Displaying publications 1 - 20 of 31 in total

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  1. Fulltext Easy lens cleaning solution for laboratory microscopes
    Pramanik T, Ghosh A, Roychowdhury P
    Med J Malaysia, 2005 Mar;60(1):116.
    PMID: 16250297
    Matched MeSH terms: Ether*
  2. Quantitative and Qualitative Bibliometric Scope Toward the Synthesis of Rose Oxide as a Natural Product in Perfumery
    Ziarani GM, Mohajer F, Jamali SM, Ebrahim NA
    Curr Org Synth, 2020;17(8):610-624.
    PMID: 32703138 DOI: 10.2174/1872208314666200722161044
    Rose Oxide is a monoterpene along with cyclic ether used in fragrance to produce rosy notes, in general, there are 4 stereoisomeric structures of the Rose Oxide, which the cis-configured Rose Oxide has a very unique and strong note in perfumery. In this review, several approaches were reported on account of the Rose Oxide applied in perfumery from 1864 to 2019 via quantitative and qualitative approaches.
    Matched MeSH terms: Ether; Ethers; Ethers, Cyclic
  3. Case of traumatic tetanus cured by inhalation of ether
    Smith GH
    Lancet, 1849;54:667-668.
    DOI: 10.1016/S0140-6736(02)71261-0
    Matched MeSH terms: Ether
  4. Fulltext Experimental investigation, binary modelling and artificial neural network prediction of surfactant adsorption for enhanced oil recovery application
    Belhaj AF, Elraies KA, Alnarabiji MS, Abdul Kareem FA, Shuhli JA, Mahmood SM, et al.
    Chem Eng J, 2021 Feb 15;406:127081.
    PMID: 32989375 DOI: 10.1016/j.cej.2020.127081
    Throughout the application of enhanced oil recovery (EOR), surfactant adsorption is considered the leading constraint on both the successful implementation and economic viability of the process. In this study, a comprehensive investigation on the adsorption behaviour of nonionic and anionic individual surfactants; namely, alkyl polyglucoside (APG) and alkyl ether carboxylate (AEC) was performed using static adsorption experiments, isotherm modelling using (Langmuir, Freundlich, Sips, and Temkin models), adsorption simulation using a state-of-the-art method, binary mixture prediction using the modified extended Langmuir (MEL) model, and artificial neural network (ANN) prediction. Static adsorption experiments revealed higher adsorption capacity of APG as compared to AEC, with sips being the most fitted model with R2 (0.9915 and 0.9926, for APG and AEC respectively). It was indicated that both monolayer and multilayer adsorption took place in a heterogeneous adsorption system with non-uniform surfactant molecules distribution, which was in remarkable agreement with the simulation results. The (APG/AEC) binary mixture prediction depicted contradictory results to the experimental individual behaviour, showing that AEC had more affinity to adsorb in competition with APG for the adsorption sites on the rock surface. The adopted ANN model showed good agreement with the experimental data and the simulated adsorption values for APG and AEC showed a decreasing trend as temperature increases. Simulating the impact of binary surfactant adsorption can provide a tremendous advantage of demonstrating the binary system behaviour with less experimental data. The utilization of ANN for such prediction procedure can minimize the experimental time, operating cost and give feasible predictions compared to other computational methods. The integrated workflow followed in this study is quite innovative as it has not been employed before for surfactant adsorption studies.
    Matched MeSH terms: Ether; Ethers
  5. Fulltext Preparation, Characterization, and Performance Evaluation of Polysulfone Hollow Fiber Membrane with PEBAX or PDMS Coating for Oxygen Enhancement Process
    Chong KC, Lai SO, Lau WJ, Thiam HS, Ismail AF, Roslan RA
    Polymers (Basel), 2018 Jan 28;10(2).
    PMID: 30966162 DOI: 10.3390/polym10020126
    Air pollution is a widely discussed topic amongst the academic and industrial spheres as it can bring adverse effects to human health and economic loss. As humans spend most of their time at the office and at home, good indoor air quality with enriched oxygen concentration is particularly important. In this study, polysulfone (PSF) hollow fiber membranes fabricated by dry-jet wet phase inversion method were coated by a layer of polydimethylsiloxane (PDMS) or poly(ether block amide) (PEBAX) at different concentrations and used to evaluate their performance in gas separation for oxygen enrichment. The surface-coated membranes were characterized using SEM and EDX to determine the coating layer thickness and surface chemical properties, respectively. Results from the gas permeation study revealed that the PSF membrane coated with PDMS offered higher permeance and selectivity compared to the membrane coated with PEBAX. The best performing PDMS-coated membrane demonstrated oxygen and nitrogen gas permeance of 18.31 and 4.01 GPU, respectively with oxygen/nitrogen selectivity of 4.56. Meanwhile, the PEBAX-coated membrane only showed 12.23 and 3.11 GPU for oxygen and nitrogen gas, respectively with a selectivity of 3.94. It can be concluded the PDMS coating is more promising for PSF hollow fiber membrane compared to the PEBAX coating for the oxygen enrichment process.
