MyMedR

Fulltext Kimura's disease in Malaysian patients : three case reports

Roslan Abdul Rahman, Fadzilah Ismail, Roszalina Ramli, Ghazali Mat Nor, Sha Primuharsa Putra

Jurnal Sains Kesihatan Malaysia, 2005;3(1):1-8.

MyJurnal

Kimura's disease is a chronic inflammatory disorder which affects the subcutaneous tissues of the head and neck, axilla and upper limb as well as the groin region. In the head and neck region, major salivary glands and regional lymph nodes are mainly involved with associated eosinophilia and an elevated IgE concentration. Three cases of Kimura's disease involving the parotid glands, lymph nodes and cheek are presented with a brief review of the literature.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Fulltext Clozapine and Polycythemia Rubra Vera: a rare side effect or a separate medical condition? – a case report

Tan, H.P.J.

Malaysian Journal of Psychiatry, 2016;25(2):0-0.

MyJurnal

This article highlights the case of a 44-year old Malay man who is diagnosed as having treatment resistant schizophrenia on Clozapine, which then developed Polycythemia Rubra Vera (PRV). It is known that a major side effect for Clozapine is of agranulocytosis, that is a potentially fatal side effect. However, there have been reported disturbances of other hematological parameters, which result in other abnormalities including leucopenia, leucocytosis, thrombocytopenia, thrombocytosis and eosinophilia. Could this case be a pure medical condition of PRV or is there a relation to the effects of Clozapine? In this paper, the aim is to report a case of blood dyscrasia in a 44-year old male who developed Polycythemia Rubra Vera a year after he was observed to have abnormal full blood count results.

Matched MeSH terms: Eosinophilia

Fulltext Kimura Disease: A differential diagnosis in a nephrotic child

Aziz A, Mohamad I, Zawawi N

Malays Fam Physician, 2018;13(2):32-35.

PMID: 30302182

Kimura disease presents as benign lesion and is commonly present among the Asian population. It is a disease with a favourable prognosis and a peak age of onset in the third decade. It is a chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissues of the head and neck region. We report a case of a 15-year-old boy with multiple Kimura lymphadenopathies involving the left posterior auricular region as well as the anterior and posterior triangles of the neck.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Intradermal tests with Dirofilaria immitis extract in eosinophilic lung (tropical eosinophilia)

Danaraj TJ, Schacher JF

Am J Trop Med Hyg, 1959;8:640-643.

The intradermal test using as antigen a 1 per cent saline extract of Dirofilaria immitis powder was performed in Singapore on 69 persons with eosinophilic lung, 32 with mild eosinophilia, 49 with filariasis, 75 normal Asians, and 66 normal Britishers. The test was positive in 100 per cent of the cases of eosinophilic lung, 73.5 per cent of the filariasis group, 59.4 per cent of cases of mild eosinophilia, 53.3 per cent of normal Asians, and 4.5 per cent of the Britishers. The filarial complement fixation test using a 1 per cent alcoholic extract of the same antigen gave a positive rate of 100 per cent in the eosinophilic lung group, whereas only 24.5 per cent of the filariasis patients gave a positive reaction. Skin sensitivity to D. immitis antigen persisted in the cases of eosinophilic lung even when the previously positive serologic reactions had become negative following treatment with diethylcarbamazine. Therefore, the intradermal test cannot be useful in the diagnosis of either filariasis or eosinophilic lung in Singapore. In view of the skin sensitivity to a filarial antigen demonstrated in patients suffering from eosinophilic lung, the etiologic possibility of an infection by a species of filarial worm found normally in nonhuman hosts is discussed.

Matched MeSH terms: Eosinophilia

Fulltext Kimura's Disease: A Rare Cause of Nephrotic Syndrome with Lymphadenopathy

Othman SK, Daud KM, Othman NH

Malays J Med Sci, 2011 Oct;18(4):88-90.

PMID: 22589678

Kimura's disease is a rare condition and typically presents as non-tender subcutaneous swellings in the head and neck region, usually in the pre-auricular and submandibular areas. It is associated with lymphadenopathy (both local and distal), marked peripheral eosinophilia, and an elevated IgE level. It can easily be mistaken for a malignant disorder. Fine needle aspiration can be misleading, and a diagnosis is established only by histopathological examination. Renal involvement, which may affect up to 60% of patients, is the only systemic manifestation. We report a case of Kimura's disease in a Malay patient who was associated with steroid-responsive nephrotic syndrome.

