Browse publications by year: 1999

  1. Enserink M
    Science, 1999 Apr 16;284(5413):407, 409-10.
    PMID: 10232977 DOI: 10.1126/science.284.5413.407
    MeSH terms: Agricultural Workers' Diseases/epidemiology*; Agricultural Workers' Diseases/virology; Animals; Disease Outbreaks*; Encephalitis, Japanese/epidemiology; Humans; Malaysia/epidemiology; Paramyxoviridae/isolation & purification*; Swine/virology*; Swine Diseases/epidemiology; Swine Diseases/transmission; Swine Diseases/virology; Paramyxoviridae Infections/epidemiology*; Paramyxoviridae Infections/transmission; Paramyxoviridae Infections/virology
  2. Choon SE, Khoo JJ
    Br. J. Dermatol., 1999 Mar;140(3):557-8.
    PMID: 10233296
    MeSH terms: Administration, Oral; Adult; Antifungal Agents/therapeutic use*; Coccidioides; Coccidioidomycosis/drug therapy*; Coccidioidomycosis/epidemiology; Humans; Malaysia/epidemiology; Male; Itraconazole/therapeutic use*
  3. Amar HS, Ho JJ, Mohan AJ
    J Paediatr Child Health, 1999 Feb;35(1):63-6.
    PMID: 10234638
    To determine the community prevalence of human immunodeficiency virus (HIV) in women at the time of delivery in a Malaysian setting.
    MeSH terms: Female; Fetal Blood/virology; Humans; Infant, Newborn; Malaysia/epidemiology; Pregnancy; Pregnancy Complications, Infectious/diagnosis*; Pregnancy Complications, Infectious/ethnology; Pregnancy Complications, Infectious/immunology; Pregnancy Complications, Infectious/epidemiology*; Residence Characteristics; AIDS Serodiagnosis/methods*; HIV Seroprevalence*; HIV Infections/diagnosis*; HIV Infections/ethnology; HIV Infections/immunology; HIV Infections/epidemiology*; HIV Infections/transmission; Neonatal Screening/methods*; Infectious Disease Transmission, Vertical/statistics & numerical data*; Delivery, Obstetric*
  4. Craig ME, Vale T, Robertson P, Rawlinson WD, Gould B
    J Paediatr Child Health, 1999 Feb;35(1):107-8.
    PMID: 10234649
    MeSH terms: Australia/ethnology; Child, Preschool; Disease Outbreaks/statistics & numerical data*; Emigration and Immigration*; Enterovirus Infections/classification*; Enterovirus Infections/genetics; Enterovirus Infections/epidemiology*; Enterovirus Infections/virology*; Female; Humans; Malaysia/epidemiology; Male; Myocarditis/virology; Serotyping; Reverse Transcriptase Polymerase Chain Reaction
  5. Chiu CL, Wang CY
    Paediatr Anaesth, 1999;9(3):268-70.
    PMID: 10320610
    Two children with Tetralogy of Fallot presented for dental extraction. Anaesthesia was induced rapidly and smoothly by inhalation of sevoflurane. We discussed the advantages of sevoflurane as an induction agent as compared to halothane in these children.
    MeSH terms: Anesthesia Recovery Period; Anesthesia, Dental*; Anesthesia, Inhalation*; Atracurium/administration & dosage; Child; Neuromuscular Nondepolarizing Agents/administration & dosage; Female; Halothane/administration & dosage; Humans; Male; Methyl Ethers/administration & dosage*; Tetralogy of Fallot/complications*; Tooth Extraction*; Anesthetics, Inhalation/administration & dosage*; Neuromuscular Blockade
  6. Halder D, Dharap AS, Than M
    Anthropol Anz, 1999 Mar;57(1):69-75.
