Displaying publications 161 - 180 of 191 in total

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  1. Ramanunny AK, Wadhwa S, Gulati M, Singh SK, Kapoor B, Dureja H, et al.
    Eur J Pharmacol, 2021 Jan 05;890:173691.
    PMID: 33129787 DOI: 10.1016/j.ejphar.2020.173691
    Skin diseases are the fourth leading non-fatal skin conditions that act as a burden and affect the world economy globally. This condition affects the quality of a patient's life and has a pronounced impact on both their physical and mental state. Treatment of these skin conditions with conventional approaches shows a lack of efficacy, long treatment duration, recurrence of conditions, systemic side effects, etc., due to improper drug delivery. However, these pitfalls can be overcome with the applications of nanomedicine-based approaches that provide efficient site-specific drug delivery at the target site. These nanomedicine-based strategies are evolved as potential treatment opportunities in the form of nanocarriers such as polymeric and lipidic nanocarriers, nanoemulsions along with emerging others viz. carbon nanotubes for dermatological treatment. The current review focuses on challenges faced by the existing conventional treatments along with the topical therapeutic perspective of nanocarriers in treating various skin diseases. A total of 213 articles have been reviewed and the application of different nanocarriers in treating various skin diseases has been explained in detail through case studies of previously published research works. The toxicity related aspects of nanocarriers are also discussed.
    Matched MeSH terms: Nanotubes, Carbon
  2. Saleemi MA, Hosseini Fouladi M, Yong PVC, Chinna K, Palanisamy NK, Wong EH
    Chem Res Toxicol, 2021 01 18;34(1):24-46.
    PMID: 33319996 DOI: 10.1021/acs.chemrestox.0c00172
    Carbon nanotubes (CNTs) are the most studied allotropic form of carbon. They can be used in various biomedical applications due to their novel physicochemical properties. In particular, the small size of CNTs, with a large surface area per unit volume, has a considerable impact on their toxicity. Despite of the use of CNTs in various applications, toxicity is a big problem that requires more research. In this Review, we discuss the toxicity of CNTs and the associated mechanisms. Physicochemical factors, such as metal impurities, length, size, solubilizing agents, CNTs functionalization, and agglomeration, that may lead to oxidative stress, toxic signaling pathways, and potential ways to control these mechanisms are also discussed. Moreover, with the latest mechanistic evidence described in this Review, we expect to give new insights into CNTs' toxicological effects at the molecular level and provide new clues for the mitigation of harmful effects emerging from exposure to CNTs.
    Matched MeSH terms: Nanotubes, Carbon/adverse effects*; Nanotubes, Carbon/chemistry
  3. Tarawneh MA, Saraireh SA, Chen RS, Ahmad SH, Al-Tarawni MAM, Yu LJ
    Radiat Phys Chem Oxf Engl 1993, 2021 Feb;179:109168.
    PMID: 33100612 DOI: 10.1016/j.radphyschem.2020.109168
    A thermoplastic elastomer (TPE) based nanocomposite with the same weight ratio of hybrid nanofillers composed of carbon nanotubes (CNTs) and montmorillonite nanoclay (DK4) was prepared using a melt blending technique with an internal mixer. The TPE composite was blended from polylactic acid (PLA), liquid natural rubber (LNR) as a compatibilizer and natural rubber (NR) in a volume ratio of 70:10:20, respectively. The weight ratio of CNTs and DK4 was 2.5 wt%. The prepared samples were exposed to gamma radiation at range of 0-250 kGy. After exposure to gamma radiation, the mechanical, thermo-mechanical, thermal and electrical conductivity properties of the composites were significantly higher than unirradiated TPE composites as the irradiation doses increased up to 150 kGy. Transmission electron microscopy (TEM) micrographs revealed the good distribution and interaction between the nano-fillers and the matrix in the prepared TPE hybrid nanocomposites. In summary, the findings from this work definite that gamma irradiation might be a viable treatment to improve the properties of TPE nanocomposite for electronic packaging applications.
