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  1. Human dried amniontic membrane (H-DAM) as a biomaterial patch on gastric perforation wound healing: macroscopic evaluation
    Ramadhani AT, Setiawan A
    Med J Malaysia, 2024 Aug;79(Suppl 4):68-71.
    PMID: 39215418
    INTRODUCTION: Gastric perforation is a rare occurrence, particularly in neonates. This is an emergency case in this population. The incidence of spontaneous gastric perforation in neonates is 1:2900 live births, with high mortality and morbidity rates. The primary treatment is surgical debridement and repair of the perforation, which has a high incidence of anastomotic leakage. At present, there is a plethora of studies investigating the efficacy of human dried amniotic membrane (H-DAM) technology in promoting wound healing. Consequently, researchers sought to ascertain whether there were differences in the number of adhesion and abscess classifications for the macroscopic evaluation of gastric perforation repair with HDAM as a biomaterial in New Zealand white rabbits.

    MATERIAL AND METHODS: A total of 30 male New Zealand rabbits underwent laparotomy and gastric perforation. These animals were then divided into three groups, with each group comprising 10 rabbits. Group 1 underwent primary repair, group 2 underwent omental patch repair, and group 3 underwent H-DAM patch repair. The rabbits were euthanised on the 7th day and the adhesion score and abscess classification were evaluated.

    RESULT: A total of 30 samples of rabbits were homogeneous. On macroscopic evaluation, it was found that the H-DAM had the lowest mean adhesion score and the lowest incidence of abscess formation compared to all other groups.

    CONCLUSIONS: It can be concluded that the utilisation of HDAM as a biomaterial patch in the treatment of gastric perforation in the rabbit model did not result in any instances of leakage, adhesion or infection.

    Matched MeSH terms: Animals
  2. Advances in psoriasis research: From pathogenesis to therapeutics
    Sugumaran D, Yong ACH, Stanslas J
    Life Sci, 2024 Oct 15;355:122991.
    PMID: 39153596 DOI: 10.1016/j.lfs.2024.122991
    Psoriasis is a chronic inflammatory condition affecting approximately 2 % to 3 % of the global population. The pathogenesis of psoriasis is complex, involving immune dysregulation, hyperproliferation and angiogenesis. It is a multifactorial disease which is influenced by genetic and environmental factors. The development of various therapeutic agents, such as JAK inhibitors, small molecules, and biologics with potential anti-psoriatic properties was possible with the vast understanding of the pathogenesis of psoriasis. Various signalling pathways, including NF-κB, JAK-STAT, S1P, PDE-4, and A3AR that are involved in the pathogenesis of psoriasis as well as the preclinical models utilised in the research of psoriasis have been highlighted in this review. The review also focuses on technological advancements that have contributed to a better understanding of psoriasis. Then, the molecules targeting the respective signalling pathways that are still under clinical trials or recently approved as well as the latest breakthroughs in therapeutic and drug delivery approaches that can contribute to the improvement in the management of psoriasis are highlighted in this review. This review provides an extensive understanding of the current state of research in psoriasis, giving rise to opportunities for researchers to discover future therapeutic breakthroughs and personalised interventions. Efficient treatment options for individuals with psoriasis can be achieved by an extensive understanding of pathogenesis, therapeutic agents, and novel drug delivery strategies.
    Matched MeSH terms: Animals
  3. Fulltext Silicon-based induced resistance in maize against fall armyworm [Spodoptera frugiperda (Lepidoptera: Noctuidae)]
    Haq IU, Khurshid A, Inayat R, Zhang K, Liu C, Ali S, et al.
    PLoS One, 2021;16(11):e0259749.
    PMID: 34752476 DOI: 10.1371/journal.pone.0259749
    The fall armyworm (Spodoptera frugiperda) is a major economic pest in the United States and has recently become a significant concern in African and Asian countries. Due to its increased resistance to current management strategies, including pesticides and transgenic corn, alternative management techniques have become more necessary. Currently, silicon (Si) is being used in many pest control systems due to its ability to increase plant resistance to biotic and abiotic factors and promote plant growth. The current experiments were carried out at the College of Plant Protection, Gansu Agricultural University, Lanzhou, China, to test the effect of Si on lifetable parameters and lipase activity of fall armyworm and vegetative and physiological parameters of maize plants. Two sources of Si (silicon dioxide: SiO2 and potassium silicate: K2SiO3) were applied on maize plants with two application methods (foliar application and soil drenching). The experiment results revealed that foliar applications of SiO2 and K2SiO3 significantly (P≤0.05) increased mortality percentage and developmental period and decreased larval and pupal biomass of fall armyworm. Similarly, both Si sources significantly (P≤0.05) reduced lipase activity of larvae, and fecundity of adults, whereas prolonged longevity of adults. Among plant parameters, a significant increase in fresh and dry weight of shoot, stem length, chlorophyll content, and antioxidant activity was observed with foliar applications of Si. Root fresh and dry weight was significantly (P ≤ 0.05) higher in plants treated with soil drenching of SiO2 and K2SiO3. Moreover, SiO2 performed better for all parameters as compared to K2SiO3 and control treatment. The study conclusively demonstrated a significant negative effect on various biological parameters of fall armyworm when plants were treated with Si, so it can be a promising strategy to control this pest.
    Matched MeSH terms: Animals
  4. Chromosome-level genome sequence of the Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) highlights regions of introgression with O. mossambicus
    Etherington GJ, Nash W, Ciezarek A, Mehta TK, Barria A, Peñaloza C, et al.
    BMC Genomics, 2022 Dec 15;23(1):832.
    PMID: 36522771 DOI: 10.1186/s12864-022-09065-8
    BACKGROUND: The Nile tilapia (Oreochromis niloticus) is the third most important freshwater fish for aquaculture. Its success is directly linked to continuous breeding efforts focusing on production traits such as growth rate and weight. Among those elite strains, the Genetically Improved Farmed Tilapia (GIFT) programme initiated by WorldFish is now distributed worldwide. To accelerate the development of the GIFT strain through genomic selection, a high-quality reference genome is necessary.

