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Fulltext Sodium-Glucose Co-transporter 2 Inhibitors in Heart Failure: Recent Data and Implications for Practice

Rosano G, Quek D, Martínez F

Card Fail Rev, 2020 Mar;6:e31.
PMID: 33294215 DOI: 10.15420/cfr.2020.23

Heart failure is a shared chronic phase of many cardiac diseases and its prevalence is on the rise globally. Previous large-scale cardiovascular outcomes trials of sodium.glucose co-transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes (T2D) have suggested that these agents may help to prevent primary and secondary hospitalisation due to heart failure and cardiovascular death in these patients. Data from the Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure (DAPA-HF) and Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction (EMPEROR-Reduced) have demonstrated the positive clinical impact of SGLT2 inhibition in patients with heart failure with reduced ejection fraction both with and without T2D. These data have led to the approval of dapagliflozin for the treatment of patients with heart failure with reduced ejection fraction, irrespective of T2D status. This article reviews the latest data reported from the DAPA-HF and EMPEROR-Reduced trials and their clinical implications for the treatment of patients with heart failure.

Matched MeSH terms: Sodium; Sodium-Glucose Transporter 2
In reply

Tan PC, Norazilah MJ, Omar SZ

Obstet Gynecol, 2013 Jun;121(6):1360.
PMID: 23812475 DOI: 10.1097/AOG.0b013e31829395ef
Matched MeSH terms: Sodium Chloride/therapeutic use*
Fulltext Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide

Zaharani L, Ghaffari Khaligh N, Shahnavaz Z, Rafie Johan M

Turk J Chem, 2020;44(3):535-542.
PMID: 33488175 DOI: 10.3906/kim-2002-26

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste.

Matched MeSH terms: Sodium Chloride; Sodium Chloride, Dietary
New crown-shaped polyoxovanadium(V) cluster cation with a mu(6)-sulfato anion and zwitterionic mu-(beta-alanine): crystal structure of [V(6)O(12)(OH)(3)(O(2)CCH(2)CH(2)NH(3))(3)(SO(4))][Na][SO(4)].13H(2)O

Ng CH, Lim CW, Teoh SG, Fun HK, Usman A, Ng SW

Inorg Chem, 2002 Jan 14;41(1):2-3.
PMID: 11782136

Treatment of vanadium(V) oxide with an ethanol-concentrated sulfuric acid mixture, followed by the addition of an equimolar amount of beta-alanine and sodium hydroxide, and finally raising the pH to 3.9 with sodium carbonate solution, under continuous heating in a water bath and in the presence of air, leads to the polyionic sodium cyclo-[mu(6)-(sulfato-O,O',O'')tris[mu-(beta-alanine-O,O')-mu-oxo]tris(mu-hydroxo-mu-oxo)hexa[oxovanadium(V)]] sulfate tridecahydrate which crystallizes in the monoclinic P2(1)/n space group [a = 9.5192(4), b = 20.1185(9), c = 22.6174(9) A, beta = 97.011(1) degrees; Z = 4]. The crown-shaped polyoxovanadium(V) cluster cation, with carboxylate-bridging amino acid ligands, has an Anderson structure with two unique capping sulfato ligands. Its structural analysis, together with IR, UV-vis, and preliminary data on its solution properties, is presented.

Matched MeSH terms: Sodium; Sodium Hydroxide
Effect of pulping variables on the characteristics of oil-palm frond-fiber

Wan Rosli WD, Law KN, Zainuddin Z, Asro R

Bioresour Technol, 2004 Jul;93(3):233-40.
PMID: 15062817

Caustic pulping of oil-palm frond-fiber strands was conducted following a central composite design using a two-level factorial plan involving three pulping variables (temperature: 160-180 degrees C, time: 1-2 h, alkali charge: 20-30% NaOH). Responses of pulp properties to the process variables were analyzed using a statistical software (DESIGN-EXPERT). The results indicated that frond-fiber strands could be pulped with ease to about 35-45% yield. Statistically, the reaction time was not a significant factor while the influences of the treatment temperature and caustic charge were in general significantly relative to the properties of the resultant pulps.