    Matched MeSH terms: Nanotubes, Carbon
  4. Idris NJ, Bakar SA, Mohamed A, Muqoyyanah M, Othman MHD, Mamat MH, et al.
    Environ Sci Pollut Res Int, 2021 Feb;28(6):6966-6979.
    PMID: 33025441 DOI: 10.1007/s11356-020-10904-y
    In this work, sand/zinc oxide (ZnO)/titanium dioxide (TiO2)-based photocatalysts were hybridized with graphene oxide (GO) and GO_multi-walled carbon nanotubes (MWCNTs) hybrid solution. The novel hybrid was then used in photocatalysis to degrade dye contamination. The nanocomposite photocatalyst was initially fabricated by growing ZnO nanorods (NRs) via sol-gel immersion followed by synthesizing TiO2 NRs for different times (5 and 20 h) using a hydrothermal method on sand as a substrate. Prior to the hybridization, the initial GO was synthesized using electrochemical exfoliation and further mixed with 1 wt% MWCNTs to form GO_MWCNTs hybrid solution. The synthesized GO and GO_MWCNTs hybrid solution were then incorporated onto sand/ZnO/TiO2 nanocomposite-based photocatalysts through immersion. Various sand/ZnO/TiO2-based photocatalysts were then tested for methylene blue (MB) dye degradation within 3 days. On the basis of UV-Vis measurement, the highest MB degradation was achieved by using sand/ZnO NRs/TiO2 NRs (5 h)/GO_MWCNTs (92.60%). The high surface area and high electrical conductivity of GO_MWCNTs prolonged the lifetime of electron/hole separation and thus enhanced the photocatalytic performance.
    Matched MeSH terms: Nanotubes, Carbon*
  5. Yusof Y, Moosavi S, Johan MR, Badruddin IA, Wahab YA, Hamizi NA, et al.
    ACS Omega, 2021 Feb 16;6(6):4184-4191.
    PMID: 33644542 DOI: 10.1021/acsomega.0c04864
    This study presents the electromagnetic (EM) characterization of a multiwalled carbon nanotubes (MWCNT)-silver nanoparticles (AgNP)-reinforced poly(vinyl alcohol) (PVA) hybrid nanocomposite fabricated via the solution mixing technique. Primarily, the structure and morphological properties of the PVA/MWCNT-AgNP hybrid nanocomposite are confirmed by X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The complex permittivity (ε*) and permeability (μ*), as well as the electromagnetic scattering parameters are measured using a PNA network analyzer equipped with X-band waveguide. The results showed an enhanced permittivity (ε' ≈ 25) value of the hybrid nanocomposite in the frequency range of 8-12 GHz. However, the permeability decreased to almost zero (μ' ≈ 0.4) since the inclusion of AgNP with an average particle size of 40 nm is not susceptible to magnetization and causes higher magnetic losses (tan δμ) than dielectric losses (tan δε). Remarkably, the hybrid nanocomposite reduced transmission of electromagnetic (EM) wave by nearly 60% in comparison to PVA/MWCNT. This is attributed to the enhanced absorption and reflection at the nanotubes, and metal-dielectric interfaces have induced multiple internal reflections owing to the porous structure of the nanocomposite. The prospect of the PVA/MWCNT-AgNP hybrid nanocomposite is favorable as a thin absorbing material for EM shielding applications.
    Matched MeSH terms: Nanotubes, Carbon
  6. Ahmad W, Jabbar B, Ahmad I, Mohamed Jan B, Stylianakis MM, Kenanakis G, et al.
    Materials (Basel), 2021 Feb 22;14(4).