    RESULTS: Using a combination of short (10X Genomics) and long read (PacBio HiFi, PacBio CLR) sequencing and a genetic map for the GIFT strain, we generated a chromosome level genome assembly for the GIFT. Using genomes of two closely related species (O. mossambicus, O. aureus), we characterised the extent of introgression between these species and O. niloticus that has occurred during the breeding process. Over 11 Mb of O. mossambicus genomic material could be identified within the GIFT genome, including genes associated with immunity but also with traits of interest such as growth rate.

    CONCLUSION: Because of the breeding history of elite strains, current reference genomes might not be the most suitable to support further studies into the GIFT strain. We generated a chromosome level assembly of the GIFT strain, characterising its mixed origins, and the potential contributions of introgressed regions to selected traits.

    Matched MeSH terms: Animals
  5. Fulltext Plastic waste associated with the COVID-19 pandemic: Crisis or opportunity?
    Khoo KS, Ho LY, Lim HR, Leong HY, Chew KW
    J Hazard Mater, 2021 Sep 05;417:126108.
    PMID: 34020352 DOI: 10.1016/j.jhazmat.2021.126108
    Coronavirus Diseases 2019 (COVID-19) pandemic has a huge impact on the plastic waste management in many countries due to the sudden surge of medical waste which has led to a global waste management crisis. Improper management of plastic waste may lead to various negative impacts on the environment, animals, and human health. However, adopting proper waste management and the right technologies, looking in a different perception of the current crisis would be an opportunity. About 40% of the plastic waste ended up in landfill, 25% incinerated, 16% recycled and the remaining 19% are leaked into the environment. The increase of plastic wastes and demand of plastic markets serve as a good economic indicator for investor and government initiative to invest in technologies that converts plastic waste into value-added product such as fuel and construction materials. This will close the loop of the life cycle of plastic waste by achieving a sustainable circular economy. This review paper will provide insight of the state of plastic waste before and during the COVID-19 pandemic. The treatment pathway of plastic waste such as sterilisation technology, incineration, and alternative technologies available in converting plastic waste into value-added product were reviewed.
    Matched MeSH terms: Animals
  6. Fulltext Computational modelling of potentially emerging SARS-CoV-2 spike protein RBDs mutations with higher binding affinity towards ACE2: A structural modelling study
    Khan A, Hussain S, Ahmad S, Suleman M, Bukhari I, Khan T, et al.
    Comput Biol Med, 2022 Feb;141:105163.
    PMID: 34979405 DOI: 10.1016/j.compbiomed.2021.105163
    The spike protein of SARS-CoV-2 and the host ACE2 receptor plays a vital role in the entry to the cell. Among which the hotspot residue 501 is continuously subjected to positive selection pressure and induces unusual virulence. Keeping in view the importance of the hot spot residue 501, we predicted the potentially emerging structural variants of 501 residue. We analyzed the binding pattern of wild type and mutants (Spike RBD) to the ACE2 receptor by deciphering variations in the amino acids' interaction networks by graph kernels along with evolutionary, network metrics, and energetic information. Our analysis revealed that N501I, N501T, and N501V increase the binding affinity and alter the intra and inter-residue bonding networks. The N501T has shown strong positive selection and fitness in other animals. Docking results and repeated simulations (three times) confirmed the structural stability and tighter binding of these three variants, correlated with the previous results following the global stability trend. Consequently, we reported three variants N501I, N501T, and N501V could worsen the situation further if they emerged. The relations between the viral fitness and binding affinity is a complicated game thus the emergence of high affinity mutations in the SARS-CoV-2 RBD brings up the question of whether or not positive selection favours these mutations or not?
