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Dietary astaxanthin augments disease resistance of Asian seabass, Lates calcarifer (Bloch, 1790), against Vibrio alginolyticus infection

Lim KC, Yusoff FM, Shariff M, Kamarudin MS

Fish Shellfish Immunol, 2021 Jul;114:90-101.
PMID: 33838221 DOI: 10.1016/j.fsi.2021.03.025

This investigation describes the impacts of dietary provisioning with astaxanthin on hemato-biochemistry, non-specific immunity, and disease resistance of the Asian seabass, Lates calcarifer, against the virulent Vibrio alginolyticus; with specific reference to dose-response associations and variations over different post-infection periods (0-, 7-, and 14-day). Triplicate groups of fish weighing 28 g, on average, were fed various diets (C, the control or astaxanthin-free; AXT50, 50 mg astaxanthin kg-1 diet; AXT100, 100 mg astaxanthin kg-1 diet; and AXT150, 150 mg astaxanthin kg-1 diet) for 90 days and subsequently challenged with V. alginolyticus at the end of the feeding period. Experimental infection unveiled that supplemented fish demonstrated significant improvements (P

Matched MeSH terms: Triglycerides
Fulltext A randomised controlled trial of a facebook-based physical activity intervention for government employees with metabolic syndrome

Chee, H.P., Hazizi, A.S., Barakatun Nisak, M.Y., Mohd Nasir, M.T.

Malays J Nutr, 2014;20(2):165-181.
MyJurnal

Introduction: This study aimed to ascertain the effects of a Facebook-based physical activity intervention on improvements in step counts and metabolic syndrome. Methods: Government employees with metabolic syndrome were randomly assigned by cluster to the Facebook group (n = 44) or the control group (n = 103). All participants were asked to complete self-administered questionnaires at baseline, after the first and second phases. Data from anthropometric (weight, body mass index, fat mass, body fat percentage, waist circumference, hip circumference and waist-to-hip ratio), biochemical (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and fasting glucose) and clinical examinations (systolic blood pressure and diastolic blood pressure) were collected. The number of steps per day was determined by a Lifecorder e- STEP accelerometer. Results: A significant difference in the number of steps per day between the baseline and the first phase (p

Matched MeSH terms: Triglycerides
Fulltext Which is a better anthropometric indicator of cardiovascular risk factors in type 2 diabetes mellitus patients? Waist hip ratio or body mass index?

Koo, H.C., S, Daniel Robert, Hamid Jan

Malays J Nutr, 2013;19(2):163-172.
MyJurnal

Introduction: The increasing prevalence of adiposity is associated with the development of type 2 diabetes mellitus (T2DM). The two most popular methods to measure adiposity are body mass index (BMI) and waist-hip-ratio (WHR), which measure the overall and abdominal adiposity, respectively. The aim of this study was to determine whether BMI or WHR was more strongly associated with macronutrient intakes and lipid profiles in T2DM patients. Methods: In this cross-sectional study, a total of 210 T2DM patients, mean age of 56.73(SD 10.23) years, were recruited from Penang. Information on socio-demographic, body measurements (height, weight, waist circumference and hip circumference)and macronutrient intakes (three 24-hour dietary recalls) were recorded. Routine laboratory tests (fasting blood glucose, HbA1c, LDL, HDL, triglyceride and total cholesterol) were performed according to standard procedure. Results:Among the respondents, 84% had abdominal and 63% had overall adiposity respectively.There was a significant correlation between WHR and the total calorie(r=0.27; p

Matched MeSH terms: Triglycerides
Fulltext The effect of increased consumption of edible palm oil on the nutritional status, lipid profiles and lipid peroxidation among Malaysian aborigines

Iskandar Zulkarnain Alias, Zaleha Md. Isa, Osman Ali, Khalid Abdul Kadir

Malays J Nutr, 2002;8(2):137-156.
MyJurnal

This study was conducted to determine the effects of increased edible palm oil consumption on community health status in the aboriginal communities in Tual Post (treatment group) and Sinderut Post (control group), Kuala Lipis, Pahang. Nutritional status, blood pressure, lipid profiles, fasting blood glucose (FBG), vitamin E (alpha-tocopherol) levels and lipid peroxidation product (malonaldehyde) levels were taken as indicators of health status. This is a pre-and post-controlled community trial in which similar variables were measured in each group. Every family of 2–6 household members was given 2–5 kg cooking palm oil per month for a period of 18 months. All subjects were measured for height (cm), weight (kg) and waist-hip ratio (WHR). For calorie intake measurement, house-to-house interviews were conducted using 24-hour dietary recall method. Blood pressure, percent body fat, lipid profiles, namely total cholesterol, high density lipoprotein cholesterol, triglyceride and fasting blood glucose (FBG) were also measured. Vitamin E (alpha-tocopherol) levels and lipid peroxidation products (MDA) were also determined. There was a significant increase (p