    PMID: 33671689 DOI: 10.3390/ma14041037
    Polymer composites are favorite materials for sensing applications due to their low cost and easy fabrication. In the current study, composite nanofibers consisting of polyethylene oxide (PEO), oxidized multi-walled carbon nanotubes (MWCNT) and copper oxide (CuO) nanoparticles with 1% and 3% of fillers (i.e., PEO-CuO-MWCNT: 1%, and PEO-CuO-MWCNT: 3%) were successfully developed through electrospinning for humidity sensing applications. The composite nanofibers were characterized by FTIR, XRD, SEM and EDX analysis. Firstly, they were loaded on an interdigitated electrode (IDE), and then the humidity sensing efficiency was investigated through a digital LCR meter (E4980) at different frequencies (100 Hz-1 MHz), as well as the percentage of relative humidity (RH). The results indicated that the composite nanofibers containing 1% and 3% MWCNT, combined with CuO in PEO polymer matrix, showed potent resistive and capacitive response along with high sensitivity to humidity at room temperature in an RH range of 30-90%. More specifically, the PEO-CuO-MWCNT: 1% nanocomposite displayed a resistive rapid response time within 3 s and a long recovery time of 22 s, while the PEO-CuO-MWCNT: 3% one exhibited 20 s and 11 s between the same RH range, respectively.
    Matched MeSH terms: Nanotubes, Carbon
  7. Pahlevanzadeh F, Bakhsheshi-Rad HR, Kharaziha M, Kasiri-Asgarani M, Omidi M, Razzaghi M, et al.
    J Mech Behav Biomed Mater, 2021 04;116:104320.
    PMID: 33571842 DOI: 10.1016/j.jmbbm.2021.104320
    Polymethyl methacrylate (PMMA) bone cements (BCs) have some drawbacks, including limited bioactivity and bone formation, as well as inferior mechanical properties, which may result in failure of the BC. To deal with the mentioned issues, novel bioactive polymethyl methacrylate-hardystonite (PMMA-HT) bone cement (BC) reinforced with 0.25 and 0.5 wt% of carbon nanotube (CNT) and reduced graphene oxide (rGO) was synthesized. In this context, the obtained bone cements were evaluated in terms of their mechanical and biological characteristics. The rGO reinforced bone cement exhibited better mechanical properties to the extent that the addition of 0.5 wt% of rGO where its compressive and tensile strength of bioactive PMMA-HT/rGO cement escalated from 92.07 ± 0.72 MPa, and 40.02 ± 0.71 MPa to 187.48 ± 5.79 MPa and 64.92 ± 0.75 MPa, respectively. Besides, the mechanisms of toughening, apatite formation, and cell interaction in CNT and rGO encapsulated PMMA have been studied. Results showed that the existence of CNT and rGO in BCs led to increase of MG63 osteoblast viability, and proliferation. However, rGO reinforced bone cement was more successful in supporting MG63 cell attachment compared to the CNT counterpart due to its wrinkled surface, which made a suitable substrate for cell adhesion. Based on the results, PMMA-HT/rGO can be a proper bone cement for the fixation of load-bearing implants.
    Matched MeSH terms: Nanotubes, Carbon*
  8. Sirajudeen AAO, Annuar MSM, Subramaniam R
    Biotechnol Appl Biochem, 2021 Apr;68(2):307-318.
    PMID: 32314420 DOI: 10.1002/bab.1928
    A microbial fuel cell is a sustainable and environmental-friendly device that combines electricity generation and wastewater treatment through metabolic activities of microorganisms. However, low power output from inadequate electron transfer to the anode electrode hampers its practical implementation. Nanocomposites of oxidized carbon nanotubes and medium-chain-length polyhydroxyalkanoates (mcl-PHA) grafted with methyl acrylate monomers enhance the electrochemical function of electrodes in microbial fuel cell. Extensive polymerization of methyl acrylate monomers within mcl-PHA matrix, and homogenous dispersion of carbon nanotubes within the graft matrix are responsible for the enhancement. Modified electrodes exhibit high conductivities, better redox peak and reduction of cell internal resistance up to 76%. A stable voltage output at almost 700 mV running for 225 H generates maximum power and current density of 351 mW/m2 and 765 mA/m2 , respectively. Superior biofilm growth on modified surface is responsible for improved electron transfer to the anode hence stable and elevated power output generation.
