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  1. Fulltext Ultrasonic-assisted extraction to enhance the recovery of bioactive phenolic compounds from Commiphora gileadensis leaves
    Bin Mokaizh AA, Nour AH, Kerboua K
    Ultrason Sonochem, 2024 May;105:106852.
    PMID: 38518410 DOI: 10.1016/j.ultsonch.2024.106852
    The "ultrasonic-assisted extraction (UAE)" method was utilized in this work to assess how different process parameters affected the yield and recovery of phenolic compounds from the leaf of Commiphora gileadensis, which is one of the medicinal plants with a variety of biological functions. Its leaf is used for a various of therapeutic applications, such as the treatment of bacterial infections, inflammation, and wound healing. The "One-Factor-At-a-Time (OFAT)" approach was employed to examine the impacts of various UAE process parameters on the process of extraction, which include time of extraction, sample/solvent ratio, ultrasonic frequency, and solvent (ethanol) concentration. The extracts were then investigated for the presence of several phytochemicals using analytical techniques such as "Gas Chromatography-Mass Spectroscopy (GC-MS)" and "Fourier Transform Infrared Spectroscopy (FTIR)" studies. The findings showed that the maximum extraction yield, the total phenolic content (TPC), and the total flavonoids content (TFC) of the ethanolic extract of the leaves of C. gileadensis using the UAE method were at 31.80 ± 0.41 %, 96.55 ± 2.81 mg GAE/g d.w. and 31.66 ± 2.01 mg QE/g d.w. accordingly under a procedure duration of 15 min, ultrasonic frequency of 20 kHz, solvent/sample ratio of 1:20 g/mL, and solvent concentration of 40 % v/v. The leaves extract of C. gileadensis included 25 phenolic compounds that were previously unreported, and GC-MS analysis confirmed their presence. Hence, it follows that the UAE technique can successfully extract the phytochemicals from C. gileadensis for a variety of therapeutic uses.
    Matched MeSH terms: Solvents/chemistry
  2. Fulltext Isolation and characterisation of lignin using natural deep eutectic solvents pretreated kenaf fibre biomass
    Meraj A, Jawaid M, Singh SP, Nasef MM, Ariffin H, Fouad H, et al.
    Sci Rep, 2024 Apr 15;14(1):8672.
    PMID: 38622317 DOI: 10.1038/s41598-024-59200-6
    Extraction of lignin via green methods is a crucial step in promoting the bioconversion of lignocellulosic biomasses. In the present study, utilisation of natural deep eutectic solvent for the pretreatment of kenaf fibres biomass is performed. Furthermore, extracted lignin from natural deep eutectic solvent pretreated kenaf biomass was carried out and its comparative study with commercial lignin was studied. The extracted lignin was characterized and investigated through Infrared Fourier transform spectroscopy, X-ray Diffraction, thermogravimetric analysis, UV-Vis spectroscopy, and scanning electron microscopy. FTIR Spectra shows that all samples have almost same set of absorption bands with slight difference in frequencies. CHNS analysis of natural deep eutectic solvent pretreated kenaf fibre showed a slight increase in carbon % from 42.36 to 43.17% and an increase in nitrogen % from - 0.0939 to - 0.1377%. Morphological analysis of commercial lignin shows irregular/uneven surfaces whereas natural deep eutectic solvent extracted lignin shows smooth and wavy surface. EDX analysis indicated noticeable peaks for oxygen and carbon elements which are present in lignocellulosic biomass. Thermal properties showed that lignin is constant at higher temperatures due to more branching and production of extremely condensed aromatic structures. In UV-VIS spectroscopy, commercial lignin shows slightly broad peak between 300 and 400 nm due to presence of carbonyl bond whereas, natural deep eutectic solvent extracted lignin does not show up any peak in this range. XRD results showed that the crystallinity index percentage for kenaf and natural deep eutectic solvent treated kenaf was 70.33 and 69.5% respectively. Therefore, these innovative solvents will undoubtedly have significant impact on the development of clean, green, and sustainable products for biocatalysts, extraction, electrochemistry, adsorption applications.
    Matched MeSH terms: Solvents/chemistry
  3. A review on chitin dissolution as preparation for electrospinning application
    Dzolkifle NAN, Wan Nawawi WMF
    Int J Biol Macromol, 2024 Apr;265(Pt 1):130858.
