Displaying publications 1 - 20 of 127 in total

  1. Abdullah MI, Lee CC, Mat Junit S, Ng KL, Hashim OH
    PeerJ, 2016;4:e2450.
    PMID: 27672505 DOI: 10.7717/peerj.2450
    Papillary thyroid cancer (PTC) is mainly diagnosed using fine-needle aspiration biopsy. This most common form of well-differentiated thyroid cancer occurs with or without a background of benign thyroid goiter (BTG).
    Matched MeSH terms: Thyroid Neoplasms
  2. Wong HH, Pang NTP
    BMJ Case Rep, 2021 Oct 14;14(10).
    PMID: 34649855 DOI: 10.1136/bcr-2021-242333
    A woman in her 30s with underlying Graves' disease, who recently completed radioactive iodine treatment, presented with 2 weeks of acutely altered behaviour associated with auditory hallucinations and religious preoccupations. Laboratory investigation demonstrated elevated free thyroxine levels and suppressed thyroid-stimulating hormone levels. Additionally, there was a presence of antithyroid peroxidase antibodies consistent with autoimmune thyroid disease. She responded to antipsychotics and achieved biochemical euthyroidism. Subsequently, antipsychotic was tapered off during outpatient follow-up at the patient's own request, with supplement thyroxine continuing. After 1 week, acute hallucinations and religious preoccupations re-emerged, driving her to inflict self-injuries by swallowing coins and nails and banging her head against the wall, sustaining laceration wounds. Furthermore, she hammered a roofing nail into the external genitalia, embedded in the symphysis pubis. After supplemental thyroxine was stopped and olanzapine was started, she achieved biochemical euthyroid followed by remission of psychosis within 1 week. This case illustrates the importance of elucidating organic causes of psychosis as they are easily and swiftly reversible.
    Matched MeSH terms: Thyroid Neoplasms*
  3. Abdullah M
    ANZ J Surg, 2002 Sep;72(9):660-4.
    PMID: 12269919
    There have been few detailed studies on thyroid cancer (TC) in Malaysia, a multiethnic country with three major races - Malays, Chinese and Indians.
    Matched MeSH terms: Thyroid Neoplasms/ethnology; Thyroid Neoplasms/epidemiology*; Thyroid Neoplasms/pathology; Thyroid Neoplasms/therapy
  4. Abdul Rahman WF, Md Hashim MN, Win TT, Bakrin IH
    BMJ Case Rep, 2013;2013.
    PMID: 23749834 DOI: 10.1136/bcr-2013-010001
    Solid variant of papillary thyroid carcinoma (PTC) is a rare, poorly characterised variant and predominantly reported in children with a history of radiation exposure. This variant has a high propensity for extra-thyroidal extension and cervical lymph node metastases. A 14-year-old Malay girl who had no history of radiation exposure, presented with multiple cervical lymphadenopathy and it was clinically suspicious for tuberculosis or lymphoma. An incisional biopsy revealed a metastatic PTC. The patient underwent total thyroidectomy with bilateral lateral neck dissection and histopathology report was solid variant of PTC. Whole-body I(131) scan was performed which revealed an intense tracer uptake in the neck. She was planned for radioactive iodine ablation and now on regular follow-up for monitoring of possible tumour metastasis.
    Matched MeSH terms: Thyroid Neoplasms/diagnosis*; Thyroid Neoplasms/pathology
  5. Iftikhar A, Naseeb AK, Khwaja A, Mati H, Karim K, Hameeda N
    Med J Malaysia, 2011 Oct;66(4):322-5.
    PMID: 22299551
    The incidence of thyroid cancer is increasing in several countries. The main objective of this retrospective study was to find and describe province-specific estimates of incidence in males and females by age groups for differentiated thyroid cancer (DTC). This study reports on 87 cases of DTC from Baluchistan province of Pakistan treated with post operative radioiodine at the Center for Nuclear Medicine and Radiotherapy (CENAR) Quetta from January 2003 to December 2009. The patient data has been collected from CENAR Quetta. Patients with DTC were confirmed by clinical examination, thyroid scintigraphy (Thyroid scan), blood tests (T3, T4, TSH) and histopathalogy tests and then treated with radioiodine. The Median age of the patients was 35.5 years (Range 12-70 years). The final histological diagnosis was papillary carcinoma in 71 (81.6 %) cases, follicular carcinoma in 6 (6.9%) cases while 10 (11.5%) cases presented with mixed papillary and follicular carcinoma. About 53 % cases were found in females with age 21-40 years. No strike predominance was observed in any age group for males. Four patients presented with recurrence while six patients showed metastasis in cervical lymph nodes. The small annual incidence did not follow any definite pattern. DTC has a small incidence in Baluchistan due to lack of education and health care facilities. The incidence of DTC is higher in females when compared with males as per this study. This preliminary study will provide an insight to incidence of DTC, its treatment facilities and future planning strategies in Baluchistan, Pakistan.
    Matched MeSH terms: Thyroid Neoplasms/etiology; Thyroid Neoplasms/epidemiology*
  6. Wan Muhaizan WM, Phang KS, Sharifah NA, al Amin D
    Malays J Pathol, 1998 Dec;20(2):109-11.
    PMID: 10879272
    A rare case of primary squamous cell carcinoma of the thyroid is reported herein. A 64-year-old Malay lady presented with a gradually enlarging thyroid nodule for the past 6 months and underwent total thyroidectomy. Histopathology revealed a squamous cell carcinoma of the thyroid with complete resection. Possible primary tumour elsewhere was excluded. Postoperative irradiation was given and patient is still alive after 2 years of follow-up.
    Matched MeSH terms: Thyroid Neoplasms/pathology*; Thyroid Neoplasms/surgery
  7. Win TT, Othman NH, Mohamad I
    Indian J Pathol Microbiol, 2017 Apr-Jun;60(2):167-171.
    PMID: 28631629 DOI: 10.4103/IJPM.IJPM_457_16
    INTRODUCTION: Poorly differentiated thyroid carcinoma (PDTC) is a rare aggressive malignancy of thyroid follicular cells and has unique features in morphology and behavior. This study was aimed to describe the experience of a tertiary medical center with PDTC within a 10-year period.

