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Penyelesaian masalah data ketakpastian menggunakan splin-B kabur

Abd. Fatah Wahab, Jamaludin Md. Ali, Ahmad Abd. Majid, Abu Osman Md. Tap

Sains Malaysiana, 2010;39.

Pembinaan model geometri berbantukan komputer (CAGD) dengan titik data yang mempunyai ketakpastian adalah sukar dan mencabar. Dalam kertas ini, pembinaan model splin-B kabur sebagai perwakilan matematik bagi lengkung dengan data ketakpastian menggunakan titik kawalan kabur dan titik kawalan penyahkaburan dibincangkan. Lengkung splin-B kabur atau splin-B penyahkaburan kubik untuk masalah data ketakpastian akan diperihalkan dengan menggunakan kaedah penghampiran splin-B kubik yang ditakrif menerusi titik kawalan kabur dan titik kawalan penyahkaburan. Bagi menyelesaikan masalah mengenai titik data ketakpastian pula, kaedah pengkaburan dan penyahkaburan titik data berkomponen kabur (penyahkaburan) beserta modelnya diperkenalkan. Bagi menguji tahap keberkesanan model, beberapa contoh lengkung simulasi data tersebut juga dibincangkan.

Matched MeSH terms: Diabetic Neuropathies
Fulltext Pengenalpastian mikroflora bakteria selain bacillus sp. Dari kolam air panas Bentong, Pahang, Malaysia

Abdul Hamid Abdul Aziz, Nur Fariza Mat Reffin, Mohamed Kamel Abd Ghani, Hing, Hiang Lian, Ahmad Zorin Sahalan

Jurnal Sains Kesihatan Malaysia, 2012;10(2):53-55.
MyJurnal

Suatu kajian mengenai pemencilan dan pengenalpastian mikroflora bakteria dari kolam air panas telah dilakukan di kolam air panas Bentong, Pahang. Kebanyakan bakteria yang dipencil dari kolam air panas adalah dari Bacillus sp. kerana ia mempunyai ciri adaptasi yang membolehkannya hidup di kawasan suhu yang tinggi dengan pembentukan endospora. Objektif kajian adalah untuk mengenal pasti spesies bakteria selain daripada spesies Bacillus sp. yang boleh dipencilkan dari kolam air panas. Tiga buah kolam air panas (A, B dan C) dikenal pasti dengan julat suhunya antara 36°C-52°C dan nilai pH antara 7.88-8.65. Kajian ini telah berjaya memencilkan dua pencilan bakteria kokus Gram positif dan tiga spesies basilus Gram negatif. Spesies Gram positif tersebut adalah dari genus Streptococcus dan Staphylococcus, manakala bagi Gram negatif pula terdapat masalah dalam pengenalpastian dan hanya dikenali sebagai X, XI and XII.

Matched MeSH terms: Diabetic Neuropathies
Explorative study on diabetes neuropathy among type II diabetic patients in Universiti Sains Malaysia Hospital

Abougalambou SS, Abougalambou AS

Diabetes Metab Syndr, 2012 Jul-Sep;6(3):167-72.
PMID: 23158982 DOI: 10.1016/j.dsx.2012.09.002

OBJECTIVE: The aim of this study was to determine risk factors and prevalence of diabetic neuropathy (DN) among type II diabetic patients in Malaysian hospital setting.
SUBJECTS AND METHODS: a observational prospective longitudinal follow up study design was selected, total no of respondents were 1077 type 2 diabetes mellitus outpatients recruited via attended the diabetes clinics at Hospital Universiti Sains Malaysia (HUSM) in Kelantan. The diagnosis of neuropathy was confirmed by nerve conduction studies. Logistic regression analysis was used to assess the independent variables that affect the development of neuropathy.
RESULTS: The prevalence of nephropathy is 54.3%. Longitudinal logistic regression identified four predictive variables on the development and progression of diabetic neuropathy that are: duration of diabetes, retinopathy, HbA1c at second visit, and creatinine clearance third visit.
CONCLUSION: Findings of this study show high prevalence of diabetic neuropathy. HbA1c and creatinine clearance are two modifiable risk factors for the development of diabetic neuropathy.
Study site: Diabetes clinics, Hospital Universiti Sains Malaysia (HUSM), Kelantan, Malaysia