Matched MeSH terms: Triglycerides
Fulltext Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats

Mansooreh, Sadat Mojani, Asmah Rahmat, Rajesh, Ramasamy, Vahid, Hosseinpour Sarmadi, Pratheep, Sandrasaigaran, Shalini, Vellasamy, et al.

Malays J Nutr, 2016;22(3):421-432.
MyJurnal

Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats.

Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle.

Results: The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-a (TNF-a) (p

Matched MeSH terms: Triglycerides
Fulltext Body mass index as the predictor of high sensitivity C-reactive protein: a risk marker of cardiovascular diseases

Norshafawati, A.A., Rosita, J., Norhaizan, M.E.

Malays J Nutr, 2014;20(3):291-301.
MyJurnal

Introduction: High sensitivity C-reactive protein (hs-CRP) is an emerging risk marker for cardiovascular diseases (CVD). In Malaysia, CVD has become a major health problem and the risk factors of CVD have also increased among the middle- aged. Thus, this study aimed to determine factors that influence the level of hs- CRPamongMalaysianadultsaged30-55years-old. Methods:One-hundredand twenty-two (n=122) adults working at an institution were selected systematically in this cross-sectional study. Body weight, height, hip and waist circumference, systolic and diastolic blood pressure, hs-CRP level, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein were measured. Body mass index (BMI), waist-to-hip ratio, and total cholesterol: high-density lipoprotein ratio were calculated. Results: The sample consisted of 40.2% male and 59.8% female subjects with a mean age± SD of 41.93 ± 8.26 years. Pearson's correlation coefficient showed significant positive correlations between log hs-CRP level (mean± SD= 0.22 ± 0.50 mg/L; 95% CI= 0.13 - 0.31) and age, waist circumference, hip circumference, BMI, systolic blood pressure, total cholesterol, low-density lipoprotein, triglycerides, and total cholesterol: high-density lipoprotein ratio. However, multivariate analysis showed only BMI (R = 0.489, R2 = 0.239, adjusted R2 = 0.232, F = 37.626, p< 0.001) was a predictor of hs-CRP, the risk marker of CVD. Hs-CRP level was greater in overweight (25 - 29.9 kg/m2), and obese(> 30 kg/ m2) subjects (ANOVA p< 0.05) compared to normal weight subjects. Conclusion: BMI is a modifiable risk factor with the change being important for reducing CVD events among adults.

Matched MeSH terms: Triglycerides
Therapeutic effects of Schistosoma mansoni soluble egg antigen in high fat diet induced dyslipidemia, hepatic and cardiovascular pathology in mice

Toulah FH, El-Aswad BEW, Harba NM, Naguib YM

Trop Biomed, 2018 Dec 01;35(4):893-907.
PMID: 33601839

High-fat diet (HFD) can cause hyperlipidemia, fatty liver and cardiovascular disorders. Herein, we evaluated therapeutic effects and possible underlying mechanisms of actions of Schistosoma mansoni soluble egg antigen (SEA) against experimental HFD induced dyslipidemia, hepatic and cardiovascular pathology. Forty Swiss albino mice were divided into four groups (10 each); mice fed standard diet (SD), mice fed HFD, mice fed HFD for 8 weeks then infected by S. mansoni cercaria (HFD+I) and mice fed HFD for 8 weeks then treated with SEA (HFD+SEA), all mice were euthanized 16 weeks after starting the experiment. HFD+SEA mice showed significantly (p<0.001) reduced total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), and significantly (p<0.05) increased high-density lipoprotein cholesterol (HDL-C) comparing to HFD mice with non-significant difference with HFD+I mice group. Doppler flowmetry showed significantly (p<0.01) lower arterial resistance and significantly (p<0.05) higher blood flow velocity in HFD+SEA and HFD+I mice groups than HFD mice. HFD+SEA mice revealed improving in liver and aortic pathology and these were better than HFD+I mice group. HFD+SEA and HFD+I mice groups had less myocardium lipid deposits, but still showing some congested blood vessels. HFD myocardium revealed strong CD34+ expression on immunohistochemistry study, while that of HFD+SEA showed weak and HFD+I mice had moderate expressions. HFD+SEA mice had significantly (p<0.01) lower serum IL-1β and vascular endothelial growth factor (VEGF) and significantly (p<0.001) higher serum transforming growth factor beta 1 (TGF-β1) and IL-10 than HFD mice with non-significant difference with HFD+I mice. In conclusion, SEA lowered serum lipids, improved aortic function, decreased liver and cardiovascular pathology in HFD mice, so, it is recommended to purify active molecules from SEA to develop anti-dyslipidemic treatment.