    MATERIALS AND METHODS: This is a descriptive retrospective study of eight cases of PDTC among 418 various thyroid carcinomas. All cases of PDTC were retrieved along with the clinicopathological information.

    RESULTS: Only eight cases (1.9%) of PDTC were diagnosed among 418 thyroid carcinomas. Mean age was 48.12 with 3:5 (male:female) and tumor size ranged 3-12 cm. PDTC were diagnosed coexisting with one or more other pathologies; nodular hyperplasia (four cases), papillary carcinoma (one case), follicular carcinoma (three cases), and Hashimoto thyroiditis (two cases); with ≥60% PDTC component. Six cases associated with high-grade features died within 3 years after diagnosis.

    DISCUSSION: Mean age in this study was younger including a 20-year-old girl. Younger age was associated with better prognosis. Most of the cases had underlying benign thyroid lesions and differentiated thyroid carcinoma. Most of the PDTC had poor prognosis associated with PDTC component ≥60%, tumor necrosis, high mitotic count, lymph node involvement, vascular invasion and distant metastasis; and these cases died within 3 years after diagnosis.

    CONCLUSION: Although treatment of PDTC remains surgery followed by radioiodine therapy, correct histopathological diagnosis is important for clinicians and oncologists to predict the prognosis. All thyroid carcinoma should be sampled thoroughly not to miss small foci of PDTC component.
    Matched MeSH terms: Thyroid Neoplasms/epidemiology*; Thyroid Neoplasms/pathology*
  8. Jayaram G
    Diagn Cytopathol, 2000 Apr;22(4):227-9.
    PMID: 10787142
    Columnar cell variant of papillary carcinoma (CCV-PC) thyroid is a rare and aggressive tumor composed of tall columnar cells that form papillae, glands and solid structures. This paper describes fine needle aspiration (FNA) cytologic features in a case of CCV-PC occurring in the right thyroid lobe of a 27-year-old female. Smears showed tall columnar cells in monolayered, three-dimensional, acinar and occasional papillary clusters. Nuclei were oval or elongated and monomorphic. Nuclear pseudostratification, resembling that seen in respiratory epithelial cells, was present in some of the cell clusters. Occasional cells showed squamous or Hurthle cell metaplasia. Nuclear grooves and intranuclear cytoplasmic inclusions were not seen. Sections of the right lobectomy specimen showed an well-encapsulated CCV-PC with capsular and vascular permeation. Tall cell variant of papillary carcinoma (TCV-PC) can be distinguished from CCV-PC by the oxyphilia of the tumor cells and the absence of nuclear pseudostratification. Colorectal and endometrial adenocarcinomas metastatic to the thyroid may be difficult to distinguish from CCV-PC.
    Matched MeSH terms: Thyroid Neoplasms/pathology*; Thyroid Neoplasms/surgery
  9. Jayaram G, Cheah PL, Yip CH
    Acta Cytol., 2000 May-Jun;44(3):375-9.
    PMID: 10833994
    BACKGROUND: Teratoma of the thyroid in adults is extremely rare, and most are malignant. Only nine cases have been adequately documented in the English-language literature, and there are no reports detailing the fine needle aspiration (FNA) cytologic characteristics.

