Displaying publications 61 - 80 of 302 in total

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  1. Suratman S, Hussein A, Latif M, Weston K
    Sains Malaysiana, 2014;43:1127-1131.
    Setiu Wetland is located in the southern part of South China Sea, Malaysia. This wetland has diverse ecosystems that represent a vast array of biological diversity and abundance in utilizable natural resources. However, there are large scales of aquaculture activities within and nearby the wetland which could threaten the ecosystems of this area. Thus, the main goal of the study was to assess the impact of these activities through the measurement of physico-chemical water quality parameters and then compare this to a previous study carried out in the same study area. The parameters (salinity, temperature, pH, dissolved oxygen, biological oxygen demand and total suspended solids) were monitored monthly at the surface water from July to October 2008. The results showed that the impact of aquaculture activities on the water quality in the area with dissolved oxygen and total suspended solids concentrations were considerably lower than those observed previously. With respect to the Malaysian Marine Water Quality Criteria and Standard, most of the level of parameters measured remained Class 1, suggesting the physico-chemical environment were in line with sustainable conservation of the marine protected areas and marine parks of this wetland area.
    Matched MeSH terms: Goals
  2. Azlan Jaafar, Wan Mohamad Nasir, Nazirah Ab Mumin, Nur Najwa Athirah Elias, Muhaimin Afnan Mohd Sabri
    MyJurnal
    One of the roles expected of dental personnel is to promote dental seeking behaviour to the public. It is to ensure that adults maintain an optimum number of teeth for overall health and quality of life by enabling them to eat, speak and socialise without pain, discomfort or embarrassment. The objective of this study was to determine the reasons for seeking dental care and the factors that influence this decision among adult patients. This was a retrospective study of clinical records among patients of 18 years old and above who attended Universiti Sains Islam Malaysia (USIM) Dental Polyclinic, an academic dental centre, for the first time from January 2015 to December 2016. Socio-demographic data on age, gender and occupation as well as the reason for the visit were retrieved from the clinical records. Analysis of data was conducted using SPSS software version 21.0 and the pvalue was set at p
    Matched MeSH terms: Goals
  3. Bonn GB
    Front Psychol, 2013;4:920.
    PMID: 24367349 DOI: 10.3389/fpsyg.2013.00920
    This paper examines the concept of free will, or independent action, in light of recent research in psychology and neuroscience. Reviewing findings in memory, prospection, and mental simulation, as well as the neurological mechanisms underlying behavioral control, planning, and integration, it is suggested in accord with previous arguments (e.g., Wegner, 2003; Harris, 2012) that a folk conception of free will as entirely conscious control over behavior should be rejected. However, it is argued that, when taken together, these findings can also support an alternative conception of free will. The constructive nature of memory and an integrative "default network" provide the means for novel and creative combinations of information, such as the imagining of counterfactual scenarios and alternative courses of action. Considering recent findings of extensive functional connections between these systems and those that subsume motor control and goal maintenance, it is argued that individuals have the capability of producing novel ideas and translating them into actionable goals. Although most of these processes take place beneath conscious awareness, it is argued that they are unique to the individual and thus, can be considered a form of independent control over behavior, or free will.
    Matched MeSH terms: Goals
  4. Ng WY, Low CX, Putra ZA, Aviso KB, Promentilla MAB, Tan RR
    Heliyon, 2020 Dec;6(12):e05730.
    PMID: 33364497 DOI: 10.1016/j.heliyon.2020.e05730
    Existing mitigation strategies to reduce greenhouse gas (GHG) emissions are inadequate to reach the target emission reductions set in the Paris Agreement. Hence, the deployment of negative emission technologies (NETs) is imperative. Given that there are multiple available NETs that need to be evaluated based on multiple criteria, there is a need for a systematic method for ranking and prioritizing them. Furthermore, the uncertainty in estimating the techno-economic performance levels of NETs is a major challenge. In this work, an integrated model of fuzzy analytical hierarchy process (AHP) and interval-extended Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is proposed to address the multiple criteria, together with data uncertainties. The potential of NETs is assessed through the application of this hybrid decision model. Sensitivity analysis is also conducted to evaluate the robustness of the ranking generated. The result shows Bioenergy with Carbon Capture and Storage (BECCS) as the most optimal alternative for achieving negative emission goals since it performed robustly in the different criteria considered. Meanwhile, energy requirement emerged as the most preferred or critical criterion in the deployment of NETs based on the decision-maker. This paper renders a new research perspective for evaluating the viability of NETs and extends the domains of the fuzzy AHP and interval-extended TOPSIS hybrid model.