Matched MeSH terms: Angiolymphoid Hyperplasia with Eosinophilia

Fulltext Hematological changes in subperiodic Brugia malayi infection of the leaf-monkey, Presbytis cristata

Choong MF, Mak JW

Southeast Asian J. Trop. Med. Public Health, 1991 Jun;22(2):168-70.

PMID: 1948274

Hematological changes were monitored in the leaf-monkey, Presbytis cristata, infected experimentally with 200 subperiodic Brugia malayi infective larvae. Prepatent periods were 54-86 days and peak microfilarial geometric mean counts (GMCs) were 1324 per ml blood. Total leukocyte and differential counts were measured at pre-infection, and then at weakly intervals before and during patency. Blood eosinophil level increased to about thrice the initial level at 3 weeks post-infection and this was maintained for the next 13 weeks before it started to rise again, increasing to more than 5 times the initial level at 20 weeks post-infection. The observed pattern of eosinophilia is probably related to the level of microfilaremia and the destruction of microfilariae in the spleen. There was no significant change in the total leukocyte counts during the period of observation.

Matched MeSH terms: Eosinophilia/blood

Fulltext A study of 31 patients with easy bruising from University Hospital, Kuala Lumpur

Chin NS, Koong PL

Med J Malaysia, 1990 Dec;45(4):325-8.

PMID: 2152054

Thirty one patients were investigated for the main complaint of easy bruising. These patients had normal platelet count with no past history of immune thrombocytopenia or systemic disorders known to predispose to bruising and a negative drug history. The evaluation of these patients included clinical review (history and physical examination) plus coagulation tests consisting of bleeding time, prothrombin time, partial thromboplastin time, thrombin time, fibrinogen level, FXIII screen and platelet functions test. Seven of the paediatric patients had acquired platelet dysfunction with eosinophilia (APDE). In 17 (94.4%) of the 18 adult patients no abnormality was demonstrated. Hence APDE was the commonest cause of easy bruising in children while the haemostatic defect contributing to easy bruising in adults remained unknown.

Matched MeSH terms: Eosinophilia/complications

Acute organic brain syndrome due to drug-induced eosinophilia

Ng SC, Lee MK, Teh A

Postgrad Med J, 1989 Nov;65(769):843-4.

PMID: 2616421

A 72 year old man developed acute organic brain syndrome associated with marked eosinophilia following self medication with a variety of drugs. Investigations revealed no other known causes of eosinophilia. Withdrawal of drugs resulted in dramatic drop in eosinophil count paralleled by clinical resolution of neurological problems. To our knowledge drug-induced eosinophilia has not previously been associated with acute organic brain syndrome.

Matched MeSH terms: Eosinophilia/chemically induced*

Fulltext Cutaneous drug eruptions

Adam BA

Med J Malaysia, 1982 Jun;37(2):110-3.

PMID: 6215559

Patients attending a referral Skin Clinic were studied to identify the spectrum of drug eruptions and the offending drugs. There were 51 patients with an incidence of five per thousand and equal sex incidence. Though the pattern of eruption was broadly similar to other reports, unusual reactions were observed. In addition to the skin manifestation, fever and lymphadenopathy were present in most patients. Raised erythrocyte sedimentation rate and eosinopoenia were commonly observed. Clinical acumen and the list of drugs ingested are still the best clues to the diagnosis ofdrug eruption.
Study site: Skin clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia

Matched MeSH terms: Eosinophilia/complications

Filarial antibodies and eosinophilia in human subjects in an endemic area

Wong MM, Guest MF

Trans R Soc Trop Med Hyg, 1969;63(6):796-800.

PMID: 5368008

Matched MeSH terms: Eosinophilia/etiology*

Intestinal parasites, eosinophilia, haemoglobin and gamma globulin of Malay, Chinese and Indian schoolchildren

Bisseru B, Abdul Aziz bin Ahmad

Med J Malaya, 1970 Sep;25(1):29-33.

PMID: 4098546

Matched MeSH terms: Eosinophilia/epidemiology*

Visceral larva migrans in Malaya. Report of a case

Lee HF, Danaraj TJ

Am J Trop Med Hyg, 1972 Mar;21(2):174-7.

