Displaying publications 1 - 20 of 49 in total

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  1. Soil chemistry and pollution study of a closed landfill site at Ampar Tenang, Selangor, Malaysia
    Mohd Adnan SN, Yusoff S, Piaw CY
    Waste Manag Res, 2013 Jun;31(6):599-612.
    PMID: 23528999 DOI: 10.1177/0734242X13482031
    A total of 20 landfills are located in State of Selangor, Malaysia. This includes the Ampar Tenang landfill site, which was closed on 26 January 2010. It was reported that the landfill has been upgraded to a level I type of sanitary classification. However, the dumpsite area is not being covered according to the classification. In addition, municipal solid waste was dumped directly on top of the unlined natural alluvium formation. This does not only contaminate surface and subsurface soils, but also initiates the potential risk of groundwater pollution. Based on previous studies, the Ampar Tenang soil has been proven to no longer be capable of preventing pollution migration. In this study, metal concentrations of soil samples up to 30 m depth were analyzed based on statistical analysis. It is very significant because research of this type has not been carried out before. The subsurface soils were significantly polluted by arsenic (As), lead (Pb), iron (Fe), copper (Cu) and aluminium (Al). As and Pb exceeded the safe limit values of 5.90 mg/kg and 31.00 mg/kg, respectively, based on Provincial Sediment Quality Guidelines for Metals and the Interim Sediment Quality Values. Furthermore, only Cu concentrations showed a significantly decreasing trend with increasing depth. Most metals were found on clay-type soils based on the cluster analysis method. Moreover, the analysis also differentiates two clusters: cluster I-Pb, As, zinc, Cu, manganese, calcium, sodium, magnesium, potassium and Fe; cluster II-Al. Different clustering may suggest a different contamination source of metals.
  2. Efficacy of an inactivated recombinant vaccine encoding a fimbrial protein of Pasteurella multocida B:2 against hemorrhagic septicemia in goats
    Mohd Yasin IS, Mohd Yusoff S, Mohd ZS, Abd Wahid Mohd E
    Trop Anim Health Prod, 2011 Jan;43(1):179-87.
    PMID: 20697957 DOI: 10.1007/s11250-010-9672-5
    This study was carried out to determine the antibody responses and protective capacity of an inactivated recombinant vaccine expressing the fimbrial protein of Pasteurella multocida B:2 following intranasal vaccination against hemorrhagic septicemia in goats. Goats were vaccinated intranasal with 10(6) CFU/mL of the recombinant vaccine (vaccinated group) and 10(6) CFU/mL of pET32/LIC vector without fimbrial protein (control group). All three groups were kept separated before all goats in the three groups were challenged with 10(9) CFU/mL of live pathogenic P. multocida B:2. During the course of study, both serum and lung lavage fluid were collected to evaluate the antibody levels via enzyme-linked immunosorbent assay. It was found that goats immunized with the inactivated recombinant vaccine developed a strong and significantly (p 
  3. Fulltext Mode choice between private and public transport in Klang Valley, Malaysia
    Chiu Chuen O, Karim MR, Yusoff S
    ScientificWorldJournal, 2014;2014:394587.
    PMID: 24701165 DOI: 10.1155/2014/394587
    In 2010, Klang Valley has only 17% trips each day were completed using public transport, with the rest of the 83% trips were made through private transport. The inclination towards private car usage will only get worse if the transport policy continues to be inefficient and ineffective. Under the National Key Economic Area, the priority aimed to stimulate the increase of modal share of public transport in the Klang Valley to 50% by 2020. In the 10th Malaysia Plan, the Klang Valley Mass Rapid Transit was proposed, equipped with 141 km of MRT system, and will integrate with the existing rail networks. Nevertheless, adding kilometers into the rail system will not help, if people do not make the shift from private into public transport. This research would like to assess the possible mode shift of travellers in the Klang Valley towards using public transport, based on the utility function of available transport modes. It intends to identify the criteria that will trigger their willingness to make changes in favour of public transport as targeted by the NKEA.