    Matched MeSH terms: Nanotubes, Carbon/chemistry*
  9. Azman AR, Mahat NA, Wahab RA, Ahmad WA, Puspanadan JK, Huri MAM, et al.
    Biotechnol Lett, 2021 Apr;43(4):881-898.
    PMID: 33389272 DOI: 10.1007/s10529-020-03052-3
    OBJECTIVE: Optimisation of the green novel nanobio-based reagent (NBR) for rapid visualisation of groomed fingerprints on wet non-porous substrates using response surface methodology and assessment of its stability and sensitivity were attempted for forensic applications.

    RESULTS: Scanning electron microscopy images demonstrated successful attachments of NBR onto the constituents of fingerprints on the substrates. The highest average quality of visualised fingerprints was attained at the optimum condition (100 mg of CRL; 75 mg of acid-functionalised multi-walled carbon nanotubes; 5 h of immobilisation). The NBR produced comparable average quality of fingerprints with the commercially available small particle reagent, even after 4 weeks of storage (without any preservatives) in both chilled and sultry conditions. The NBR was sensitive enough to visualise the increasingly weaker fingerprints, particularly on glass slides.

    CONCLUSION: The optimised novel NBR could be the relatively greener option for visualising latent fingerprints on wet, non-porous substrates for forensic applications.

    Matched MeSH terms: Nanotubes, Carbon/chemistry*
  10. Basivi PK, Ramesh S, Kakani V, Yadav HM, Bathula C, Afsar N, et al.
    Sci Rep, 2021 May 10;11(1):9918.
    PMID: 33972653 DOI: 10.1038/s41598-021-89430-x
    In this study, a novel nanohybrid composite containing nitrogen-doped multiwalled carbon nanotubes/carboxymethylcellulose (N-MWCNT/CMC) was synthesized for supercapacitor applications. The synthesized composite materials were subjected to an ultrasonication-mediated solvothermal hydrothermal reaction. The synthesized nanohybrid composite electrode material was characterized using analytical methods to confirm its structure and morphology. The electrochemical properties of the composite electrode were investigated using cyclic voltammetry (CV), galvanic charge-discharge, and electrochemical impedance spectroscopy (EIS) using a 3 M KOH electrolyte. The fabricated composite material exhibited unique electrochemical properties by delivering a maximum specific capacitance of approximately 274 F g-1 at a current density of 2 A g-1. The composite electrode displayed high cycling stability of 96% after 4000 cycles at 2 A g-1, indicating that it is favorable for supercapacitor applications.
    Matched MeSH terms: Nanotubes, Carbon
  11. Al-Salih M, Samsudin S, Arshad SS
    J Genet Eng Biotechnol, 2021 May 18;19(1):76.
    PMID: 34003402 DOI: 10.1186/s43141-021-00161-y
    BACKGROUND: Environmental contamination by microbes is a major public health concern. A damp environment is one of the potential sources for microbe proliferation. Smart synthesis nanocatalytic coatings on surfaces, food, and material from different pathogen bacteria can inhibit using the Fe3O4/CNTs as anti-microbial growth can effectively curb this growing threat. In this present work, the anti-microbial efficacy of synthesis of a compound nanoparticle-containing iron oxide-multi-walled carbon nanotube was combined by laser ablation PLAL and explored the anti-bacterial action of colloidal solution of Fe3O4/CNTs NPs that was evaluated against bacteria which is classified as gram-negative (Escherichia coli (E. coli), Klebsiella pneumonia (K. pneumonia), and also that is identified as gram-positive (Streptococcus pyogenes (S .pyogenes) and Staphylococcus aureus (S. aureus) under visible light irradiation.