Matched MeSH terms: Triglycerides
Fulltext The polycystic ovarian syndrome and infertility: a metabolic disorder that needs early diagnosis and treatment

Arumugam, K., Majeed, N.A.

JUMMEC, 2011;14(1):6-9.
MyJurnal

We investigated the association between polycystic ovarian syndrome, dyslipidemia and glucose intolerance in a cross sectional analysis comparing 50 patients with polycystic ovary syndrome and 50 patients without the disease (control group) who were attending the Infertility clinic. Variables of interest were their body-mass index (Kg/m2), fasting and blood glucose levels after a 75 gram oral glucose tolerance test and their total cholesterol (mmol/L), total triglycerides (mmol/L), high density cholesterol lipoprotein (HDL) cholesterol (mmol/L) and, low density lipoprotein cholesterol (mmol/L) levels. Except for HDL where significantly lower values were observed, significantly higher levels were detected in patients with PCOS than that of the control group. The difference persisted even when the obesity index were adjusted and matched. We conclude that both glucose intolerance and dyslipidemia were significantly associated with PCOS irrespective of the obesity index.

Matched MeSH terms: Triglycerides
Fulltext Should statins be started in all type 2 diabetics irrespective of LDL-cholesterol level?

Vasanthakumar SS, Teng CL

Malays Fam Physician, 2007;2(2):74-75.
PMID: 25606085 MyJurnal

Mr S is a 38 year old Indian man who has type 2 diabetes mellitus for 3 years. He is currently on metformin 500mg BD. His BMI is 24.9 kg/m2 (weight 72 kg, height 170 cm). His blood glucose is well controlled (HbA1c 6%). His fasting lipid levels are as follow: Total cholesterol 5.0 mmol/L, HDL-C 1.60 mmol/L, LDL-C 2.6 mmol/L and triglyceride 0.9 mmol/L. He has no family history of acute myocardial infarction. He is a smoker (14 sticks/day, 12 years) but non-hypertensive. He asks if he should take atorvastatin, a lipid-lowering drug that his father is taking. Should statins be started in type 2 diabetic patients without pre-existing coronary artery disease whose lipid level is not elevated?

Matched MeSH terms: Triglycerides
Evaluation of the safety of heated vegetable oils containing 25% of polar compounds

Ng, Tony Kock Wai

Malaysian Journal of Medicine and Health Sciences, 2006;2(1):25-39.
MyJurnal

Introduction: The content of polar compounds (PC) and polymeric triglycerides build up in fried and recycled/reused oils and therefore, these undesirable components are often used as markers of deterioration in edible oil quality. Expert and authoritative agencies have recommended an upper limit of 25% for PC in fried/reused edible oils; beyond this level the oil is considered unsuitable for human consumption. The safety of recycled or repeatedly-heated oils is still very much a concern of both the health authorities and the general public.
Objective: The present study evaluates the safety of long-tern consumption of heated vegetable oils containing 25% of PC on growth, effect on major body organs and reproduction outcome, using the Sprague-Dawley rat model.
Methods: Refined, bleached and deodorised palm olein (PO) and partially hydrogenated soybean oil (HSBO) were repeatedly heated for 5 hours daily with no topping-up at Isoac until a polar compound (PC) content of25% was attained. Refined soybean oil was similarly heated up to 50% PC and used in the positive control diet. All five experimental oils, namely unheated PO (No PC), heated PO (25% PC), unheated HSBO (No PC), heated HSBO (25% PC), and positive control oil (50% PC) were separately incorporated at 30% energy (15% w/w) as the sole dietary fat into nutritionally-adequate purified diets. Each experimental diet was provided ad libitum to a different dietary group comprising 14 male and 20 female Swiss albino rats. After 13 weeks (90 days), 10 males were selected from each group and each male was paired with two females from the same dietary group for the reproductive study. After 4 weeks into the reproductive study (total of 17 weeks on the experimental diets), all 10 males in each group were sacrificed and the usual toxicity tests consisting of blood cell type counts, liver and kidney function tests, and examination (organ-to-body weight ratios and histology) of the liver, kidney, heart and spleen were performed.
Results: The heated PO and HSBO diets were well-tolerated by the animals. However, these heated test oils inhibited growth marginally (p>0.05), enlarged the liver, kidney and heart, and markedly raised serum alkaline phosphatase (liver function test) compared to the unheated oils (p