    PMID: 38490398 DOI: 10.1016/j.ijbiomac.2024.130858
    Electrospinning has been acknowledged as an efficient technique for the fabrication of continuous nanofibers from polymeric based materials such as polyvinyl alcohol (PVA), cellulose acetate (CA), chitin nanocrystals and others. These nanofibers exhibit chemical and mechanical stability, high porosity, functionality, high surface area and one-dimensional orientation which make it extremely beneficial in industrial application. In recent years, research on chitin - a biopolymer derived from crustacean and fungal cell wall - had gained interest due to its unique structural arrangement, excellent physical and chemical properties, in which make it biodegradable, non-toxic and biocompatible. Chitin has been widely utilized in various applications such as wound dressings, drug delivery, tissue engineering, membranes, food packaging and others. However, chitin is insoluble in most solvents due to its highly crystalline structure. An appropriate solvent system is required for dissolving chitin to maximize its application and produce a fine and smooth electrospun nanofiber. This review focuses on the preparation of chitin polymer solution through dissolution process using different types of solvent system for electrospinning process. The effect of processing parameters also discussed by highlighting some representative examples. Finally, the perspectives are presented regarding the current application of electrospun chitin nanofibers in selected fields.
    Matched MeSH terms: Solvents
  4. Review of the application of bimetallic catalysts coupled with internal hydrogen donor for catalytic hydrogenolysis of lignin to produce phenolic fine chemicals
    Ewuzie RN, Genza JR, Abdullah AZ
    Int J Biol Macromol, 2024 Apr;265(Pt 2):131084.
    PMID: 38521312 DOI: 10.1016/j.ijbiomac.2024.131084
    Lignocellulosic biomass contains lignin, an aromatic and oxygenated substance and a potential method for lignin utilization is achieved through catalytic conversion into useful phenolic and aromatic monomers. The application of monometallic catalysts for lignin hydrogenolysis reaction remains one of the major reasons for the underutilization of lignin to produce valuable chemicals. Monometallic catalysts have many limitations such as limited catalytic sites for interacting with different lignin linkages, poor catalytic activity, low lignin conversion, and low product selectivity. It is due to lack of synergy with other metallic catalysts that can enhance the catalytic activity, stability, selectivity, and overall catalytic performance. To overcome these limitations, works on the application of bimetallic catalysts that can offer higher activity, selectivity, and stability have been initiated. In this review, cutting-edge insights into the catalytic hydrogenolysis of lignin, focusing on the production of phenolic and aromatic monomers using bimetallic catalysts within an internal hydrogen donor solvent are discussed. The contribution of this work lies in a critical discussion of recent reported findings, in-depth analyses of reaction mechanisms, optimal conditions, and emerging trends in lignin catalytic hydrogenolysis. The specific effects of catalytic active components on the reaction outcomes are also explored. Additionally, this review extends beyond current knowledge, offering forward-looking suggestions for utilizing lignin as a raw material in the production of valuable products across various industrial processes. This work not only consolidates existing knowledge but also introduces novel perspectives, paving the way for future advancements in lignin utilization and catalytic processes.
    Matched MeSH terms: Solvents/chemistry
  5. Glycols: The ubiquitous solvent for dermal formulations
    Yu HL, Goh CF
    Eur J Pharm Biopharm, 2024 Mar;196:114182.
    PMID: 38224756 DOI: 10.1016/j.ejpb.2024.114182
    Glycols stand out as one of the most commonly employed safe and effective excipients for pharmaceutical and cosmeceutical products. Their widespread adoption can be attributed to their exceptional solvency characteristics and their ability to interact effectively with skin lipids and keratin for permeation enhancement. Notably, propylene glycol enjoys significant popularity in this regard. Ongoing research endeavours have been dedicated to scrutinising the impact of glycols on dermal drug delivery and shedding light on the intricate mechanisms by which glycols enhance skin permeation. This review aims to mitigate the discordance within the existing literature, assemble a holistic understanding of the impact of glycols on the percutaneous absorption of active compounds and furnish the reader with a profound comprehension of the foundational facets pertaining to their skin permeation enhancement mechanisms, while simultaneously delving deeper into the intricacies of these processes.
