Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone

Roffeei SN 1 , Reynolds GP , Zainal NZ , Said MA , Hatim A , Aida SA Show all authors , Mohamed Z

Affiliations 

  • 1 Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Hum Psychopharmacol, 2014 Jan;29(1):38-45.
PMID: 24424705 DOI: 10.1002/hup.2366

Abstract

Various genetic polymorphisms have been reported to be associated with antipsychotic-induced weight gain. In this study, we aimed to determine whether risk polymorphisms in 12 candidate genes are associated with reduction in body mass index (BMI) of patients following switching of antipsychotics to aripiprazole or ziprasidone.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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