    RESULTS: Doping of a minute fraction of iron(III) salt (0.5 mol%) in a volatile solvent (ethanol) was carried out via the sol-gel technique. Fe3O4 was further calcined at various temperatures (in the range of 500-700 °C) to evaluate the thermal stability of the Fe3O4 nanoporous oxidizer nanoparticles. The physicochemical properties of the samples were characterized through X-ray diffraction (XRD), atomic force microscopy (AFM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and UV-Visible spectroscopy techniques. XRD results revealed that the nanoparticles framework of Fe3O4 was maintained well up to 650 °C by the Fe dopant. UV-Vis results suggested that absorption property of combination Fe3O4/CNTs nanopowder by PLAL was enhanced and the band gap is reduced into 2.0 eV.

    CONCLUSIONS: Density functional theory (DFT) studies emphasize the introduction of Fe+ and Fe2+ ions by replacing other ions in the CNT lattice, therefore creating oxygen vacancies. These further promoted anti-microbial efficiency. A significantly high bacterial inactivation that indicates results was evaluated and that the mean estimations of restraint were determined from triple assessment in every appraisal at 400 ml which represent the best anti-bacterial action against gram-positive and gram-negative microbes.

    Matched MeSH terms: Nanotubes, Carbon
  12. Khan FSA, Mubarak NM, Tan YH, Khalid M, Karri RR, Walvekar R, et al.
    J Hazard Mater, 2021 07 05;413:125375.
    PMID: 33930951 DOI: 10.1016/j.jhazmat.2021.125375
    Industrial effluents contain several organic and inorganic contaminants. Among others, dyes and heavy metals introduce a serious threat to drinking waterbodies. These pollutants can be noxious or carcinogenic in nature, and harmful to humans and different aquatic species. Therefore, it is of high importance to remove heavy metals and dyes to reduce their environmental toxicity. This has led to an extensive research for the development of novel materials and techniques for the removal of heavy metals and dyes. One route to the removal of these pollutants is the utilization of magnetic carbon nanotubes (CNT) as adsorbents. Magnetic carbon nanotubes hold remarkable properties such as surface-volume ratio, higher surface area, convenient separation methods, etc. The suitable characteristics of magnetic carbon nanotubes have led them to an extensive search for their utilization in water purification. Along with magnetic carbon nanotubes, the buckypaper (BP) membranes are also favorable due to their unique strength, high porosity, and adsorption capability. However, BP membranes are mostly used for salt removal from the aqueous phase and limited literature shows their applications for removal of heavy metals and dyes. This study focuses on the existence of heavy metal ions and dyes in the aquatic environment, and methods for their removal. Various fabrication approaches for the development of magnetic-CNTs and CNT-based BP membranes are also discussed. With the remarkable separation performance and ultra-high-water flux, magnetic-CNTs, and CNT-based BP membranes have a great potential to be the leading technologies for water treatment in future.
    Matched MeSH terms: Nanotubes, Carbon
  13. Azami MS, Jalil AA, Hassan NS, Hussain I, Fauzi AA, Aziz MAA
    J Hazard Mater, 2021 07 15;414:125524.
    PMID: 33647620 DOI: 10.1016/j.jhazmat.2021.125524
    In this work, fibrous silica-titania (FST) was successfully prepared by the microemulsion method prior to the addition of three types of carbonaceous materials: graphitic-carbon nitride, g-C3N4 (CN), graphene nanoplatelets (GN), and multi-wall carbon nanotubes, MWCNT (CNT), via a solid-state microwave irradiation technique. The catalysts were characterized using XRD, FESEM, TEM, FTIR, UV-Vis DRS, N2 adsorption-desorption, XPS and ESR, while their photoactivity was examined on the degradation of toxic 2-chlorophenol (2-CP). The result demonstrated that the initial reaction rate was in the following order: CNFST (5.1 × 10-3 mM min-1) > GNFST (2.5 × 10-3 mM min-1) > CNTFST (2.3 × 10-3 mM min-1). The best performance was due to the polymeric structure of g-C3N4 with a good dispersion of C and N on the surface FST. This dispersion contributed towards an appropriate quantity of defect sites, as a consequence of the greater interaction between g-C3N4 and the FST support, that led to narrowed of band gap energy (2.98 eV to 2.10 eV). The effect of scavenger and ESR studies confirmed that the photodegradation over CNFST occurred via a Z-scheme mechanism. It is noteworthy that the addition of green carbonaceous materials on the FST markedly enhanced the photodegradation of toxic 2-CP.
