MyMedR

Fulltext The achilles tendon: myth and true facts

Levin, K.B, Das, S.

Journal of Surgical Academia, 2011;1(1):81-82.

MyJurnal

In this article, we speculate the reasons behind the death of Achilles during the Trojan war. Roots of Medicine can be traced to ancient Greek history. From the Hippocrates Oath to the Achilles tendon, it all has a long story to tell. In the history of ancient Greece, Gods played an important role in their lives and the immortals existed.

Fulltext Expression of miR-630 associated with tyrosine kinase inhibitor therapeutic response in lung adenocarcinoma cases

Das S

J Thorac Dis, 2019 Mar;11(Suppl 3):S253-S255.

PMID: 30997190 DOI: 10.21037/jtd.2019.01.92

Effect of antioxidants and nutrients in patients with allergy and asthma

Das S

J Allergy Clin Immunol, 2014 Sep;134(3):763.

PMID: 25065724 DOI: 10.1016/j.jaci.2014.06.011

Health-care professionals exposed to latex allergy: a cause of concern?

Das S

ANZ J Surg, 2008 Nov;78(11):939.

PMID: 18959687 DOI: 10.1111/j.1445-2197.2008.04708.x

Supratrochlear foramen of the humerus

Das S

Anat Sci Int, 2008 Jun;83(2):120; author reply 121.

PMID: 18507622 DOI: 10.1111/j.1447-073X.2008.00232.x

Fulltext Surgical site infections in any hospital: the true facts

Das S

Indian J Surg, 2009 Apr;71(2):111.

PMID: 23133131 DOI: 10.1007/s12262-009-0032-5

Commentary regarding Severinsson E. discovering the value of research supervision. Nursing & Health Sciences 2010; 12: 400-401

Das S

Nurs Health Sci, 2011 Mar;13(1):9.

PMID: 21392195 DOI: 10.1111/j.1442-2018.2011.00580.x

Fulltext Sub acromial debridement surgery with acromioplasty for chronic shoulder pain - biomechanical challenges in physical rehabilitation

Leonar, J.H., Siti Salmiah, M.D., Das, S., Ayiesah, H.R.

Journal of Surgical Academia, 2011;1(1):76-80.

MyJurnal

Arthroscopic sub acromial debridement surgery with acromioplasty is one of the shoulder surgeries performed to treat chronic shoulder pain. This surgical procedure is usually indicated in sub acromial impingement syndrome of shoulder, degenerative rotator cuff tears, severe functional limitation of shoulder joint and often surgery was performed in cases where all the conservative management had failed in the treatment of chronic shoulder pain. Even though the patient would be referred for early rehabilitation, post operative management of this surgical condition is highly challenging. Movement of the shoulder joint is often related with scapulo-thoracic joint, acromio-clavicular joint and sternoclavicular joint and the shoulder movements are governed by various different muscular forces from these joints. Failure to understand this biomechanical complexity of shoulder joint during post operative rehabilitation results in failure of the surgical outcome and might cause severe functional limitation with recurrent shoulder pain. Often in clinical practice, greater emphasis is given to achieve and regain movements in shoulder joint at the expense of the joint stability. However, inadequate scapular stability might further predispose the shoulder joint to excessive loading and results in repetitive injuries leading to chronic shoulder pain. This might affect the surgical and clinical outcome of the acromioplasty and result in surgical failure. Hence, surgeons and clinicians need to understand the biomechanical contributions in the post operative rehabilitation of the shoulder joint. The present case report emphasises the biomechanical model of post operative rehabilitation of a patient who had arthroscopic sub acromial debridement with acromioplasty.

The Role of MicroRNAs in Diagnosis, Prognosis, Metastasis and Resistant Cases in Breast Cancer

Teoh SL, Das S

Curr Pharm Des, 2017;23(12):1845-1859.