    Matched MeSH terms: Goals
  5. Kunasegaran T, Mustafa MR, Achike FI, Murugan DD
    Eur J Pharmacol, 2017 Mar 15;799:160-170.
    PMID: 28213289 DOI: 10.1016/j.ejphar.2017.02.022
    Pioglitazone is an anti-diabetic drug with potential to cause adverse effects following prolonged use. This study, therefore, investigated the effects of combination treatment of a subliminal concentration of pioglitazone and quercetin, a potent antioxidant, on vascular reactivity of aorta isolated from fructose-streptozotocin (F-STZ)-induced diabetic rats. Relaxation to acetylcholine and sodium nitroprusside, and contraction to phenylephrine were tested in organ bath chambers following pre-incubation with vehicle (DMSO; 0.05%), quercetin (10-7 M), pioglitazone (10-7 M), or their combination (P+Q; 10-7 M each drug). Subliminal concentration of quercetin or pioglitazone did not alter the acetylcholine- induced relaxation nor the phenylephrine-induced contraction in both normal rat and diabetic F-STZ induced tissues. However, P+Q combination synergistically improved the impaired acetylcholine-induced relaxation and decreased the elevated phenylephrine-induced contraction in aortic rings from diabetic, but not in the normal rats. Neither mono nor combination treatment altered sodium nitroprusside-induced relaxation. The combination also synergistically decreased superoxide anion and increased nitric oxide production compared to the individual treatments in aorta from diabetic rats. Overall, these data demonstrated a synergistic effect, in which, a combination (P+Q; 10-7 M each drug) caused a significantly greater effect than 10-6 M of either agent in improving endothelial function of isolated diabetic aorta. In conclusion, a combination of subliminal concentrations of pioglitazone and quercetin is able to decrease oxidative stress and provide synergistic vascular protection in type 2 diabetes mellitus and thus the possibility of using quercetin as a supplement to pioglitazone in the treatment of diabetes with the goal of reducing pioglitazone toxicity.
    Matched MeSH terms: Goals
  6. Tan, J.H., Aishah A. Fauzi, Hasnan, N.
    JUMMEC, 2017;20(2):31-33.
    MyJurnal
    There is a high incidence of 36% to 83% of respiratory dysfunction in patients with acute cervical spinal cord
    injury. Complications arising from respiratory dysfunction remain one of the most common causes of morbidity
    and mortality in the spinal cord injured population. Specialized pulmonary care and therapy can help individuals
    with tetraplegia to maintain a stable respiratory status allowing active participation in active rehabilitation.
    This would allow them to achieve rehabilitation goals of independent function and community reintegration.
    Mechanical insufflation-exsufflation (MIE) therapy is an option for secretion management in individuals with
    acute spinal cord injury. In this paper, we present our experience using MIE as an adjunct to management of
    secretions in the spinal cord injured population at the University of Malaya Medical Centre.
    Matched MeSH terms: Goals
  7. Schramm J, Sivalingam S, Moreno GE, Thanh DQL, Gauvreau K, Doherty-Schmeck K, et al.
    Children (Basel), 2021 Mar 06;8(3).
    PMID: 33800765 DOI: 10.3390/children8030198
    Pulmonary vein stenosis (PVS) is a rare, but high mortality and resource intensive disease caused by mechanical obstruction or intraluminal myofibroproliferation, which can be post-surgical or idiopathic. There are increasing options for management including medications, cardiac catheterization procedures, and surgery. We queried the International Quality Improvement Collaborative for Congenital Heart Disease (IQIC) database for cases of PVS and described the cohort including additional congenital lesions and surgeries as well as infectious and mortality outcomes. IQIC is a quality improvement project in low-middle-income countries with the goal of reducing mortality after congenital heart surgery. Three cases were described in detail with relevant images. We identified 57 cases of PVS surgery, with similar mortality to higher income countries. PVS should be recognized as a global disease. More research and collaboration are needed to understand the disease, treatments, and outcomes, and to devise treatment approaches for low resource environments.
    Matched MeSH terms: Goals
  8. Chai S, Kueh YC, Yaacob NM, Kuan G
    Malays J Med Sci, 2019 Jan;26(1):115-124.