    Matched MeSH terms: Nanotubes, Carbon
  14. Yunus MA, Ramli MM, Osman NH, Mohamed R
    Arch Immunol Ther Exp (Warsz), 2021 Jul 29;69(1):20.
    PMID: 34327598 DOI: 10.1007/s00005-021-00625-6
    Sole nanomaterials or nanomaterials bound to specific biomolecules have been proposed to regulate the immune system. These materials have now emerged as new tools for eliciting immune-based therapies to treat various cancers. Graphene, graphene oxide (GO) and reduced GO (rGO) are the latest nanomaterials among other carbon nanotubes that have attracted wide interest among medical industry players due to their extraordinary properties, inert-state, non-toxic and stable dispersion in a various solvent. Currently, GO and rGO are utilized in various biomedical application including cancer immunotherapy. This review will highlight studies that have been carried out in elucidating the stimulation of GO and rGO on selected innate and adaptive immune cells and their effect on cancer progression to shed some insights for researchers in the development of various GO- and rGO-based immune therapies against various cancers.
    Matched MeSH terms: Nanotubes, Carbon*
  15. Aghalari Z, Dahms HU, Sillanpää M
    Life Sci Soc Policy, 2021 Sep 13;17(1):8.
    PMID: 34511108 DOI: 10.1186/s40504-021-00116-8
    OBJECTIVE: The use of nanotechnologies is important to reduce environmental health problems in Iran, so the present study was conducted to determine the effectiveness of nanotechnologies in environmental health. This is a cross-sectional descriptive study for 11-year periods (2008-2018) on all articles published in three specialized journals of environmental health with emphasis on the use of nanotechnologies in various fields of environmental health (water, air, sewage, waste, food, radiation, etc).

    RESULTS: In this study, 774 articles related to 114 issues of 3 specialized environmental health journals were reviewed. A review of 774 articles showed that 80 articles (10.3%) were published in the field of nanotechnologies. Out of 80 articles published in the field of nanotechnology, 66 articles (82.5%) were published on the subject of water, 9 articles (11.3%) on wastewater and 5 articles (6.2%) on air pollution. Subject review of articles showed that articles using carbon nanotubes to remove natural organic pollutants, surfactants, hydroxybenzenes, phenol, dimethyl phthalates, use of titanium dioxide nanoparticles, iron-magnesium nanoparticles for wastewater treatment, Silver nanoparticles were used to remove air pollution. The results showed that published articles on nanotechnology in the field of environmental health were few.

    Matched MeSH terms: Nanotubes, Carbon*
  16. Ong CB, Annuar MSM
    J Food Biochem, 2021 10;45(10):e13924.
