Displaying publications 81 - 100 of 306 in total

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  1. Amin L, Jahi JM, Nor AR
    ScientificWorldJournal, 2013;2013:516742.
    PMID: 24381520 DOI: 10.1155/2013/516742
    Public acceptance of genetically modified (GM) foods has to be adequately addressed in order for their potential economic and social benefits to be realized. The objective of this paper is to assess the attitude of the Malaysian public toward GM foods (GM soybean and GM palm oil) and GM medicine (GM insulin). A survey was carried out using self-constructed multidimensional instrument measuring attitudes towards GM products. The respondents (n = 1017) were stratified according to stakeholders' groups in the Klang Valley region. Results of the survey show that the overall attitude of the Malaysian stakeholders towards GM products was cautious. Although they acknowledged the presence of moderate perceived benefits associated with GM products surveyed and were moderately encouraging of them, they were also moderately concerned about the risks and moral aspects of the three GM products as well as moderately accepting the risks. Attitudes towards GM products among the stakeholders were found to vary not according to the type of all GM applications but rather depend on the intricate relationships between the attitudinal factors and the type of gene transfers involved. Analyses of variance showed significant differences in the six dimensions of attitude towards GM products across stakeholders' groups.
  2. Ima-Nirwana S, Merican Z, Jamaluddin M, Viswanathan P, Khalid BA
    Asia Pac J Clin Nutr, 1996 Jun;5(2):100-4.
    PMID: 24394519
    The atherogenic potential of soybean oil (Sb) and palm oil (PO) was compared by measuring lipid profile, lipid peroxidation (LP) and activity of the antioxidant enzyme glutathione peroxidase (GSHPx) in rat sera and liver and heart homogenates. Male Rattus norwegicus rats were fed a basal diet, or basal diet fortified with 20% weight/ weight Sb or PO for 4 or 9 months. There was no difference in high density lipoprotein cholesterol:low density lipoprotein cholesterol ratio between the two groups, but triglyceride concentrations were higher in the PO fed rats compared to the Sb fed rats, although the difference diminished after 9 months. No differences in serum LP and GSHPx activity were seen between the two groups. In the liver and heart, LP was lower in PO after 4 months feeding, but the reverse was seen after 9 months. Liver and heart GSHPx activity was higher in the PO group after both treatment periods. In conclusion, both PO and Sb fed rats appeared comparable in their lipid profile, but the PO food had a temporary beneficial effect on the LP process in liver and heart. GSHPx activity however did not correlate well with LP in liver and heart, suggesting involvement of other antioxidants.
  3. Jamaluddin Ahmad M, Lott PW, Khaliddin N, Singh S
    Med J Malaysia, 2020 07;75(4):461-463.
    PMID: 32724020
    A 33-year-old man presented with a four-day history of redness and blurring of vision of the right eye. A clinical diagnosis of adenoviral keratitis was made with a differential of microsporidia epithelial keratitis. The patient subsequently developed nummular keratitis which was resistant to topical steroids. He continued to develop multiple recurrences of the condition. Treatment with tacrolimus ointment was started as the patient had an elevated intraocular pressure due to prolonged steroid use. Tacrolimus ointment showed a favourable outcome in the management of recurrent nummular keratitis.
  4. Ahmad FN, Jamaluddin R, Esa NM
    Toxicon, 2020 Oct 30;186:120-125.
    PMID: 32771393 DOI: 10.1016/j.toxicon.2020.07.022
    A study was conducted to screen the occurrence and level of aflatoxin M1 (AFM1) in urine samples of 206 urban and rural residents in Terengganu, Malaysia. The level of AFM1 was quantified by competitive enzyme-linked immune-absorbent assay (ELISA). Of the 206 samples, 84 were positive for AFM1 (40.8%) in a range of 0.07-5.53 ng/ml (mean = 0.589 ng/ml). Residents of Terengganu are moderately exposed to AFM1. Age, ethnicity, marital status and employment status were associated with urinary level of AFM1. Subjects aged 30 years and above, non-Malays, married, and those unemployed had significantly higher levels of urinary AFM1 (p 
  5. Karimi G, Jamaluddin R, Mohtarrudin N, Ahmad Z, Khazaai H, Parvaneh M
    Nutr Metab Cardiovasc Dis, 2017 Oct;27(10):910-918.