    Matched MeSH terms: Animals
  7. Omics approaches to unravel insecticide resistance mechanism in Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae)
    Rosli MAF, Syed Jaafar SN, Azizan KA, Yaakop S, Aizat WM
    PeerJ, 2024;12:e17843.
    PMID: 39247549 DOI: 10.7717/peerj.17843
    Bemisia tabaci (Gennadius) whitefly (BtWf) is an invasive pest that has already spread worldwide and caused major crop losses. Numerous strategies have been implemented to control their infestation, including the use of insecticides. However, prolonged insecticide exposures have evolved BtWf to resist these chemicals. Such resistance mechanism is known to be regulated at the molecular level and systems biology omics approaches could shed some light on understanding this regulation wholistically. In this review, we discuss the use of various omics techniques (genomics, transcriptomics, proteomics, and metabolomics) to unravel the mechanism of insecticide resistance in BtWf. We summarize key genes, enzymes, and metabolic regulation that are associated with the resistance mechanism and review their impact on BtWf resistance. Evidently, key enzymes involved in the detoxification system such as cytochrome P450 (CYP), glutathione S-transferases (GST), carboxylesterases (COE), UDP-glucuronosyltransferases (UGT), and ATP binding cassette transporters (ABC) family played key roles in the resistance. These genes/proteins can then serve as the foundation for other targeted techniques, such as gene silencing techniques using RNA interference and CRISPR. In the future, such techniques will be useful to knock down detoxifying genes and crucial neutralizing enzymes involved in the resistance mechanism, which could lead to solutions for coping against BtWf infestation.
    Matched MeSH terms: Animals
  8. Occurrence of Austroglycyphagus malaysiensis on the egg laying bowl of Culex quinquefasciatus
    Ho TM
    Southeast Asian J Trop Med Public Health, 1984 Sep;15(3):426-7.
    PMID: 6523179
    Matched MeSH terms: Animals
  9. Current status of filariasis in Southeast Asia. Proceedings of the 34th SEAMEO TROPMED regional semiar. Kuala Lumpur, Malaysia, 26-27 June 1992
    Southeast Asian J Trop Med Public Health, 1993;24 Suppl 2:1-112.
    PMID: 7973936
    Matched MeSH terms: Animals
  10. Presence of Anopheles aberrans Harrison and Scanlon a newly described specie in the A. aitkeni group from peninsula Malaysia
    Cheong WH, Mahadevan S
    Southeast Asian J Trop Med Public Health, 1978 Sep;9(3):459-60.
    PMID: 749235
    Matched MeSH terms: Animals
  11. Fulltext International co-operation in postgraduate medical education in Malaya
    MONTEIRO ES
    Br Med J, 1959 Sep 05;2(5148):330-2.
    PMID: 14423683
    Matched MeSH terms: Animals
  12. Vector-borne diseases on Borneo island: a scoping review
    Ong SQ, Safree ASA, Ismai NBA
    Malar J, 2024 Nov 11;23(1):337.
    PMID: 39529029 DOI: 10.1186/s12936-024-05132-5
    BACKGROUND: Borneo, the third largest island in the world, is facing a significant burden of emerging and re-emerging vector-borne diseases due to rapid changes in primary tropical rainforests and urban landscapes. These vector-borne diseases include the endemic epidemic cycles that occur in the more populated and urbanized areas, as well as the possible transmission through enzootic and sylvatic transmission cycles that occur mainly in the overlapping landscapes or among the indigenous population in the forest. The island will be changed significantly in the future due to the increase in human activities, especially mega events such as the relocation of the Indonesian capital to Nusantara in East Kalimantan Borneo, increasing urbanization, agriculture, hydropower projects, ecotourism activities in Sabah, North Borneo, and Sarawak, Central and South Borneo. Therefore, an overview of the current situation of vector-borne diseases is crucial for the next possible epidemic preparedness.