  4. Cyclospora sp causing diarrhea in man
    Sinniah B, Rajeswari B, Johari S, Ramakrishnan K, Yusoff SW, Rohela M
    Southeast Asian J. Trop. Med. Public Health, 1994 Mar;25(1):221-3.
    PMID: 7825021
  5. Coastal meteorology on the dispersion of air particles at the Bachok GAW Station
    Rahim HA, Khan MF, Ibrahim ZF, Shoaib A, Suradi H, Mohyeddin N, et al.
    Sci Total Environ, 2021 Aug 15;782:146783.
    PMID: 33838363 DOI: 10.1016/j.scitotenv.2021.146783
    Meteorology over coastal region is a driving factor to the concentration of air particles and reactive gases. This study aims to conduct a research to determine the level of year-round air particles and the interaction of the meteorological driving factors with the particle number and mass in 2018, which is moderately influenced by Southeast Asian haze. We obtained the measurement data for particle number count (PNC), mass, reactive gases, and meteorological factors from a Global Atmospheric Watch (GAW) station located at Bachok Marine Research Center, Bachok, Kelantan, Malaysia. For various timeseries and correlation analyses, a 60-second resolution of the data has been averaged hourly and daily and visualized further. Our results showed the slight difference in particle behavior that is either measured by unit mass or number count at the study area. Diurnal variations showed that particles were generally high during morning and night periods. Spike was observed in August for PM2.5/PNC2.5 and PM10/PNC10 and in November for PMCoarse/PNCCoarse. From a polar plot, the particles came from two distinct sources (e.g., seaside and roadside) at the local scale. Regional wind vector shows two distinct wind-blown directions from northeast and southwest. The air mases were transported from northeast (e.g., Philippines, mainland China, and Taiwan) or southwest (e.g., Sumatra) region. Correlation analysis shows that relative humidity, wind direction, and pressure influence the increase in particles, whereas negative correlation with temperature is observed, and wind speed may have a potential role on the decline of particle concentration. The particles at the study area was highly influenced by the changes in regional wind direction and speed.
  6. El Niño driven haze over the Southern Malaysian Peninsula and Borneo
    Khan MF, Hamid AH, Rahim HA, Maulud KNA, Latif MT, Nadzir MSM, et al.
    Sci Total Environ, 2020 Aug 15;730:139091.
    PMID: 32413602 DOI: 10.1016/j.scitotenv.2020.139091
    The Southeast Asian (SEA) region is no stranger to forest fires - the region has been suffering from severe air pollution (known locally as 'haze') as a result of these fires, for decades. The fires in SEA region are caused by a combination of natural (the El Niño weather pattern) and manmade (slash-and-burn and land clearing for plantations) factors. These fires cause the emissions of toxic aerosols and pollutants that can affect millions of people in the region. Thus, this study aims to identify the impact of the SEA haze on the Southern region of the Malaysian Peninsula and Borneo region of East Malaysia using the entire air quality observation data at surface level in 2015. Overall, the concentration of PM10 was about two-fold higher during the haze period compared to non-haze period. The concentrations of CO, flux of CO and flux of BC were aligned with PM10 during the entire observation period. The wind field and cluster of trajectory indicated that the Southern Malaysian Peninsula and Borneo were influenced mainly from the wildfires and the combustion of peat soil in the Indonesian Borneo. This study finds that wildfires from Borneo impacted the Southern Malaysian Borneo more seriously than that from Sumatra region.
  7. Fulltext Rising from the dead!
    Low DW, Looi I, Manocha AB, Ang HA, Nagalingam M, Ayop NA, et al.
    Med J Malaysia, 2012 Oct;67(5):538-9.
    PMID: 23770879 MyJurnal
    A report of a patient with Lazarus phenomenon (the return of spontaneous circulation after cardiopulmonary resuscitation) following cardiac arrest (myocardium ischemia) is presented. A 65 year patient was found unconscious at home. He taken to the emergency department On arrival he was unconscious, his pupils fixed and dilated bilaterally. Resuscitation proceeded for 55 minutes. He was then pronounced dead. Forty minutes later spontaneous breathing was noted and his blood pressure was 110/48 and heart rate 90bpm. He survived a further 13 days in the coronary care unit. The implications for management of cardiac arrest in the emergency and medical department are discussed.
