• 1 Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore
  • 2 Department of Paediatrics, Sarawak General Hospital, Kuching 93587, Sarawak, Malaysia
  • 3 Institute of Health &Community Medicine, Universiti Malaysia Sarawak (UNIMAS), Kota Samarahan 94300, Malaysia
  • 4 Institute of Infectious Disease and Epidemiology (IIDE), Tan Tock Seng Hospital, Singapore 308433, Singapore
Sci Rep, 2016 05 16;6:26097.
PMID: 27180811 DOI: 10.1038/srep26097


Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.