.
    Matched MeSH terms: Body Weight/drug effects
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