Matched MeSH terms: Diabetic Neuropathies/blood; Diabetic Neuropathies/epidemiology*; Diabetic Neuropathies/physiopathology
Fulltext Kepesatan pembangunan dan pemodenan angkatan tentera malaysia (atm) di era perang dingin dan pasca perang dingin

Ahmad Shah Pakeer Mohamed, Nazariah Osman, Mohamad Faisol Keling

Malaysian Journal of Social Sciences and Humanities, 2020;5(12):160-169.
MyJurnal

“Fenomena anarki” telah mempengaruhi kebanyakan negara untuk memberikan tumpuan dan
perhatian terhadap pembangunan Angkatan ketenteraan bagi menjamin keselamatan untuk tujuan
kelangsungan hidup. Manakala merujukkan kepada teori neo-realisme, teori ini mengatakan dilema
keselamatan sebagai situasi yang sentiasa ada ancaman yang cuba untuk menggugat keselamatan
negara mahupun ianya dari bentuk unsur ancaman tradisional mahupun dari unsur dari ancaman bukan
dari tradisional. Akibat dari senario keselamatan dan sifat anarki dalam sistem antarabangsa, keadaan
ini akan menyebabkan negara perlu bergantung pada diri sendiri untuk kelangsungan hidup. Ini
merujuk kepada konsep self help atau self reliance di mana setiap negara mempunyai kepentingan
negara mereka tersendiri dalam meneruskan kelangsungan hidup dalam sistem antarabangsa. Melihat
dari sudut Angkatan Tentera Malaysia (ATM,) perspektif pembangunan dan pemodenan ATM semasa
era Perang Dingin dan Pasca Perang Dingin ternyata mempunyai perubahan yang signifikan di mana
pembangunan ATM sebelum tahun 1990 lebih bersifat konvensional dan pasca Perang Dingin
memperlihatkan pembangunan ATM bersifat lebih strategik.

Matched MeSH terms: Diabetic Neuropathies
Fulltext An Asian regional analysis of cost-effectiveness of early irbesartan treatment versus conventional antihypertensive, late amlodipine, and late irbesartan treatments in patients with type 2 diabetes, hypertension, and nephropathy

Annemans L, Demarteau N, Hu S, Lee TJ, Morad Z, Supaporn T, et al.

Value Health, 2008 May-Jun;11(3):354-64.
PMID: 17888064 DOI: 10.1111/j.1524-4733.2007.00250.x

OBJECTIVE: The prevalence of type 2 diabetes, often leading to diabetic nephropathy, has increased globally, especially in Asia. Irbesartan treatment delays the progression of kidney disease at the early (microalbuminuria) and late (proteinuria) stages of nephropathy in hypertensive type 2 diabetics. This treatment has proven to be cost-effective in Western countries. This study assessed the cost-effectiveness of early irbesartan treatment in Asian settings.
METHODS: An existing lifetime model was reprogrammed in Microsoft Excel to compare irbesartan started at an early stage to irbesartan or amlodipine started at a late stage, and standard treatments from a health-care perspective in China, Malaysia, Thailand, South Korea, and Taiwan. The main effectiveness parameters were incidences of end-stage renal disease, time in dialysis, and life expectancy. All costs were converted to 2004 US$ using official purchasing power parity. Local data were obtained for costs, transplantation,dialysis, and mortality rates. Probabilities regarding disease progression after treatment with the investigated drugs were extracted from two published clinical trials. A probabilistic sensitivity analysis was performed.
RESULTS: Early use of irbesartan yielded the largest clinical and economic benefits reducing need for dialysis by 61% to 63% versus the standard treatment, total costs by 9% (Thailand) to 42% (Taiwan), and increasing life expectancy by 0.31 to 0.48 years. Early irbesartan had a 66% (Thailand) to 95% (Taiwan) probability of being dominant over late irbesartan.
CONCLUSION: Although the absolute results varied in different settings, reflecting differences in epidemiology, management, and costs, early irbesartan treatment was a cost-effective alternative in the Asian settings.