Matched MeSH terms: Triglycerides
Fulltext Prevalence of obesity, lipid and glucose abnormalities in outpatients prescribed clozapine in University Malaya Medical Center, Kuala Lumpur

Sharmilla, T., Ahmad, H.S., Jambunathan, S.T.

Malaysian Journal of Psychiatry, 2008;17(2):1-10.
MyJurnal

Objective: The objectives of this study were to asses body mass index, fasting blood sugar , serum cholesterol levels and prevalence of Diabetes Mellitus among outpatients attending the Clozapine clinic at University Malaya Medical Center. Method: 36 patients had their height and weight taken at the start of the study. Their BMI (body mass index) was calculated. Fasting blood sugar, (FBS) and Fasting Serum Lipid (FSL) were performed. Result: The mean body mass index was 24.63. The prevalence of obesity was 13.89%. The prevalence of overweight was 27.8 % and the prevalence of underweight was 5.55%. The prevalence of Diabetes Mellitus was 2.78 %. Serum triglyceride levels appear to be elevated in those receiving Clozapine.Conclusion: It appears that Clozapine may predispose one to obesity. From our study we cannot conclude if Clozapine causes Diabetes Mellitus. However treatment with Clozapine may be associated with elevated levels of serum triglycerides.

Study site: Clozapine clinic at University Malaya Medical Center

Matched MeSH terms: Triglycerides
Fulltext Prevalence and risk factors of premature coronary artery disease: a comparative cross-sectional study between two time frames in Malaysia

Shamsul Azhar Shah, Lee, Jing, Muhammad Syahmi Khalid, Fatimah Najid, Intan Sabrina Haniff, Azmee Mohd Ghazi

Malaysian Journal of Public Health Medicine, 2015;15(3):157-166.
MyJurnal

Limited studies on prevalence and risk factors of Premature Coronary Artery Disease (PCAD) were done in Malaysia, primarily on lipid profile. This cross sectional study aims to identify any changing patterns in prevalence and risk factors of Premature CAD between 2000 and 2012. From 2000 to 2012 we included 21862 patients who underwent the first Percutaneous Coronary Intervention (PCI). Analysis of risk factors was done to 1660 and 2098 patients from year 2007 and 2012 respectively. Age of less than 45 years was taken as PCAD. Data was collected from PCI database of National Heart Institute (NHI), NHI TrakCare System, and patients’ medical records. PCAD significantly decreased from 18.8% (2000) to 11.6% (2012). Malay ethnicity showed increasing trend over the years from 55.1% to 66.9%. Multiple logistic regression analysis in 2007 showed that smoking had the higher risk (AOR=2.52), followed by male gender (AOR=2.06), family history of PCAD (AOR=1.96), Indian ethnicity, (AOR=1.65), triglycerides level (AOR=1.20) and BMI (AOR=1.06). In 2012, family history of PCAD had the highest risk (AOR=2.00) followed by smoking (AOR=1.91) and BMI (AOR=1.11). There are changes in risk factors patterns of premature CAD between 2007 and 2012. Most of them are preventable at earlier stage.

Matched MeSH terms: Triglycerides
Fulltext Glycaemic Control, Lipid Profile, Blood Pressure and Body Weight Status Among Diabetics in Rural Malaysia

Hazizi, A.S., Zaitun, Y., Kandiah, M., Chan, S.P.