    Matched MeSH terms: Ether
  6. Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies
    Taha M, Imran S, Ismail NH, Selvaraj M, Rahim F, Chigurupati S, et al.
    Bioorg Chem, 2017 10;74:1-9.
    PMID: 28719801 DOI: 10.1016/j.bioorg.2017.07.001
    A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives (1-23) were synthesized and characterized by EI-MS and 1H NMR, and screened for their α-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC50=0.38±0.82µM) and 23 (IC50=1.66±0.14µM), showed excellent activity whereas the remaining compounds, except 10 and 17, showed good to moderate inhibition in the range of IC50=1.77-2.98µM when compared with the standard acarbose (IC50=1.66±0.1µM). A plausible structure-activity relationship has also been presented. In addition, in silico studies was carried out in order to rationalize the binding interaction of compounds with the active site of enzyme.
    Matched MeSH terms: Ether/chemical synthesis; Ether/pharmacology*; Ether/chemistry
  7. The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression
    Teah YF, Abduraman MA, Amanah A, Adenan MI, Sulaiman SF, Tan ML
    Food Chem Toxicol, 2017 Sep;107(Pt A):293-301.
    PMID: 28689918 DOI: 10.1016/j.fct.2017.07.011
    Elephantopus scaber Linn and its major bioactive component, deoxyelephantopin are known for their medicinal properties and are often reported to have various cytotoxic and antitumor activities. This plant is widely used as folk medicine for a plethora of indications although its safety profile remains unknown. Human ether-a-go-go-related gene (hERG) encodes the cardiac IKr current which is a determinant of the duration of ventricular action potentials and QT interval. The hERG potassium channel is an important antitarget in cardiotoxicity evaluation. This study investigated the effects of deoxyelephantopin on the current, mRNA and protein expression of hERG channel in hERG-transfected HEK293 cells. The hERG tail currents following depolarization pulses were insignificantly affected by deoxyelephantopin in the transfected cell line. Current reduction was less than 40% as compared with baseline at the highest concentration of 50 μM. The results were consistent with the molecular docking simulation and hERG surface protein expression. Interestingly, it does not affect the hERG expression at both transcriptional and translational level at most concentrations, although higher concentration at 10 μM caused protein accumulation. In conclusion, deoxyelephantopin is unlikely a clinically significant hERG channel and Ikr blocker.
    Matched MeSH terms: Ether-A-Go-Go Potassium Channels/genetics*; Ether-A-Go-Go Potassium Channels/metabolism
  8. Polarity dependent photoisomerization of ether substituted azodyes: Synthesis and photoswitching behavior
    Gan SM, Pearl ZF, Yuvaraj AR, Lutfor MR, Gurumurthy H
    Spectrochim Acta A Mol Biomol Spectrosc, 2015 Oct 5;149:875-80.
    PMID: 26004096 DOI: 10.1016/j.saa.2015.05.027
    Two new ether substituted azodyes were synthesized and characterized by different spectral analysis such as (1)H NMR, (13)C NMR, FTIR and UV/Vis. Synthesized compounds were used to study the photoisomerization phenomenon by using UV-Vis spectro-photometer. Interesting polarity dependent effect is observed for the first time on these materials. Trans-cis (E-Z) and cis-trans (Z-E) conversion occurred within 41 s and 445 min, respectively for both the compounds in solutions. Polarizing optical microscopy studies revealed that there is no liquid crystal phase for both the compounds. The dramatic variation in the optical property is speculated to be the polarity of the chemical species. These derivatives are useful to fabricate optical data storage devices.
    Matched MeSH terms: Ether; Ethers
  9. Functionalized fluorescent terephthalate monomers and their attempted polyester formation
    Choo YSL, Giamberini M, Antonio J, Waddell PG, Benniston AC
    Org Biomol Chem, 2020 Nov 04;18(42):8735-8745.
