Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas

Saeed AA 1 , Sims AH 2 , Prime SS 3 , Paterson I 4 , Murray PG 5 , Lopes VR 6

Affiliations 

  • 1 Department of Oral Surgery, Edinburgh Postgraduate Dental Institute, University of Edinburgh, Lauriston Place, Lauriston Building, EH3 9HA Edinburgh, UK. Electronic address: anas.saeed@ed.ac.uk
  • 2 Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research Centre, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address: andrew.sims@ed.ac.uk
  • 3 Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Dentistry, Queen Mary University of London, Turner Street, Whitechapel E1 2AD, UK. Electronic address: stephensprime@gmail.com
  • 4 Dental Research and Training Unit, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: ipaterson@um.edu.my
  • 5 School of Cancer Sciences, Birmingham Cancer Research UK Centre, Birmingham University, Edgbaston B15 2TT, Birmingham, UK. Electronic address: p.g.murray@bham.ac.uk
  • 6 Head and Neck Directorate NHS Lothian and University of Edinburgh, UK. Electronic address: vlopes@staffmail.ed.ac.uk
Oral Oncol, 2015 Mar;51(3):237-46.
PMID: 25560800 DOI: 10.1016/j.oraloncology.2014.12.004

Abstract

It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim of this study is to examine gene expression, related carcinogenic pathways and molecular processes that might be responsible for the phenotypic heterogeneity of OSCC between UK and Sri Lankan population groups.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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