    PMID: 28821417 DOI: 10.1016/j.numecd.2017.06.020
    BACKGROUND AND AIM: Recent studies have reported beneficial effects of specific probiotics on obesity. However, the difference in the anti-obesity effects of probiotics as single species and dual species is still uncertain. Therefore, we aimed to compare the efficacy of single and dual species of bacteria on markers of obesity in high-fat diet-induced obese rats.

    METHODS AND RESULTS: A total of 40 male Sprague-Dawley rats were assigned to one of five groups of varying diets as follows: standard diet, high fat diet (HFD), HFD supplemented with Lactobacillus casei strain Shirota, HFD supplemented with Bifidobacterium longum and HFD supplemented with a mixture of these two bacterial species. After 15 weeks of supplementation, the animals were examined for changes in body weight, body fat, total count of bacteria in fecal, blood serum lipid profile, leptin, adiponectin and inflammatory biomarkers. Histological analysis of the liver and adipose tissue was performed and the hepatic mRNA expression levels of genes related to lipid metabolism were measured. It was found that probiotic supplementation of either B. longum or a mixture of B. longum and LcS bacteria significantly reduced weight and triglycerides in the HFD groups. Supplementation of B. longum bacteria showed better results in terms of modulating leptin level, fat mass, adipocyte size and lipoprotein lipase expression, as well as increasing adiponectin and peroxisome proliferator-activated receptors-γ expression compared to dual species of bacteria. No significant differences were observed in the total count of fecal bacteria, glucose and inflammatory biomarker levels between supplemented groups.

    CONCLUSIONS: B. longum supplementation in obesity was more beneficial in metabolic profile changes than the mixture species.

  6. Jackson N, Hashim ZA, Zainal NA, Jamaluddin N
    Singapore Med J, 1995 Apr;36(2):230-1.
    PMID: 7676276
    A 30-year-old Malay lady, with no previous or family history of bleeding, presented with severe gum bleeding 25 days post-partum. The factor VIII:c was 0.03 iu/ml with evidence of a slow-acting factor VIII inhibitor. Von Willebrand factor antigen (VWF:age) varied from less that 0.05 to 0.17 iu/ml, and there was absent ristocetin-induced platelet aggregation. Anti-nuclear and anti-DNA antibodies were present, but there were no other features of systemic lupus erythematosus. There was some clinical response to cryoprecipitate and tranexamic acid, and slight improvement with corticosteroid. Fifteen months later, the patient has no active bleeding problem, and her VWF-ag is increasing spontaneously. However, factor VIII:c is less than 0.01 iu/ml and her factor VIII inhibitor titre is still > 20 Bethesda units/ml.
  7. George E, Wong HB, Jamaluddin M, Huisman TH
    Singapore Med J, 1993 Jun;34(3):241-4.
    PMID: 8266182
    Following complete DNA characterisation patients with Hb H disease were assigned into two groups: deletional (alpha +/alpha o) and non deletional (HbCS/alpha o). Earlier studies have indicated that the group with (HbCS/alpha o) has more severe clinical problems. The serum malonyldialdehyde (MDA) levels, a secondary product of lipid peroxidation were within the normal range, though significantly higher levels of MDA were seen in the non-deletional type of Hb H disease when compared with the deletional type. Markedly low vitamin E levels were also seen in the former group. There were no significant differences in clinical severity may be attributed to an interplay of the accelerated destruction of damaged mature red blood cells secondary to the oxidative denaturation of Hb H and inclusion precipitation; higher levels of Hb H and more inclusion precipitation were seen in the group with (HbCS/alpha o). Low levels of vitamin E in the (HbCS/alpha o) group being due to its consumption in the neutralisation of free radicals formed with the oxidation of globin chains.