Matched MeSH terms: Sodium Hydroxide/chemistry
Isolation and characterization of a mo -reducing bacterium

Ghani B, Takai M, Hisham NZ, Kishimoto N, Ismail AK, Tano T, et al.

Appl Environ Microbiol, 1993 Apr;59(4):1176-80.
PMID: 16348915

A Mo -reducing bacterium (strain 48), which grew on medium supplemented with 200 mM Mo, was isolated from stream water obtained from Chengkau, Malaysia. The chemical properties of strain 48 conform to the characteristics of Enterobacter cloacae. Under anaerobic conditions in the glucose-yeast extract medium containing phosphate ion (2.9 mM) and Mo (10 mM), the bacterium reduced Mo to form molybdenum blue. Approximately 27% of Mo added to the medium was reduced after 28 h of cultivation. The reduction of Mo with glucose as an electron donor was strongly inhibited by iodoacetic acid, sodium fluoride, and sodium cyanide, suggesting an involvement of the glycolytic pathway and electron transport in Mo reduction. NADH and N,N,N',N' -tetramethyl-p-phenylenediamine served as electron donors for Mo reduction. When NADH was used as an electron donor, at first cytochrome b in the cell extract was reduced, and then molybdenum blue was formed. Sodium cyanide strongly inhibited Mo reduction by NADH (5 mM) but not the reduction of cytochrome b in the cell extract, suggesting that the reduced component of the electron transport system after cytochrome b serves as an electron donor for Mo reduction. Both ferric and stannous ions strongly enhanced the activity of Mo reduction by NADH.

Matched MeSH terms: Sodium Cyanide; Sodium Fluoride
Fulltext Continuous ambulatory peritoneal dialysis--a preliminary report on 7 patients

Chua CT, Wang F

Med J Malaysia, 1983 Sep;38(3):244-50.
PMID: 6672569

Study site: CAPD, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia

Matched MeSH terms: Sodium/blood
Fulltext Effects of marinating ingredients on physicochemical, microstructural and sensory properties of golek chicken

Komoltri, P., Pakdeechanuan, P.

International Food Research Journal, 2012;19(4):1449-1455.
MyJurnal

Marination directly affects the texture and flavor of meat and is important for product yield. This research investigated the effects of various marinating solutions on the physicochemical, microstructural and sensory properties of golek chicken, a popular dish in Malaysia, Indonesia and southern Thailand. Non-marinated meat (Tr1-control) was compared with five marinating treatments: distilled water (Tr2); sodium chloride (Tr3); a mixture of sodium chloride and sodium tripolyphosphate (STPP) (Tr4); a mixture of sodium chloride, STPP and citric acid (Tr5); and a mixture of sodium chloride, STPP and sodium bicarbonate (Tr6). Marinating meat in Tr3–Tr6 resulted in higher water-holding capacity and cooking yield, as well as lower shear force value and cooking loss, when compared to Tr1 and Tr2 (p

Matched MeSH terms: Sodium Chloride; Sodium Bicarbonate
Fulltext Mineral composition and pasting properties of banana pseudo-stem flour from Musa acuminata X balbisiana cv. Awak grown locally in Perak, Malaysia

Ho, L.H., Noor Aziah, A.A., Rajeev Bhat

International Food Research Journal, 2012;19(4):1479-1485.
MyJurnal

The banana pseudo-stem is not currently utilised in the food industry. The aim of this research was to investigate the chemical and pasting profile of banana pseudo-stem flour (BPF). Wheat flour were substituted with BPF (0, 5, 15 and 30%) and the pasting profile were determined. Results from mineral analysis showed that the levels of sodium (Na), potassium (K), calcium (Ca), magnesium (Mg) and phosphorus (P) were higher than those of iron (Fe), zinc (Zn) and manganese (Mn). The BPF had a 0.04% total titratable acidity (TTA) and a total soluble solid (TSS) of 1.30⁰ Brix with pH 5.41. BPF contained 28.26% total starch, 12.81% resistant starch and a total digestible starch value of 15.45%. An increased substitution level of BPF into wheat flour significantly (p