    PMID: 10320927
    Early identification of a syndrome at birth is of paramount importance for genetic counselling and possible prevention. Often malformation of the hands and fingers are cardinal manifestations of recognizable syndromes. As there are no published standards for hand and finger size for Malay newborn infants, this study was undertaken to establish normal values for hand, middle finger and palmar lengths, and their indices. A cross-sectional study was done on 509 consecutive newborn Malay babies between 34 and 42 weeks of gestation. Measurements were made on the right hand according to the recommended guidelines of Bergsma & Feingold (1975). The mean values for the measurements did not differ significantly between boys and girls, or change with gestation. For the whole group the mean value for total hand length was 64.4 +/- 3.42 mm, middle finger length 37.1 +/- 2.91 mm, palmar length 27.4 +/- 2.15 mm, finger index 0.425 +/- 0.03 and palmar index 0.58 +/- 0.03. A comparison with published measurements for newborns of different racial origin shows significant differences for the total hand length, middle finger length and palm length from Indian and Jewish infants, but not from Japanese infants. The indices were similar in Malay, Indian, Jewish and Japanese newborn infants.
    MeSH terms: Anthropometry; Female; Fingers/physiology*; Gestational Age*; Hand/physiology*; Humans; Infant, Newborn/physiology*; Malaysia; Male; Pregnancy; Reference Values; European Continental Ancestry Group/genetics; Asian Continental Ancestry Group/genetics
  7. Sakai S, Kato M, Inoue T
    Am. J. Bot., 1999 May;86(5):646-58.
    PMID: 10330067
    The pollinators of 29 ginger species representing 11 genera in relation to certain floral morphological characteristics in a mixed-dipterocarp forest in Borneo were investigated. Among the 29 species studied, eight were pollinated by spiderhunters (Nectariniidae), 11 by medium-sized Amegilla bees (Anthophoridae), and ten by small halictid bees. These pollination guilds found in gingers in Sarawak are comparable to the pollination guilds of neotropical Zingiberales, i.e., hummingbird-, and euglossine-bee-pollinated guilds. Canonical discriminant analysis revealed that there were significant correlations between floral morphology and pollination guilds and suggests the importance of plant-pollinator interactions in the evolution of floral morphology. Most species in the three guilds were separated on the plot by the first and second canonical variables. Spiderhunter-pollinated flowers had longer floral tubes, while Amegilla-pollinated flowers had wider lips than the others, which function as a platform for the pollinators. Pistils and stamens of halictid-pollinated flowers were smaller than the others. The fact that gingers with diverse morphologies in a forest with high species diversity were grouped into only three pollination guilds and that the pollinators themselves showed low species diversity suggests that many species of rare understory plants have evolved without segregating pollinators in each pollination guild.
  8. Ismail R
    Clin. Dermatol., 1999 Mar-Apr;17(2):127-35; discussion 105-6.
    PMID: 10330595 DOI: 10.1016/S0738-081X(99)00005-X
    This article reports on the prevalence of AIDS and sexually transmitted diseases (STDs) in Southeast Asia. The spread of HIV infection in this region has been predicted to be worse than that of Africa. The high-prevalence countries are Thailand, Cambodia, and Myanmar, where prevalence rates in the population at risk (15-49 year olds) are up to 2%; while low prevalence countries with rates of 0.1% include the Philippines, Indonesia, Laos, Brunei, and Singapore. Heterosexual transmission in Southeast Asia is the main mode of spread of HIV. Another route is through migration, rural-to-urban or international migration of people seeking jobs; with concurrent loneliness and anonymity, they become vulnerable to STDs and HIV infection. Intravenous drug use poses an increasing risk of transmission. The unavailability of data in some countries makes it difficult to evaluate the extent of the epidemic or if there's an impending epidemic. There are a number of caveats to the data compilation from various countries. These include the following: under-reporting of cases; underdiagnosis; missed diagnosis; and differences in the time of data collection. It is clear that poverty, illiteracy, and poor access to educational information in most countries in this region facilitate the rapid spread of HIV. These coupled with lack of primary health care services, and in most instances, enormously high cost of drugs make the pain and suffering due to the HIV/AIDS epidemic a human disaster far worse than the ravages of war.