  8. Fulltext Guidelines for nucleic acid detection and analysis in hematological disorders
    Hassan R, Husin A, Sulong S, Yusoff S, Johan MF, Yahaya BH, et al.
    Malays J Pathol, 2015 Aug;37(2):165-73.
    PMID: 26277676 MyJurnal
  9. Fulltext Potential use of cord blood for Hb E hemoglobinopathy screening programme using capillary electrophoresis
    Wan Mohd Saman WA, Hassan R, Mohd Yusoff S, Che Yaakob CA, Abdullah NA, Ghazali S, et al.
    Malays J Pathol, 2016 Dec;38(3):235-239.
    PMID: 28028293 MyJurnal
    BACKGROUND: Thalassemia and hemoglobinopathies are inherited red blood cell disorders found worldwide. Hemoglobin (Hb) E disorder is one of the hemoglobinopathies known to have the high prevalence in South East Asia. Most of transfusion-dependent thalassemias were genotypically compound heterozygous Hb E/ β-thalassemia. In Malaysia, the national screening program for thalassemia was implemented for early pregnancy or secondary school girls; however many participants do not turn-up and missed the screening test. Screening for thalassemia using samples from cord blood is an alternative choice as it is a readily available source of blood and hence early detection of the disease. The purpose of this study was to determine the potential use of cord blood for the screening of HbE hemoglobinopathy by using capillary electrophoresis (CE).

    METHODS: Cord blood samples were collected from 300 newborns of healthy mothers. Hematological parameters were determined and hemoglobin quantitation for all cord blood samples were performed using capillary electrophoresis system (CES) and high performance liquid chromatography (HPLC).

    RESULTS: Majority of cord blood samples (63%) revealed Hb AF followed by Hb AFA2 (20%). Hb AFE was detected in 10.7% with the mean value of Hb E ranging from 2.3%-11.1%.

    CONCLUSION: Hemoglobin E was detected in cord blood using capillary electrophoresis system. It can be recommended in areas where Hb E/β is prevalent. Implementation of a screening strategy using CE on cord blood sampling will identify the disease early. With regular follow-up on these patients, the status of their disease can be determined earlier and appropriate management implemented.

  10. The Validity and Reliability of Malay Version Child Exposure to Domestic Violence Scale
    Norazman TA, Yusoff S, Mohd Niza Nizal H, Taib F
    Malays J Med Sci, 2023 Aug;30(4):175-192.
    PMID: 37655138 DOI: 10.21315/mjms2023.30.4.15
    BACKGROUND: Domestic violence has a significant impact on growing children. However, existing evidence is limited and often under reported. Consequently, the Child Exposure to Domestic Violence (CEDV) scale has been developed for global use. This study aims to provide a cross-cultural translation, adaptation and validation of the CEDV based on Malay language.

    METHODS: CEDV scale was translated from the original English version to Malay. Content and face validity were examined before field-testing. The study comprised a cross sectional study using the Malay version of the CEDV (CEDV-M) scale conducted at a secondary school in Perlis, Malaysia and investigated 235 children aged 13 years old-16 years old using an online platform. The construct validity, internal consistency and stability of the tool were assessed.

    RESULTS: The CEDV-M scale's content and face validity both yielded a value exceeding 0.80. Furthermore, the tool demonstrated has good stability reliability, using the intra-class correlation value for all items ranging from 0.659 to 1.00. The exploratory factor analysis of the 36 items of the CEDV scale revealed possibilities of five or six factor domains. However, the five factor domains were most conceptually equivalent. Consequently, this study found that the CEDV-M scale is reliable with a total Cronbach's alpha of 0.87.

    CONCLUSION: CEDV-M scale is a valid and reliable tool for measuring a child's experience of domestic violence. Future studies recommend confirmatory factor analysis and standard settings for scoring systems.