Matched MeSH terms: Diabetic Neuropathies/drug therapy*; Diabetic Neuropathies/economics
Relationship between ultrasonographic nerve morphology and severity of diabetic sensorimotor polyneuropathy

Arumugam T, Razali SN, Vethakkan SR, Rozalli FI, Shahrizaila N

Eur J Neurol, 2016 Feb;23(2):354-60.
PMID: 26498575 DOI: 10.1111/ene.12836

In the current study, the aim was to characterize the nerve ultrasound cross-sectional areas (CSAs) of type 2 diabetic patients with diabetic sensorimotor polyneuropathy (DSP) of different severities.

Matched MeSH terms: Diabetic Neuropathies
Analisis prestasi nutrien pengkomposan sisa industri sawit bagi skala industri dalam tempoh tiga tahun

Asis T, Zahrim AY, Assis K

Sains Malaysiana, 2017;46:1201-1210.

Pengkomposan tandan buah kosong (EFB) dan sisa efluen kilang (POME) merupakan pendekatan lestari bagi menukarkan EFB dan POME kepada baja kompos. Pengkomposan adalah satu proses biologi yang memerlukan pengawalan yang optimum agar nutrien yang terhasil adalah tinggi dan stabil. Cabaran utama yang dihadapi oleh industri kompos ialah untuk menghasilkan kompos yang bernutrien tinggi dan stabil. Objektif kajian ini ialah untuk menganalisis prestasi jangka panjang bagi loji kompos terpilih melalui kandungan nutrien kompos yang dihasilkan. Penyelidikan ini mengkaji prestasi tiga tahun bagi empat loji kompos di Malaysia iaitu loji kompos Merotai, loji kompos Binuang, loji kompos Tanah Merah dan loji kompos Elphil. Prestasi kandungan nutrien yang diambil kira termasuklah nitrogen, kalium, nisbah karbon kepada nitrogen, kandungan kelembapan dan agregat kompos. Sebanyak 1,465 set data nutrien dianalisis secara deskriptif. Secara keseluruhannya, prestasi kandungan nutrien kesemua loji kompos yang dikaji berjaya memenuhi keperluan minimum industri sawit. Namun terdapat kes kompos yang dihasilkan mengandungi nutrien kalium yang tidak mencapai keperluan minimum industri dan kandungan kelembapan kompos yang tinggi. Kesimpulannya, masih terdapat ruang untuk penambahbaikan dalam proses pengkomposan agar kompos yang dihasilkan mengandungi nutrien yang stabil dan memenuhi keperluan minimum industri

Matched MeSH terms: Diabetic Neuropathies
Kesan suhu celupan ke atas mikrostruktur dan kekerasan salutan aluminium pada keluli karbon

Azman Jalar, Norinsan Kamil Othman, Emee Marina Salleh, Zaifol Samsu

Sains Malaysiana, 2018;47:1251-1257.

Keluli karbon amat mudah terkakis dalam pelbagai persekitaran terutamanya dalam keadaan berudara lembap dan suhu tinggi. Oleh sebab itu, permukaan keluli karbon perlu dilindungi dengan bahan atau logam yang mampu menangani serangan kakisan yang agresif dengan membentuk lapisan oksida dan lapisan antara logam yang bersifat pelindung. Kajian ini dijalankan untuk menentukan mikrostruktur permukaan dan kekerasan salutan aluminium (Al) tulen yang telah dihasilkan melalui teknik celupan panas. Celupan panas dalam leburan Al tulen dilakukan pada suhu berbeza untuk mendapatkan lapisan salutan yang optimum. Keputusan teknik celupan panas menunjukkan dua lapisan utama terhasil iaitu lapisan luar Al dan lapisan dalam aluminit (Fe-Al). Manakala lapisan dalam aluminida terdiri daripada dua lapisan yang berbeza iaitu lapisan nipis luar FeAl3 dan lapisan tebal dalam Fe2Al5. Keputusan daripada ujian mikrokekerasan Vickers menunjukkan bahawa nilai kekerasan lapisan aluminida meningkat dengan peningkatan suhu leburan Al manakala lapisan Al tidak menunjukkan sebarang perubahan yang ketara.