PMID: 28231756 DOI: 10.2174/1381612822666161027120043

The incidence and mortality due to breast cancer is increasing worldwide. There is a constant quest to know the underlying molecular biology of breast cancer in order to arrive at diagnosis and plan better treatment options. MicroRNAs (miRNAs) are small non-coding and single stranded RNAs which influence the gene expression and physiological condition in any tumor. The miRNAs may act on different pathways in various cancers. Recently, there are research reports on various miRNAs being linked to breast cancers. The important miRNAs associated with breast cancers include miR-21, miR-155, miR-27a, miR-205, miR-145 and miR-320a. In the present review we discuss the role of miRNAs in breast cancer, its importance as diagnostic markers, prognosis and metastasis markers. We also highlight the role of miRNAs with regard to resistance to few anticancerous drugs such as Tamoxifen and Trastuzumab. The role of miRNA in resistance to treatment is one of the core issues discussed in the present review. Much information on the miRNA roles is available particularly in the neoadjuvant chemotherapy setting, because this protocol allows the rapid association of miRNA expression with the treatment response. This review opens the door for designing better therapeutic options in drug resistance cases in breast cancer.

The effect of alcohol level on male and female drivers: Important facts

Murthy JK, Das S

Drug Alcohol Depend, 2020 Sep 01;214:108146.

PMID: 32634715 DOI: 10.1016/j.drugalcdep.2020.108146

Serum neurofilament light chain level as a biomarker of neurodegeneration and predictor of white-matter abnormality progression

Murthy JK, Das S

Eur J Neurol, 2020 10;27(10):e55.

PMID: 32526090 DOI: 10.1111/ene.14389

Fulltext Personal Protective Equipment (PPE) and Its Use in COVID-19: Important Facts

Das S, Rajalingham S

Indian J Surg, 2020 May 28.

PMID: 32837060 DOI: 10.1007/s12262-020-02411-8

Role of hormonal fluctuations in temporomandibular disorder pain: facts to ponder

Das S, Rajalingham S

Pain, 2012 Jan;153(1):250-251.

PMID: 22119339 DOI: 10.1016/j.pain.2011.10.039

Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment

Teoh SL, Das S

Tumour Biol., 2016 Nov;37(11):14363-14380.

PMID: 27623943

Obesity continues to be a major global problem. Various cancers are related to obesity and proper understanding of their aetiology, especially their molecular tumour biology is important for early diagnosis and better treatment. Genes play an important role in the development of obesity. Few genes such as leptin, leptin receptor encoded by the db (diabetes), pro-opiomelanocortin, AgRP and NPY and melanocortin-4 receptors and insulin-induced gene 2 were linked to obesity. MicroRNAs control gene expression via mRNA degradation and protein translation inhibition and influence cell differentiation, cell growth and cell death. Overexpression of miR-143 inhibits tumour growth by suppressing B cell lymphoma 2, extracellular signal-regulated kinase-5 activities and KRAS oncogene. Cancers of the breast, uterus, renal, thyroid and liver are also related to obesity. Any disturbance in the production of sex hormones and insulin, leads to distortion in the balance between cell proliferation, differentiation and apoptosis. The possible mechanism linking obesity to cancer involves alteration in the level of adipokines and sex hormones. These mediators act as biomarkers for cancer progression and act as targets for cancer therapy and prevention. Interestingly, many anti-cancerous drugs are also beneficial in treating obesity and vice versa. We also reviewed the possible link in the mechanism of few drugs which act both on cancer and obesity. The present review may be important for molecular biologists, oncologists and clinicians treating cancers and also pave the way for better therapeutic options.

The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications

Teoh SL, Das S

Curr Drug Targets, 2017 Nov 30;18(16):1880-1892.

PMID: 27628948 DOI: 10.2174/1389450117666160907153338

BACKGROUND: The incidence of lung cancers has increased globally. Increased exposure to tobacco, passive smoking, less consumption of vegetables and fruits and occupational exposure to asbestos, arsenic and chromium are the main risk factors. The pathophysiology of lung cancer is complex and not well understood. Various microRNAs, genes and pathways are associated with lung cancers. The genes involved in lung cancers produce proteins involved in cell growth, differentiation, different cell cycles, apoptosis, immune modulation, tumor spread and progression. The Hippo pathway (also known as the Salvador-Warts-Hippo pathway) is the latest emerging concept in cancers. The Hippo pathway plays an important role in controlling the size of the tissue and organ by virtue of its action on cell proliferation and apoptosis.