    METHODS: This study conducted the PRISMA-ScR scoping review and formulated a set of research questions to identify current trends in vector-borne diseases in Borneo. These questions aim to identify which diseases have been studied, what geographical areas have been covered by the research, how the One Health approach-encompassing human, animal and environmental factors-is integrated, and what gaps and challenges exist in addressing these diseases.

    RESULTS: A total of 2241 references were screened for eligibility and 117 articles were selected for review. The majority of the materials focused on mosquitoes and malaria, and the One Health elements focused mainly on humans.

    CONCLUSIONS: This review has identified the most and least studied vector-borne diseases and highlighted some of the gaps in knowledge and research on vector-borne diseases on the island of Borneo. Future studies should particularly focus on other neglected diseases such as Zika, chikungunya, Japanese encephalitis, filariasis and tick-borne diseases. In addition, advanced surveillance systems will be developed to improve early detection and response specifically for remote regions where vector-borne diseases are endemic or emerging.

    Matched MeSH terms: Animals
  13. Long-term PS micro/nano-plastic exposure: Particle size effects on hepatopancreas injury in Parasesarma pictum
    Liang J, Abdullah ALB, Li Y, Wang H, Xiong S, Han M
    Sci Total Environ, 2024 Dec 01;954:176530.
    PMID: 39332714 DOI: 10.1016/j.scitotenv.2024.176530
    With the widespread use of plastic products, microplastics and nanoplastics have emerged as prevalent pollutants in coastal aquatic ecosystems. Parasesarma pictum, a common estuarine crab species, was selected as a model organism. P. pictum was exposed to polystyrene (PS) particles of sizes 80 nm (80PS), 500 nm (500PS), and 1000 nm (1000PS), as well as to clean seawater (CK) for 21 days. Histological and fluorescent staining results showed that PS particles of all three sizes induced hepatopancreatic nuclear pyknosis, cell junction damage, and necrosis. The degree of damage was observed as 1000PS > 80PS > 500PS. Transcriptomic analysis revealed that major differentially expressed genes (DEGs) were associated with cellular processes, membrane components, and catalytic activity. The respiratory chain disruptions and immune exhaustion induced by 1000PS were notably stronger than those by 80PS and 500PS. Additionally, necrosis caused hepatopancreas injury in P. pictum rather than apoptosis or autophagy after long-term PS particle exposure. Furthermore, PS particles of all three sizes inhibited innate immunity, while the complement pathway was not significantly affected in the 80PS group. This study elucidated potential distinctions in how plastic particles of varying sizes (nanoplastics, microplastics, and micro/nanoplastics) impact P. pictum, providing a reference for toxicological mechanism research on microplastics and nanoplastics in aquatic organisms. Future research should focus on exploring long-term effects and potential mitigation strategies for microplastics and nanoplastics of more types and a wider range of particle size pollution in aquatic environments.
    Matched MeSH terms: Animals
  14. Review on flower-visiting behaviour of orthopterans and setting priorities for further studies
    Rácz IA, Szanyi S, Nagy A
    Biol Futur, 2023 Dec;74(4):393-400.
    PMID: 38349457 DOI: 10.1007/s42977-024-00203-9
    The importance of pollination and pollinators is easy to underestimate and impossible to overstate, since its importance goes far beyond the crop production and even the maintenance of plant populations. Most terrestrial ecosystems ultimately depend on the plant-pollinator interactions formed by million years coevolution. This is essential for both the daily functioning of the ecosystems and the long-term development of biodiversity. At the same time, the loss of biodiversity caused by climate change and human activities will soon lead to an ecological crisis, a catastrophe, which could endanger our life: For example, through the decline and loss of various ecosystem services. Such may be the pollination crisis, resulted from a significant loss of pollinating insects' diversity and abundance. The discovery of a pollinator Orthoptera species has encouraged researchers in the densely populated region of Indo-Malaysia to explore the potential role of orthopterans as pollinators. Although the flower visitation of some species has been already known, the role of orthopterans in pollination is scarcely revealed. Here, we collected and reviewed the available data in order to point out some factors of their importance and set priorities that may serve as a basis for further investigations regarding ecological, evolutionary and practical points of view.