Matched MeSH terms: Diabetic Neuropathies
Fulltext Pengetahuan pedagogi kandungan (ppk) guru bukan pengkhususan reka bentuk dan teknologi (rbt) di sekolah menengah

Cathrine Binti Masingan, Sabariah Bte Sharif

Malaysian Journal of Social Sciences and Humanities, 2019;4(6):64-71.
MyJurnal

Kajian ini bertujuan untuk meneroka kefahaman Pengetahuan Pedagogi Kandungan (PPK) guru bukan pengkhususan mata pelajaran Reka Bentuk dan Teknologi (RBT) di Sekolah Menengah. Kajian ini adalah kajian kualitatif single case yang melibatkan dua orang guru bukan pengkhususan mata pelajaran RBT dipilih sebagai peserta kajian. Pengumpulan data menggunakan kaedah temu bual, pemerhatian dan juga analisis dokumen. Proses analisis data melibatkan tiga peringkat koding dalam Grounded Theory iaitu open coding, axial coding dan selective coding. Hasil kajian mendapati kedua peserta belum memahami dan menguasai sepenuhnya hala tuju, matlamat dan fokus KSSM RBT. Selain itu, mereka juga masih menghadapi masalah dalam menguasai isi kandungan mata pelajaran tersebut dengan baik. Dari aspek pengetahuan pedagogi, walaupun peserta kajian sedar tentang pendekatan-pendekatan PdPc yang dicadangkan dalam DSKP KSSM mata pelajaran RBT, namun mereka kurang menggunakan pendekatan tersebut dan masih cenderung menggunakan pendekatan pengajaran tradisional yang lebih berpusatkan kepada guru dan menggunakan kaedah syarahan semasa proses PdPc.

Matched MeSH terms: Diabetic Neuropathies
Fulltext Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity in Type 2 Diabetes Mellitus Patients in a Phase II Double-Blind, Randomized Controlled Clinical Trial

Chuar PF, Ng YT, Phang SCW, Koay YY, Ho JI, Ho LS, et al.

Nutrients, 2021 Oct 25;13(11).
PMID: 34836025 DOI: 10.3390/nu13113770

Diabetic peripheral neuropathy (DPN) is the most common microvascular complication of diabetes that affects approximately half of the diabetic population. Up to 53% of DPN patients experience neuropathic pain, which leads to a reduction in the quality of life and work productivity. Tocotrienols have been shown to possess antioxidant, anti-inflammatory, and neuroprotective properties in preclinical and clinical studies. This study aimed to investigate the effects of tocotrienol-rich vitamin E (Tocovid SuprabioTM) on nerve conduction parameters and serum biomarkers among patients with type 2 diabetes mellitus (T2DM). A total of 88 patients were randomized to receive 200 mg of Tocovid twice daily, or a matching placebo for 12 months. Fasting blood samples were collected for measurements of HbA1c, renal profile, lipid profile, and biomarkers. A nerve conduction study (NCS) was performed on all patients at baseline and subsequently at 2, 6, 12 months. Patients were reassessed after 6 months of washout. After 12 months of supplementation, patients in the Tocovid group exhibited highly significant improvements in conduction velocity (CV) of both median and sural sensory nerves as compared to those in the placebo group. The between-intervention-group differences (treatment effects) in CV were 1.60 m/s (95% CI: 0.70, 2.40) for the median nerve and 2.10 m/s (95% CI: 1.50, 2.90) for the sural nerve. A significant difference in peak velocity (PV) was also observed in the sural nerve (2.10 m/s; 95% CI: 1.00, 3.20) after 12 months. Significant improvements in CV were only observed up to 6 months in the tibial motor nerve, 1.30 m/s (95% CI: 0.60, 2.20). There were no significant changes in serum biomarkers, transforming growth factor beta-1 (TGFβ-1), or vascular endothelial growth factor A (VEGF-A). After 6 months of washout, there were no significant differences from baseline between groups in nerve conduction parameters of all three nerves. Tocovid at 400 mg/day significantly improve tibial motor nerve CV up to 6 months, but median and sural sensory nerve CV in up to 12 months of supplementation. All improvements diminished after 6 months of washout.