    Matched MeSH terms: Solvents/pharmacology
  6. Taguchi approach for assessing supercritical CO2 (sCO2) fluid extraction of polyhydroxyalkanoate (PHA) from Chlorella Vulgaris sp. microalgae
    Abdul Rahman SNS, Chai YH, Lam MK
    J Environ Manage, 2024 Mar;355:120447.
    PMID: 38460326 DOI: 10.1016/j.jenvman.2024.120447
    This research explicitly investigates the utilization of Chlorella Vulgaris sp. microalgae as a renewable source for lipid production, focusing on its application in bioplastic manufacturing. This study employed the supercritical fluid extraction technique employing supercritical CO2 (sCO2) as a green technology to selectively extract and produce PHA's precursor utilizing CO2 solvent as a cleaner solvent compared to conventional extraction method. The study assessed the effects of three extraction parameters, namely temperature (40-60 °C), pressure (15-35 MPa), and solvent flow rate (4-8 ml/min). The pressure, flowrate, and temperature were found to be the most significant parameters affecting the sCO2 extraction. Through Taguchi optimization, the optimal parameters were determined as 60 °C, 35 MPa, and 4 ml/min with the highest lipid yield of 46.74 wt%; above-average findings were reported. Furthermore, the pretreatment process involved significant effects such as crumpled and exhaustive structure, facilitating the efficient extraction of total lipids from the microalgae matrix. This study investigated the microstructure of microalgae biomatrix before and after extraction using scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). Fourier-transform infrared spectroscopy (FTIR) was utilized to assess the potential of the extracted material as a precursor for biodegradable plastic production, with a focus on reduced heavy metal content through inductively coupled plasma-optical emission spectrometry (ICP-OES) analysis. The lipid extracted from Chlorella Vulgaris sp. microalgae was analysed using gas chromatography-mass spectrometry (GC-MS), identifying key constituents, including oleic acid (C18H34O2), n-Hexadecanoic acid (C16H32O2), and octadecanoic acid (C18H36O2), essential for polyhydroxyalkanoate (PHA) formation.
    Matched MeSH terms: Solvents/chemistry
  7. Fulltext Molecular Cloning, Characterization, and Application of Organic Solvent-Stable and Detergent-Compatible Thermostable Alkaline Protease from Geobacillus thermoglucosidasius SKF4
    Allison SD, AdeelaYasid N, Shariff FM, Abdul Rahman N
    J Microbiol Biotechnol, 2024 Feb 28;34(2):436-456.
    PMID: 38044750 DOI: 10.4014/jmb.2306.06050
    Several thermostable proteases have been identified, yet only a handful have undergone the processes of cloning, comprehensive characterization, and full exploitation in various industrial applications. Our primary aim in this study was to clone a thermostable alkaline protease from a thermophilic bacterium and assess its potential for use in various industries. The research involved the amplification of the SpSKF4 protease gene, a thermostable alkaline serine protease obtained from the Geobacillus thermoglucosidasius SKF4 bacterium through polymerase chain reaction (PCR). The purified recombinant SpSKF4 protease was characterized, followed by evaluation of its possible industrial applications. The analysis of the gene sequence revealed an open reading frame (ORF) consisting of 1,206 bp, coding for a protein containing 401 amino acids. The cloned gene was expressed in Escherichia coli. The molecular weight of the enzyme was measured at 28 kDa using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The partially purified enzyme has its highest activity at a pH of 10 and a temperature of 80°C. In addition, the enzyme showed a half-life of 15 h at 80°C, and there was a 60% increase in its activity at 10 mM Ca2+ concentration. The activity of the protease was completely inhibited (100%) by phenylmethylsulfonyl fluoride (PMSF); however, the addition of sodium dodecyl sulfate (SDS) resulted in a 20% increase in activity. The enzyme was also stable in various organic solvents and in certain commercial detergents. Furthermore, the enzyme exhibited strong potential for industrial use, particularly as a detergent additive and for facilitating the recovery of silver from X-ray film.
    Matched MeSH terms: Solvents
  8. Fulltext Degradation effects of dietary solvents on microhardness and inorganic elements of computer-aided design/computer-aided manufacturing dental composites
    Munusamy SM, Helen-Ng LC, Farook MS
    BMC Oral Health, 2024 Feb 01;24(1):162.
