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Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

Bhoo-Pathy N 1 , Peeters PH 2 , Uiterwaal CS 3 , Bueno-de-Mesquita HB 4 , Bulgiba AM 5 , Bech BH 6 Show all authors , Overvad K 7 , Tjønneland A 8 , Olsen A 9 , Clavel-Chapelon F 10 , Fagherazzi G 11 , Perquier F 12 , Teucher B 13 , Kaaks R 14 , Schütze M 15 , Boeing H 16 , Lagiou P 17 , Orfanos P 18 , Trichopoulou A 19 , Agnoli C 20 , Mattiello A 21 , Palli D 22 , Tumino R 23 , Sacerdote C 24 , van Duijnhoven FJ 25 , Braaten T 26 , Lund E 27 , Skeie G 28 , Redondo ML 29 , Buckland G 30 , Pérez MJ 31 , Chirlaque MD 32 , Ardanaz E 33 , Amiano P 34 , Wirfält E 35 , Wallström P 36 , Johansson I 37 , Nilsson LM 38 , Khaw KT 39 , Wareham N 40 , Allen NE 41 , Key TJ 42 , Rinaldi S 43 , Romieu I 44 , Gallo V 45 , Riboli E 46 , van Gils CH 47

Affiliations 

  • 1 Julius Center for Health Sciences and Primary Care, University Medical Center, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands. ovenjjay@gmail.com
  • 2 Julius Center for Health Sciences and Primary Care, University Medical Center, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands. p.h.m.peeters@umcutrecht.nl
  • 3 Julius Center for Health Sciences and Primary Care, University Medical Center, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands. c.s.p.m.uiterwaal@umcutrecht.nl
  • 4 Department of Social and Preventive Medicine, Faculty of Medicine, Julius Centre University of Malaya, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. bas.bueno.de.mesquita@rivm.nl
  • 5 Department of Social and Preventive Medicine, Faculty of Medicine, Julius Centre University of Malaya, University of Malaya, Lembah Pantai, Kuala Lumpur, Malaysia. awang@ummc.edu.my
  • 6 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. bhb@soci.au.dk
  • 7 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. ko@dce.au.dk
  • 8 Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. annet@cancer.dk
  • 9 Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. anja@cancer.dk
  • 10 Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, "Nutrition, Hormones, and Women's Health" Team, Institut Gustave Roussy, F-94805, Villejuif, France. francoise.clavel@igr.fr
  • 11 Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, "Nutrition, Hormones, and Women's Health" Team, Institut Gustave Roussy, F-94805, Villejuif, France. guy.fagherazzi@igr.fr
  • 12 Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, "Nutrition, Hormones, and Women's Health" Team, Institut Gustave Roussy, F-94805, Villejuif, France. florence.perquier@igr.fr
  • 13 Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. b.teucher@dkfz-heidelberg.de
  • 14 Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. r.kaaks@dkfz-heidelberg.de
  • 15 Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. m.schuetze@dife.de
  • 16 Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. boeing@dife.de
  • 17 Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, 75 M. Asias Avenue, Goudi, GR-115 27, Athens, Greece. pdlagiou@med.uoa.gr
  • 18 Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, 75 M. Asias Avenue, Goudi, GR-115 27, Athens, Greece. orfanos@nut.uoa.gr
  • 19 Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, 75 M. Asias Avenue, Goudi, GR-115 27, Athens, Greece. atrichopoulou@hhf-greece.gr
  • 20 Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian, 1, 20133, Milan, Italy. claudia.agnoli@istitutotumori.mi.it
  • 21 Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Via Pansini, 5 80131, Naples, Italy. amattiel@unina.it
  • 22 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy. d.palli@ispo.toscana.it
  • 23 Cancer Registry and Histopathology Unit, "Civile - M.P.Arezzo" Hospital, ASP 7, Ragusa, Italy. rtumino@tin.it
  • 24 HuGeF Foundation and CPO-Piemonte, Torino, Italy. carlotta.sacerdote@cpo.it
  • 25 National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. franzel.van.duijnhoven@rivm.nl
  • 26 Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. tonje.braaten@uit.no
  • 27 Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. eiliv.lund@uit.no
  • 28 Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. guri.skeie@uit.no
  • 29 Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain. marialuisa.redondocornejo@asturias.org
  • 30 Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. gbuckland@iconcologia.net
  • 31 Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain. mariajose.sanchez.easp@juntadeandalucia.es
  • 32 Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. mdolores.chirlaque@carm.es
  • 33 Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. me.ardanaz.aicua@cfnavarra.es
  • 34 Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. epicss-san@ej-gv.es
  • 35 Department of Clinical Sciences in Malmö/Nutrition Epidemiology, Lund University, Malmö, Sweden. elisabet.wirfalt@med.lu.se
  • 36 Department of Clinical Sciences in Malmö/Nutrition Epidemiology, Lund University, Malmö, Sweden. peter.wallstrom@med.lu.se
  • 37 Department of Odontology, Umeå University, Umeå, Sweden. ingegerd.johansson@odont.umu.se
  • 38 Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umea, Sweden. lena.nilsson@nutrires.umu.se
  • 39 University of Cambridge School of Clinical Medicine, Cambridge, UK. kk101@medschl.cam.ac.uk
  • 40 Medical Research Council, Epidemiology Unit, Cambridge, UK. nick.wareham@mrc-epid.cam.ac.uk
  • 41 Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK. naomi.allen@ctsu.ox.ac.uk
  • 42 Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK. tim.key@ceu.ox.ac.uk
  • 43 International Agency for Research on Cancer, Lyon, France. rinaldi@iarc.fr
  • 44 International Agency for Research on Cancer, Lyon, France. iromieu@gmail.com
  • 45 School of Public Health, Imperial College London, London, UK. v.gallo@imperial.ac.uk
  • 46 School of Public Health, Imperial College London, London, UK. e.riboli@imperial.ac.uk
  • 47 Julius Center for Health Sciences and Primary Care, University Medical Center, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands. c.vangils@umcutrecht.nl
Breast Cancer Res, 2015 Jan 31;17:15.
PMID: 25637171 DOI: 10.1186/s13058-015-0521-3

Abstract

INTRODUCTION: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.

METHODS: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated.

RESULTS: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR=0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; Ptrend=0.029. While there was no significant effect modification by hormone receptor status (P=0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P=0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR=0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (Ptrend=0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR=0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer.

CONCLUSIONS: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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