  11. Fulltext Clinical predictors of acute kidney injury in children with acute post-streptococcal glomerulonephritis: a tertiary centre experience
    Wan Yusof WA, Yaacob NM, Nasir A, Yusoff S, Ilias MI
    Singapore Med J, 2023 Jan 06.
    PMID: 36695277 DOI: 10.4103/singaporemedj.SMJ-2021-092
  12. Fulltext Evaluating teachers' pedagogical content knowledge in implementing classroom-based assessment: A case study among esl secondary school teachers in Selangor, Malaysia
    Abdul Razak R, Mat Yusoff S, Hai Leng C, Mohamadd Marzaini AF
    PLoS One, 2023;18(12):e0293325.
    PMID: 38157377 DOI: 10.1371/journal.pone.0293325
    The Malaysian Education Blueprint (PPPM) 2013-2025 has spurred significant reforms in the Primary School Standard Curriculum (KSSR) and Secondary School Standard Curriculum (KSSM), particularly concerning classroom-based assessment (CBA). CBA evaluates students' understanding and progress, informs instruction, and enhances the learning outcomes. Teachers with robust pedagogical content knowledge (PCK) are better equipped to design and implement effective CBA strategies that accurately assess students' comprehension and growth, provide personalised feedback, and guide instruction. This study aims to investigate the relationship between PCK and CBA among English as a Second Language (ESL) secondary school teachers in Selangor, Malaysia. A 5-point Likert-scale questionnaire was administered to 338 teachers across 27 regional secondary schools in Selangor. The Covariance-based structural equation modelling (SEM) was used to analyse the data. The findings revealed that the secondary school teachers demonstrated a high level of PCK, with content knowledge (CK) obtaining the highest mean, followed by pedagogical knowledge (PK) and pedagogical content knowledge (PCK). The CBA practices among these teachers were also found to be high. SEM analysis showed a positive association between PK and CBA practices and between PCK and CBA. However, no positive association was observed between CK and CBA practices. In order to enhance teachers' PCK and ensure the effective implementation of CBA, which is crucial for student learning outcomes in Malaysian ESL secondary schools, it is recommended that continuous professional development opportunities be provided, specifically focusing on PCK and CBA.
  13. Increased Expression of Phosphatidylinositol 3-Kinase p110α and Gene Amplification of PIK3CA in Nasopharyngeal Carcinoma
    Yip WK, He PY, Abdullah MA, Yusoff S, Seow HF
    Pathol Oncol Res, 2016 Apr;22(2):413-9.
    PMID: 26581613 DOI: 10.1007/s12253-015-0007-8
    Molecular alterations in PIK3CA oncogene that encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K p110α) are commonly found in human cancers. In this study, we examined the expression of PI3K p110α and PIK3CA gene amplification in 74 nasopharyngeal carcinoma (NPC) cases. Immunohistochemical staining demonstrated overexpression of PI3K p110α protein in 44.6% (33/74) of NPCs and 4.8% (2/42) of the adjacent normal nasopharyngeal mucosa. Copy number of PIK3CA gene was successfully analyzed in 51 of the total NPC cases and 19 non-malignant nasopharynx tissues by quantitative real-time PCR. Using mean + 2(standard deviation) of copy numbers in the non-malignant nasopharynx tissues as a cutoff value, PIK3CA copy number gain was found in 10 of 51 (19.6%) NPC cases. High PI3K p110α expression level was correlated with increased PIK3CA copy number (Spearman's rho =0.324, P = 0.02). PI3K p110α expression and PIK3CA copy number did not associate with Akt phosphorylation, and patient and tumor variables. This study suggests that PI3K p110α overexpression, which is attributed, at least in part, to PIK3CA gene amplification, may contribute to NPC pathogenesis. However, these molecular aberrations may not be responsible for activation of Akt signaling in NPC.
  14. Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma
    Yip WK, Leong VC, Abdullah MA, Yusoff S, Seow HF
    Oncol Rep, 2008 Feb;19(2):319-28.