    PMID: 30914899 MyJurnal DOI: 10.21315/mjms2019.26.1.11
    Background: Understanding the individual aspirations of exercise participation is important for promoting physical activity. However, there is a lack of evidence to validate a measurement instrument for exercise-based goal content among Malaysian populations. The purpose of this study was to determine the validity and reliability of the Malay version of the Goal Content in Exercise Questionnaire (GCEQ) for a sample of Malaysian undergraduates.

    Methods: The original English version of the GCEQ underwent forward and backward translation into the Malay language. A cross-sectional study was conducted. The finalised Malay version was administered to 674 undergraduate students at the Health Campus of the Universiti Sains Malaysia (USM) with a mean age of 20.27 years (SD = 1.35 years). Confirmatory factor analysis (CFA) was conducted for the psychometric evaluation.

    Results: The measurement model consisted of 20 observed items and five latent factors. CFA demonstrated adequate fit to the data: comparative fit index = 0.929; standardised root mean square residual = 0.052; root mean square error of approximation = 0.061 (90% CI = 0.056, 0.067). The composite reliability coefficients for the five latent factors ranged from 0.777 to 0.851. All the correlations between the factors were less than 0.85, so discriminant validity was achieved.

    Conclusion: The findings suggested that the Malay version of the GCEQ is valid and reliable for assessing goal content in the exercise context of undergraduates at the Health Campus, USM.

    Matched MeSH terms: Goals
  9. Mou‘ad A.Tarawneh, Sahrim Hj. Ahmad, Ku Zarina K, Ibrahim N. Hassan, Yu Lih jiun, Moayad Husein Flaifel, et al.
    Sains Malaysiana, 2013;42:503-507.
    The main goal of this paper was to study the effect of ultrasonic treatment time on the mechanical properties of thermoplastic natural rubber(TPNR) reinforced with hybrid MWNTs-OMMT. The intercalation of TPNR enhancement into layers of clay by increasing the d-spacing was found using X-ray diffraction. The tensile properties of nanocomposites treated with ultrasonic increased when compared with untreated nanocomposites. The optimum ultrasonic treatment time was obtained at 3 h. The transmission electron microscope micrograph showed a combination of intercalated-exfoliated structure of the TPNR composites with organic clay and dispersion of MWNTs. The ultrasonic treatment can promote the dispersion of MWNTs-OMMT in TPNR and also improved the compatibility of hybrid filler and the TPNR matrix.
    Matched MeSH terms: Goals
  10. Gaaz TS, Sulong AB, Akhtar MN, Kadhum AA, Mohamad AB, Al-Amiery AA
    Molecules, 2015;20(12):22833-47.
    PMID: 26703542 DOI: 10.3390/molecules201219884
    The aim of this review was to analyze/investigate the synthesis, properties, and applications of polyvinyl alcohol-halloysite nanotubes (PVA-HNT), and their nanocomposites. Different polymers with versatile properties are attractive because of their introduction and potential uses in many fields. Synthetic polymers, such as PVA, natural polymers like alginate, starch, chitosan, or any material with these components have prominent status as important and degradable materials with biocompatibility properties. These materials have been developed in the 1980s and are remarkable because of their recyclability and consideration of the natural continuation of their physical and chemical properties. The fabrication of PVA-HNT nanocomposites can be a potential way to address some of PVA's limitations. Such nanocomposites have excellent mechanical properties and thermal stability. PVA-HNT nanocomposites have been reported earlier, but without proper HNT individualization and PVA modifications. The properties of PVA-HNT for medicinal and biomedical use are attracting an increasing amount of attention for medical applications, such as wound dressings, drug delivery, targeted-tissue transportation systems, and soft biomaterial implants. The demand for alternative polymeric medical devices has also increased substantially around the world. This paper reviews individualized HNT addition along with crosslinking of PVA for various biomedical applications that have been previously reported in literature, thereby showing the attainability, modification of characteristics, and goals underlying the blending process with PVA.
    Matched MeSH terms: Goals
  11. Chan CK, Cameron LD
    J Behav Med, 2012 Jun;35(3):347-63.
    PMID: 21695405 DOI: 10.1007/s10865-011-9360-6
    Self-regulation theory and research suggests that different types of mental imagery can promote goal-directed behaviors. The present study was designed to compare the efficacy of approach imagery (attainment of desired goal states) and process imagery (steps for enacting behavior) in promoting physical activity among inactive individuals. A randomized controlled trial was conducted with 182 inactive adults who received one of four interventions for generating mental images related to physical activity over a 4-week period, with Approach Imagery (approach versus neutral) and Process Imagery (process versus no process) as the intervention strategies. Participants received imagery training and practiced daily. Repeated measures ANOVAs revealed that Approach Imagery: (1) increased approach motivations for physical activity at Week 4; (2) induced greater intentions post-session, which subsequently induced more action planning at Week 4; (3) enhanced action planning when combined with process images at post-session and Week 1; and (4) facilitated more physical activity at Week 4 via action planning. These findings suggest that inducing approach orientation via mental imagery may be a convenient and low-cost technique to promote physical activity among inactive individuals.
