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Adherence to antiretroviral therapy, stigma and behavioral risk factors in HIV-infected adolescents in Asia

Prasitsuebsai W 1 , Sethaputra C 2 , Lumbiganon P 3 , Hansudewechakul R 4 , Chokephaibulkit K 5 , Truong KH 6 Show all authors , Nguyen LV 7 , Mohd Razali KA 8 , Nik Yusoff NK 9 , Fong MS 10 , Teeraananchai S 1 , Ananworanich J 11 , Durier N 2 , TApHOD ACASI study group of IeDEA Asia-Pacific

Affiliations 

  • 1 a The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) , The Thai Red Cross AIDS Research Centre , Bangkok , Thailand
  • 2 b TREAT Asia/amfAR-The Foundation for AIDS Research , Bangkok , Thailand
  • 3 c Faculty of Medicine , Srinagarind Hospital, Khon Kaen University , Khon Kaen , Thailand
  • 4 d Chiangrai Prachanukroh Hospital , Chiang Rai , Thailand
  • 5 e Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand
  • 6 f Children's Hospital 1, Ho Chi Minh City , Vietnam
  • 7 g National Hospital of Pediatrics , Hanoi , Vietnam
  • 8 h Pediatric Institute , Hospital Kuala Lumpur , Kuala Lumpur , Malaysia
  • 9 i Hospital Raja Perempuan Zainab II , Kelantan , Malaysia
  • 10 j Hospital Likas , Kota Kinabalu , Malaysia
  • 11 k US Military HIV Research Program , Walter Reed Army Institute of Research , Silver Spring , USA
AIDS Care, 2018 06;30(6):727-733.
PMID: 29336591 DOI: 10.1080/09540121.2018.1425363

Abstract

We studied behavioral risks among HIV-infected and uninfected adolescents using an audio computer-assisted self-interview. A prospective cohort study was initiated between 2013 and 2014 in Malaysia, Thailand, and Vietnam. HIV-infected adolescents were matched to uninfected adolescents (4:1) by sex and age group (12-14 and 15-18 years). We enrolled 250 HIV-infected (48% male; median age 14.5 years; 93% perinatally infected) and 59 uninfected (51% male; median age 14.1 years) adolescents. At enrollment, HIV-infected adolescents were on antiretroviral therapy (ART) for a median (IQR) of 7.5 (4.7-10.2) years, and 14% had HIV-RNA >1000 copies/mL; 19% reported adherence <80%. Eighty-four (34%) HIV-infected and 26 (44%) uninfected adolescents reported having ever smoked cigarettes or drunk alcohol (p = 0.13); 10% of HIV-infected and 17% of uninfected adolescents reported having initiated sexual activity; 6 of the HIV-infected adolescents had HIV-RNA >1000 copies/mL. Risk behaviors were common among adolescents, with few differences between those with and without HIV.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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