Matched MeSH terms: Sodium; Sodium, Dietary
Fulltext Effects of extraction time on the functional properties of silver catfish (Pangasius sutchi) skin gelatin

Normah Ismail, Najihah Shukor, Zainal Samicho

Scientific Research Journal, 2013;10(1):0-0.
MyJurnal

Silver catfish (Pangasius sutchi) skin gelatin was extracted to determine the effects of extraction time on the functional properties of the gelatin in terms of solubility, protein solubility as a function of pH and sodium chloride concentration, emulsifying capacity and stability, water holding capacity, fat binding capacities and foaming properties. Silver catfish skins were washed in sodium chloride (NaCl) solution prior to pre-treatment in sodium hydroxide (NaOH) and acetic acid solution. Gelatin was extracted at 50ºC for 6, 8, 10 and 12 hours extraction time followed by freeze drying. The extraction of silver catfish skin gelatin at 50 ºC for 12 hours was more effective than extraction at 6, 8 and 10 hours where the gelatin was characterized by higher emulsifying capacity (52.63%), emulsifying stability (47.83%), water holding capacity (31.78 mL/g), fat binding capacities (54.76%), foaming capacity (41.47 mL) and foaming stability (56.42%) than gelatins extracted at other extraction time. The longer the extraction time, the better the functional properties of the gelatin. Based on its good functional properties, silver catfish skin gelatin may be useful in various food applications such as soups, sauces and gravies.

Matched MeSH terms: Sodium Chloride; Sodium Hydroxide
Fulltext Preliminary study of the nutritional content of Malaysian edible bird’s nest

Norhayati, M.K., Azman, O., Wan Nazaimoon, W.M.

Malays J Nutr, 2010;16(3):389-396.
MyJurnal

Malaysian edible bird’s nests (EBN) are from the swiflet species, Aerodromus fuciphagus. The objective of this study was to determine and compare the nutrient composition of EBN obtained from different parts of Peninsular Malaysia, collected at three different harvesting seasons, to four commercial brands. A total of 18 raw, unprocessed EBN samples from the North, South and East Coast zones of Peninsular Malaysia and duplicate samples of 4 commercial brands (processed) of EBN samples were analysed. The protein and mineral contents of unprocessed EBN samples between zones and harvesting seasons were comparable. Mean (± SEM) protein content of unprocessed EBN was 61.5 ± 0.6 g/100g and the top four minerals detected were calcium, sodium, magnesium and potassium with mean (± SEM) concentration of 553.1 ± 19.5 mg/100g, 187.9 ± 10.4 mg/100g, 92.9 ± 2.0 mg/100g and 6.3 ± 0.4 mg/100g respectively. Sialic acid content ranged between 0.7 to 1.5%, and remained comparable between samples from different zones and harvesting seasons. The commercial brands were found to contain higher amounts of calcium, sodium, magnesium, potassium and phosphorus compared to unprocessed EBN, warranting further investigation and verification with more samples. Since the nutrient contents of EBN may be affected by seasonal variations and even breeding sites, it is recommended that a more comprehensive study be conducted involving more samples and breeding sites as such data are important to ensure sustainability of the EBN industry in this country.

Matched MeSH terms: Sodium; Sodium, Dietary
The effect of thyroxine on the renal function of asphyxiated neonates

Rostenberghe, H.V., Haider, D., Abdullah, Y., Amir, H., Abdul Razak, A.R.