    PMID: 38302972 DOI: 10.1186/s12903-024-03905-7
    BACKGROUND: Computer-aided design/computer-aided manufacturing (CAD/CAM) dental composites were introduced with superior mechanical properties than conventional dental composites. However, little is known on effects of dietary solvents on microhardness or inorganic elemental composition of CAD/CAM composites.

    OBJECTIVES: The objectives of this study were to evaluate the degradation effects of each dietary solvent on the microhardness of the different CAD/CAM dental composites and to observe the degradation effects of dietary solvent on the inorganic elements of the dental composites investigated.

    METHODS: Fifty specimens with dimensions 12 mm x 14 mm x 1.5 mm were prepared for direct composite (Filtek Z350 XT [FZ]), indirect composite (Shofu Ceramage [CM]), and three CAD/CAM composites (Lava Ultimate [LU], Cerasmart [CS], and Vita Enamic [VE]). The specimens were randomly divided into 5 groups (n = 10) and conditioned for 1-week at 37°C in the following: air (control), distilled water, 0.02 N citric acid, 0.02 N lactic acid and 50% ethanol-water solution. Subsequently, the specimens were subjected to microhardness test (KHN) using Knoop hardness indenter. Air (control) and representative postconditioning specimens with the lowest mean KHN value for each material were analyzed using energy dispersive X-ray spectroscopy (EDX). Statistical analysis was done using one-way ANOVA and post hoc Bonferroni test at a significance level of p = 0.05.

    RESULTS: Mean KHN values ranged from 39.7 ± 2.7 kg/mm2 for FZ conditioned in 50% ethanol-water solution to 79.2 ± 3.4 kg/mm2 for VE conditioned in air (control). With exception to LU, significant differences were observed between materials and dietary solvents for other dental composites investigated. EDX showed stable peaks of the inorganic elements between air (control) and representative postconditioning specimens.

    CONCLUSIONS: The microhardness of dental composites was significantly affected by dietary solvents, except for one CAD/CAM composite [LU]. However, no changes were observed in the inorganic elemental composition of dental composites between air (control) and 1-week postconditioning.

    Matched MeSH terms: Solvents
  9. Biomonitoring of Exposures to Solvents and Metals in Electronics Manufacturing Facilities in Batam, Indonesia
    Lee JH, Gatera VA, Smith T, Panimbang F, Gonzalez A, Abdulah R, et al.
    New Solut, 2024 Feb;33(4):220-235.
    PMID: 38112404 DOI: 10.1177/10482911231218478
    Concerns about chemical exposure in the electronics manufacturing industry have long been recognized, but data are lacking in Southeast Asia. We conducted a study in Batam, Indonesia, to evaluate chemical exposures in electronics facilities, using participatory research and biological monitoring approaches. A convenience sample of 36 workers (28 exposed, 8 controls) was recruited, and urine samples were collected before and after shifts. Five solvents (acetone, methyl ethyl ketone, toluene, benzene, and xylenes) were found in 46%-97% of samples, and seven metals (arsenic, cadmium, cobalt, tin, antimony, lead, and vanadium) were detected in 60%-100% of samples. Biological monitoring and participatory research appeared to be useful in assessing workers' exposure when workplace air monitoring is not feasible due to a lack of cooperation from the employer. Several logistical challenges need to be addressed in future biomonitoring studies of electronics workers in Asia in factories where employers are reluctant to track workers' exposure and health.
    Matched MeSH terms: Solvents/analysis
  10. Acetic acid as a protic solvent for reducing sulphuric acid concentrations in the production of cellulose nanocrystals alongside transition metal co-catalysts
    Lim CSS, Chan EWC, Wong CW
    Int J Biol Macromol, 2024 Feb;259(Pt 2):129303.