    MeSH terms: Acquired Immunodeficiency Syndrome/economics; Acquired Immunodeficiency Syndrome/epidemiology*; Acquired Immunodeficiency Syndrome/transmission; Adolescent; Adult; Asia, Southeastern/epidemiology; Child; Developing Countries/statistics & numerical data; Disease Outbreaks; Female; Humans; Male; Middle Aged; Pregnancy; Pregnancy Complications, Infectious/epidemiology; Prostitution; Risk-Taking; Sexually Transmitted Diseases/economics; Sexually Transmitted Diseases/epidemiology*; Sexually Transmitted Diseases/transmission; Socioeconomic Factors; HIV Infections/economics; HIV Infections/epidemiology*; HIV Infections/transmission; Substance Abuse, Intravenous; Prevalence; AIDS-Related Opportunistic Infections/epidemiology; Homosexuality, Male; Heterosexuality
  9. Tan CE, Emmanuel SC, Tan BY, Jacob E
    Diabetes Care, 1999 Feb;22(2):241-7.
    PMID: 10333940
    OBJECTIVE: The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore.

    RESEARCH DESIGN AND METHODS: A combination of disproportionate stratified sampling and systematic sampling were used to select the sample for the survey. The final number of respondents was 3,568, giving a response rate of 72.6%. All subjects fasted for 10 h and were given a 75-g glucose load, except those known to have diabetes. Blood was taken before and 2 h after the glucose load. Diagnosis of diabetes was based on 2-h glucose alone.

    RESULTS: The age-standardized prevalence of diabetes in Singapore residents aged 18-69 years was 8.4%, with more than half (58.5%) previously undiagnosed. Prevalence of diabetes was high across all three ethnic groups. The prevalence of impaired glucose tolerance was 16.1%, that of hypertension was 6.5%, and 19.0% were regular smokers. The total cholesterol (mean +/- SD) of nondiabetic Singaporeans was 5.18 +/- 1.02 mmol/l; 47.9% had cholesterol > 5.2 mmol/l, while 15.4% had levels > 6.3 mmol/l. Mean LDL cholesterol was 3.31 +/- 0.89 mmol/l; HDL cholesterol was 1.30 +/- 0.32 mmol/l, and triglyceride was 1.23 +/- 0.82 mmol/l.

    CONCLUSIONS: Prevalence of diabetes was high across all three ethnic groups. Ethnic differences in prevalence of diabetes, insulin resistance, central obesity, hypertension, smoking, and lipid profile could explain the differential coronary heart disease rates in the three major ethnic groups in Singapore.
    MeSH terms: Adolescent; Adult; Age Factors; Aged; Body Constitution; Cardiovascular Diseases/epidemiology*; China/ethnology; Cholesterol/blood; Diabetes Mellitus/epidemiology*; Diabetic Angiopathies/epidemiology*; Ethnic Groups/statistics & numerical data*; Female; Health Surveys*; Humans; India/ethnology; Insulin Resistance; Malaysia/ethnology; Male; Middle Aged; Prediabetic State; Risk Factors; Sex Factors; Singapore; Singapore/epidemiology; Triglycerides/blood; Body Mass Index; Prevalence; Diabetes Complications
  10. Indudharan R, Haq JA, Aiyar S
    Ann. Otol. Rhinol. Laryngol., 1999 May;108(5):440-5.
    PMID: 10335703
    Conservative medical management of chronic suppurative otitis media (CSOM) is an important step in achieving a dry ear. Topical antibiotic ear drops and aural toilet form the mainstay of medical management of noncholesteatomatous CSOM. This study analyzes the causal organisms and their sensitivity to various antibiotics. Out of 382 swabs examined, the major organisms isolated were Pseudomonas aeruginosa (27.2%), followed by Staphylococcus aureus (23.6%). The sensitivity of P. aeruginosa was 100% to ceftazidime, 98.9% to ciprofloxacin, 96.3% to gentamicin, and 95.4% to polymyxin B, whereas the sensitivity of S. aureus was 98.6% to ciprofloxacin, 97.4% to cloxacillin sodium, 96.5% to cotrimoxazole, and 90.7% to gentamicin. Pseudomonas aeruginosa was almost completely resistant to ampicillin (97.6%) and chloramphenicol (96.6%), whereas S. aureus was almost completely resistant to ampicillin (73.8%) and polymyxin B (98.3%). Among the available topical antibiotic preparations for use in the ear, we found that ciprofloxacin and gentamicin are the best choices.