  8. Karniza Khalid, Thyagarajan, Dandaithapani, Muhammad Zul Azri Mohammad Yusof, Ruzita Jamaluddin
    MyJurnal
    Medical professionals work in a constantly stressful environment. The nature of the profession requires routine extended working hours, but little is known about the effect of long working hours on selective physiological measures. A cross-sectional feasibility study was conducted from 1 October 2017 until 30 April 2018 on medical doctors in a tertiary health centre in northwest Malaysia. There was a total of 55 study participants recruited. The overall systolic blood pressure (SBP) was highest after working 24-hour stretch (p=0.006) and the overall diastolic blood pressure (DBP) were highest after working for 33 hours in a single stretch, at the end of on call rotation (p
  9. Aszrin A, Azarisman SM, Jamaluddin RA, Tariq RA, Noriah NM
    Introduction: Prehypertension precedes overt hypertension and has been acknowledged by many guidelines. Hypertension is an important risk factor for cardiovascular disease in Malaysia. Hypertension prevalence is at 42.6% and population-based control is poor at 26.8%. The objective of the study is to ascertain the cardiovascular risk profile of prehypertensive and mildly hypertensive young adults against age-matched controls in rural Malaysia. Methods: 484 (four hundred and eighty four) subjects attending primary care clinic were screened. 91 (Ninety one) young adults with pre/mild hypertension and normotensive, agematched controls were enrolled. The blood pressure and biochemical profiles for both groups were assessed and compared. Results: Fifty-four subjects and 37 controls were enrolled. Amongst subjects, 46.3% had prehypertension and 53.7% had mild hypertension. Mean values compared to age-matched controls for MAP were 102.68 ± 7.48 vs 83.25 ± 6.08 mmHg (p< 0.001), LDL 3.75 ± 0.95 vs 3.32 ± 0.93 mmol/L (p=0.03), FBG 4.65 ± 0.54 vs 4.33 ± 0.42 mmol/L (p=0.03), BMI 28.81 ± 5.16 vs 24.12 ± 4.91 (p< 0.001). The mean BP was significantly associated with BMI, FBG, triglycerides, HDL and the TC/HDL ratio. Conclusions: Greater BMI, FBG, HDL, triglyceride levels and TC/HDL ratio characterised the young adults with pre/mild hypertension. The data suggests that hypertension in young adults is secondary to metabolic syndrome. © 2018, International Islamic University Malaysia.
  10. Low, Pei Kit, Hazizi Abu Saad, Rosita Jamaluddin, Chee, Huei Phing
    MyJurnal
    Introduction: Overweight and obesity has been emerging as one of the most common and preventable
    nutritional problems worldwide. In 2016, 39% and 13% of the adult population worldwide was classified as
    overweight and obese, respectively. Materials and Methods: We conducted a cross-sectional study at 12
    selected health clinics in Perak, Malaysia, and we used multi-stage cluster random sampling to determine the
    prevalence of overweight and obesity among the primary healthcare workers and the associate factors of
    obesity indices. Each respondent was required to complete a self-administered questionnaire on their sociodemographic characteristics. In addition, we took anthropometric measurements, including height, weight,
    BMI, waist circumference, and body fat percentage, of the participants. Results: We recruited 261 primary
    healthcare workers. Overall, 49.9% of the healthcare workers were overweight or obese, 51.0% were at risk
    of having abdominal obesity, and 79.6% had a high body fat percentages. Age and self-reported health status
    were significantly associated with all the obesity indices. Educational level showed significant association
    with BMI and waist circumference, while occupational status showed an association only with BMI. Older age
    and professionals were predictors for high obesity indices. Conclusion: The prevalence of obesity among the
    primary healthcare workers was higher than among the general population. An immediate intervention
    programme is needed to reduce the prevalence of overweight and obesity among primary healthcare
    workers.
  11. Muhammad Aniq Qayyum Mohamad Sukry, Norazlina Subani, Muhammad Arif Hannan, Faizzuddin Jamaluddin, Ahmad Danial Hidayatullah Badrolhisam
    MyJurnal
    Partial differential equations involve results of unknown functions when there are multiple independent variables. There is a need for analytical solutions to ensure partial differential equations could be solved accurately. Thus, these partial differential equations could be solved using the right initial and boundaries conditions. In this light, boundary conditions depend on the general solution; the partial differential equations should present particular solutions when paired with varied boundary conditions. This study analysed the use of variable separation to provide an analytical solution of the homogeneous, one-dimensional heat equation. This study is applied to varied boundary conditions to examine the flow attributes of the heat equation. The solution is verified through different boundary conditions: Dirichlet, Neumann, and mixed-insulated boundary conditions. the initial value was kept constant despite the varied boundary conditions. There are two significant findings in this study. First, the temperature profile changes are influenced by the boundary conditions, and that the boundary conditions are dependent on the heat equation’s flow attributes.