    PMID: 38216018 DOI: 10.1016/j.ijbiomac.2024.129303
    Cellulose nanocrystals (CNC) conventionally involve highly concentrated sulphuric acid, which typically resulted in the formation of undesirable by-products. Although less corrosive mineral acids have been explored as alternatives, high concentrations are still required. In this study, CNC was successfully isolated from Leucaena leucocephala wood using mild sulphuric acid with acetic acid as protic solvent, and it was further studied with the addition of Lewis acids in the form of multivalent transition metal salts as co-catalyst. Selected divalent and trivalent transition metal salts including (Cr(NO3)3, Fe(NO3)3, Co(NO3)2, and Ni(NO3)2) were investigated. The morphology, chemical structure, particle size, and physicochemical properties of the CNCs were determined. Controlled depolymerization of cellulose was observed using transmission electron microscopy (TEM). Rod-like morphology for all CNCs was obtained during the hydrolysis process with the smallest CNC particles found at an average length of 278.1 ± 35.1 nm and a diameter of 13.4 ± 3.0 nm. The results showed that higher valence state metal ions resulted in better cellulose hydrolysis efficiency. In addition, the use of transition metal salt as a co-catalyst improved production efficiency and minimised carbonization of CNC while maintaining desired crystallinity and thermal properties.
    Matched MeSH terms: Solvents
  11. Effects of electrospun nanofiber fabrications on immobilization of recombinant Escherichia coli for production of xylitol from glucose
    Mohamad Sukri N, Abdul Manas NH, Jaafar NR, A Rahman R, Abdul Murad AM, Md Illias R
    Enzyme Microb Technol, 2024 Jan;172:110350.
    PMID: 37948908 DOI: 10.1016/j.enzmictec.2023.110350
    A suitable nanofiber sheet was formulated and developed based on its efficacy in the immobilization of recombinant Escherichia coli (E. coli) to enhance xylitol production. The effects of different types of nanofibers and solvents on cell immobilization and xylitol production were studied. The most applicable nanofiber membrane was selected via preliminary screening of four types of nanofiber membrane, followed by the selection of six different solvents. Polyvinylidene fluoride (PVDF) nanofiber sheet synthesized using dimethylformamide (DMF) solvent was found to be the most suitable carrier for immobilization and xylitol production. The thin, beaded PVDF (DMF) nanofibers were more favourable for microbial adhesion, with the number of immobilized cells as high as 96 × 106 ± 3.0 cfu/ml. The attraction force between positively charged PVDF nanofibers and the negatively charged E. coli indicates that the electrostatic interaction plays a significant role in cell adsorption. The use of DMF has also produced PVDF nanofibers biocatalyst capable of synthesizing the highest xylitol concentration (2.168 g/l) and productivity (0.090 g/l/h) and 55-69% reduction in cell lysis compared with DMSO solvent and free cells. This finding suggests that recombinant E. coli immobilized on nanofibers shows great potential as a whole-cell biocatalyst for xylitol production.
    Matched MeSH terms: Solvents/metabolism
  12. Natural deep eutectic solvents for the extraction of lentinan from shiitake mushroom: COSMO-RS screening and ANN-GA optimizing conditions
    Wang D, Zhang M, Law CL, Zhang L
    Food Chem, 2024 Jan 01;430:136990.
    PMID: 37536067 DOI: 10.1016/j.foodchem.2023.136990
    Using natural deep eutectic solvents (NDES) for green extraction of lentinan from shiitake mushroom is a high-efficiency method. However, empirical and trial-and-error methods commonly used to select suitable NDES are unconvincing and time-consuming. Conductor-like screening model for realistic solvation (COSMO-RS) is helpful for the priori design of NDES by predicting the solubility of biomolecules. In this study, 372 NDES were used to evaluate lentinan dissolution capability via COSMO-RS. The results showed that the solvent formed by carnitine (15 wt%), urea (40.8 wt%), and water (44.2 wt%) exhibited the best performance for the extraction of lentinan. In the extraction stage, an artificial neural network coupled with genetic algorithm (ANN-GA) was developed to optimize the extraction conditions and to analyze their interaction effects on lentinan content. Therefore, COSMO-RS and ANN-GA can be used as powerful tools for solvent screening and extraction process optimization, which can be extended to various bioactive substance extraction.
    Matched MeSH terms: Solvents
  13. Skin hydration modulatory activities of Ficus deltoidea extract
    Ariffin NHM, Hasham R, Hamzah MAAM, Park CS
    Fitoterapia, 2024 Jan;172:105755.