    MeSH terms: Adolescent; Adult; Aged; Anti-Bacterial Agents/therapeutic use*; Bacteria/isolation & purification; Child; Child, Preschool; Chronic Disease; Humans; Infant; Microbial Sensitivity Tests*; Middle Aged; Otitis Media, Suppurative/drug therapy; Otitis Media, Suppurative/microbiology*
  11. Razali SM, Hasanah CI
    Aust N Z J Psychiatry, 1999 Apr;33(2):283-4.
    PMID: 10336231
    MeSH terms: Adult; Antidepressive Agents, Tricyclic/economics*; Antidepressive Agents, Tricyclic/therapeutic use*; Cost-Benefit Analysis; Depressive Disorder/drug therapy*; Developing Countries*; Humans; Malaysia; Time Factors
  12. Singh HJ, Mohammad NH, Nila A
    J Matern Fetal Med, 1999 May-Jun;8(3):95-100.
    PMID: 10338062
    To ascertain the calcium status in normal pregnant Malay women.
    MeSH terms: Adult; Body Weight; Calcium/blood*; Calcium/urine; Creatinine/urine; Cross-Sectional Studies; Diuresis; Female; Gestational Age; Hematocrit; Humans; Parathyroid Hormone/blood*; Potassium/blood; Potassium/urine; Pregnancy/blood*; Sodium/blood; Sodium/urine
  13. Thong MK, Rudzki Z, Hall J, Tan JA, Chan LL, Yap SF
    Hum. Mutat., 1999;13(5):413.
    PMID: 10338100
    Beta-thalassemia major is one of the commonest genetic disorders in South-East Asia. The spectrum of beta-thalassemia mutations in the various ethnic sub-populations on the island of Borneo is unknown. We studied 20 Dusun children from the East Malaysian state of Sabah (North Borneo) with a severe beta-thalassemia major phenotype, using a combination of Southern analysis, polymerase chain reaction analysis and direct sequencing. We found the children to be homozygous for a large deletion, which has a 5' breakpoint at position -4279 from the cap site of the beta-globin gene (HBB) with the 3' breakpoint located in a L1 family of repetitive sequences at an unknown distance from the beta-globin gene. This was similar to a recent finding of a large deletion causing beta-thalassemia first described in unrelated beta-thalassemia heterozygotes of Filipino descent. This report describes the first 20 families with homozygosity of the deletion causing a severe phenotype. It provides the first information on the molecular epidemiology of beta-thalassemia in Sabah. This finding has implications for the population genetics and preventative strategies for beta-thalassemia major for nearly 300 million individuals in South-East Asia.
    MeSH terms: Globins/genetics*; Humans; Malaysia; Phenotype; Blotting, Southern; Polymerase Chain Reaction; beta-Thalassemia/genetics*; Gene Deletion*; Sequence Analysis, DNA
  14. Norhaya MR, Yap TM, Zainudin BM
    Respirology, 1999 Mar;4(1):77-81.
    PMID: 10339734 DOI: 10.1046/j.1440-1843.1999.00153.x
    The effect of adding inhaled salmeterol to inhaled corticosteroids was studied in patients with poorly controlled nocturnal asthma. In a double-blind, cross-over study, 20 patients were randomized to receive either salmeterol 50 micrograms twice daily or placebo via a Diskhaler after a 1-week run-in period. After 4 weeks of treatment, patients were subsequently crossed over to receive the other treatment for a further 4 weeks with a 2-week wash-out period in between. The response to treatment was assessed by peak expiratory flow rates (PEF) measured in the morning and evening, symptom scores of asthma, number of bronchodilators used, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at regular intervals. Patients' preference for the Diskhaler or metered-dose inhaler was assessed at the last visit. The results showed that morning PEF was significantly higher while on salmeterol than on placebo (296.9 +/- 70.2 vs 274.6 +/- 77.4 L/min). Evening PEF showed a trend towards a higher value while on salmeterol than on placebo (321.1 +/- 73.4 vs 288.7 +/- 79.4 L/min), but the difference was not significant. There was no statistically significant improvement in symptom scores, number of rescue bronchodilators used and FEV1 or FVC between the two treatment groups. The occurrence of side effects in terms of tremors and palpitations between treatment and placebo were similar. There were more patients who preferred Diskhaler to metered-dose inhaler (70% vs 30%). We conclude that salmeterol 50 micrograms twice daily produces significant improvement in morning PEF and is well tolerated in patients with nocturnal asthma. Diskhaler is a device which is easy to use and preferred to a metered-dose inhaler.