    CASE: A 32-year-old female presented with a left-sided nodular thyroid mass with left cervical lymphadenopathy. FNA cytology of the thyroid and lymph nodes was done. The cytologic and immunocytochemical features were that of a small round cell tumor with neuroepithelial (NE) differentiation, metastasizing to the cervical nodes. Microscopic study of the thyroidectomy specimen showed a tumor showing an NE pattern with occasional islands of squamous and cuboidal epithelium, leading to a diagnosis of malignant teratoma.

    CONCLUSION: Knowledge of FNA cytologic features of rare but highly malignant lesions like thyroid teratomas allow early recognition so that suitable and possibly aggressive treatment protocols can be adopted in the hope of prolonging survival.
    Matched MeSH terms: Thyroid Neoplasms/pathology*
  10. Jayaram G, Wong KT, Jalaludin MA
    Malays J Pathol, 1998 Jun;20(1):45-8.
    PMID: 10879264
    Primary mucoepidermoid carcinoma (MEC) of thyroid is an uncommon tumour and reports on its' cytology are consequently scanty. A 46-year-old male presented with a thyroid nodule of nine months duration. Fine needle aspiration (FNA) cytology of the nodule showed features of a malignant tumor that was different from the usual types of thyroid carcinoma. Monolayers and syncytial clusters of round and spindle tumour cells with large vesicular nuclei and single macronucleoli were present. A diagnosis of carcinoma was given with the comment that this was unlike any of the usual types of thyroid cancer and that a metastatic malignancy should be ruled out. The cytological picture of MEC may not always be distinctive enough for accurate tumour typing. Nevertheless the cytological features are usually sufficiently different to rule out all of the usual types of thyroid carcinoma. This distinction may be important from the point of view of differing prognosis in MEC of thyroid (as compared to differentiated thyroid cancers) and the need to exclude a metastatic carcinoma, especially from a primary in one of the salivary glands.
    Matched MeSH terms: Thyroid Neoplasms/pathology*
  11. Dharmalingam SK, Narasimha K
    Med J Malaya, 1972 Sep;27(1):73-6.
    PMID: 4264829
    Matched MeSH terms: Thyroid Neoplasms/diagnosis*
  12. Voralu K, Norsa'adah B, Naing NN, Biswal BM
    Singapore Med J, 2006 Aug;47(8):688-92.
    PMID: 16865209
    The aim of this study was to identify the prognostic factors that influence the survival of differentiated thyroid cancer patients treated at Hospital Universiti Sains Malaysia (HUSM).
    Matched MeSH terms: Thyroid Neoplasms/diagnosis*; Thyroid Neoplasms/mortality*; Thyroid Neoplasms/pathology
  13. Sathasivam H, Loh YM, Saw CL, Khalid N
    Gerodontology, 2017 Jun;34(2):276-279.
    PMID: 27384017 DOI: 10.1111/ger.12240
    OBJECTIVE: A case of oral metastatic follicular thyroid carcinoma is presented.

    BACKGROUND: Metastatic tumours are more frequent in older individuals and can be the only sign/symptom of an undiagnosed primary malignancy.

    CASE REPORT: A 69-year-old lady presented with an enlarging mandibular swelling. Incisional biopsy and imaging studies were suggestive of metastatic follicular thyroid carcinoma.

    CONCLUSION: Metastatic tumours should be considered in the differential diagnosis of mandibular swellings especially in older individuals.

