METHODS: A systematic search was conducted in PubMed, Web of Science, Embase, and CINAHL, following the JBI methodology for scoping reviews. Data extraction and analysis were performed using JBI SUMARI software, focusing on peer-reviewed published literature reporting the use of TDR and participatory approaches in NTDs, with an emphasis on individual and community perspectives.
RESULTS: The review examined seventeen articles from Africa, Asia, South America, and Australia, highlighting the increasing use of TDR and participatory approaches to address common NTDs such as leprosy, schistosomiasis, rabies, Buruli ulcer, and trypanosomiasis. These approaches engaged diverse stakeholders to develop practical, community-oriented solutions. Key strategies included enhancing public awareness, improving screening programmes, and implementing measures to control NTDs. However, challenges such as fragmented strategies and weak health systems hindered efforts to reduce the burden of NTDs.
CONCLUSION: TDR and participatory approaches contribute to a holistic approach in addressing and managing NTD-related challenges by engaging diverse stakeholders and fostering a comprehensive understanding of community needs and on-the-ground realities. The findings demonstrate their effectiveness in translating evidence-informed knowledge into actionable interventions to benefit affected individuals and their communities.
METHODS: The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness, using a modified Delphi approach with a requirement of ≥75% agreement.
RESULTS: CONCLUSION: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients.
OBJECTIVES: The aim of this study was to assess the economic impact of AML and determine the major cost-driving factors for its treatment in the EU.
METHODS: This systematic review is in accordance with PRISMA guidelines. A systematic search was conducted using PubMed, Embase, ScienceDirect, SCOPUS, and Google Scholar databases to identify relevant studies on the economic impact of AML in various countries of the EU, published before April 15, 2024. Original studies investigating direct costs including expenses for treatment and healthcare services, or resource utilization for AML management were included. The systematic review excluded commentaries, editorials, and pharmacoeconomic modeling studies. Two reviewers independently performed data extraction and quality assessment, and the third reviewer resolved disagreements. We employed the Allison Larg Cost-of-Illness Studies evaluation checklist to assess the risk of bias. The mean cost per patient for induction, consolidation, and transplantation was calculated, and the results were converted into 2024 Euros.
RESULTS: Twenty-eight studies met our inclusion criteria, with the sample size of AML patients ranging from 12 to 39,568. The calculated per-patient direct costs of induction chemotherapy in Spain, France, Netherlands, Germany, and Italy were €92,378, €77,844, €61,643, €46,113, and €20,254, respectively. The mean per-patient direct cost of consolidation chemotherapy in the Netherlands and Germany was €42,137, and €32,220, respectively. The mean per-patient direct costs of transplantation in Sweden, Austria, France, Netherlands, and Spain were €192,628, €188,453, €132,352, €122,760, and €47,968, respectively. The cost-driving factors associated with AML treatment were inpatient hospitalization and medication costs.
CONCLUSION: AML seems to incur substantial direct economic expenses. Reducing the days of hospitalization can significantly decrease the economic burden of AML in the European Union. Moreover, there is a necessity for studies that comprehensively evaluate the economic implications, particularly concerning total and indirect costs.
REGISTRATION: Registered in PROSPERO under the registration number 'CRD42024537725'.
METHODS: A thorough search of databases, including Web of Science Core, SPORTDiscus, PubMed, and SCOPUS, was conducted, with data up to July 2024. The PEDro scale assessed study quality and RevMan 5.3 evaluated bias risk. Effect sizes (ES) were calculated from means and standard deviations, with heterogeneity assessed using the I² statistic. Publication bias was evaluated using an extended Egger test.
RESULTS: Eleven RCTs involving 499 healthy athletes from sports such as soccer, basketball, tennis, and handball met the inclusion criteria. The SAQ interventions lasted between 4 and 12 weeks, with a frequency of two to three sessions per week. The analysis revealed significant improvements in 5-meter sprint (ES = 0.63, p 60 min: ES = 0.24; p = 0.059).
CONCLUSIONS: SAQ training effectively enhances sprint performance, COD ability, reaction time, lower limb strength, and flexibility, with effect sizes ranging from small to moderate. The findings suggest that shorter training durations (≤ 60 min) may be more beneficial for improving COD performance, although this effect did not reach statistical significance. Further trials are recommended to determine the optimal training dosage, along with high-quality studies covering a broader range of sports, particularly in athletes aged 14 to 18.
METHODS: Electronic searches were conducted in EMBASE, PubMed, Web of Science, CNKI, and Wanfang databases using keywords including stroke, depression, and PHQ-9. The assessment tool Quality Assessment of Diagnostic Accuracy Studies-2 was utilized to evaluate the risk of bias in diagnostic studies.
RESULTS: A total of 2049 articles were retrieved, with 9 meeting the inclusion criteria. The PHQ-9 demonstrated pooled sensitivity and specificity of 0.84 and 0.90, respectively, and a summary receiver operating characteristic (sROC) curve of 0.93. At the 10-cut-off value, pooled sensitivity, specificity, and sROC were 0.77, 0.85, and 0.86, respectively. At the 9-cut-off value, the sensitivity, specificity, and sROC were 0.87, 0.85, and 0.92, respectively. At the 5-cut-off value, sensitivity, specificity, and sROC are 0.90, 0.91, and 0.96, respectively. No publication bias was identified.
CONCLUSION: The PHQ-9 is an effective tool for screening poststroke depressive symptoms with significant clinical utility. However, further research is needed to establish optimal diagnostic thresholds.
METHODS: We analysed data from 19 714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire, and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis.
RESULTS: Both physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = -7.59; 95%CI -8.60, -6.58; I2 = 78.5%) than for the mental component (coefficient = -3.50; 95%CI -4.36, -2.63; I2 = 71.4%). The association between physical component and breathlessness was stronger in high-income countries (coefficient = -8.82; 95%CI -10.15, -7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking.
CONCLUSION: Quality of life is worse in people with breathlessness, but this association varies widely across the world.