Matched MeSH terms: Diabetic Neuropathies/etiology; Diabetic Neuropathies/physiopathology; Diabetic Neuropathies/therapy*
Penilaian kualiti fizikokimia nuget ikan komersial

Desmelati, Mohd Khan Ayob, Aminah Abdullah, Abdul Salam Babji

Sains Malaysiana, 2011;40:1123-1127.

Sebanyak 6 jenis sampel nuget ikan komersial yang dipasarkan di Malaysia telah ditentukan komposisi proksimat (kandungan air, protein, lemak, abu dan karbohidrat), warna, kehilangan memasak, keupayaan memegang air, aktiviti air dan pH. Hasil analisis menunjukkan terdapat perbezaan bererti (p<0.05) bagi komposisi proksimat dan ciri-ciri warna, kehilangan memasak dan keupayaan memegang air. Kandungan air, protein, lemak, abu dan karbohidrat masing-masing berada dalam julat 58.97-64.58%, 9.30-11.60%, 0.14-5.23%, 1.95-2.84% dan 22.81-23.69%. Nilai L*, a* dan b* bagi warna, masing-masing adalah antara 49.72-56.80, 16.64-19.57 dan 38.40-59.58. Walau bagaimanapun tiada perbezaan yang bererti (p>0.05)untuk nilai aktiviti air dan pH antara sampel nuget ikan.

Matched MeSH terms: Diabetic Neuropathies
Pencirian transistor karbon tiub nano berdinding tunggal yang dihasilkan melalui kaedahpertumbuhan langsung

Farah Dzilhani Zulkefli, Mohd Ambri Mohamed, Burhanuddin Yeop Majlis

Sains Malaysiana, 2017;46:1141-1145.

Transistor berasaskan karbon tiub nano (CNTFET) telah dihasilkan melalui kaedah pertumbuhan langsung menggunakan alkohol pemangkin pemendapan wap kimia. Sifat struktur dan ciri elektrik peranti telah dikaji. FET ini menunjukkan operasi ambikutub dan ia selaras dengan jenis-Schottky FET. Ia telah didapati bahawa ketinggian halangan Schottky yang wujud antara sentuhan elektrod dan CNT, boleh termodulat oleh aplikasi berkesan daripada voltan pincang (VDS) dan voltan get (VGS). Aplikasi voltan pincang sahaja tidak mudah untuk merendahkan ketinggian halangan Schottky dan ketebalan halangan Shottky, tetapi ia berkait rapat dengan aplikasi voltan get. Bagi konfigurasi peranti dalam kajian ini, keberkesanan medan boleh dikaitkan dengan VGS:VDS = 10:-1. Peningkatan arus didapati disebabkan oleh pengurangan tenaga pengaktifan. Kaitan yang jelas antara kesan voltan pincang, voltan get dan tenaga pengaktifan telah diperhati dalam kajian ini.

