Employment, work hours, and wages in adults with myelin oligodendrocyte glycoprotein antibody disease: An international cohort study

Ham AS 1 , Gomez Hjerthen I 1 , Sudhir A 2 , Pandit L 2 , Reddy YM 3 , Murthy JM 3 Show all authors , Tian DC 4 , Gu H 5 , Gao W 5 , Broadley SA 6 , Leitner U 6 , Aw AYY 7 , Tan K 7 , Yeo T 8 , Reyes S 9 , Toro J 9 , Gaitán J 9 , Ramírez DA 10 , Comme-Debroth R 10 , Báez JPM 10 , Gulec B 11 , Uygunoglu U 11 , Tutuncu M 11 , Siva A 11 , Iorio R 12 , Sabatelli E 12 , Huda S 13 , Kelly P 13 , Rojas JI 14 , Cristiano E 15 , Patrucco L 15 , Oliveira EML 16 , Portugal RP 16 , Zaidan PPT 16 , Viswanathan S 17 , Koh K 17 , Lim SY 18 , Mateen FJ 1

Affiliations 

  • 1 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
  • 2 Centre for Advanced Neurological Research, Nitte University, Mangalore, India
  • 3 CARE Institute of Neurological Sciences, CARE Hospitals, Hyderabad, India
  • 4 Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  • 5 Hongmian Cancers and Rare Disorders Charity Foundation of Guangzhou, Beijing, China
  • 6 School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia
  • 7 National Neuroscience Institute, Singapore, Singapore
  • 8 National Neuroscience Institute, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore
  • 9 Fundación Santa Fe de Bogotá, Bogotá, Colombia
  • 10 Hospital Padre Billini, Santo Domingo, Dominican Republic
  • 11 Istanbul University-Cerrahpasa, Istanbul, Turkey
  • 12 Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Neurologia, Rome, Italy
  • 13 Walton Centre NHS Foundation Trust, Liverpool, UK
  • 14 Hospital Universitario de CEMIC, Buenos Aires, Argentina
  • 15 Centro de Esclerosis Multiple de Buenos Aires, Buenos Aires, Argentina
  • 16 Universidade Federal de Sao Paulo, São Paulo, Brazil
  • 17 Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
  • 18 School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Selangor, Malaysia
Mult Scler, 2024 Nov;30(13):1674-1682.
PMID: 39392718 DOI: 10.1177/13524585241286671

Abstract

OBJECTIVES: The objectives were to understand the employment impacts of myelin oligodendrocyte glycoprotein-associated antibody disease (MOGAD) on adults in an international cohort by determining lost employment, work hours, and wages.

BACKGROUND: Clinically, MOGAD can be associated with significant disability; however, its socioeconomic consequences for adults are barely reported.

METHODS: Participants of potential working age (18-70 years old) with neurologist-diagnosed MOGAD were recruited from clinical sites in 13 countries, April 2022 to August 2023. Each participant completed a one-time survey. Regression models assessed associations with post-MOGAD (1) unemployment and (2) work hours.

RESULTS: A total of 117 participants (66.7% female), mean age 39.7 years, median disease duration 3 years (25th, 75th percentile: 1, 7) were analyzed. Employment post-MOGAD reduced from 74 (63.2%) to 57 (48.7%) participants. Participants employed pre-diagnosis reduced their work hours, on average, from 31.6 hours/week to 19.5 hours/week post-diagnosis. Residence in a high-income country was statistically significantly associated with post-diagnosis employment and higher weekly work hours. Depressed mood was associated with unemployment. MOGAD-related pain and history of myelitis were independently associated with lost work hours.

CONCLUSION: MOGAD can have significant impacts on adult employment, particularly in non-high-income countries. Depressed mood and pain are potentially modifiable factors related to socioeconomic status in MOGAD.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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