    PMID: 38000761 DOI: 10.1016/j.fitote.2023.105755
    Ficus deltoidea was known for its potent antioxidant, anti-melanogenic and photoprotective skin barrier activities. These properties are contributed by its biomarkers which are vitexin and isovitexin. This study aims to optimize the yield of methanolic extraction of Ficus deltoidea leaves (EFD) and evaluate their effects on skin barrier function and hydration. For optimization, Box-Behnken design was utilized to investigate the effects of methanol concentration, sonication time, and solvent-to-sample ratio on the yields of vitexin and isovitexin in EFD. The optimal yields obtained were 32.29 mg/g for vitexin and 35.87 mg/g for isovitexin. The optimum extraction conditions were 77.66% methanol concentration, 20.03 min sonication time, and 19.88 mL/g solvent-to-sample ratio. The quantitative real-time polymerase chain reaction was utilized to measure variant marker genes of transglutaminase-1, caspase 14, ceramide synthase 3, involucrin, and filaggrin of EFD-induced keratinocyte differentiation by in vitro study. Exposure to EFD has elevated the mRNA levels of all tested marker genes by 0.7-9.2 folds. Then, in vivo efficacy study was conducted on 20 female subjects for 14 days to evaluate skin biophysical assessment of hydration. EFD topical formulation treatment successfully increased skin hydration on day 7 (43.74%) and day 14 (47.23%). In silico study by molecular docking was performed to identify intermolecular binding interactions of vitexin and isovitexin with the interested proteins of tested marker genes. The result of molecular docking to the interested proteins revealed a similar trend with real-time PCR data. In conclusion, EFD potentially enhanced the skin barrier function and hydration of human skin cells.
    Matched MeSH terms: Solvents
  14. Revolutionizing lignocellulosic biomass: A review of harnessing the power of ionic liquids for sustainable utilization and extraction
    Norfarhana AS, Ilyas RA, Ngadi N, Othman MHD, Misenan MSM, Norrrahim MNF
    Int J Biol Macromol, 2024 Jan;256(Pt 1):128256.
    PMID: 38000585 DOI: 10.1016/j.ijbiomac.2023.128256
    The potential for the transformation of lignocellulosic biomass into valuable commodities is rapidly growing through an environmentally sustainable approach to harness its abundance, cost-effectiveness, biodegradability, and environmentally friendly nature. Ionic liquids (ILs) have received considerable and widespread attention as a promising solution for efficiently dissolving lignocellulosic biomass. The fact that ILs can act as solvents and reagents contributes to their widespread recognition. In particular, ILs are desirable because they are inert, non-toxic, non-flammable, miscible in water, recyclable, thermally and chemically stable, and have low melting points and outstanding ionic conductivity. With these characteristics, ILs can serve as a reliable replacement for traditional biomass conversion methods in various applications. Thus, this comprehensive analysis explores the conversion of lignocellulosic biomass using ILs, focusing on main components such as cellulose, hemicellulose, and lignin. In addition, the effect of multiple parameters on the separation of lignocellulosic biomass using ILs is discussed to emphasize their potential to produce high-value products from this abundant and renewable resource. This work contributes to the advancement of green technologies, offering a promising avenue for the future of biomass conversion and sustainable resource management.
    Matched MeSH terms: Solvents
  15. Lipidomics insight on differences in lipid profiles and phytosterol compositions of coconut oils extracted by classical and green solvents
    Cui J, Yang Z, Xu Y, Tan CP, Zhang W
    Food Res Int, 2023 Dec;174(Pt 2):113653.
    PMID: 37981374 DOI: 10.1016/j.foodres.2023.113653
    Searching for green and ecofriendly solvents to replace classical solvents for industrial scale extraction of coconut oil is of great interest. To explore these possibilities, this study performed comprehensive comparative analyses of lipid profiles and phytosterol compositions in coconut oils obtained by extraction with n-hexane, absolute ethyl alcohol, deep eutectic solvent/n-hexane, dimethyl carbonate (DME) and cyclopentyl methyl ether (CPME) using a foodomics approach. Results indicated that CPME (64.23 g/100 g dry matter) and DME (65.64 g/100 g dry matter) showed comparable capacity for total lipid extraction of total lipids to classical solvents (63.5-65.66 g/100 g dry matter). Considering the phytosterol yield, CPME (644.26 mg/kg) exhibited higher selectivity than other solvents (535.64-622.13 mg/kg). No significant difference was observed in the fatty acid composition of coconut oil by the different solvents assayed. Additionally, total 468 lipid molecules were identified in the samples. For glycerolipid and sphingolipid, the five solvents showed comparable extraction capabilities. However, CPME exhibited higher extraction efficiency of polar lipids (glycerophospholipid and saccharolipid) than other solvents. Overall, these results may be a useful guide for the application of green solvents in industrial production of coconut oil.