    Matched MeSH terms: Animals
  15. Fulltext Realising a global One Health disease surveillance approach: insights from wastewater and beyond
    Hill R, Stentiford GD, Walker DI, Baker-Austin C, Ward G, Maskrey BH, et al.
    Nat Commun, 2024 Jun 22;15(1):5324.
    PMID: 38909028 DOI: 10.1038/s41467-024-49417-4
    One Health is a recognition of the shared environment inhabited by humans, animals and plants, and the impact of their interactions on the health of all organisms. The COVID-19 pandemic highlighted the need for a framework of pathogen surveillance in a tractable One Health paradigm to allow timely detection and response to threats to human and animal health. We present case studies centered around the recent global approach to tackle antimicrobial resistance and the current interest in wastewater testing, with the concept of "one sample many analyses" to be further explored as the most appropriate means of initiating this endeavor.
    Matched MeSH terms: Animals
  16. Tick-borne pathogens isolated from ticks, rodents, and a shrew in Gangwon and Gyeonggi provinces in the Republic of Korea
    Choi YJ, Kim JY, Kang TU, Park HJ, Kim HC, Lee IY, et al.
    Trop Biomed, 2024 Jun 01;41(2):176-182.
    PMID: 39154270 DOI: 10.47665/tb.41.2.007
    The prevalence of tick-borne pathogens (TBP), Orientia tsutsugamushi, Rickettsia and Borrelia spp. in wild small animals, namely wild rodents, is now widely investigated. This study is to present the prevalence and distribution of O. tsutsugamushi, Rickettsia and Borrelia spp. in wild small animals and ticks collected from Gyeonggi and Gangwon provinces, Republic of Korea (ROK) in 2014. A total of 131 wild small animals, rodents and shrews, and 2,954 ticks were collected from Gyeonggi and Gangwon provinces from May to November 2014. The wild small animals (KR1-9) and ticks (K1-17) were grouped in accordance with capture dates and locations. Among the wild small animals, a total of 393 tissues and blood samples were extracted from six selected small animal series (KR1-3, KR6-8). Also, each date and location-grouped ticks were identified for its species and pooled according to the stage of development. Molecular identification for Rickettsia, Orientia, and Borrelia species was performed using polymerase chain reaction (PCR). To detect TBPs among wild small animals and ticks, primer sets targeting the 56 kDa protein encoding gene of Orientia spp., outer membrane protein B gene (OmpB) of Rickettsia spp., and 5S-23S intergenic spacer region (IGS) gene of Borrelia spp. were used. Of the 393 wild small animals' blood and tissue samples, 199 (50.6%) were positive for Orientia spp., 158 (40.2%) were positive for Borrelia spp., and 55 (14.0%) were positive for Rickettsia spp. Moreover, a total of 14 tick pools (n = 377) was positive for Rickettsia spp. (n=128, 34.0%) and Borrelia spp. (n=33, 8.8%). High prevalence of Orientia spp. and Rickettsia spp. in rodents and shrews were observed. This study presents significant insights by presenting data collected in 2014 that the prevalence of TBP was already high in mid 2010s. This study highlights the sustainable routine surveillance model for TBP.
    Matched MeSH terms: Animals; Animals, Wild/microbiology; Animals, Wild/parasitology
  17. Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances
    Aslam Khan MU, Aslam MA, Bin Abdullah MF, Stojanović GM
    ACS Appl Bio Mater, 2024 Aug 19;7(8):5082-5106.
    PMID: 39007509 DOI: 10.1021/acsabm.4c00362
    In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, and interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs and regenerates fractured bones. Bone is a multihierarchical complex structure, and it performs several essential biofunctions, including maintaining mineral balance and structural support and protecting soft organs. Protein-based polymers have gained interest in developing ideal scaffolds as emerging biomaterials for bone fractured healing and regeneration, and it is challenging to design ideal bone substitutes as perfect biomaterials. Several protein-based polymers, including collagen, keratin, gelatin, serum albumin, etc., are potential materials due