    Matched MeSH terms: Goals*
  12. Niestanak, S. Abedi, Faieza, A.A., Sulaiman, S., Rosnah, M.Y.
    MyJurnal
    This study of the implementation of enterprise resource planning (ERP) in a customer driven environment analyzes the critical success factors throughout the initialization phase. The dynamic and stochastic nature of customer driven environments results in a massive workload of product structure configuration tasks related to new arrivals on one hand and a constant updating process on the other. Meanwhile, the development and implementation of an ERP system was studied from the very first step (i.e. the feasibly study for implementing an ERP) to the last step (i.e. testing the outputs of the implemented system) in an office furniture company for three years. The study involved analyzing of the data collected that were from a series of interviews, as well as direct observations and reviewing of the company’s documents. Based on the output of the analysis phase, a top-down hierarchical analysis of goals and CSFs were carried out according to the CSF analysis method. Three top level objectives included reducing project failure risk, project cost, and project time. Analysing the primary results of the study (i.e. activity model, data flow diagram DFD of different levels, system problems and potential solutions descriptions, etc.) revealed that the critical phase of the implementation project would be product structure initialization and this should be taken into consideration as the bottleneck of production planning in customer driven environment, which dramatically reduced the ERP efficiency in this kind of environment. Moreover, initializing issues of the same process is the main obstacle to the success of the ERP implementation, as it considerably raises the project failure risk and cost. Therefore, the simplification, facilitation, and automation of the PSCM process, which lead to acceleration of this process, are the most significant success factors for the ERP implementation projects in customer driven environment.
    Matched MeSH terms: Goals
  13. Amarra, Sofia, Chan, Pauline
    Malays J Nutr, 2013;19(1):139-142.
    MyJurnal
    Introduction: The Infant and Early Childhood Nutrition Task Force, International Life Sciences Institute Southeast Asia (ILSI SEA) Region, organised the 1st and 2nd Expert Consultation and Planning Meeting on Infant and Early Childhood Nutrition in 2009 and 2011, respectively. The goal of the consultations was “to generate and promote relevant science-based information that will help improve nutritional status, growth and development of infants and young children in Southeast Asia.” Methods: An Expert Panel Core Group was created whose role is to provide advice and recommendations through a review of current scientific knowledge regarding issues related to early childhood growth and nutrition. The Panel is composed of experts representing 7 countries (China, Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam). In July 2012, the Panel convened the 3rd Expert Consultation and Planning Meeting on Infant and Young Child Nutrition in Singapore. This report presents the highlights of the meeting and recommendations made by the Panel on ways to improve infant and young child nutrition in Southeast Asia. Results and Conclusion: The effective use of WHO indicators for assessing infant and young child feeding practices, mitigating the effects of maternal employment on breastfeeding, using behaviour change communication, updating the education of health personnel, and improving maternal health were considered important actions to be taken. Since current feeding practices in Southeast Asia fall short of WHO recommendations, studies are needed to develop strategies which take into consideration the diverse cultural settings that characterise the region.
    Matched MeSH terms: Goals
  14. Babalola Sunday Oyetayo, Abdulrahman Alias, Tan, Choon Liant, Mohammed Jawalludeen Sani, Shuaibu Umar
    MyJurnal
    One of the prime inspirations for this work emerge from the need to deal with our
    common assets (the Land). To build up a formal approach that can be utilized to
    address the issues emerges from a mind boggling circumstance in land
    administration. The capacity to track the progressions as it is connected to land
    everywhere throughout the year. A considerable lot of the land exchanges are as yet
    in light of 2D ideal models that have frustrated fast advancement in thickly urban
    condition. The consideration of 3D enhanced the functionalities of different models.