    Matched MeSH terms: Thyroid Neoplasms
  14. Marjmin, O., Rohaizak, M., Naqiyah, I., Imtiaz, H., Hartinie, S.M.
    Primary thyroid lymphoma is a rare tumour of the thyroid gland, accounting for 1-2 % of all thyroid malignancies. Diagnosis by fine needle aspiration cytology occasionally inconclusive, needing bigger biopsy or even thyroidectomy. This study reviews our experience with primary thyroid lymphoma.
    Matched MeSH terms: Thyroid Neoplasms
  15. Zanial AZ, Hamzah F
    Thyroid disorders could be broadly categorised into benign and malignant diseases. Approaches for the
    management of benign and malignant thyroid disorders have been well documented including the treatment
    using radioactive iodine (RAI). RAI has long been used to treat hyperthyroidism and well differentiated
    thyroid cancer. Nevertheless, there are various factors that may influence the outcome of RAI treatment
    including matters related to patient preparations. Thus, healthcare personnel play an important role in
    assisting patients to make the necessary preparations. This article aims to give nurses and clinicians of
    various specialities an insight into the overview of RAI treatment for thyroid disorders particularly in
    Malaysia and further discusses the issues related to preparations of patients.
    Matched MeSH terms: Thyroid Neoplasms
  16. Rashid MZ, Ariffin MH, Rhani SA, Baharudin A, Ibrahim K
    Malays Orthop J, 2017 Nov;11(3):53-55.
    PMID: 29326769 MyJurnal DOI: 10.5704/MOJ.1711.005
    Osteoradionecrosis, a rare complication of radiation therapy, is a slow progression disease which affects the surrounding structures of spinal components. It essentially weakens the soft tissue and bony configuration and can cause nerve impingement or cord compression. We describe a patient who underwent radiotherapy for thyroid cancer and presented with cervical kyphosis with anterolisthesis of C3/C4 and C4/C5 some 32 years later. We explore the role of anterior and posterior fusion, as well as hyperbaric oxygen therapy in promoting healing.
    Matched MeSH terms: Thyroid Neoplasms
  17. Hsu CD, Mathura Y
    J Vet Med Sci, 2018 Feb 20;80(2):320-322.
    PMID: 29311490 DOI: 10.1292/jvms.17-0383
    In January 2016, a 20-year-old female oriental small-clawed otter (Aonyx cinereus) from Night Safari in Singapore was euthanized and diagnosed with a thyroid gland carcinoma. Postmortem examination and histology also revealed metastasis to the regional lymph nodes and severe visceral pentastomiasis. Grossly, the lymph nodes were infested, and encapsulation was observed on the visceral serosal surface. Histopathologically, the lymph nodes were encysted by a thick fibrous connective capsule with minimal inflammatory response. Pentastomiasis has been previously reported in the smooth-coated otter (Lutrogale perspicillata) in Malaysia. This report is the first case of severe visceral pentastomiasis in an oriental small-clawed otter with functional thyroid carcinoma.
    Matched MeSH terms: Thyroid Neoplasms/complications; Thyroid Neoplasms/pathology; Thyroid Neoplasms/veterinary*
  18. Abdullah Suhaimi SN, Nazri N, Nani Harlina ML, Md Isa N, Muhammad R
    Malays J Med Sci, 2015 Jul-Aug;22(4):69-72.
    PMID: 26715910 MyJurnal
    Papillary thyroid carcinoma (PTC) associated with familial adenomatous polyposis (FAP) is rare. It is usually associated with the cribriform-morular variant of PTC, with unusual patterns on detailed histology examination. This variant is known to have a good prognosis. Papillary thyroid carcinoma associated with FAP commonly occurs in females in their 30s and rarely in the elderly. We report a case of a 69-year-old female presenting with thyroid swelling and a history of FAP.
    Matched MeSH terms: Thyroid Neoplasms
  19. Kuan YC, Tan FH
    QJM, 2014 Jun;107(6):475-6.
    PMID: 24106316 DOI: 10.1093/qjmed/hct204
    Matched MeSH terms: Thyroid Neoplasms/diagnosis*
  20. Othman NH, Omar E, Naing NN
    Asian Pac J Cancer Prev, 2009;10(1):87-90.
    PMID: 19469631
    INTRODUCTION: Endemic goitre is a major concern in many nations including Malaysia. Seven states in the country have been identified by Ministry of Health of Malaysia to have high incidence of goitre and one of these is Kelantan.

    METHODS: This is a retrospective study over an 11-year period from 1994 to 2004 on all thyroid specimens submitted to the Pathology Department, Hospital Universiti Sains Malaysia (HUSM), in Kelantan. Epidemiological data were retrieved from the patients' records and pathology findings from the pathology reports.

    RESULTS: During this period, Department of Pathology HUSM received a total of 1,486 thyroid specimens. The female to male ratio was 6:1 and the median age was 40.0 years. The duration of goitre ranged from one to 15 years. Histopathological examination showed 71.9 percent were non-neoplastic and 28.1 percent neoplastic lesions. The hospital-based incidence of nodular hyperplasia was 9.9 per 100,000 admitted patients per year. The hospital-based incidence of all types of malignant thyroid cancers was 3.5 per 100,000. The most common malignancy was papillary carcinoma 76.6 percent. The majority of the cancers (59.5 percent) occurred in a background of nodular hyperplasia. Thyroid cancers made up 4.9 percent of all cancers seen in HUSM.

    CONCLUSION: This study suggests that malignant thyroid lesions arising from multi-nodular goitre are high in a population living in an iodine-deficiency area.
    Matched MeSH terms: Thyroid Neoplasms/epidemiology*
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