    Study site: Respiratory Clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
    MeSH terms: Salmeterol Xinafoate; Adult; Albuterol/analogs & derivatives*; Albuterol/therapeutic use; Asthma/drug therapy*; Bronchodilator Agents/therapeutic use*; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids/therapeutic use*; Hospitals, University; Humans; Malaysia; Male; Middle Aged; Outpatient Clinics, Hospital; Peak Expiratory Flow Rate; Matched-Pair Analysis; Cross-Over Studies; Statistics, Nonparametric
  15. Goh AY, Chan PW
    Respirology, 1999 Mar;4(1):97-9.
    PMID: 10339738
    Acute myopathy complicating treatment of status asthmaticus has been increasingly recognized since its original description in 1977. We report a case of an 11-year-old boy with severe asthma requiring mechanical ventilation. He was given high doses of parenteral steroids and neuromuscular blockade with non-depolarizing agents in order to achieve controlled hypoventilation with an ensuing hypercapnoea. He developed rhabdomyolysis with elevated creatinine kinase and renal impairment secondary to myoglobinuria. Electrophysiological studies revealed myopathic abnormalities. The aetiology for this myopathy appears to be related to therapy with parenteral steroids, muscle-relaxant agents and respiratory acidosis. Patients treated with steroids and neuromuscular blocking agents should be regularly monitored for development of myopathy.
    MeSH terms: Acidosis/complications*; Acidosis/etiology; Acute Disease; Anti-Inflammatory Agents/adverse effects*; Child; Humans; Male; Cardiomyopathies/etiology*; Neuromuscular Depolarizing Agents/adverse effects*; Respiration, Artificial/adverse effects*; Status Asthmaticus/complications; Status Asthmaticus/therapy*; Steroids
  16. Huang X, Butow P, Meiser B, Goldstein D
    Aust N Z J Med, 1999 Apr;29(2):207-13.
    PMID: 10342019
    The information needs of ethnic minorities often differ from that of the dominant culture, leading to dissatisfaction among both patients and health professionals.
    MeSH terms: Attitude to Health/ethnology*; Australia; China/ethnology; Clinical Trials as Topic/psychology; Communication; Family/ethnology; Family/psychology; Humans; Medical Oncology; Neoplasms/ethnology*; Neoplasms/psychology; Physician-Patient Relations*; Prognosis
  17. JAMA, 1999 May 19;281(19):1787-8.
    PMID: 10340348
    MeSH terms: Abattoirs; Animals; Animal Husbandry*; Disease Outbreaks*; Humans; Malaysia/epidemiology; Male; Middle Aged; Occupational Diseases/diagnosis; Occupational Diseases/epidemiology*; Respirovirus Infections/diagnosis; Respirovirus Infections/epidemiology*; Respirovirus Infections/transmission; Respirovirus Infections/veterinary; Singapore/epidemiology; Swine; Swine Diseases/transmission; Cluster Analysis; Respirovirus/immunology; Respirovirus/isolation & purification*; Encephalitis, Viral/diagnosis; Encephalitis, Viral/epidemiology*; Encephalitis, Viral/transmission
  18. Navookarasu NT, Rahman AR, Abdullah I
    Int. J. Clin. Pract., 1999 Jan-Feb;53(1):25-30.