Matched MeSH terms: Diabetic Neuropathies
Fulltext Risk determinants of peripheral neuropathy in patients with type II diabetes mellitus attending follow-up clinics at Universiti Kebangsaan Malaysia Medical Center (UKMMC): a cross-sectional study

Fatimah AB, Aziz N A, Amaramalar SN, Aznida FAA, Hamid MZA, Norlaila M

Medicine & Health, 2010;5(1):34-40.
MyJurnal

Peripheral neuropathy is highly associated with foot complications among diabetics. This
study aimed to identify risk factors associated with the development of peripheral neuropathy in diabetic patients and their association with degree of severity of peripheral neuropathy. A cross-sectional study was conducted in follow-up clinics at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Malaysia involving 72 diabetic patients and 19 controls. Exclusion criteria were those with amputated limbs, gross foot deformity and existing peripheral neuropathy. Controls were non diabetics who walked normally, had no history of foot problem and attended the clinic as subjects’ companion. Quantitative assessment of neuropathy was done using Semmes-Weinstein monofilament. Neuropathy Disability Score (NDS) were used to quantify severity of diabetic neuropathy. Spearman’s Rank test and Mann-Whitney test were used to determine correlation between variables and their differences. Logistic regression analysis was used to determine risk factors associated with peripheral neuropathy. The mean HbA1c among diabetics was 8.6% + 4.1, and mean NDS was 7.0 + 6.0. A total of 79.1% demonstrated various level of neuropathy with presence of callus was associated with higher NDS scores. Older age (P=0.02), body weight (P=0.03), HbA1c (P=0.005) and duration of diabetes (P <0.005) showed positive correlation with NDS. Proper foot care program for diabetics should include recognition of the callus, with special emphasis given to those with heavier weight and increasing age.
Key words: diabetes mellitus, peripheral neuropathy, Neuropathy Disability Score
(NDS), Semmes Weinstein monofilament (SWMF), callus

Study site: follow-up clinics at the Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)

Matched MeSH terms: Diabetic Neuropathies
Fulltext Prestasi penglihatan binokular lemah konvergens

Faudziah Abd Manan, Nor Aini Hanafi, Norliza Mohd Fadzil

Jurnal Sains Kesihatan Malaysia, 2010;8(1):39-43.
MyJurnal

Lemah konvergens (CI) adalah anomali penglihatan binokular yang melibatkan kesukaran dua mata menumpu semasa penglihatan dekat. Kajian ini mengkaji prestasi penglihatan binokular subjek CI. Prestasi binokular iaitu, akuiti penglihatan (VA) binokular jauh, VA binokular dekat dan stereoakuiti dibandingkan antara subjek CI dengan subjek normal. Seramai 30 subjek CI purata umur 17.33 ± 5.49 tahun dan 30 subjek normal purata umur 18.77 ± 6.08 tahun mempunyai VA 6/6 atau lebih baik, ralat refraksi sfera tidak melebihi ± 4.00 DS, astigmatisme tidak lebih daripada 2.00 DC, tiada juling dan tidak pernah menjalani terapi penglihatan, mempunyai kesihatan am dan kesihatan okular yang baik mengambil bahagian dalam kajian ini. VA monokular mata kanan, VA monokular mata kiri, VA binokular dan stereoakuiti dua kumpulan subjek diukur dan dibandingkan. Keputusan kajian mendapati perbezaan yang signifikan bagi VA binokular jauh (t = 2.31, p < 0.05), VA binokular dekat (t = 0.89, p < 0.05) dan stereoakuiti (Z = -2.81, p < 0.01) antara subjek CI dengan subjek normal. Kesimpulan kajian menunjukkan subjek kumpulan CI mengalami penurunan prestasi penglihatan binokular jauh, prestasi penglihatan binokular dekat dan stereoakuiti yang signifikan lebih rendah berbanding kumpulan normal.

Matched MeSH terms: Diabetic Neuropathies
Fulltext Risk factors of diabetic foot Charcot arthropathy: a case-control study at a Malaysian tertiary care centre

Fauzi AA, Chung TY, Latif LA

Singapore Med J, 2016 Apr;57(4):198-203.
PMID: 27075668 DOI: 10.11622/smedj.2016074

TThis study aimed to determine the risk factors of diabetic Charcot arthropathy of the foot among diabetic patients with and without foot problems.