    Matched MeSH terms: Solvents
  16. A review on natural based deep eutectic solvents (NADESs): fundamentals and potential applications in removing heavy metals from soil
    Lai ZY, Yiin CL, Lock SSM, Chin BLF, Zauzi NSA, Sar-Ee S
    Environ Sci Pollut Res Int, 2023 Nov;30(55):116878-116905.
    PMID: 36917382 DOI: 10.1007/s11356-023-26288-8
    Natural based deep eutectic solvent (NADES) is a promising green solvent to replace the conventional soil washing solvent due to the environmental benign properties such as low toxicity, high biodegradability, high polarity or hydrophilicity, and low cost of fabrication process. The application of NADES is intensively studied in the extraction of organic compounds or natural products from vegetations or organic matters. Conversely, the use of the solvent in removing heavy metals from soil is severely lacking. This review focuses on the potential application of NADES as a soil washing agent to remove heavy metal contaminants. Hydrophilicity is an important feature of a NADES to be used as a soil washing solvent. In this context, choline chloride is often used as hydrogen bond acceptor (HBA) whereby choline chloride based NADESs showed excellent performance in the extraction of various solutes in the past studies. The nature of NADES along with its chemistry, preparation and designing methods as well as potential applications were comprehensively reviewed. Subsequently, related studies on choline chloride-based NADES in heavy metal polluted soil remediation were also reviewed. Potential applications in removing other soil contaminants as well as the limitations of NADES were discussed based on the current advancements of soil washing and future research directions were also proposed.
    Matched MeSH terms: Solvents/chemistry
  17. The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties
    Siddiqui R, Khodja A, Ibrahim T, Khamis M, Anwar A, Khan NA
    World J Microbiol Biotechnol, 2023 Oct 04;39(12):330.
    PMID: 37792153 DOI: 10.1007/s11274-023-03760-8
    With the rise of antibiotic resistance globally, coupled with evolving and emerging infectious diseases, there is an urgent need for the development of novel antimicrobials. Deep eutectic solvents (DES) are a new generation of eutectic mixtures that depict promising attributes with several biological implications. DES exhibit unique properties such as low toxicity, biodegradability, and high thermal stability. Herein, the antimicrobial properties of DES and their mechanisms of action against a range of microorganisms, including bacteria, amoebae, fungi, viruses, and anti-cancer properties are reviewed. Overall, DES represent a promising class of novel antimicrobial agents as well as possessing other important biological attributes, however, future studies on DES are needed to investigate their underlying antimicrobial mechanism, as well as their in vivo effects, for use in the clinic and public at large.
    Matched MeSH terms: Solvents
  18. Physicochemical and thermal characteristics of choline chloride-based deep eutectic solvents
    Sazali AL, AlMasoud N, Amran SK, Alomar TS, Pa'ee KF, El-Bahy ZM, et al.
    Chemosphere, 2023 Oct;338:139485.