    PMID: 34490635 DOI: 10.1111/jfbc.13924
    Multi-walled carbon nanotubes (MWCNT)-tannase composite was investigated as an immobilized biocatalyst on the basis of its facile preparation, low cost, and excellent aqueous dispersibility. Cross-linked tannase enzymes, obtained in the presence of glutaraldehyde, were composited with MWCNT via physical adsorption. Multiple techniques were applied to investigate, and corroborate the successful adsorption of cross-linked tannase onto the MWCNT structure. Green tea infusion extract post-treatment using the composite preparation showed elevated radical scavenging activities relative to the control. Green tea infusion extract exhibited a markedly reduced EC50 value on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals following its treatment with the enzyme composite, which represents 20%-34% enhancement in its free radical scavenging capacity. Stoichiometry and number of reduced DPPH were determined and compared. The antioxidative potential of a widely consumed, health-beneficial green tea is elevated by the treatment with MWCNT-tannase composite. PRACTICAL APPLICATIONS: Cross-linked tannase enzymes were composited with pristine multi-walled carbon nanotubes via simple physical adsorption. The composite presents key advantages such as low specific volume compared to other well-known immobilization media, inert, facile enzyme composition, and ease of recovery for repeated use. The work demonstrated carbon nanotube prosthetic utility in the biotransformation of food-based health commodity sought after for its nutritional benefits. The approach is of both industrial- and agricultural importance, and is a promising and viable strategy to obtain a natural, functional food supplement for the multi-billion dollar well-being and health-related industries.
    Matched MeSH terms: Nanotubes, Carbon*
  17. Abdul Manaf SA, Mohamad Fuzi SFZ, Low KO, Hegde G, Abdul Manas NH, Md Illias R, et al.
    Appl Microbiol Biotechnol, 2021 Nov;105(21-22):8531-8544.
    PMID: 34611725 DOI: 10.1007/s00253-021-11616-0
    Carbon nanomaterials, due to their catalytic activity and high surface area, have potential as cell immobilization supports to increase the production of xylanase. Recombinant Kluyveromyces lactis used for xylanase production was integrated into a polymeric gel network with carbon nanomaterials. Carbon nanomaterials were pretreated before cell immobilization with hydrochloric acid (HCl) treatment and glutaraldehyde (GA) crosslinking, which contributes to cell immobilization performance. Carbon nanotubes (CNTs) and graphene oxide (GO) were further screened using a Plackett-Burman experimental design. Cell loading and agar concentration were the most important factors in xylanase production with low cell leakage. Under optimized conditions, xylanase production was increased by more than 400% compared to free cells. Immobilized cell material containing such high cell densities may exhibit new and unexplored beneficial properties because the cells comprise a large fraction of the component. The use of carbon nanomaterials as a cell immobilization support along with the entrapment method successfully enhances the production of xylanase, providing a new route to improved bioprocessing, particularly for the production of enzymes. KEY POINTS: • Carbon nanomaterials (CNTs, GO) have potential as cell immobilization supports. • Entrapment in a polymeric gel network provides space for xylanase production. • Plackett-Burman design screen for the most important factor for cell immobilization.
    Matched MeSH terms: Nanotubes, Carbon*
  18. Sharma N, Zahoor I, Sachdeva M, Subramaniyan V, Fuloria S, Fuloria NK, et al.
    Environ Sci Pollut Res Int, 2021 Nov;28(43):60459-60476.
    PMID: 34545518 DOI: 10.1007/s11356-021-16570-y
    Meningitis is an inflammation of the protective membranes called meninges and fluid adjacent the brain and spinal cord. The inflammatory progression expands all through subarachnoid space of the brain and spinal cord and occupies the ventricles. The pathogens like bacteria, fungi, viruses, or parasites are main sources of infection causing meningitis. Bacterial meningitis is a life-threatening health problem that which needs instantaneous apprehension and treatment. Nesseria meningitidis, Streptococcus pneumoniae, and Haemophilus flu are major widespread factors causing bacterial meningitis. The conventional drug delivery approaches encounter difficulty in crossing this blood-brain barrier (BBB) and therefore are insufficient to elicit the desired pharmacological effect as required for treatment of meningitis. Therefore, application of nanoparticle-based drug delivery systems has become imperative for successful dealing with this deadly disease. The nanoparticles have ability to across BBB via four important transport mechanisms, i.e., paracellular transport, transcellular (transcytosis), endocytosis (adsorptive transcytosis), and receptor-mediated transcytosis. In this review, we reminisce distinctive symptoms of meningitis, and provide an overview of various types of bacterial meningitis, with a focus on its epidemiology, pathogenesis, and pathophysiology. This review describes conventional therapeutic approaches for treatment of meningitis and the problems encountered by them while transmitting across tight junctions of BBB. The nanotechnology approaches like functionalized polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, nanoemulsion, liposomes, transferosomes, and carbon nanotubes which have been recently evaluated for treatment or detection of bacterial meningitis have been focused. This review has also briefly summarized the recent patents and clinical status of therapeutic modalities for meningitis.
