• 1 The George Institute for Global Health, Sydney Medical School, University of Sydney, King George V Building, 83-117 Missenden Rd, Camperdown, NSW, 2050, Australia.
  • 2 Queen Mary Hospital, Hong Kong, SAR, China
  • 3 Sir Ganga Ram Hospital, New Delhi, India
  • 4 Sarawak General Hospital, Kuching, Malaysia
  • 5 National Heart Centre Singapore, Singapore, Singapore
  • 6 Seoul National University Hospital, Seoul, South Korea
  • 7 Siriraj Hospital, Bangkok, Thailand
  • 8 Cho Ray Hospital, Ho Chi Minh City, Vietnam
  • 9 London School of Hygiene and Tropical Medicine, London, UK
  • 10 Observational Research Centre, Global Medical Affairs, AstraZeneca, Madrid, Spain
  • 11 AstraZeneca, Osaka, Japan
  • 12 Peking University First Hospital, Beijing, China
BMC Cardiovasc Disord, 2018 07 04;18(1):139.
PMID: 29973147 DOI: 10.1186/s12872-018-0859-4


BACKGROUND: The EPICOR Asia (long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) study (NCT01361386) was an observational study of patients hospitalized for acute coronary syndromes (ACS) enrolled in 218 hospitals in eight countries/regions in Asia. This study examined costs, length of stay and the predictors of high costs during an ACS hospitalization.

METHODS AND RESULTS: Data for patients hospitalized for an ACS (n = 12,922) were collected on demographics, medical history, event characteristics, socioeconomic and insurance status at discharge. Patients were followed up at 6 weeks' post-hospitalization for an ACS event to assess associated treatment costs from a health sector perspective. Primary outcome was the incurring of costs in the highest quintile by country and index event diagnosis, and identification of associated predictors. Cost data were available for 10,819 patients. Mean length of stay was 10.1 days. The highest-cost countries were China, Singapore, and South Korea. Significant predictors of high-cost care were age, male sex, income, country, prior disease history, hospitalization in 3 months before index event, no dependency before index event, having an invasive procedure, hospital type and length of stay.

CONCLUSIONS: Substantial variability exists in healthcare costs for hospitalized ACS patients across Asia. Of concern is the observation that the highest costs were reported in China, given the rapidly increasing numbers of procedures in recent years.


* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.