    PMID: 37442394 DOI: 10.1016/j.chemosphere.2023.139485
    It is essential to investigate the physicochemical and thermal properties of choline chloride (ChCl)-based deep eutectic solvents (DESs) as hydrogen bond acceptor (HBA) with various hydrogen bond donor (HBD) functional groups, such as α-hydroxy acid (lactic acid) or polyol (glycerol). It is important to consider how molar ratios impact these properties, as they may be altered for particular applications. This study aimed to examine the physicochemical and thermal properties of ChCl-based DESs with lactic acid (LA) or glycerol (Gly) at different molar ratios (1:2-1:10). The pH of ChCl:LA (0-1.0) is lower than that of ChCl:Gly (4.0-5.0) because of the hydrogen bonds between ChCl and LA. A higher amount of LA/Gly resulted in higher densities of ChCl:Gly (1.20-1.22 g cm-3) and ChCl:LA (1.16-1.19 g cm-3) due to the stronger hydrogen bonds and tighter packing of the molecules. The refractive index of ChCl:Gly (1.47-1.48) was higher than ChCl:LA (1.44-1.46), with a trend similar to density. The viscosities of ChCl:Gly (0.235-0.453 Pa s) and ChCl:LA (0.04-0.06 Pa s) increased with increasing LA/Gly molar ratio but decreased with temperature due to the high kinetic energy from heating, lowering the attractive forces between molecules. The activation energy for ChCl:LA (15.29-15.55 kJ mol-1) is greater than for ChCl:Gly (7.77-8.78 kJ mol-1), indicating that ChCl:LA has a greater viscosity-temperature dependence than ChCl:Gly. The DESs decomposition temperatures are 179.73-192.14 °C for ChCl:LA and 189.69-197.41 °C for ChCl:Gly. Freezing temperatures are correlated with the molecular weight of HBDs, with lower values causing a larger decrease in freezing temperatures. The interactions of polyols with anions were stronger than those of α-hydroxy acids with anions. The variations in HBA to HBD molar ratios affected DESs properties, providing a fundamental understanding of the properties critical for their diverse applications.
    Matched MeSH terms: Solvents/chemistry
  19. Green ultrasonication-assisted extraction of microalgae Chlorella sp. for polysaturated fatty acid (PUFA) rich lipid extract using alternative solvent mixture
    Hui GT, Meng TK, Kassim MA
    Bioprocess Biosyst Eng, 2023 Oct;46(10):1499-1512.
    PMID: 37580470 DOI: 10.1007/s00449-023-02917-x
    Conventionally, microalgal lipid extraction uses volatile organic compounds as an extraction solvent. However, these solvents are harmful to human and environmental health. Therefore, this study evaluated the feasibility of alternative green solvents, namely, ethanol, dimethyl carbonate (DMC), cyclopentyl methyl ether (CPME), and 2-methyltetrahydrofuran (2-MeTHF) in lipid extraction from Chlorella sp. via ultrasound-assisted extraction (UAE). This study indicated that extraction parameters, such as ethanol-to-2-MeTHF ratio, solvent-to-biomass ratio, temperature, and time, significantly affected the crude lipid yield (P 
    Matched MeSH terms: Solvents
  20. An integrated life cycle assessment and techno-economic analysis: Evaluation on the production of polymers of intrinsic microporosity (PIM-1) and UiO-66-NH2 as membrane materials
    Goh WHD, Lau HS, Yong WF
    Sci Total Environ, 2023 Sep 20;892:164582.
    PMID: 37277034 DOI: 10.1016/j.scitotenv.2023.164582
    Material synthesis requires an enormous amount of organic solvents which leads to huge environmental burdens. Being so, the necessity to utilize non-toxic chemicals is of growing interest in the global market. Harnessing a green fabrication strategy could be a sustainable remedy. Herein, life cycle assessment (LCA) and techno-economic assessment (TEA) using a cradle-to-gate approach to select the green synthesis route for the production of main components in mixed matrix membranes such as polymer and fillers were studied. Five representative synthesis routes of polymers of intrinsic microporosity (PIM-1) and fillers such as UiO-66-NH2 (UiO: University of Oslo) were conducted. Our findings revealed that the tetrachloroterephthalonitrile (TCTPN) synthesized PIM-1 using a novel approach (e.g., P5-Novel synthesis) and solvent-free synthesized UiO-66-NH2 (e.g., U5-Solvent-free) demonstrated the least environmental impact and are most economically feasible. The environmental burden and cost of PIM-1 synthesized by P5-Novel synthesis route decreased by 50 % and 15 %, respectively, while that of UiO-66-NH2 produced via U5-Solvent-free route reduced by 89 % and 52 %, respectively. Additionally, solvent reduction was found to have an apparent effect on cost-saving, whereby the production cost declined 13 % with a 30 % solvent reduction. Alleviation of environmental burdens could also be found through recovering solvents or substituting with a greener alternative (e.g., water). The fundamentals gained on the environmental impacts and economic feasibility of PIM-1 and UiO-66-NH2 production from this LCA-TEA study may provide a preliminary evaluation for the development of green and sustainable materials.
    Matched MeSH terms: Solvents
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