    Matched MeSH terms: Nanotubes, Carbon*
  19. Ashraf MA, Islam A, Butt MA, Hussain T, Khan RU, Bashir S, et al.
    Int J Biol Macromol, 2021 Nov 30;191:872-880.
    PMID: 34571131 DOI: 10.1016/j.ijbiomac.2021.09.131
    Mixed matrix membranes (MMMs) of cellulose acetate/poly(vinylpyrrolidone) (CA/PVP) infused with acid functionalized multiwall carbon nanotubes (f-MWCNTs) were fabricated by an immersion phase separation technique for hemodialysis application. Membranes were characterized using FTIR, water uptake, contact angle, TGA, DMA and SEM analysis. The FTIR was used to confirm the bonding interaction between CA/PVP membrane matrix and f-MWCNTs. Upon addition of f-MWCNTs, TGA thermograms and glass transition temperature indicated improved thermal stability of MMMs. The surface morphological analysis demonstrated revealed uniform distribution of f-MWCNTs and asymmetric membrane structure. The water uptake and contact angle confirmed that hydrophilicity was increased after incorporation of f-MWCNTs. The membranes demonstrated enhancement in water permeate flux, bovine serum albumin (BSA) rejection with the infusion of f-MWCNTs; whereas BSA based anti-fouling analysis using flux recovery ratio test shown up to 8.4% improvement. The urea and creatinine clearance performance of MMMs were evaluated by dialysis experiment. It has been found that f-MWCNTs integrated membranes demonstrated the higher urea and creatinine clearance with increase of 12.6% and 10.5% in comparison to the neat CA/PVP membrane. Thus, the prepared CA/PVP membranes embedded with f-MWCNTs can be employed for wide range of dialysis applications.
    Matched MeSH terms: Nanotubes, Carbon/chemistry*
  20. Muthu BR, Pushpa EP, Dhandapani V, Jayaraman K, Vasanthakumar H, Oh WC, et al.
    Sensors (Basel), 2021 Dec 22;22(1).
    PMID: 35009576 DOI: 10.3390/s22010033
    Aerospace equipages encounter potential radiation footprints through which soft errors occur in the memories onboard. Hence, robustness against radiation with reliability in memory cells is a crucial factor in aerospace electronic systems. This work proposes a novel Carbon nanotube field-effect transistor (CNTFET) in designing a robust memory cell to overcome these soft errors. Further, a petite driver circuit to test the SRAM cells which serve the purpose of precharge and sense amplifier, and has a reduction in threefold of transistor count is recommended. Additionally, analysis of robustness against radiation in varying memory cells is carried out using standard GPDK 90 nm, GPDK 45 nm, and 14 nm CNTFET. The reliability of memory cells depends on the critical charge of a device, and it is tested by striking an equivalent current charge of the cosmic ray's linear energy transfer (LET) level. Also, the robustness of the memory cell is tested against the variation in process, voltage and temperature. Though CNTFET surges with high power consumption, it exhibits better noise margin and depleted access time. GPDK 45 nm has an average of 40% increase in SNM and 93% reduction of power compared to the 14 nm CNTFET with 96% of surge in write access time. Thus, the conventional MOSFET's 45 nm node outperforms all the configurations in terms of static noise margin, power, and read delay which swaps with increased write access time.
    Matched MeSH terms: Nanotubes, Carbon*
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