Malaysian Journal of Paediatrics and Child Health, 1998;10(2):19-23.
MyJurnal

Thyroxine has been shown to have a beneficial effect on renal function in cases of impending renal failure in ani-mal studies.'5 Studies of the use of thyroxine in humans in impending renal failure are scarce. The aim of this study was to assess the effect of oral thyroxine on the renal function of asphyxiated term neonates who often have renal impairment.
A randomised control trial was conducted, involving 30 term asphyxiated neonates. The study group (n=15) was given thyroxine (50 pg) orally on days 1, 2 and 3 of life and placebo was given to the control group (n=15). Renal function was studied on day 1 and day 4 of life. The two groups did not differ significantly as regards gestational age, birth weight, severity of asphyxia, preg-nancy or delivery complications, fluids administered and drugs used. There was no significant difference in urine output, creatinine clearance and fractional excretion of sodium on day 1 but there was a trend towards a worse renal function on day 1 in the treatment group. The creatinine clearance was significantly better in the treat-ment group on day 4 (p = 0.017). Urine output and fractional excretion of sodium on day 4 were better in the treatment group but the differences did not reach statistical significance (p = 0.14 and 0.057 respectively). Statistical analysis on the differences between day 4 and day 1 showed statistical significance only for creatinine clearance: creatinine clearance day 4 minus creatinine clearance day 1 was 52.6 (±32.4) for the thyroxine group and 7.3 (±7.8) for the controls (p= 0.006).
These data support the hypothesis that thyroxine may have a significant beneficial effect on the renal function in term neonates with perinatal asphyxia. Thyroxine may be proven useful in future for patients with impending renal failure.

Matched MeSH terms: Sodium; Sodium, Dietary
Fulltext Determination of mineral content in the ficus deltoidea leaves

Nihayah Mohammad, Yong, Kar Wei, Nur Faizah Abu Bakar

Jurnal Sains Kesihatan Malaysia, 2012;10(2):25-29.
MyJurnal

Ficus deltoidea leaves were widely used as a tea beverages in Malaysia with no information of its mineral content. Hence the mineral content of two species of Ficus deltoidea leaves were investigated. The dried leaves of F. deltoidea var. angustifolia and F. deltoidea var. deltoidea were acid digested and mineral elements of Na, Mg, K, Ca, Mn, Cr, Fe and Zn were determined using ICP–MS. Magnesium, potassium, sodium, manganese, iron and zinc were found to be present in the leaves of F. deltoidea var. angustifolia and F. deltoidea var. deltoidea. Concentration of magnesium (1934 mg/L), manganese (58.37 mg/L), iron (6.89 mg/L) and zinc (1.77 mg/L) in F. deltoidea var. deltoidea species were significantly (P < 0.05) higher than in F. deltoidea var. angustifolia species with concentration of 317 mg/L, 29.62 mg/L, 4.55 mg/L and 1.26 mg/L for magnesium, manganese, iron and zinc respectively. Meanwhile, concentration of sodium in F. deltoidea var. deltoidea species (3.13 mg/L) was found to be significantly (P < 0.05) lower than the concentration in F. deltoidea var. angustifolia species (9.11 mg/L). The finding showed that the leaves of F. deltoidea var. deltoidea has higher nutritional value than the leaves of F. deltoidea var. angustifolia. Leaves of Ficus deltoidea especially the F. deltoidea var. deltoidea species contain high amount of magnesium, manganese and potassium. Therefore, tea made of this leaves can be served as a good source of minerals for human consumption.

Matched MeSH terms: Sodium; Sodium, Dietary
Fulltext Characterization of Immunoglobulin E-Binding Proteins (IgE) of Scomberomorus commerson Lacepede

Rosmilah Misnan, Shahnaz Murad, Masita Arip, Noormalin Abdullah, Jamaludin Mohamed

Jurnal Sains Kesihatan Malaysia, 2005;3(2):79-87.
MyJurnal

The objective of this study was to determine the Immunoglobulin E-binding proteins (IgE) and major allergens of Scomberomorus commerson Lacepede (Narrow-barred Spanish mackerel). Allergen extracts were obtained from uncooked and cooked fish by homogenization in phosphate-buffered saline followed by continuous extraction at 4oC or on ice. Protein profiles and IgEbinding patterns were then detected by means of sodium dodecyl polyacrylamide gel electrophoresis (SDS PAGE) and immunoblotting using sera from patients sensitized to the fish. SDS-PAGE of the uncooked fish extracts revealed 26 protein bands in the range of about 11 to >175 kD, while the cooked extracts produced fewer protein bands. Immunoblotting demonstrated 17 IgE-binding bands, ranging in molecular weight from 11 to 151 kD. Two components with molecular weight of about ~50 and 42 kD showed the highest frequency of IgE-binding (62.2 and 51.4% respectively) and were identified as the major allergens of this fish allergy. Other IgE-binding proteins including a protein at ~12 kD which was equivalent in size to parvalbumin were identified as the minor allergens.