PMID: 5061275

Matched MeSH terms: Eosinophilia/etiology

Ethanol extracts of various helminths in a complement fixation test for eosinophilic lung (tropical eosinophilia)

Pacheco G, Danaraj TJ

Am J Trop Med Hyg, 1963 Sep;12(5):745-7.

PMID: 14070764

Sera taken fortnightly from fourteen patients with eosinophilic lung (tropical eosinophilia) were tested by complement fixation with ethanol extracts of Dirofilaria immitis, Ascaris lumbricoides, Toxocara canis, Gnathostoma procyonis, Fasciola gigantica and Dipylidium caninum. Initially, sera from ten patients had high antibody titers with each of the extracts while antibodies were not detected in sera from the other four; after treatment with diethylcarbamazine the high titers decreased. It is concluded that the reactions obtained with these various extracts do not indicate infection with any particular helminth.

Matched MeSH terms: Eosinophilia*

Fulltext Vitamin D deficiency causing eosinophilic esophagogastroenteritis and ascites: a rare association

Qua CS, Peh KB, Saravannan K, Goh KL

BMJ Case Rep, 2021 Feb 04;14(2).

PMID: 33541947 DOI: 10.1136/bcr-2020-240039

A 54-year-old Chinese man presented with ascites for 2 weeks. He had a preceding 2-year history of intermittent dysphagia, lethargy and general malaise. Blood investigations revealed leucocytosis with eosinophilia of 26.5%, whereas paracentesis showed turbid fluid with high protein content (45 g/L) and a high white blood cell count of 5580/µL, predominantly eosinophils (90%). An incidental assay of vitamin D showed a very low level of 13.5 ng/mL. No other cause of ascites was found. Gastroscopy was normal except for duodenitis. However, biopsies from lower oesophagus confirmed the presence of eosinophilic infiltration. Following vitamin D replacement, the patient experienced marked improvement in symptoms of dysphagia within 2 weeks and no recurrence of ascites after 3 months. The reason for the patient's vitamin D deficiency remains unclear. The marked improvement in the patient's health indicates a causative role of vitamin D deficiency in causing eosinophilic esophagogastroenteritis and associated eosinophilic ascites.

Matched MeSH terms: Eosinophilia/diagnosis*

Genetic variants associated with phenytoin-related severe cutaneous adverse reactions

Chung WH, Chang WC, Lee YS, Wu YY, Yang CH, Ho HC, et al.

JAMA, 2014 Aug 6;312(5):525-34.

PMID: 25096692 DOI: 10.1001/jama.2014.7859

The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions remains unknown.

Matched MeSH terms: Eosinophilia/chemically induced*; Eosinophilia/genetics

Kinetics of IgA and eosinophils following a low-dose, predominantly Haemonchus contortus infection of Boer goats

Hayyan BN, Sharma RSK, Raimy N, Nisha M, Hussain K, Busin VM, et al.

Parasite Immunol., 2020 06;42(6):e12707.

PMID: 32118305 DOI: 10.1111/pim.12707

AIMS: Most breeds of goat are more susceptible to nematode infection than sheep, and this appears to be a consequence of less effective immune responses. Several papers have considered the effectiveness of eosinophils and immunoglobulin A (IgA) in goats but differences in the induction of responses have not been studied in the same detail. The aim of this study was to look at the induction of eosinophil and IgA responses in Boer goats reared indoors under intensive conditions.

METHODS AND RESULTS: The goats were experimentally infected with a low dose of 2400 Haemonchus contortus, Trichostrongylus spp. and Oesophagostomum spp. at a 6:1:1 ratio. Faecal egg counts (FEC), packed cell volume (PCV), IgA activity against third-stage larvae and peripheral eosinophilia were measured twice a week for eight weeks. The infection generated an IgA response but did not significantly increase peripheral eosinophilia in the 25 infected kids compared with the 4 control animals. FEC was not associated with IgA activity or eosinophilia.

CONCLUSION: A detailed analysis of IgA and eosinophil responses to deliberate nematode infection in Boer goats showed that there was an increase in nematode-specific IgA activity but no detectable eosinophil response. In addition, there was no association between increased IgA activity or eosinophilia with egg counts and worm burdens. These suggest that IgA and eosinophils do not act to control nematode infection in goats.