    PMID: 18202777
    The Akt pathway is one of the most common molecular alterations in various human malignancies. However, its involvement in nasopharyngeal carcinoma (NPC) tumorigenesis has not been well established. In this study, the status of Akt activation and expression of its upstream and downstream molecules was investigated in 64 NPC and 38 non-malignant nasopharyngeal tissues by immunohistochemistry. The hotspot mutations of PIK3CA, encoding the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), were also determined in 25 of these NPC tissues. No hotspot mutations were found in any of the samples tested. Akt was activated in 27 (42.2%) and 23 (35.9%) NPCs, as indicated by p-Akt (Thr308) and p-Akt (Ser473) immunoreactivity, respectively. PTEN loss did not correlate statistically with activated Akt. However, a positive correlation was observed between activated Akt and phospho-epidermal growth factor receptor (p-EGFR), suggesting that the EGFR signaling might be one of the upstream regulators of the Akt pathway. The phosphorylation of forkhead (FKHR) and Bcl-2 associated death domain (BAD), but not mammalian target of rapamycin and glycogen synthase kinase-3beta, was significantly correlated with Akt activation. This implies that Akt promotes cell proliferation (as estimated by Ki-67) and survival, at least, through the inactivation of FKHR and BAD in NPC. Our data revealed that the EGFR/PI3K/Akt signaling pathway is important in NPC pathogenesis and that PIK3CA hotspot mutations are rare in NPC.
  15. Fulltext Spinal cryptoccoma mimicking a spinal cord tumor complicated by cryptococcal meningitis in an immunocompetent patient
    Carol L, Tai MS, Yusoff SM, Rose N, Rafia MH, Viswanathan S
    Neurol India, 2018 7 25;66(4):1181-1183.
    PMID: 30038119 DOI: 10.4103/0028-3886.237012
  16. Fulltext Feasibility Studies of Palm Oil Mill Waste Aggregates for the Construction Industry
    Kanadasan J, Fauzi AFA, Razak HA, Selliah P, Subramaniam V, Yusoff S
    Materials (Basel), 2015 Sep 22;8(9):6508-6530.
    PMID: 28793579 DOI: 10.3390/ma8095319
    The agricultural industry in Malaysia has grown rapidly over the years. Palm oil clinker (POC) is a byproduct obtained from the palm oil industry. Its lightweight properties allows for its utilization as an aggregate, while in powder form as a filler material in concrete. POC specimens obtained throughout each state in Malaysia were investigated to evaluate the physical, chemical, and microstructure characteristics. Variations between each state were determined and their possible contributory factors were assessed. POC were incorporated as a replacement material for aggregates and their engineering characteristics were ascertained. Almost 7% of density was reduced with the introduction of POC as aggregates. A sustainability assessment was made through greenhouse gas emission (GHG) and cost factor analyses to determine the contribution of the addition of POC to the construction industry. Addition of POC helps to lower the GHG emission by 9.6% compared to control specimens. By channeling this waste into the construction industry, an efficient waste-management system can be promoted; thus, creating a cleaner environment. This study is also expected to offer some guides and directions for upcoming research works on the incorporation of POC.
  17. Fulltext Coracoid Process Morphology using 3D-CT Imaging in a Malaysian Population
    Imma II, Nizlan NM, Ezamin AR, Yusoff S, Shukur MH
    Malays Orthop J, 2017 Jul;11(2):30-35.