    PMID: 33094783 DOI: 10.1039/d0ob01533d
    The reaction of diethyl 2,5-bis(tert-butyl)phenoxy-3,6-dihydroxyterephthalate (1) with tetraethylene glycol di(p-toluenesulfonate) under high-dilution conditions afforded several isolated products. Two products were identified as macrocycles with one being the 1 + 1 crown ether derivative 3 (10% yield), and the second being the 2 + 2 crown ether compound D3 (19% yield). The X-ray structure for 3 was determined with the asymmetric unit observed to comprise half of the molecule. The small crown ether ring of 3 interacts with K+ or H+ ions in MeOH, but binding is weak and the macrocyclic cavity is too small to fully encapsulate the K+ ion. Transesterification of compounds 1, its methylated version 2 and 3 with diols such as ethylene glycol or 1,4-butandiol produced monomers (M1-M3) which were reacted with terephthaloyl chloride. Short oligomers were produced (PolyM1-PolyM3) rather than extensive polymeric materials and all displayed solid state fluorescence. The absorption and fluorescence properties of M1-M2 and their polymers can be related to subtle structural changes. The Stokes shift for M2 of 15 627 cm-1 in DCM is one of the largest observed for a simple organic chromophore in fluid solution.
    Matched MeSH terms: Ether; Crown Ethers
  10. Supported liquid membrane extraction of nickel using stable composite SPEEK/PVDF support impregnated with a sustainable liquid membrane
    Sulaiman RNR, Jusoh N, Othman N, Noah NFM, Rosly MB, Rahman HA
    J Hazard Mater, 2019 12 15;380:120895.
    PMID: 31351388 DOI: 10.1016/j.jhazmat.2019.120895
    A sustainable and stable supported liquid membrane (SLM) extraction of nickel was developed via impregnation of sustainable liquid membrane in the composite membrane support consisting of polyvinylidene fluoride (PVDF) and sulfonated poly (ether ether ketone) (SPEEK). Bis-2-ethylhexyl phosphate (D2EHPA), 1-octanol, refined palm oil and sulfuric acid were employed as extractant, synergist extractant, diluent and strippant, respectively. Variables studied including effect of refined palm oil compositions as well as the configurations and thicknesses of SPEEK. Lifespan of SLM was evaluated by recycling the composite membrane support. Results revealed that upon using 100% refined palm oil, about 100% of nickel was extracted and recovered in 10 and 14 h, respectively. Composite SPEEK/PVDF stabilized SLM by reducing liquid membrane loss from 47 to 23% upon applying SPEEK at the feed side of PVDF support. High permeability and flux values were obtained at 9.26 x 10-4 cms-1 and 6.48 x 10-7 molcm-2s-1 when increasing SPEEK thickness from 0.025 to 0.055 mm, respectively. The lifespan of SLM was extended up to ninth cycles with low weight loss percentage of the impregnated composite membrane (8%). In conclusion, the SPEEK/PVDF impregnated with refined palm oil has improved the stability of SLM extraction of nickel ions from industrial wastewater.
    Matched MeSH terms: Ether
  11. Thermomechanical investigations of PEKK-HAp-CS composites
    Singh R, Singh G, Singh J, Kumar R, Rahman MM, Ramakrishna S
    Proc Inst Mech Eng H, 2019 Nov;233(11):1196-1203.
    PMID: 31545132 DOI: 10.1177/0954411919877979
    In this experimental study, a composite of poly-ether-ketone-ketone by reinforcement of hydroxyapatite and chitosan has been prepared for possible applications as orthopaedic scaffolds. Initially, different weight percentages of hydroxyapatite and chitosan were reinforced in the poly-ether-ketone-ketone matrix and tested for melt flow index in order to check the flowability of different compositions/proportions. Suitable compositions revealed by the melt flow index test were then taken forward for the extrusion of filament required for fused deposition modelling. For thermomechanical investigations, Taguchi-based design of experiments has been used with input variables in the extrusion process as follows: temperature, load applied and different composition/proportions. The specimens in the form of feedstock filament produced by the extrusion process were made to undergo tensile testing. The specimens were also inspected by differential scanning calorimetry and photomicrographs. Finally, the specimen showing the best performance from the thermomechanical viewpoint has been selected to extrude the filament for the fused deposition modelling process.