International Medical Journal Malaysia, 2009;8(2):21-28.
MyJurnal

Introduction: Diabetes is associated with a high risk of cardiovascular disease. The management of blood glucose, dyslipidaemia and other modifiable risk factor, is a key element in the multifactorial approach to prevent complications of type 2 diabetes. Materials and Methods: A cross sectional study was conducted to determine the level of glycaemic control, lipid profile, blood pressure and body weight status among type 2 diabetics in rural Malaysia. A total of 237 diabetic subjects participated in this study. Physical examination was carried out, including measurements of height, weight, waist and hip circumferences, and systolic and diastolic blood pressure. Fasting venous blood samples were collected to determine the glucose level and lipid profile. Results: About 70% of the subjects had a high body mass index (BMI), equal to or above 25 kg/m2. More than 60% of the subjects had systolic blood pressure >= 140 mmHg and/or diastolic >=90 mmHg. Mean fasting blood glucose was 9.84±4.54 mmol/L. Mean total cholesterol was 5.18±1.35 mmol/L. High density lipoprotein cholesterol (HDLC) and triglyceride (TG) and glucose levels were higher in male than in female, but not statistically significant (p>0.05). However, low density lipoprotein cholesterol (LDLC) was higher in females than males (p

Matched MeSH terms: Triglycerides
Fulltext Food security status: It’s association with inflammatory marker and lipid profile among young adult

Nur Atiqah, A., Norazmir, M.N., Khairil Anuar, M.I., Mohd Fahmi, M., Norazlanshah, H.

International Food Research Journal, 2015;22(5):1855-1863.
MyJurnal

Food insecurity, the inability to have sufficient, safe and nutritious food for an active and healthy life, was found to be closely associated with adverse health outcomes. However, limited studies can be found that clearly explains lipid profile and inflammatory events among food secure and insecure individuals, especially among young adults in university, thus creating the need for further research. This study investigated both groups including their gender distribution to determine lipid profile such as total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) and inflammatory marker, high sensitivity C reactive protein (hs-CRP), with waist circumference (WC), fat mass index (FMI) and waist-to-height-ratio (WHTR). A comparative cross-sectional study was carried out among participants aged between 18 to 25 years old (N=124) who were selected through the Adults Food Security Survey Module (AFSSM) and participated in blood draw procedures. Well-established blood markers of lipid profile and inflammatory marker were measured. Percentage of food secure individuals (56.5%) was slightly higher than food insecure (43.5%). Although mean (M) of Hs-CRP for male and female (M=1.000, M=0.645) was higher in food secure group, all other variables showed higher measurements among the food insecure groups. Lipid profiles, TC (M=5.175, M=5.062) and LDL (M=3.100, M=2.914) were high for both male and female respectively, while TG is high for male (M=0.817) (p=0.037) and HDL for female (M=1.826). For body composition such as FMI (M=4.494, M=5.452), WC (M=77.46, M=76.82) and WHtR (M=0.471, M=0.497), male and female respectively, in food insecure group showed higher results but only FMI showed a significant difference (p = 0.016). Statistics showed an association between food security status and lipid profile (TG) and with FMI. However, no significant association was found with inflammatory marker. This study will continue further in depth in gene expression of peroxisome proliferator activated receptor gamma (PPAR-y) and endothelial dysfunction to better understand this issue. Regardless, current data provides knowledge and understanding of food insecurity experienced by young adults in university campus and may help them in making healthier food choices and be appreciative of the risk of chronic illnesses.

Matched MeSH terms: Triglycerides
Fulltext A biomarker feasibility study in the South East Asia Community Observatory health and demographic surveillance system

Partap U, Young EH, Allotey P, Sandhu MS, Reidpath DD

Glob Health Epidemiol Genom, 2018;3:e14.
PMID: 30263138 DOI: 10.1017/gheg.2018.13

Background: Integration of biomarker data with information on health and lifestyle provides a powerful tool to enhance the scientific value of health research. Existing health and demographic surveillance systems (HDSSs) present an opportunity to create novel biodata resources for this purpose, but data and biological sample collection often presents challenges. We outline some of the challenges in developing these resources and present the outcomes of a biomarker feasibility study embedded within the South East Asia Community Observatory (SEACO) HDSS.
Methods: We assessed study-related records to determine the pace of data collection, response from potential participants, and feedback following data and sample collection. Overall and stratified measures of data and sample availability were summarised. Crude prevalence of key risk factors was examined.
Results: Approximately half (49.5%) of invited individuals consented to participate in this study, for a final sample size of 203 (161 adults and 42 children). Women were more likely to consent to participate compared with men, whereas children, young adults and individuals of Malay ethnicity were less likely to consent compared with older individuals or those of any other ethnicity. At least one biological sample (blood from all participants - finger-prick and venous [for serum, plasma and whole blood samples], hair or urine for adults only) was successfully collected from all participants, with blood test data available from over 90% of individuals. Among adults, urine samples were most commonly collected (97.5%), followed by any blood samples (91.9%) and hair samples (83.2%). Cardiometabolic risk factor burden was high (prevalence of elevated HbA1c among adults: 23.8%; of elevated triglycerides among adults: 38.1%; of elevated total cholesterol among children: 19.5%).
Conclusions: In this study, we show that it is feasible to create biodata resources using existing HDSS frameworks, and identify a potentially high burden of cardiometabolic risk factors that requires further evaluation in this population.