Matched MeSH terms: Diabetic Neuropathies
Korelasi pekali kekasaran kekar (JRC) dengan sudut geseran puncak satah ketakselanjaran batuan granit, semenanjung Malaysia

Goh T, Ghani Rafek A, Hariri Arifin M

Sains Malaysiana, 2014;43:751-756.

Kekasaran permukaan satah ketakselanjaran adalah parameter penting untuk penilaian kestabilan struktur pengorekan dalam jasad batuan kerana ia mempengaruhi tingkah-laku ricihan dan nilai sudut geseran puncak satah tersebut. Beberapa kaedah boleh digunakan untuk menentukan kekasaran permukaan ketakselanjaran. Kertas ini memperkenalkan satu pendekatan yang mudah dalam bentuk tiga (3) persamaan polinominal untuk mengkorelasikan sudut geseran puncak ketakselanjaran (fp) batuan granit segar, terluluhawa sedikit dan terluluhawa sederhana dengan pekali kekasaran kekar, (JRC). Persamaan polinominal ketakselanjaran batuan granit segar ialah fp1 = -0.071JRC2 + 3.56JRC + 35.6. Persamaan polinominal ketakselanjaran batuan granit terluluhawa sedikit dan terluluhawa sederhana masing-masing ialah fp2 = -0.087JRC2 + 4.32JRC + 34.1 dan fp3 = -0.133JRC2 + 5.08JRC + 29. Hasil kajian ini memberikan satu kaedah alternatif penganggaran nilai fp satah ketakselanjaran daripada penentuan nilai PKK pada permukaan ketakselanjaran batuan granit di lapangan.

Matched MeSH terms: Diabetic Neuropathies
Sistem pemarkahan berasaskan pemberat dan persentil taburan

Hamizun Ismail, Azmin Sham Rambely, Rokiah Rozita Ahmad

Sains Malaysiana, 2012;41:1043-1049.

Kaedah pemarkahan dan penggredan sering dibincangkan dalam aspek penilaian pelajar. Kertas kerja ini bertujuan untuk membincangkan kaedah pemarkahan dan penggredan menggunakan persentil taburan markah. Kaedah pemarkahan dengan menggunakan min dan songsangan varians markah bagi setiap soalan dalam suatu peperiksaan sebagai pemberat kepada soalan berkenaan dibincangkan. Dalam membincangkan penggredan menggunakan persentil taburan markah, persentil boleh ditentukan dengan menganggar taburan bagi markah peperiksaan. Penganggaran dan penentuan persentil bagi dua taburan iaitu taburan normal dan taburan gamma digunakan. Perbandingan dilakukan terhadap keputusan bagi beberapa senario yang diperoleh. Keputusan menunjukkan bahawa kaedah pemarkahan berpemberat yang menggunakan pemberat yang berasaskan kepada tahap kesukaran soalan boleh digunakan untuk mernghasilkan peringkat gred yang lebih jelas dalam kalangan pelajar.

Matched MeSH terms: Diabetic Neuropathies
Statins-related peripheral neuropathy among diabetic patients

Hammad MA, Syed Sulaiman SA, Alghamdi S, Mangi AA, Aziz NA, Mohamed Noor DA

Diabetes Metab Syndr, 2020 04 09;14(4):341-346.
PMID: 32305775 DOI: 10.1016/j.dsx.2020.04.005

