Cognitive complaints and predictors of perceived cognitive dysfunction in adults with major depressive disorder: Findings from the Cognitive Dysfunction in Asians with Depression (CogDAD) study

Srisurapanont M 1 , Mok YM 2 , Yang YK 3 , Chan HN 4 , Della CD 5 , Zainal NZ 6 Show all authors , Jambunathan S 6 , Amir N 7 , Kalita P 8

Affiliations 

  • 1 Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address: manit.s@cmu.ac.th
  • 2 Department of Mood and Anxiety, Institute of Mental Health, Singapore
  • 3 Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
  • 4 Department of Psychiatry, Singapore General Hospital, Singapore
  • 5 Department of Psychiatry & Behavioral Medicine, College of Medicine & Philippine General Hospital, University of the Philippines, Manila, Philippines
  • 6 Department of Psychological Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 7 Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakata, Indonesia
  • 8 Lundbeck Singapore Pte. Ltd., Singapore
J Affect Disord, 2018 05;232:237-242.
PMID: 29499506 DOI: 10.1016/j.jad.2018.02.014

Abstract

BACKGROUND: Several studies have described the presence of perceived cognitive dysfunction amongst Asian patients with major depressive disorder (MDD). To date, no study has been conducted investigating the predictors of perceived cognitive dysfunction amongst Asian MDD patients.

METHODS: This was a post-hoc analysis of the Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Descriptive statistics were used to describe the most common cognitive complaints by patients. Univariate and multivariate analyses were performed to determine variables associated with perceived cognitive dysfunction (Perceived Deficit Questionnaire-Depression, PDQ-D).

RESULTS: The CogDAD study population is comprised of MDD patients with mild-to-moderate depression (Patient Health Questionnaire 9-item [PHQ-9]: 11.3 ± 6.9) who reported perceived cognitive dysfunction (PDQ-D = 22.6 ± 16.2). The most common cognitive complaints were: mind drifting (42.3%), trouble making decision (39.6%) and trouble concentrating (38.0%). Predictors of perceived cognitive dysfunction were: being Southeast Asians (vs. Taiwanese) (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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