Matched MeSH terms: Eosinophilia/immunology*; Eosinophilia/parasitology

Fulltext ANCA-associated vasculitis - revisited, and its association with autoimmune thyroid disease

Lai Y, Nik Yahya NH, Ong SG

Med J Malaysia, 2014 Apr;69(2):98-100.

PMID: 25241822

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of uncommon diseases. Given its rarity and multisystem clinical presentation which are usually serious and potentially fatal, prompt recognition and early treatment are of utmost importance. We report a case of AAV that presented with digital infarcts, cutaneous vasculitis, rapidly progressive glomerulonephritis, mononeuritis multiplex, eosinophilia and positive myeloperoxidase (MPO)-ANCA antibody. Apart from renal damage, there was complete recovery in other systems following intravenous cyclophosphamide and high-dose glucocorticoids albeit the response was delayed. This response obviates the need for second-line therapy with newer agent such as rituximab (anti-CD20 monoclonal antibody). We would also like to highlight that this is the first case of AAV that is associated with autoimmune thyroid disease to be reported from Malaysia.

Matched MeSH terms: Eosinophilia

Fulltext Cutaneous Vasculitis as Early Presentation of Eosinophilic Granulomatosis with Polyangiitis without Systemic Symptoms

Sulaiman W, Abdullah AC, Chung SF, Karim N, Tang JJ

Oman Med J, 2019 Jul;34(4):345-349.

PMID: 31360325 DOI: 10.5001/omj.2019.67

Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) is a rare vasculitis in children. It commonly presents with respiratory symptoms, especially asthma, allergic rhinitis, and peripheral eosinophilia. Involvement of other systems, such as renal and cardiac, may carry a poor prognosis. Anti-neutrophil cytoplasmic antibodies have been found less frequently in children with this condition. We report a case of a 15-year-old male who presented with indurated and pruritic papules on both legs and peripheral eosinophilia without other system involvement. Histopathological findings from a skin biopsy were suggestive of eosinophilic granulomatosis with polyangiitis. Anti-neutrophil cytoplasmic antibodies were negative.

Matched MeSH terms: Eosinophilia

Personalised management of Chronic Obstructive Pulmonary Disease (COPD): Malaysian consensus algorithm for appropriate use of inhaled corticosteroid (ICS) in COPD patients

Marzuki NM, Jaeb MZM, Ban A, Ismail AI, Ali IAH, Razali NM, et al.

Med J Malaysia, 2020 11;75(6):717-721.

PMID: 33219183

BACKGROUND: Regarding the long-term safety issues with the use of inhaled corticosteroids (ICS) and the clinical predominance of dual bronchodilators in enhancing treatment outcomes in chronic obstructive pulmonary disease (COPD), ICS is no longer a "preferred therapy" according to the Global Initiative for Chronic Obstructive Lung Disease except on top of a dual bronchodilator. This has necessitated a change in the current therapy for many COPD patients.

OBJECTIVE: To determine a standardised algorithm to reassess and personalise the treatment COPD patients based on the available evidence.

METHODS: A consensus statement was agreed upon by a panel of pulmonologists in from 11 institutes in Malaysia whose members formed this consensus group.

RESULTS: According to the consensus, which was unanimously adopted, all COPD patients who are currently receiving an ICS-based treatment should be reassessed based on the presence of co-existence of asthma or high eosinophil counts and frequency of moderate or severe exacerbations in the previous 12 months. When that the patients meet any of the aforementioned criteria, then the patient can continue taking ICS-based therapy. However, if the patients do not meet the criteria, then the treatment of patients need to be personalised based on whether the patient is currently receiving long-acting beta-agonists (LABA)/ICS or triple therapy.

CONCLUSION: A flowchart of the consensus providing a guidance to Malaysian clinicians was elucidated based on evidences and international guidelines that identifies the right patients who should receive inhaled corticosteroids and enable to switch non ICS based therapies in patients less likely to benefit from such treatments.

Matched MeSH terms: Eosinophilia

The comparison of basal physiological values in racial groups. Part 3. Leucocytes (Total, differential and polynuclear (Arneth) cell counts)

Macgregor RGS, Loh GL

Journal of the Malaya Branch of the British Medical Association, 1941;4:405-37.

Matched MeSH terms: Eosinophilia

Displaying publications 41 - 60 of 85 in total