to their inherent cytocompatibility, controlled biodegradability, high biofunctionalization, and tunable mechanical characteristics. While numerous studies have indicated the encouraging possibilities of proteins in BTE, there are still major challenges concerning their biodegradability, stability in physiological conditions, and continuous release of growth factors and bioactive molecules. Robust scaffolds derived from proteins can be used to replace broken or diseased bone with a biocompatible substitute; proteins, being biopolymers, provide excellent scaffolds for bone tissue engineering. Herein, recent developments in protein polymers for cutting-edge bone tissue engineering are addressed in this review within 3-5 years, with a focus on the significant challenges and future perspectives. The first section discusses the structural fundamentals of bone anatomy and ideal scaffolds, and the second section describes the fabrication techniques of scaffolds. The third section highlights the importance of proteins and their applications in BTE. Hence, the recent development of protein polymers for state-of-the-art bone tissue engineering has been discussed, highlighting the significant challenges and future perspectives.
    Matched MeSH terms: Animals
  18. Fulltext The Tetragnatha kauaiensis Genome Sheds Light on the Origins of Genomic Novelty in Spiders
    Cerca J, Armstrong EE, Vizueta J, Fernández R, Dimitrov D, Petersen B, et al.
    Genome Biol Evol, 2021 Dec 01;13(12).
    PMID: 34849853 DOI: 10.1093/gbe/evab262
    Spiders (Araneae) have a diverse spectrum of morphologies, behaviors, and physiologies. Attempts to understand the genomic-basis of this diversity are often hindered by their large, heterozygous, and AT-rich genomes with high repeat content resulting in highly fragmented, poor-quality assemblies. As a result, the key attributes of spider genomes, including gene family evolution, repeat content, and gene function, remain poorly understood. Here, we used Illumina and Dovetail Chicago technologies to sequence the genome of the long-jawed spider Tetragnatha kauaiensis, producing an assembly distributed along 3,925 scaffolds with an N50 of ∼2 Mb. Using comparative genomics tools, we explore genome evolution across available spider assemblies. Our findings suggest that the previously reported and vast genome size variation in spiders is linked to the different representation and number of transposable elements. Using statistical tools to uncover gene-family level evolution, we find expansions associated with the sensory perception of taste, immunity, and metabolism. In addition, we report strikingly different histories of chemosensory, venom, and silk gene families, with the first two evolving much earlier, affected by the ancestral whole genome duplication in Arachnopulmonata (∼450 Ma) and exhibiting higher numbers. Together, our findings reveal that spider genomes are highly variable and that genomic novelty may have been driven by the burst of an ancient whole genome duplication, followed by gene family and transposable element expansion.
    Matched MeSH terms: Animals
  19. Fulltext Natural Plasmodium inui Infections in Humans and Anopheles cracens Mosquito, Malaysia
    Liew JWK, Bukhari FDM, Jeyaprakasam NK, Phang WK, Vythilingam I, Lau YL
    Emerg Infect Dis, 2021 10;27(10):2700-2703.
    PMID: 34545786 DOI: 10.3201/eid2710.210412
    We detected 2 natural, asymptomatic Plasmodium inui monoinfections in humans in Malaysia by using nested PCR on concentrated high-volume blood samples. We found a P. inui-positive Anopheles cracens mosquito in the same site as the human infections. Investigators should use ultrasensitive detection methods to identify simian malaria parasite transmission in humans.
    Matched MeSH terms: Animals
  20. Fulltext Natural Human Infections with Plasmodium cynomolgi, P. inui, and 4 other Simian Malaria Parasites, Malaysia
    Yap NJ, Hossain H, Nada-Raja T, Ngui R, Muslim A, Hoh BP, et al.
    Emerg Infect Dis, 2021 08;27(8):2187-2191.
    PMID: 34287122 DOI: 10.3201/eid2708.204502
    We detected the simian malaria parasites Plasmodium knowlesi, P. cynomolgi, P. inui, P. coatneyi, P. inui-like, and P. simiovale among forest fringe-living indigenous communities from various locations in Malaysia. Our findings underscore the importance of using molecular tools to identify newly emergent malaria parasites in humans.
    Matched MeSH terms: Animals
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