Six-year multicenter study on short-term peripheral venous catheters-related bloodstream infection rates in 727 intensive care units of 268 hospitals in 141 cities of 42 countries of Africa, the Americas, Eastern Mediterranean, Europe, South East Asia, and Western Pacific Regions: International Nosocomial Infection Control Consortium (INICC) findings

Rosenthal VD 1 , Bat-Erdene I 2 , Gupta D 3 , Belkebir S 4 , Rajhans P 5 , Zand F 6 Show all authors , Myatra SN 7 , Afeef M 8 , Tanzi VL 9 , Muralidharan S 10 , Al-Abdely HM 11 , El-Kholy A 12 , AlKhawaja SAA 13 , Demiroz AP 14 , Mehta Y 15 , Rai V 16 , Hung NV 17 , Sayed AF 18 , Salgado-Yepez E 19 , Elahi N 20 , Del Rayo Morfin-Otero M 21 , Luxsuwong M 22 , De-Carvalho BM 23 , Tapang ARD 24 , Velinova VA 25 , Quesada-Mora AM 26 , Anguseva T 27 , Ikram A 28 , Aguilar-de-Moros D 29 , Duszynska W 30 , Mejia N 31 , Horhat FG 32 , Belskiy V 33 , Mioljevic V 34 , Di-Silvestre G 35 , Furova K 36 , Gamar-Elanbya MO 37 , Gupta U 38 , Abidi K 39 , Raka L 40 , Guo X 41 , Jayatilleke K 42 , Ben-Jaballah N 43 , Sandoval-Castillo HR 44 , Trotter A 45 , Valderrama-Beltrán SL 46 , Leblebicioglu H 47 , Guanche-Garcell H 48 , de Lourdes-Dueñas M 49

Affiliations 

  • 1 International Nosocomial Infection Control Consortium, Buenos Aires, Argentina
  • 2 Infection Control Professionals of Mongolia, and Intermed Hospital, Ulaanbaatar, Mongolia
  • 3 BM Birla Heart Research Centre, and The Calcutta Medical Research Institute, Calcutta, India
  • 4 An Najah National University Hospital, Nablus, Palestine
  • 5 Deenanath Mangeshkar Hospital, Pune, India
  • 6 Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • 7 Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
  • 8 King Hussein Cancer Center, Amman, Jordan
  • 9 Hammoud Hospital University Medical Center, Saida, Lebanon
  • 10 G Kuppusamy Naidu Memorial Hospital, Coimbatore, India
  • 11 General Directorate of Infection Prevention and Control, Ministry of Health, Kingdom of Saudi Arabia
  • 12 Dar Al Fouad Hospital, 6th of October City, and Cairo University Hospital, Cairo, Egypt
  • 13 General Directorate of Infection Prevention and Control, Ministry of Health, Bahrain
  • 14 Ankara Training and Research Hospital, Ankara, Turkey
  • 15 Medanta, The Medicity, New Delhi, India
  • 16 University Malaya Medical Centre, Kuala Lumpur, Malaysia
  • 17 Bach Mai Hospital, Hanoi, Vietnam
  • 18 Farwaniya Hospital, Kuwait City, Kuwait
  • 19 Clínica La Merced, Quito, Ecuador
  • 20 Dubai Hospital, Dubai, United Arab Emirates
  • 21 Hospital Civil de Guadalajara Fray Antonio Alcalde Infection Control Committee, Guadalajara, Mexico
  • 22 Phyathai 1 Hospital, Pratumthani, Thailand
  • 23 Hospital de Messejana, Fortaleza, Brazil
  • 24 Cardinal Santos Medical Center, San Juan of Philippines, Philippines
  • 25 Queen Giovanna Isul, Sofia, Bulgaria
  • 26 Hospital Clínica Bíblica, San Jose, Costa Rica
  • 27 Special Hospital for Surgical Diseases Filip Vtori, Skopje, Macedonia
  • 28 Armed Forces Institute of Pathology, Rawalpindi, Pakistan
  • 29 Hospital del Niño de Panama, Panama City, Panama
  • 30 Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland
  • 31 Hospital General de La Plaza de La Salud, Santo Domingo, Dominican Republic
  • 32 University of Medicine and Pharmacy Victor Babes Timisoara Emergency County Clinical Hospital, Timisoara, Romania
  • 33 Privolzhskiy District Medical Center, Nizhniy Novgorod, Russia
  • 34 Clinical Center of Serbia, Belgrade, Serbia
  • 35 Hospital de Clínicas Caracas, Caracas, Venezuela
  • 36 Catholic University in Ruzomberok Faculty of Health Central Military Hospital Ruzomberok, Ruzomberok, Slovakia
  • 37 Royal Care International Hospital, Khartoum, Sudan
  • 38 Port Moresby General Hospital, Port Moresby, Papua, New Guinea
  • 39 Ibn Sina Hospital of Morocco, Rabat, Morocco
  • 40 National Institute for Public Health of Kosovo and Medical School, Prishtina University, and University Clinical Center of Kosovo, Prishtina, Kosovo
  • 41 Dong E Peoples Hospital, Shandong, People's Republic of China
  • 42 Sri Jayewardenepura General Hospital, Nugegoda, Sri Lanka
  • 43 Children Hospital Bechir Hamza of Tunis, Tunis, Tunisia
  • 44 Clínica Ricardo Palma, Lima, Peru
  • 45 Grande International Hospital, Kathmandu, Nepal
  • 46 Pontificia Universidad Javeriana Hospital Universitario San Ignacio, Bogotá, Colombia
  • 47 Ondokuz Mayis University Medical School, Samsun, Turkey
  • 48 Joaquin Albarran, Havana, Cuba
  • 49 Hospital Nacional de Niños Benjamin Bloom, San Salvador, El Salvador
Infect Control Hosp Epidemiol, 2020 05;41(5):553-563.
PMID: 32183925 DOI: 10.1017/ice.2020.20

Abstract

BACKGROUND: Short-term peripheral venous catheter-related bloodstream infection (PVCR-BSI) rates have not been systematically studied in resource-limited countries, and data on their incidence by number of device days are not available.

METHODS: Prospective, surveillance study on PVCR-BSI conducted from September 1, 2013, to May 31, 2019, in 727 intensive care units (ICUs), by members of the International Nosocomial Infection Control Consortium (INICC), from 268 hospitals in 141 cities of 42 countries of Africa, the Americas, Eastern Mediterranean, Europe, South East Asia, and Western Pacific regions. For this research, we applied definition and criteria of the CDC NHSN, methodology of the INICC, and software named INICC Surveillance Online System.

RESULTS: We followed 149,609 ICU patients for 731,135 bed days and 743,508 short-term peripheral venous catheter (PVC) days. We identified 1,789 PVCR-BSIs for an overall rate of 2.41 per 1,000 PVC days. Mortality in patients with PVC but without PVCR-BSI was 6.67%, and mortality was 18% in patients with PVC and PVCR-BSI. The length of stay of patients with PVC but without PVCR-BSI was 4.83 days, and the length of stay was 9.85 days in patients with PVC and PVCR-BSI. Among these infections, the microorganism profile showed 58% gram-negative bacteria: Escherichia coli (16%), Klebsiella spp (11%), Pseudomonas aeruginosa (6%), Enterobacter spp (4%), and others (20%) including Serratia marcescens. Staphylococcus aureus were the predominant gram-positive bacteria (12%).

CONCLUSIONS: PVCR-BSI rates in INICC ICUs were much higher than rates published from industrialized countries. Infection prevention programs must be implemented to reduce the incidence of PVCR-BSIs in resource-limited countries.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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