  12. Abdullah Aszrin, Shah M. Azarisman, Rahman A. Jamaluddin, Razak A. Tariq, Noor M. Noriah
    MyJurnal
    Introduction: Prehypertension precedes overt hypertension and has been acknowledged by many guidelines.
    Hypertension is an important risk factor for cardiovascular disease in Malaysia. Hypertension prevalence is
    at 42.6% and population-based control is poor at 26.8%. The objective of the study is to ascertain the
    cardiovascular risk profile of prehypertensive and mildly hypertensive young adults against age-matched
    controls in rural Malaysia. Methods: 484 (four hundred and eighty four) subjects attending primary care
    clinic were screened. 91 (Ninety one) young adults with pre/mild hypertension and normotensive, agematched controls were enrolled. The blood pressure and biochemical profiles for both groups were assessed
    and compared. Results: Fifty-four subjects and 37 controls were enrolled. Amongst subjects, 46.3% had
    prehypertension and 53.7% had mild hypertension. Mean values compared to age-matched controls for MAP
    were 102.68 ± 7.48 vs 83.25 ± 6.08 mmHg (p< 0.001), LDL 3.75 ± 0.95 vs 3.32 ± 0.93 mmol/L (p=0.03), FBG
    4.65 ± 0.54 vs 4.33 ± 0.42 mmol/L (p=0.03), BMI 28.81 ± 5.16 vs 24.12 ± 4.91 (p< 0.001). The mean BP was
    significantly associated with BMI, FBG, triglycerides, HDL and the TC/HDL ratio. Conclusions: Greater BMI,
    FBG, HDL, triglyceride levels and TC/HDL ratio characterised the young adults with pre/mild hypertension.
    The data suggests that hypertension in young adults is secondary to metabolic syndrome.
  13. Norwaziah Mahmud, Nur Syuhada Muhammat Pazil, Hafawati Jamaluddin, Nur Aqilah Ali
    ESTEEM Academic Journal, 2021;17(2):101-111.
    MyJurnal
    Dengue is a globally known infection in which the virus is transmitted by
    mosquitoes and can lead to death. Selangor has been reported to have the
    highest incidence of dengue infections among the communities in Malaysia.
    There is currently a new pandemic, COVID-19, which occurred worldwide,
    including Selangor, which led to this study on the pattern of dengue cases
    during COVID-19. The aim of this study is to develop the best model to
    predict the future value of dengue cases in Selangor. In order to meet the
    objectives, the ARIMA method and the Holt-Winters method were used to
    evaluate dengue case data collected in Selangor. The best model was chosen
    by evaluating the Mean Square Error (MSE), Root Mean Square Error
    (RMSE) and Mean Absolute Percent Error (MAPE) measurement errors.
    Then, the forecasted number of dengue cases was calculated using the best
    model generated. The best model to forecast dengue cases in Selangor is the
    Additive Holt-Winters model since it showed the lowest values of all
    measurement errors compared to the Multiplicative Holt-Winters and
    ARIMA (1,1,0) models.