Matched MeSH terms: Triglycerides
Influence of bariatric surgery on weight reduction and control of chronic disease among obese patients in Malaysia

Tan KC, Chang CT, Cheah WK, Vinayak CR, Chan HK

Med J Malaysia, 2019 Jun;74(3):215-218.
PMID: 31256176

INTRODUCTION: This study was designed to determine the influence of bariatric surgery on changes in the body mass index (BMI), and the control of diabetes, hypertension and dyslipidaemia among obese patients in Malaysia.
MATERIALS AND METHODS: This was a retrospective cohort study undertaken at a public tertiary care centre in the state of Perak, Malaysia. Information of obese patients who underwent bariatric surgery was obtained from their medical records. The changes in the BMI, HbA1C, systolic and diastolic blood pressure (SBP and DBP), and lipid levels between three months before and after the surgery were assessed.
RESULTS: The patients (n=106) were mostly Malay (66.0%), had at least one comorbidity (61.3%), and had a mean age of 40.38±11.75 years. Following surgery, the BMI of the patients was found to reduce by 9.78±5.82kg/m2. For the patients who had diabetes (n=24) and hypertension (n=47), their mean HbA1C, SBP and DBP were also shown to reduce significantly by 2.02±2.13%, 17.19±16.97mmHg, and 11.45±12.63mmHg, respectively. Meanwhile, the mean total cholesterol, triglyceride and low-density lipoprotein levels of those who had dyslipidaemia (n=21) were, respectively, lowered by 0.91±1.18mmol/L, 0.69±1.11mmol/L and 0.47±0.52mmol/L.
CONCLUSION: The findings suggest that in addition to weight reduction, bariatric surgery is helpful in improving the diabetes, hypertension and dyslipidaemia control among obese patients. However, a large-scale trial with a control group is required to verify our findings.

Matched MeSH terms: Triglycerides
Evaluation of antihyperglycemic and antihyperlipidemic potential of Nelumbo Nucifera seeds in diabetic rats

Khan SH, Ali F, Shah A, Kamran F, Jahan S

Sains Malaysiana, 2016;45:1517-1523.

The present study was aimed at evaluating antihyperglycemic and antihyperlipidemic activity of nuciferin and
norcoclaurine constituents of N. nucifera seeds, a well-known medicinal plant. The alloxan (100 mg/kg b.w) induced
diabetic rats (200-250 g) were divided into seven groups (n = 6). Group I; normal control, Group II; diabetic control,
Group III; standard, Group lV-VII were fed with methanolic crude extracts (100, 200 mg/kg), nuciferin and norcoclaurine
(10 mg/kg b.w.), received for 15 days in dose dependent manner. The study included different parameters; examination of
oral glucose, fasting blood glucose, serum lipid profile and checking for body weight changes. In oral glucose examination,
within 60 and 80 min of treatment, extracts, nuciferin and norcoclaurine significantly reduced blood glucose (p<0.05)
and restored body weight in diabetic rats. Alloxan- induced diabetic rats showed 30-50% reduction of blood glucose
level (p<0.05) and recovered 5-20% body weight at day 15 after ingestion of crude extracts (100-200 mg/kg b.w.); and
nuciferin and norcoclaurine (each at 10 mg/kg b.w.). It also recovered significantly elevated biochemical parameters such
as triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC), serum urea and
creatinine. Our findings indicated that N. nucifera seeds possess significant antihyperglycemic and antihyperlipidemic
activity in diabetic rats.

Matched MeSH terms: Triglycerides
Hibiscus sabdariffa linn. (roselle) protects against nicotine-induced heart damage in rats

Satirah Zainalabidin, Siti Nor Farhanah Sh Nor Shabidin, Siti Balkis Budin

Sains Malaysiana, 2016;45:207-214.