    Matched MeSH terms: Ether; Ethers
  12. Fulltext Simulation and optimisation of Bioethanol purification using extractive distillation with additive solvent
    Anisuzzaman, S.M., Krishnaiah, D., Bono, A., Lahin, F.A., Suali, E., Zuyyin, I.A.Z.
    Pertanika Journal of Science & Technology, 2018;26(2):707-718.
    MyJurnal
    In this study, simulation and optimisation of the purification of bioethanol from an azeotropic mixture was done using the Aspen HYSYS and the Response Surface Methodology (RSM), respectively, to achieve an acceptable bioethanol content with minimal energy use. The objective of this study is to develop the simulation process of bioethanol production from a fermentation effluent. Additionally, the effects of parameters such as solvent temperature, number of entrainer feed stage, mass flow rate and third components of the process for production of bioethanol were studied. As bioethanol is a product of biofuel production, the main challenge facing bioethanol production is the separation of high purity ethanol. However, the separation of ethanol and water can be achieved with the addition of a suitable solvent such as 1,3-butylene glycol (13C4Diol), mixture 13C4Diol and ethylene glycol (EGlycol) and mixture 13C4Diol and glycol ethyl ether (DEG) in the extractive distillation process. For the 13C4Diol mixture, the temperature of entrainer is 90oC with 1500 kg/hr of entrainer rate, while the number of entrainer feed stage is one. The optimum conditions for mixture 13C4Diol and EGlycol require a temperature of entrainer of 90.77oC with an entrainer rate of 1500 kg/hr, while the number of entrainer feed stage is one. Lastly, for optimum conditions for the mixture 13C4Diol and DEG, the temperature of entrainer should be 90oC with an entrainer rate of 1564.04 kg/hr, while the number of entrainer feed stage is one. This study shows that process simulation and optimisation can enhance the removal of water from an azeotropic mixture.
    Matched MeSH terms: Ether; Ethers
  13. Anaesthesia for emergency operations
    Hopkin DAB
    Journal of the Malaya Branch of the British Medical Association, 1939;3:315-25.
    Matched MeSH terms: Ether
  14. Fulltext Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
    Tay YL, Amanah A, Adenan MI, Wahab HA, Tan ML
    Sci Rep, 2019 12 24;9(1):19757.
    PMID: 31874991 DOI: 10.1038/s41598-019-56106-6
    Mitragyna speciosa Korth (M. speciosa) has been widely used as a recreational product, however, there are growing concerns on the abuse potentials and toxicity of the plant. Several poisoning and fatal cases involving kratom and mitragynine have been reported but the underlying causes remain unclear. The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit underlying cardiac rapidly delayed rectifier potassium current (IKr). Pharmacological blockade of the IKr can cause acquired long QT syndrome, leading to lethal cardiac arrhythmias. This study aims to elucidate the mechanisms of mitragynine-induced inhibition on hERG1a/1b current. Electrophysiology experiments were carried out using Port-a-Patch system. Quantitative RT-PCR, Western blot analysis, immunofluorescence and co-immunoprecipitation methods were used to determine the effects of mitragynine on hERG1a/1b expression and hERG1-cytosolic chaperones interaction. Mitragynine was found to inhibit the IKr current with an IC50 value of 332.70 nM. It causes a significant reduction of the fully-glycosylated (fg) hERG1a protein expression but upregulates both core-glycosylated (cg) expression and hERG1a-Hsp90 complexes, suggesting possible impaired hERG1a trafficking. In conclusion, mitragynine inhibits hERG1a/1b current through direct channel blockade at lower concentration, but at higher concentration, it upregulates the complexation of hERG1a-Hsp90 which may be inhibitory towards channel trafficking.
    Matched MeSH terms: Ether-A-Go-Go Potassium Channels/metabolism*
  15. A novel antiamoebic agent against Acanthamoeba sp.--A causative agent for eye keratitis infection
    Kusrini E, Hashim F, Azmi WN, Amin NM, Estuningtyas A
    Spectrochim Acta A Mol Biomol Spectrosc, 2016 Jan 15;153:714-21.