    Be that as it may, the dynamic idea of the land has an imperative part in the
    advancement of the land administration framework. One of the significant reason the
    expansion in intricacy in land utilize required that Land Administration Domain Model
    (LADM) concept in land administration has an enhanced limit is to deal with the
    current 2D and 3D. The need to talk about time dimension emerges from the way
    that individuals relationship to the land has an exceptionally powerful nature, all the
    LADM packages has time (Temporal) components. LADM completely bolster forming
    (historical information) as all classes inherit from VersionObject, and all LA_RRR
    object have the quality TimeSpace. 2D/3D space and time incorporation is not
    profoundly integrated into a 3D/4D spatiotemporal portrayal. The preparatory test
    case in this study affirmed the conceivable outcomes of having a move or
    development (with time) of characteristic limits from their underlying positions. Thus,
    the dynamic idea of the land in connection to man, the benefits of this model to the
    land proprietors, land merchants, and the administration can't be over stressed. This
    study tries to clarify the current 2D/3D approach and broke down preparatory
    requirements for 4D with a specific end goal to see the estimation of the approach.
    The primary future research exertion focuses on melding on the most proficient
    method to coordinate the model completely into Country profile in the study area.
    Matched MeSH terms: Goals
  15. Jakovljevic M, Sugahara T, Timofeyev Y, Rancic N
    Risk Manag Healthc Policy, 2020;13:2261-2280.
    PMID: 33117004 DOI: 10.2147/RMHP.S266386
    Purpose: The goal of this study was to assess the effectiveness of healthcare spending among the leading Asian economies.

    Methods: We have selected a total of nine Asian nations, based on the strength of their economic output and long-term real GDP growth rates. The OECD members included Japan and the Republic of Korea, while the seven non-OECD nations were China, India, Indonesia, Malaysia, Pakistan, the Philippines, and Thailand. Healthcare systems efficiency was analyzed over the period 1996-2017. To assess the effectiveness of healthcare expenditure of each group of countries, the two-way fixed effects model (country- and year effects) was used.

    Results: Quality of governance and current health expenditure determine healthcare system performance. Population density and urbanization are positively associated with a healthy life expectancy in the non-OECD Asian countries. In this group, unsafe water drinking has a statistically negative effect on healthy life expectancy. Interestingly, only per capita consumption of carbohydrates is significantly linked with healthy life expectancy. In these non-OECD Asian countries, unsafe water drinking and per capita carbon dioxide emissions increase infant mortality. There is a strong negative association between GDP per capita and infant mortality in both sub-samples, although its impact is far larger in the OECD group. In Japan and South Korea, unemployment is negatively associated with infant mortality.

    Conclusion: Japan outperforms other countries from the sample in major healthcare performance indicators, while South Korea is ranked second. The only exception is per capita carbon dioxide emissions, which have maximal values in the Republic of Korea and Japan. Non-OECD nations' outcomes were led by China, as the largest economy. This group was characterized with substantial improvement in efficiency of health spending since the middle of the 1990s. Yet, progress was noted with remarkable heterogeneity within the group.

    Matched MeSH terms: Goals
  16. Ahmad SH, Khoon YG
    Bul Keluarga, 1973 May 7;58:1-2.
    PMID: 12276936
    Matched MeSH terms: Goals
  17. Chattu VK, Knight WA, Adisesh A, Yaya S, Reddy KS, Di Ruggiero E, et al.
    Health Promot Perspect, 2021;11(1):20-31.
    PMID: 33758752 DOI: 10.34172/hpp.2021.04
    Background: Africa is facing the triple burden of communicable diseases, non-communicable diseases (NCDs), and nutritional disorders. Multilateral institutions, bilateral arrangements, and philanthropies have historically privileged economic development over health concerns. That focus has resulted in weak health systems and inadequate preparedness when there are outbreaks of diseases. This review aims to understand the politics of disease control in Africa and global health diplomacy's (GHD's) critical role. Methods: A literature review was done in Medline/PubMed, Web of Science, Scopus, Embase, and Google scholar search engines. Keywords included MeSH and common terms related to the topics: "Politics," "disease control," "epidemics/ endemics," and "global health diplomacy" in the "African" context. The resources also included reports of World Health Organization, United Nations and resolutions of the World Health Assembly (WHA). Results: African countries continue to struggle in their attempts to build health systems for disease control that are robust enough to tackle the frequent epidemics that plague the continent. The politics of disease control requires the crafting of cooperative partnerships to accommodate the divergent interests of multiple actors. Recent outbreaks of COVID-19 and Ebola had a significant impact on African economies. It is extremely important to prioritize health in the African development agendas. The African Union (AU) should leverage the momentum of the rise of GHD to (i) navigate the politics of global health governance in an interconnected world(ii) develop robust preparedness and disease response strategies to tackle emerging and reemerging disease epidemics in the region (iii) address the linkages between health and broader human security issues driven by climate change-induced food, water, and other insecurities (iv) mobilize resources and capacities to train health officials in the craft of diplomacy. Conclusion: The AU, Regional Economic Communities (RECs), and African Centres for Disease Control should harmonize their plans and strategies and align them towards a common goal that integrates health in African development agendas. The AU must innovatively harness the practice and tools of GHD towards developing the necessary partnerships with relevant actors in the global health arena to achieve the health targets of the Sustainable Development Goals.