OBJECTIVE: In the present review, we highlight the mammalian Hippo pathway, role of its core members, its upstream regulators, downstream effectors and the resistance cases in lung cancers.

RESULTS: Specific interaction of Mer with cell surface hyaluronan receptor CD44 is vital in cell contact inhibition, thereby activating Hippo pathway. Both transcription co-activators YAP and TAZ (also known as WWTR1, being homologs of Drosophila Yki) are important regulators of proliferation and apoptosis, and serve as major downstream effectors of the Hippo pathway. Mutation of NF2, the upstream regulator of Hippo pathway is linked to the cancers.

CONCLUSION: Targeting YAP and TAZ may be important for future drug delivery and treatment.

Fulltext Comparison of fazadinium and suxamethonium for endotracheal intubation in Malaysian patients

Namazie M, Das S

Med J Malaysia, 1980 Jun;34(4):391-4.

PMID: 6111740

Notch Signalling Pathways and Their Importance in the Treatment of Cancers

Teoh SL, Das S

Curr Drug Targets, 2018;19(2):128-143.

PMID: 28294046 DOI: 10.2174/1389450118666170309143419

BACKGROUND: The Notch pathway is an evolutionarily conserved, intercellular signalling system which is present in all multicellular organisms and mammals. The Notch pathway plays an important role in the embryonic development as it controls cell proliferation, cell differentiation and binary cell fate decisions.

OBJECTIVE: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers.

RESULTS: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor synergistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer.

CONCLUSION: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.

Fulltext Pigmented 'black' adenoma: a rare cause of Conn's syndrome

Saladina, J.J., Rohaizak, M., Jasmi, A.Y., Sellymiah, A., Aishah, M.A.S., Das, S., et al.

JUMMEC, 2011;14(1):23-25.

MyJurnal

Presence of a hypofunctioning pigmented adenoma are commonly asymptomatic and is usually only found during an autopsy. In contrast, hyperfunctioning pigmented adenoma is a rare clinical entity and in the majority of cases results in Cushing's syndrome. In this case study, we report a 66-year-old male who presented instead with the clinical and biochemical features of Conn's syndrome. On laparoscopic adrenalectomy, it was found that the tumour had a functioning black adenoma which does not usually present with Conn's syndrome but rather to that of a Cushing's. The intraoperative changes and histopathological findings are discussed.

Fulltext Cardiorespiratory parameters before and after acupuncture: observations in a healthy and diseased state

Mohan V, Das S

Clinics (Sao Paulo), 2012;67(6):673-4.

PMID: 22760909

Comment on: Nascimento RC, Hossri CA, Berwanger O, Carvalho VO. Acupuncture and exercise capacity: a case report. Clinics. 2012;67(2):193–4

Delinquency, androgens, and the family: a test of evolutionary neuroandrogenic theory

Ellis L, Das S

Int J Offender Ther Comp Criminol, 2013 Aug;57(8):966-84.

PMID: 22514238 DOI: 10.1177/0306624X12440564

There is little doubt that family factors can influence involvement in delinquency, although the full nature and extent of their influences remain unclear. In recent decades, testosterone has been increasingly implicated as a contributor to adolescent offending. The present study sought to determine whether two important types of familial factors--parental socioeconomic status and amicable parent-child relationships--are interacting with testosterone (and possibly other androgens) to affect delinquency. A large sample of North American college students self-reported their involvement in eight categories of delinquency along with self-ratings of various androgen-promoted traits (e.g., muscularity and low-deep voice), parental social status, and the quality of the relationships they had with parents. In both sexes, parent-child relationships and androgens were significantly associated with delinquency but parental social status was not. Factor analysis revealed that the authors' measures of all four categories of variables exhibited strong loadings onto their respective factors. Androgens and amicable parent-child relationships were associated with delinquency but parental social status was not. About one third of the influence of parent-child relationships on delinquency appeared to be attributable to androgens. Findings are discussed from the perspective of the evolutionary neuroandrogenic theory of delinquent and criminal behavior.

Displaying publications 1 - 20 of 564 in total