    PMID: 10344062
    Despite their proven value in reducing morbidity and mortality in different grades of heart failure, angiotensin converting enzyme (ACE) inhibitors continue to be underused. One reason for this is clinicians' apprehension of first-dose hypotension. We conducted a double-blind, randomised, placebo-controlled parallel group study to investigate the effect of various ACE inhibitors on first-dose hypotension. Eighty unselected patients were randomised into five treatment groups: placebo, captopril 6.25 mg, enalapril 2.5 mg, perindopril 2 mg and lisinopril 2.5 mg. Blood pressure was measured at baseline, half hourly for two hours and hourly for three hours after drug treatment. The maximum drops in mean arterial pressure (in mmHg +/- SD) were placebo 5.89 +/- 2.65, perindopril 5.29 +/- 2.49, enalapril 13.28 +/- 3.31, lisinopril 15.04 +/- 5.74 and captopril 16.76 +/- 5.74 (all p < 0.05 vs placebo except for perindopril). Perindopril, unlike the other ACE inhibitors studied, did not produce first-dose hypotension following its initiation in patients with congestive heart failure.
    MeSH terms: Angiotensin-Converting Enzyme Inhibitors/therapeutic use*; Double-Blind Method; Enalapril/therapeutic use; Female; Heart Failure/drug therapy*; Heart Failure/physiopathology; Hemodynamics; Humans; Hypotension/chemically induced*; Indoles/therapeutic use; Malaysia; Male; Middle Aged; Lisinopril/therapeutic use; Perindopril
  19. Singh B, Bobogare A, Cox-Singh J, Snounou G, Abdullah MS, Rahman HA
    Am. J. Trop. Med. Hyg., 1999 Apr;60(4):687-92.
    PMID: 10348249
    A nested polymerase chain reaction (PCR) assay that uses Plasmodium genus-specific primers for the initial PCR (nest 1) amplification and either genus- or species-specific primers for the nest 2 amplifications was tested on laboratory and field samples. With in vitro cultured Plasmodium falciparum-infected blood samples, it was capable of detecting six parasites/microl of blood using DNA prepared from 25-microl blood spots on filter paper. The assay was evaluated on fingerprick blood samples collected on filter paper from 129 individuals living in a malaria-endemic area in Malaysia. Malaria prevalence by genus-specific nested PCR was 35.6% (46 of 129) compared with 28.7% (37 of 129) by microscopy. The nested PCR detected seven more malaria samples than microscopy in the first round of microscopic examination, malaria in three microscopically negative samples, six double infections identified as single infections by microscopy and one triple infection identified as a double infection by microscopy. The nested PCR assay described is a sensitive technique for collecting accurate malaria epidemiologic data. When coupled with simple blood spot sampling, it is particularly useful for screening communities in remote regions of the world.
    MeSH terms: Animals; Evaluation Studies as Topic; Humans; Plasmodium falciparum/genetics*; Plasmodium falciparum/isolation & purification*; Sensitivity and Specificity; Species Specificity; DNA, Protozoan/analysis; Polymerase Chain Reaction/methods*; Malaria, Falciparum/parasitology*; DNA Primers; Parasitemia/parasitology
  20. Faizah O, Merican Z, Hassan MF, Khalid BA, Mohamed J, Radzi M
    Asia Pac J Clin Nutr, 1999 Jun;8(2):106-12.
    PMID: 24393793
    Edible oils have different effects on lipid profiles and on the propensity for producing lipid peroxidation products. These two properties of edible oils can affect arterial structure, ultimately leading to atherosclerosis. Hypertension is said to be a predisposing factor for atherosclerosis and can accelerate its process. This paper investigates the effects of three edible oils, namely soya bean oil, palm oil and ghee, on the ultrastructure of the aortas of spontaneously hypertensive rats at the end of a 4 month feeding period. It was found that ghee produced significant structural changes to the aortic wall when compared with palm oil or soya bean oil, and that no noticeable structural differences were seen to occur on the aortas of the palm oil-fed and soya bean oil-fed groups of rats. This study suggests that the consumption of ghee, rather than palm or soya bean oil, is more likely to lead to the development of atherosclerosis.
    MeSH terms: Ghee; Animals; Aorta; Arteries; Hypertension; Plant Oils; Rats, Inbred SHR; Soybean Oil; Lipid Peroxidation; Causality; Atherosclerosis; Rats
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