    Matched MeSH terms: Goals
  18. Saleem Z, Hassali MA, Godman B, Versporten A, Hashmi FK, Saeed H, et al.
    Expert Rev Anti Infect Ther, 2020 09;18(9):897-910.
    PMID: 32394754 DOI: 10.1080/14787210.2020.1767593
    Introduction: In view of increasing concerns with antimicrobial resistance (AMR), the World Health Organization (WHO) instituted a Global Action Plan (GAP) to address this. Area covered: One of the strategies to achieve the goals of GAP is to conduct regular surveillance of antimicrobial use through point prevalence surveys (PPS). In this review, PubMed, EBSCO, Proquest, Cinahl, and Scopus were searched for PPS of antimicrobial use published in English between January 2000 and December 2019. After systematic database screening of 2,893 articles, 60 PPS met the inclusion criteria and consequently were incorporated in this systematic review. Expert opinion: This review highlighted that most of the PPS were conducted in upper-middle and high-income countries. Prevalence of antimicrobial use was significantly higher in non-European hospitals compared with European hospitals. The domination of third-generation cephalosporin and fluoroquinolones use across all the regions suggests substantial use of broad-spectrum antimicrobials across countries. Among all identified regions around the world, India was the region where the highest use of antimicrobials was observed. Although PPS is a useful tool to assess the pattern of antimicrobial use and provides a robust baseline; however, a standardized surveillance method is needed. In order to optimize antimicrobial use, more efforts are required to improve antimicrobial use.
    Matched MeSH terms: Goals
  19. Meor Shamsul Mahfudz Jeffry, Nur Ikhwan Mohamad
    MyJurnal
    Badminton is a court
    based racquet games to be played either in single (one versus one) or double (two versus two)
    in a court. Badminton is a famous sport especially in Asia and among the excellent team in
    badminton includes China, Indonesia, Malaysia and South Korea. Outside of Asia, badminton
    is well known in England and Denmark. One of the main tasks of strength and conditioning
    coach or trainer is to design and implement physical conditioning program. Well developed
    and implemented training programs mainly dependable on how accurate the training program
    variables being devised and manipulated, in order to serve the need and goals of involved
    athletes. Appropriate manipulation of training program variables and modifications made
    from time to time relies a lot on the accuracy and reliability of monitoring assessment used.
    The main purpose of this review is to identify what has been done previously regarding
    physiological and biomechanical profiling of badminton players. It is also the aim of this
    review to discuss on the type of test previously used in previous studies, especially with
    regards to strength and power assessment, were close enough to movement pattern perform
    by a badminton players during an actual badminton match.
    Matched MeSH terms: Goals
  20. Gaurav A, Gautam V
    Iran J Pharm Res, 2017;16(3):910-923.
    PMID: 29201082
    Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma and chronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known to reduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. This makes the development of PDE4B subtype selective inhibitors a desirable research goal. To achieve this goal, ligand based pharmacophore modeling approach is employed. Separate pharmacophore hypotheses for PDE4B and PDE4D inhibitors were generated using HypoGen algorithm and 106 PDE4 inhibitors from literature having thiopyrano [3,2-d] Pyrimidines, 2-arylpyrimidines, and triazines skeleton. Suitable training and test sets were created using the molecules as per the guidelines available for HypoGen program. Training set was used for hypothesis development while test set was used for validation purpose. Fisher validation was also used to test the significance of the developed hypothesis. The validated pharmacophore hypotheses for PDE4B and PDE4D inhibitors were used in sequential virtual screening of zinc database of drug like molecules to identify selective PDE4B inhibitors. The hits were screened for their estimated activity and fit value. The top hit was subjected to docking into the active sites of PDE4B and PDE4D to confirm its selectivity for PDE4B. The hits are proposed to be evaluated further using in-vitro assays.
    Matched MeSH terms: Goals
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