  14. Amin Faiz Nohan, Siti Nur ‘Asyura Adznam, Rosita Jamaluddin, Camilla Wahida Norazman
    MyJurnal
    Introduction: Diet quality is an essential factor in determining the adherence towards dietary guidelines. This study aims to assess the diet quality among community-dwelling older adults and identify the factors associated with the diet quality. Method: This is a cross-sectional study, conducted among 138 community-dwelling older adults living in PPR flats, Kuala Lumpur. Subjects were randomly recruited in this study. Diet Quality Index (DQI) was used to identify diet quality index of elderly. The Chi-square Test of Independence and Pearson’s correlation test were used to determine the association between tested covariates with DQI. Results: Majority of the respondents were report- ed with good diet quality (74.6%), whereas quarter of them (25.6%) had poor diet quality. Significant difference between the diet quality and the adherence on the food groups were observed for all food groups (p
  15. Low Pei Kit, Rosita Jamaluddin, Hazizi Abu Saad, Hazizi Abu Saad, Chee Huei Phing
    MyJurnal
    Overweight and obesity has been emerging as one of the most common and preventable nutritional problems worldwide. In 2016, 39% and 13% of the adult population worldwide was classified as overweight and obese, respectively. Materials and Methods:We conducted a cross-sectional study at 12 selected health clinics in Perak, Malaysia, and we used multi-stage cluster random sampling to determine the prevalence of overweight and obesity among the primary healthcare workers and the associate factors of obesity indices. Each respondent was required to complete a self-administered questionnaire on their socio-demographic characteristics. In addition, we took anthropometric measurements, including height, weight, BMI, waist circumference, and body fat percentage, of the participants. Results:We recruited 261 primary healthcare workers. Overall, 49.9% of the healthcare workers were overweight or obese, 51.0% were at risk of having abdominal obesity, and 79.6% had a high body fat percentages. Age and self-reported health status were significantly associated with all the obesity indices. Educational level showed significant association with BMI and waist circumference, while occupational status showed an association only with BMI. Older age and professionals were predictors for high obesity indices. Conclusion:The prevalence of obesity among the primary healthcare workers was higher than among the general population. An immediate intervention programme is needed to reduce the prevalence of overweight and obesity among primary healthcare workers.
  16. Zahiruddin Othman, Hasanah Che Ismail, Ruzita Jamaluddin, Muhammad Najib Mohamad Alwi
    MyJurnal
    Objective: The present study aims to assess verbal memory performance in patients with schizophrenia attending HUSM and determine the relationship between the patients’ verbal memory performance and their demographic/clinical factors. Methods: A cross sectional study of 114 patients with schizophrenia attending HUSM psychiatric services from December 2007 to May 2008 was conducted. The schizophrenia symptoms as well as verbal memory performance were assessed using the Brief Psychiatric Rating Scale, the Malay version of the Calgary Depression Scale (MVCDS), and the Malay version of the Auditory Verbal Learning Test (MVAVLT). The relationship between verbal memory performance and demographic/clinical symptoms was evaluated using Pearson Correlation. Results: Overall MVAVLT scores in all the trials were lowered in patients with schizophrenia compared to average healthy controls. There were significant relationships between occupational status and MVAVLT performance in Trial A1-A5 Total; between educational level and MVAVLT performance in Trial A1 and Trial A1-A5 Total and between severities of illness and MVAVLT performance in all indexes except Trial A1 after controlled for occupation and
    educational level. Conclusions: Patient with schizophrenia in HUSM performed significantly worse than healthy controls in verbal memory with or without interference. There were significant relationships between MVAVLT performance and patient’s occupational s tatus, educational level and severity of the illness but not depressive symptoms.

    Study site: Hospital Universiti Sains Malaysia (HUSM)
  17. Zahiruddin Othman, Muhammad Najib Muhammad Alwi, Kamarul Imran Musa, Muhammad Najib Muhammad Alwi, Ruzita Jamaluddin
    ASEAN Journal of Psychiatry, 2009;10(1):54-74.
    MyJurnal
    Objective: Many studies have emphasized the significance of verbal memory for the functional outcome in schizophrenia. A preserved capability to encode and recall verbal information is essential for the long-term efficacy of psychoeducational programs and other
    psychological intervention to ensure the successful transfer of newly acquired skills or knowledge into everyday life. Aims of this study aimed to validate the MVALT among schizophrenia patients in HUSM. Methods: The subjects were 15 schizophrenia patients
    conveniently selected from the patients that attended follow up at the psychiatry clinic in HUSM or inpatients who have been admitted during the study period and 15 healthy control subjects as a comparison. Reliability and validity of the MVAVLT were analyzed. Results: The validation study showed that the Malay version Auditory Verbal Learning Test (MVAVLT) had a good validity (factor analysis 0.66 to 0.98) and test-retest reliability (pearson correlation ranged from 0.24 to 0.84) and has been shown to be sensitive in
    discriminating between normal and schizophrenia patients. In line with the previous research, the schizophrenia patients performed significantly worse than healthy control in all indexes measured in MVAVLT. Conclusion: The screening of deficits in verbal learning
    and memory among the schizophrenia patients is important, for early detection and treatment since it can be helpful for clinicians and psychologists in their counseling sessions. Subsequently, it helps patients to reduce such cognitive difficulties and their impact by using specific rehabilitation with the usage of newer antipsychotic agents.