Nicotine has been identified as one of the causal factor for oxidative stress, hypertension and hyperlipidemia. Roselle has been widely studied for its potential as an antioxidant, antihyperlipidemic and antihypertensive. However, no studies have been done to investigate if roselle could diminish the oxidative stress caused by nicotine which could further lead to cardiac damages. Thus, this study was aimed to investigate the effect of roselle extract (HSE) on blood pressure, serum lipid profile, oxidative stress marker levels and histological changes to the heart in nicotine-treated rats. A total of 21 Sprague-Dawley rats were randomly divided into 3 groups (n=7 per group): Control group received normal saline (0.5 mL/day, i.p); nicotine group received 0.6 mg/kg/BW nicotine (i.p); and treated group received 100 mg/kg/b.w HSE through oral force feeding followed with 0.6 mg/kg/b.w nicotine (i.p) for 21 consecutive days. The results showed that HSE significantly (p>0.05) reduced the heart rate but no effect to the blood pressure. For lipid profile study, HSE increased the high-density lipoprotein concentration significantly (p<0.05) in rats given with nicotine, without any significant changes in total cholesterol, triglyceride and low-density lipoprotein (LDL) concentration. Besides, HSE treatment was also found to reverse malondialdehyde (MDA) level, superoxide dimustase (SOD) enzyme activity and protein concentration significantly (p<0.05) in nicotine-treated rats. In summary, these results indicated that HSE is an effective antioxidant against oxidative damage in heart caused by nicotine, but not as antihyperlipidemic and antihypertensive agent in this rat model.

Matched MeSH terms: Triglycerides
Fulltext Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications

Sadu Singh BK, Narayanan SS, Khor BH, Sahathevan S, Abdul Gafor AH, Fiaccadori E, et al.

Front Pharmacol, 2020;11:506.
PMID: 32410990 DOI: 10.3389/fphar.2020.00506

Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical and critically ill patients is particularly well established, and there is enough literature assigning therapeutic and adverse effects to specific LEs. This narrative review contrarily puts into perspective the fatty acid compositional (FAC) nature of LE formulations, and discusses clinical applications and outcomes according to the biological function and structural functionality of fatty acids and co-factors such as phytosterols, α-tocopherol, emulsifiers and vitamin K. In addition to soybean oil-based LEs, this review covers clinical studies using the alternate LEs that incorporates physical mixtures combining medium- and long-chain triglycerides or structured triglycerides or the unusual olive oil or fish oil. The Jaded score was applied to assess the quality of these studies, and we report outcomes categorized as per immuno-inflammatory, nutritional, clinical, and cellular level FAC changes. It appears that the FAC nature of LEs is the primary determinant of desired clinical outcomes, and we conclude that one type of LE alone cannot be uniformly applied to patient care.

Matched MeSH terms: Triglycerides
Prevalence and pattern of dyslipidemia in hyperglycemic patients and its associated factors among Pakistani population

Sarfraz M, Sajid S, Ashraf MA

Saudi J Biol Sci, 2016 Nov;23(6):761-766.
PMID: 27872574

In diabetes mellitus dyslipidemia is one of the major risk factors for cardiovascular disease. In type 2 diabetes mellitus early detection and treatment of dyslipidemia can avoid risk for cardiovascular disorder. The present study was carried to determine the prevalence and pattern of hyperlipidemia in patients with hyperglycemia. The cross sectional study was done in different laboratories of Pakistan, the laboratories served patients referred from different government and private hospitals between July 2014 and June 2015. All known cases of diabetes mellitus were evaluated for their lipid profile. Totally 200 diabetic patients were included in the study in which 120 (60%) were males and 80 (40%) were females. Prevalence of dyslipidemia among diabetic males was 97.18% while for females 87.15%. Among dyslipidemic male the proportion with mixed dyslipidemic patients was 17.5%, combined two parameters dyslipidemia was 47.5% and isolated single parameter dyslipidemia was 35%. In females these proportions in mixed, combined two parameters and isolated single parameter were 16.25%, 51.25% and 32.5%, respectively. Majority of hyperglycemic patients were dyslipidemic. The most prevalent pattern among male was combined dyslipidemia with high triglycerides (TG) and low High Density Lipoprotein (HDL) and in female it was high Low Density Lipoprotein (LDL) and low HDL. The most prevalent lipid abnormality in our study was low HDL followed by high TG.

Matched MeSH terms: Triglycerides

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