    PMID: 26474244 DOI: 10.1016/j.saa.2015.09.021
    The terbium trinitrate.trihydrate.18-crown ether-6, Tb(NO3)3(OH2)3.(18C6) complex has been characterized by elemental analysis, photoluminescence and single X-ray diffraction. The IC50 values were determined based on MTT assay while light and fluorescence microscopy imaging were employed to evaluate the cellular morphological changes. Alkaline comet assay was performed to analyze the DNA damage. The photoluminescence spectrum of the Tb complex excited at 325 nm displayed seven luminescence peaks corresponding to the (5)D4→(7)F(0, 1, 2, 3, 4, 5, 6) transitions. The cytotoxicity and genotoxicity studies indicated that the Tb(NO3)3(OH2)3.(18C6) complex and its salt form as well as the 18C6 molecule have excellent anti-amoebic activity with very low IC50 values are 7, 2.6 and 1.2 μg/mL, respectively, with significant decrease (p<0.05) in Acanthamoeba viability when the concentration was increased from 0 to 30 μg/mL. The mode of cell death in Acanthamoeba cells following treatment with the Tb complex was apoptosis. This is in contrast to the Tb(NO3)3.6H2O salt- and 18C6 molecule-treated Acanthamoeba, which exhibited necrotic type cells. The percentage of DNA damage following treatment with all the compounds at the IC25 values showed high percentage of type 1 with the % nuclei damage are 14.15±2.4; 46.00±4.2; 36.36±2.4; 45.16±0.6%, respectively for untreated, treated with Tb complex, Tb salt and 18C6 molecule. The work features promising potential of Tb(NO3)3(OH2)3.(18C6) complex as anti-amoebic agent, representing a therapeutic option for Acanthamoeba keratitis infection.
    Matched MeSH terms: Ether; Crown Ethers
  16. Synthesis of α,β-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells
    Qin HL, Leng J, Zhang CP, Jantan I, Amjad MW, Sher M, et al.
    J Med Chem, 2016 Apr 14;59(7):3549-61.
    PMID: 27010345 DOI: 10.1021/acs.jmedchem.6b00276
    Sixty-nine novel α,β-unsaturated carbonyl based compounds, including cyclohexanone, tetralone, oxime, and oxime ether analogs, were synthesized. The antiproliferative activity determined by using seven different human cancer cell lines provided a structure-activity relationship. Compound 8ag exhibited high antiproliferative activity against Panc-1, PaCa-2, A-549, and PC-3 cell lines, with IC50 value of 0.02 μM, comparable to the positive control Erlotinib. The ten most active antiproliferative compounds were assessed for mechanistic effects on BRAF(V600E), EGFR TK kinases, and tubulin polymerization, and were investigated in vitro to reverse efflux-mediated resistance developed by cancer cells. Compound 8af exhibited the most potent BRAF(V600E) inhibitory activity with an IC50 value of 0.9 μM. Oxime analog 7o displayed the most potent EGFR TK inhibitory activity with an IC50 of 0.07 μM, which was analogous to the positive control. Some analogs including 7f, 8af, and 8ag showed a dual role as anticancer and MDR reversal agents.
    Matched MeSH terms: Ether
  17. Fulltext Evaluation of Adsorptive Characteristics of Cow Dung and Rice Husk Ash for Removal of Aqueous Glyphosate and Aminomethylphoshonic Acid
    Garba J, Samsuri WA, Othman R, Hamdani MSA
    Sci Rep, 2019 11 27;9(1):17689.
    PMID: 31776374 DOI: 10.1038/s41598-019-54079-0
    Glyphosate (GLY) is a major herbicide used throughout the world, and its continuous application has become an environmental issue. Adsorption is an important mechanism for removing organic contaminant in water. The present study characterized cow dung (CD) and rice husk ash (RHA), and determined the adsorption-desorption of GLY and its metabolite, aminomethylphoshonic acid (AMPA), on to them. The results revealed that both CD and RHA were alkaline and had no or low content of arsenic, cadmium, chromium and lead. The CD had lower surface area (13.104 mg2g-1) than RHA (21.500 m2g-1). The CD contained amines, phenol, ethers and carboxylic functional groups, while in addition to carboxylic and ether, RHA contains siloxane. Both CD and RHA had high affinities for GLY and AMPA. The Freundlich sorption coefficient (Kf) on AMPA were 2.915 and 2.660 for CD and RHA, respectively, while the values on GLY were 1.168 and 1.166 (mg g-1) for CD and RHA, respectively. Desorption of GLY only occurred at lower concentrations, while no desorption of AMPA was recorded, indicating their strong adsorption on CD and RHA. Considering their availabilities and affordable prices, both CD and RHA can be recommended as economical adsorbent for the removal of GLY and AMPA.