BACKGROUND: Peripheral neuropathy (PN) is a complaint with often unidentified reasons. Some medicines, including statins therapy, are anticipated to be amongst the reasons for PN.
AIMS: This study intended to assess the association of peripheral neuropathy with statins therapy amongst Type 2 diabetic patients.
METHODS: At Penang General Hospital, 757 cases were categorized into two groups (564 with statins therapy and 193 without statins therapy). The diagnosis of PN was investigated retrospectively for a period of 10 years (2006-2016). Confounding risk factors as age, diabetes period, hypertension, glycemic control, other co-morbidity, and prescriptions were matched.
RESULTS: About 129 (22.9%) cases from 564 statins users had PN. Only 30 (15.5%) subjects had PN from 193 statins non-users. Chi-square test showed a significant variance among statins treatment cohort and statin-free cohort in the occurrence of PN (P-value: 0.001). Spearman's investigation presented a positive correlation (r: 0.078, p-value: 0.031) among statins use and PN prevalence. Binary logistic regression was statistically significant for statins therapy as a predictor of peripheral neuropathy incidence (r2: 0.006, p-value: 0.027) amid diabetic patients. The relative risk of peripheral neuropathy connected with statins therapy is (RR: 1.47, 95% CI: 1.02-2.11). The excess relative risk is 47.1%. While the absolute risk (AR) is 7.3% and the number needed to harm (NNH) is 14.
CONCLUSIONS: The study indicated a positive association between peripheral neuropathy and statins utilization. Peripheral neuropathy was higher amongst statins users than the statins-free group.

Matched MeSH terms: Diabetic Neuropathies/chemically induced; Diabetic Neuropathies/epidemiology*; Diabetic Neuropathies/pathology
Fulltext Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis

Haque F, Reaz MBI, Ali SHM, Arsad N, Chowdhury MEH

Sci Rep, 2020 12 10;10(1):21770.
PMID: 33303857 DOI: 10.1038/s41598-020-78787-0

Despite the availability of various clinical trials that used different diagnostic methods to identify diabetic sensorimotor polyneuropathy (DSPN), no reliable studies that prove the associations among diagnostic parameters from two different methods are available. Statistically significant diagnostic parameters from various methods can help determine if two different methods can be incorporated together for diagnosing DSPN. In this study, a systematic review, meta-analysis, and trial sequential analysis (TSA) were performed to determine the associations among the different parameters from the most commonly used electrophysiological screening methods in clinical research for DSPN, namely, nerve conduction study (NCS), corneal confocal microscopy (CCM), and electromyography (EMG), for different experimental groups. Electronic databases (e.g., Web of Science, PubMed, and Google Scholar) were searched systematically for articles reporting different screening tools for diabetic peripheral neuropathy. A total of 22 studies involving 2394 participants (801 patients with DSPN, 702 controls, and 891 non-DSPN patients) were reviewed systematically. Meta-analysis was performed to determine statistical significance of difference among four NCS parameters, i.e., peroneal motor nerve conduction velocity, peroneal motor nerve amplitude, sural sensory nerve conduction velocity, and sural sensory nerve amplitude (all p

Matched MeSH terms: Diabetic Neuropathies/diagnosis*; Diabetic Neuropathies/physiopathology
Fulltext Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification

Haque F, Bin Ibne Reaz M, Chowdhury MEH, Srivastava G, Hamid Md Ali S, Bakar AAA, et al.

Diagnostics (Basel), 2021 Apr 28;11(5).
PMID: 33925190 DOI: 10.3390/diagnostics11050801

BACKGROUND: Diabetic peripheral neuropathy (DSPN), a major form of diabetic neuropathy, is a complication that arises in long-term diabetic patients. Even though the application of machine learning (ML) in disease diagnosis is a very common and well-established field of research, its application in diabetic peripheral neuropathy (DSPN) diagnosis using composite scoring techniques like Michigan Neuropathy Screening Instrumentation (MNSI), is very limited in the existing literature.
METHOD: In this study, the MNSI data were collected from the Epidemiology of Diabetes Interventions and Complications (EDIC) clinical trials. Two different datasets with different MNSI variable combinations based on the results from the eXtreme Gradient Boosting feature ranking technique were used to analyze the performance of eight different conventional ML algorithms.
RESULTS: The random forest (RF) classifier outperformed other ML models for both datasets. However, all ML models showed almost perfect reliability based on Kappa statistics and a high correlation between the predicted output and actual class of the EDIC patients when all six MNSI variables were considered as inputs.
CONCLUSIONS: This study suggests that the RF algorithm-based classifier using all MNSI variables can help to predict the DSPN severity which will help to enhance the medical facilities for diabetic patients.

Matched MeSH terms: Diabetic Neuropathies

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