Matched MeSH terms: Sodium; Sodium Chloride
Structural and Ionic Transport Properties of Protonic Conducting Solid Biopolymer Electrolytes Based on Carboxymethyl Cellulose Doped with Ammonium Fluoride

Ramlli MA, Isa MI

J Phys Chem B, 2016 11 10;120(44):11567-11573.
PMID: 27723333

Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and transference number measurement (TNM) techniques were applied to investigate the complexation, structural, and ionic transport properties of and the dominant charge-carrier species in a solid biopolymer electrolyte (SBE) system based on carboxymethyl cellulose (CMC) doped with ammonium fluoride (NH4F), which was prepared via a solution casting technique. The SBEs were partially opaque in appearance, with no phase separation. The presence of interactions between the host polymer (CMC) and the ionic dopant (NH4F) was proven by FT-IR analysis at the C-O band. XRD spectra analyzed using Origin 8 software disclose that the degree of crystallinity (χc%) of the SBEs decreased with the addition of NH4F, indicating an increase in the amorphous nature of the SBEs. Analysis of the ionic transport properties reveals that the ionic conductivity of the SBEs is dependent on the ionic mobility (μ) and diffusion of ions (D). TNM analysis confirms that the SBEs are proton conductors.

Matched MeSH terms: Carboxymethylcellulose Sodium/chemistry*
Fulltext Nutritional, phytochemical and pharmacological properties of Canarium odontophyllum miq. (Dabai) fruit

Tan, Chin Xuan, Azrina Azlan

The Pertanika Journal of Scholarly Research Reviews, 2016;2(1):80-94.
MyJurnal

Canarium odontophyllum Miq. fruit, popularly recognized as dabai fruit in Sarawak, is a
seasonal fruit found in the tropical rainforest of East Malaysia. A dabai fruit can be divided into
several anatomical parts, and different parts of the fruit have different valuable phytochemicals. Due
to the lack of promotion, dabai fruit is viewed as nutritionally inferior fruit by the public. On the
contrary, the fruit is rich in nutrients such as protein, fat, carbohydrates, sodium, calcium and iron.
Many phytochemicals have been detected from different parts of dabai fruit, and these molecules have
been linked to beneficial properties such as hypolipidemic, anti-atherosclerotic, anti-cholinesterase,
antimicrobial and potentially anti-diabetic. The aim of this article is to review research studies on this
fruit in order to provide adequate baseline information for commercial exploitation as well as for
future studies.

Matched MeSH terms: Sodium; Sodium, Dietary
Protein purification for the Lowry assay: acid precipitation of proteins in the presence of sodium dodecyl sulfate and other biological detergents

Yeang HY, Yusof F, Abdullah L

Anal Biochem, 1998 Dec 15;265(2):381-4.
PMID: 9882418
Matched MeSH terms: Sodium Dodecyl Sulfate/chemistry*
Fulltext Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert

Kamarudin NB, Sharma S, Gupta A, Kee CG, Chik SMSBT, Gupta R

3 Biotech, 2017 Jun;7(2):127.
PMID: 28573397 DOI: 10.1007/s13205-017-0767-9

Uncontrolled disposal of feathers from the poultry industry and slaughterhouses is environmentally undesirable. The feathers are composed of approximately 90% of keratin which is an important ingredient of cosmetics, shampoos and hair treatment creams. This study aimed to determine the optimum conditions for the extraction of keratin from chicken feathers. The extraction of keratin using various reducing agents was studied using statistical experimental design. In the extraction process, pH, temperature, ratio of reducing agents, mass of chicken feathers and incubation time were analyzed. The keratin in the total extracted protein was purified by size exclusion chromatography, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and further characterized using amino acids profile analysis. The surface morphology and chemical composition were studied by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) analysis. Sodium sulfide (Na2S) yielded 84.5% of keratin as compared to sodium hydroxide (43.8), urea mixture (50.6), mixture of sodium dodecyl sulfate (SDS) and sodium bisulfite (18.3) and a mixture of Na2S and sodium hydroxide (41.5%) under optimized conditions. The optimum yield of keratin was achieved at 80.9 °C in 9.5 h with 0.05 M sodium sulfide using response surface methodology (RSM). Among the five parameters screened, pH was found not to be significant because the p value was greater than 0.05.

Matched MeSH terms: Sodium Dodecyl Sulfate; Sodium Hydroxide
Dietary sodium intake and its association with hypertension: A cross-sectional study in Selangor, Malaysia

Isa ZM, Ibrahim N, Ismail NH, Jaafar MH, Tamil AM, Yusof KH

J Pak Med Assoc, 2021 Feb;71(Suppl 2)(2):S68-S73.
PMID: 33785945

OBJECTIVE: To identify the prevalence of hypertension and its relationship with dietary sodium intake among the Malay population in Selangor, Malaysia.
Methods: Respondents were recruited from the year 2013 to 2015 from households in Klang Valley (urban area) and several settlements of the Federal Land Development Authority (FELDA) in Selangor (rural area). Data were collected using two questionnaires, a sociodemographic questionnaire and a food frequency questionnaire.
RESULTS: A total of 3,453 adults participated in this study. The mean age of the respondents was 50.9 (±10.23) years. The prevalence of hypertension was 23.3%. Mean dietary sodium consumption was 3.6 (±6.63) grams/day, 1.6 grams higher than the current WHO recommendation. The prevalence of hypertension was higher among males aged 60 years and older; among rural population with low education level; among housewives and those with high dietary sodium intake. After adjusting for age, gender and marital status in a multiple logistic regression analysis, rural location (OR = 5.81) and high sodium intake (OR = 2.33) have been shown to affect the incidence of hypertension.
CONCLUSIONS: A substantial proportion of Malay population in Selangor was hypertensive with a higher sodium intake than the WHO recommendation. Hypertension was associated with rural location and high sodium intake. Sustainable and cost-effective population-based health promotion and prevention interventions using a multi-sectoral approach are needed to ensure sufficient community sodium intake.

Matched MeSH terms: Sodium, Dietary*
Fulltext The New Standardized Malaysian Healthy Eating Index

Jailani M, Elias SM, Rajikan R

Nutrients, 2021 Sep 30;13(10).
PMID: 34684475 DOI: 10.3390/nu13103474

Healthy Eating Index (HEI) is a diet quality measure that assesses the population's compliance towards dietary guidelines. In Malaysia, diet quality measure, though existing, has some limitations in terms of application and relevance. This study aims to develop a new standardized Malaysian Healthy Eating Index (S-MHEI) that can measure the diet quality of all Malaysians regardless of their energy requirement level. The Malaysian Dietary Guidelines (MDG) 2010 and MDG for Children and Adolescents (MDGCA) 2013 were used as main references in developing the index components. In addition, the latest Malaysian Adults Nutrition Survey (MANS) and Adolescent Nutrition Survey (ANS) were also referred to ensure the relevance of the components selected. For adequacy components, the least restrictive method was used in setting the standard for the scoring system. Meanwhile, the scoring system for moderation components was built based on the Recommended Nutrient Intake (RNI) 2017. The new S-MHEI comprises of 11 components with a maximum total score of 100. The least restrictive method allowed the index to be used across energy requirement levels. However, the index will not be sensitive towards adhering to the specific recommended amount of intake-which in effect, made the index focus on measuring diet quality rather than diet quantity.

Matched MeSH terms: Sodium/analysis

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