  18. Mohd Kherman Suparman, Hazmyr Abdul Wahab, Nazer Berahim, Tengku Intan Baizura Tengku Jamaluddin
    Malaysian Dental Journal, 2017;2017(1):1-12.
    MyJurnal
    Platelet Rich Fibrin (PRF) is a natural autologous fibrin matrix and is an effective biomaterial product. The application of PRF in oral surgery is not limited to tissue regeneration, but it has been utilized in several minor and major oral surgical procedures. Numerous studies have proven that either alone or in combination with bone graft, PRF acts as bone and soft tissue regeneration and it is able to stimulate physiological wound healing. This case report will introduce the utilization of PRF combined with autogenous bone graft in restoring four walls dental socket defect due to post-surgical extraction complication and plan for implant placement in the future. It acts in the form of a resorbable membrane and stem cell connector to the bone. After 3 months post-surgery review, there was no signs of infection or tissue rejection and the harvested bone was still viable. The PRF is comparable to commercially available membrane in the market, where clinical results can be predicted and possibility of reduction in post-surgical complications is achieved. This is due to 1) its compatibility with bone graft materials notably autogenous type, 2) induced neovascularisation and 3) reduction in inflammatory reaction. Our team is confident that the result of PRF at the edentulous region for rehabilitation purposes is beneficial and cost-effective to our patients.
  19. Betantya Nugroho, Azli Yahya, Nor Hisham, Kamal Khalil, Abd. Rahim, Mohd Najeb Jamaluddin
    MyJurnal
    Electromagnetic pulse (EMP) is a sudden burst of wide-band, high-intensity electromagnetic radiation. EMP also called as a transient electromagnetic disturbance, a short burst of electromagnetic energy. Effect of EMP to automobile is classify as medium threats to vehicle attacks where EMP aims at damaging electronic devices such as on board sensors and processors, CPU which found in almost all models from 1990’s and forward. This paper presents a MATLAB simulation of EMP generator by means of Switch Mode Power Supply, thus the electrical shielding can be studied further. Theoretically, EMP generator is developed by implementing energy storage circuit and discharge control circuit. Sending a rapidly changing electrical current through a loop will create an electromagnetic field in the form of a pulse. The results show an increase in pulse voltage from 12 VDC to 758 VDC with a current of 1500 A. A MATLAB model on the coverage area affected by EMP pulse will be developed in the next phase of the research.
  20. Sayang Mohd Deni, Suhaila Jamaluddin, Wan Zawiah Wan Zin, Abdul Aziz Jemain
    This study attempts to trace changes in the wet spells over Peninsular Malaysia based on the daily rainfall data from 32 selected rainfall stations which include four sub-regions; northwest, west, south and east, for the period of 1975 to 2004. Six wet spells indices comprising of the main characteristics (maximum, mean, standard deviation), the persistency of two consecutive wet days and the frequency of the short and long duration of wet spells will be used to identify whether or not these indices increase or decrease over Peninsular Malaysia during the monsoon seasons. The study indicates that the eastern areas of the peninsula could be considered as the wettest areas since almost all the indices of wet spells over these areas are higher than over the other regions during the northeast monsoon (NE). The Mann-Kendall (MK) trend test revealed that almost all of the stations located in the eastern areas of the peninsula exhibited a positive trend in the mean, variability and persistency of wet spells indices during the NE monsoon, while a negative trend was observed during the southwest monsoon (SW) in these areas. Moreover, these indices showed a positive trend, and at the same time a decreasing trend was observed in the frequency of the long wet spells in most stations located over the west coast of Peninsular Malaysia during the SW monsoon for the period of 1975 to 2004.
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