    PMID: 29021876 MyJurnal DOI: 10.5704/MOJ.1707.012
    Introduction: The aims of this study are to define the coracoid process anatomy in a Malaysian population, carried out on patients in Hospital Serdang with specific emphasis on the dimension of the base of coracoid process which is important in coraco-acromial (CC) ligament reconstruction, to define the average amount of bone available for use in coracoid transfer, and to compare the size of coracoid process based on gender and race, and with findings in previous studies. Materials and Methods: Fifteen pairs of computed tomography (CT) based 3-dimensional models of shoulders of patients aged between 20 to 60 years old were examined. The mean dimensions of coracoid were measured and compared with regards to gender and race. The data were also compared to previously published studies. Results: The mean length of the coracoid process was 37.94 ± 4.30 mm. Male subjects were found to have larger-sized coracoids in all dimensions as compared to female subjects. The mean tip of coracoid dimension overall was 19.99 + 1.93mm length × 10.03 + 1.48mm height × 11.63 + 2.12mm width. The mean base of coracoid dimension was 18.96 + 3.71mm length × 13.84 + 1.76mm width. No significant differences were observed with regards to racial denomination. The overall coracoid size measurements were found to be smaller compared to previous studies done on the Western population. Conclusion: This study may suggest that Malaysians have smaller coracoid dimension compared to Caucasians. The findings further suggest that the incidence of coracoid fracture and implants pull out in Malaysian subjects may be higher.
  18. Fulltext Effect of incorporating sodium molybdate in the form of salt lick or in mixed ration on growth and performance of sheep fed palm kernel cake
    Yusoff SM, Ibrahim J, Salleh A
    Malays J Nutr, 1995 Sep;1(2):171-8.
    PMID: 22692061
    The objective of the present experiments are to determine if sheep could safely consume high amount of PKC in their diets and if sheep's consumption of PKC require a chelating agent to tie up the high copper level in PKC to protect it against toxicity. Two experiments were carried out. Experiment 1, with four treatment groups of animals, using from 30 to 100% PKC, mixed with other feed ingredients except minerals. Mineral mixtures were separately mixed with Sodium Molybdate, acting as the chelating agent, and the mineral was offered in separate feed troughs ad.libitum, in the pens for each animal group. Although all groups gave high ADG, the animals in the 100% group had high copper in their blood, which were above4 the normal physiological level at the end of the experimental duration of three months. Three animals from this group died and their liver copper contents were very high. The groups fed up to 72% PKC in their ration did not show any significant elevation of copper or toxicity. Sheep fed similar proportions of ingredients in experiment 2, but with Molybdate incorporated together into all the four similar rations as in experiment 1, did not show any signs of toxicity or elevated blood copper. The animals in all groups produced high ADG. The experiment proved that sheep can take up to 100% PKC in their diet, but a chelating agent must be incorporated into the feed to ensure its sufficient uptake to protect it against toxicity. Giving Molybdate separately from the feed would not ensure sufficient intake of the chelating agent voluntarily. This would result in copper toxicity in the animals.
  19. A Rare Case of an Infant with Left Hemiparesis: A Case Report of Bilateral Open-lip Schizencephaly
    Siti BC, Zulkifli MM, Mohd Yusoff SS, Muhamad R, Ahmad TM
    Malays Fam Physician, 2020;15(3):90-94.
    PMID: 33329869
    Schizencephaly is a very rare congenital birth defect. It is characterized by a cortical brain malformation that manifests as a grey-matter-lined cleft extending from the ependyma to the pia mater. It is a rare condition, and few cases have been reported in the literature. The exact cause is unknown. Herein, we report a case of an infant presenting with left side hemiparesis. The CT scan of her brain revealed right fronto-temporal and left parieto-temporal open-lip schizencephaly; thus, urgent referral to a pediatric neurologist was made for early intervention.
  20. Fulltext Young Lady with Bilateral Yellowish Lesions on Her Eyelids
    Ishak A, Mohd Yusoff SS, Wan Abdullah W
    Malays Fam Physician, 2018;13(3):44-46.
    PMID: 30800235 MyJurnal
    A 26-year-old woman with an unknown medical illness presented with yellowish skin lesions around both eyes, visible for the past 4 years. The lesions were neither itchy nor tender and had increased gradually in size. She had neither constitutional nor hyperthyroidism symptoms. She is the youngest out of four siblings, and none of her family members have cardiovascular disease or similar problems. Upon examination, there were bilateral yellowish plaques over the periorbital region. Her body mass index (BMI) was 23.8 kg/m2. Her vital signs were all normal at every visit.
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