    Matched MeSH terms: Ether; Ethers
  18. Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes
    Abubakar AR, Haque M
    J Pharm Bioallied Sci, 2020 01 29;12(1):1-10.
    PMID: 32801594 DOI: 10.4103/jpbs.JPBS_175_19
    Preparation of medicinal plants for experimental purposes is an initial step and key in achieving quality research outcome. It involves extraction and determination of quality and quantity of bioactive constituents before proceeding with the intended biological testing. The primary objective of this study was to evaluate various methods used in the preparation and screening of medicinal plants in our daily research. Although the extracts, bioactive fractions, or compounds obtained from medicinal plants are used for different purposes, the techniques involved in producing them are generally the same irrespective of the intended biological testing. The major stages included in acquiring quality bioactive molecule are the selection of an appropriate solvent, extraction methods, phytochemical screening procedures, fractionation methods, and identification techniques. The nitty-gritty of these methods and the exact road map followed solely depends on the research design. Solvents commonly used in extraction of medicinal plants are polar solvent (e.g., water, alcohols), intermediate polar (e.g., acetone, dichloromethane), and nonpolar (e.g., n-hexane, ether, chloroform). In general, extraction procedures include maceration, digestion, decoction, infusion, percolation, Soxhlet extraction, superficial extraction, ultrasound-assisted, and microwave-assisted extractions. Fractionation and purification of phytochemical substances are achieved through application of various chromatographic techniques such as paper chromatography, thin-layer chromatography, gas chromatography, and high-performance liquid chromatography. Finally, compounds obtained are characterized using diverse identification techniques such as mass spectroscopy, infrared spectroscopy, ultraviolet spectroscopy, and nuclear magnetic resonance spectroscopy. Subsequently, different methods described above can be grouped and discussed according to the intended biological testing to guide young researchers and make them more focused.
    Matched MeSH terms: Ether
  19. Interactions of Flavone and Steroid from A. subintegra as Potential Inhibitors for Porcine Pancreatic Lipase
    Ibrahim M, Abdul Azziz SSS, Wong CF, Bakri YM, Abdullah F
    Curr Comput Aided Drug Des, 2020;16(6):698-706.
    PMID: 31648647 DOI: 10.2174/1573409915666191015112320
    BACKGROUND: Obesity is one serious health condition that contributes to various chronic diseases. The inhibition of pancreatic lipase is a promising treatment for obesity.

    OBJECTIVE: The present study was designed to investigate anti-porcine pancreatic lipase effect of isolated compounds from Aquilaria subintegra and its mechanism.

    METHODS: Compounds were isolated with serial column chromatography and their structure were identified using spectroscopic methods. Isolated compounds were tested for anti-lipase potential activity using colorimetric assay. The prediction of energy binding between isolated compounds and enzyme was described using YASARA software.

    RESULTS: Four compounds were successfully isolated from the bark of A. subintegra, namely, 5- hydroxy-7,4'-dimethoxyflavone, luteolin-7,3',4'-trimethyl ether, 5,3'-dihydroxy-7,4'-dimethoxyflavone and β-sitosterol. The results indicated that all compounds displayed promising pancreatic lipase inhibitory activity ranging between of 6% to 53% inhibition. Compound 5-hydroxy-7,4'- dimethoxyflavone was a competitive inhibitor and decreases the enzyme catalysis. Meanwhile, β- sitosterol was a non- competitive inhibitor since the latter was bind allosterically toward enzyme.

    CONCLUSION: This finding is significant for further investigation of bioactive compounds from A. subintegra on animal study.

    Matched MeSH terms: Ether; Ethers
  20. Fulltext Ascariasis among orang asli children at pos lenjang, Pahang, malaysia
    Hartini, Y., Mohamed Kamel, A.G.
    Medicine & Health, 2010;5(2):60-65.
    MyJurnal
    A cross-sectional study was carried out in 2006 to determine the prevalence of Ascaris lumbricoides infection among Orang Asli (aborigines) children in Pos Lenjang, Pahang. A total of 71 faecal samples were collected from the children (40 girls and 31 boys) aged between 1-12 years. The samples were examined for the presence of the ova of A. lumbricoides using direct faecal smear and formalin-ether concentration techniques. 42.3%. The prevalence of A. lumbricoides infection was found to be slightly higher in males (45.2%) compared to females (40%) (p>0.05). The school-aged children showed higher prevalence of infection (48.6%) as compared to the preschool children (35.3%) (p
    Matched MeSH terms: Ether; Ethers
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