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Dynamic linkages between non-renewable energy, renewable energy and economic growth through nonlinear ARDL approach: evidence from Malaysia

Afroz R, Muhibbullah M

Environ Sci Pollut Res Int, 2022 Jul;29(32):48795-48811.
PMID: 35201582 DOI: 10.1007/s11356-022-19346-0

The purpose of this paper is to investigate the links between renewable energy (RE), non-renewable energy (NRE), capital, labour and economic growth, using the nonlinear autoregressive distributive lag (NARDL) model in Malaysia for the period of 1980-2018. The results of NARDL confirm the asymmetric effect of RE and NRE consumption on the economic growth in the long run as well as the short run in Malaysia. The findings also show that in the long and short run, positive shocks of NRE are greater than the positive shocks of RE. It indicates that Malaysia's economic growth is highly dependent on NRE which is not a good indication as NRE consumption increases carbon dioxide (CO2) emission in the country. Moreover, the empirical results of this study demonstrated that RE consumption reduction accelerates economic growth, whereas NRE consumption reduction decreases economic growth. It can have claimed that in Malaysia, RE is still more expensive than NRE. In conclusion, this study offered a variety of measures to develop RE to reduce the dependency on NRE consumption.
Revision of the leafhopper genus Smyga (Hemiptera, Cicadellidae, Typhlocybinae)

Webb MD, Xu Y

Zookeys, 2024;1198:135-141.
PMID: 38693972 DOI: 10.3897/zookeys.1198.119765

The leafhopper genus Smyga Dworakowska (Typhlocybinae, Empoascini) is reviewed and a new species, S.brevipenis Webb & Xu, sp. nov. from Brunei and Malaysia, is described based on specimens previously identified as "aberrant specimens" of Smygadistincta Dworakowska. Images of the types of S.brevipenis and S.distincta are given for the first time. A checklist and key to known species of Smyga are also provided.
Fulltext Comment on: Outcome of a newborn hearing screening program in a tertiary hospital in Malaysia: the first five years. Ann Saudi Med 2011; 31: 24-8

Al-Mendalawi MD

Ann Saudi Med, 2011;31(3):316-7.
PMID: 21623065 DOI: 10.4103/0256-4947.81534
Fulltext Bis{4-[(2-hy-droxy-5-meth-oxy-3-nitro-benzyl-idene)amino]-phen-yl} ether

Arafath MA, Kwong HC, Adam F, Mohiuddin M, Sarker MS, Salim M, et al.

Acta Crystallogr E Crystallogr Commun, 2020 Jan 01;76(Pt 1):91-94.
PMID: 31921459 DOI: 10.1107/S2056989019016852

The mol-ecule of the title compound, C28H22N4O9, exhibits crystallographically imposed twofold rotational symmetry, with a dihedral angle of 66.0 (2)° between the planes of the two central benzene rings bounded to the central oxygen atom. The dihedral angle between the planes of the central benzene ring and the terminal phenol ring is 4.9 (2)°. Each half of the mol-ecule exhibits an imine E configuration. An intra-molecular O-H⋯N hydrogen bond is present. In the crystal, the mol-ecules are linked into layers parallel to the ab plane via C-H⋯O hydrogen bonds. The crystal studied was refined as a two-component pseudomerohedral twin.
Fulltext Peritonitis complicating acute peritoneal dialysis in Northeast Malaysia

Kamaliah MD, Roziawati Y

Southeast Asian J Trop Med Public Health, 2000 Sep;31(3):540-6.
PMID: 11289017

A prospective observational study examing the incidence, predisposing factors and microbiological aspects of peritonitis complicating acute intermittent peritoneal dialysis (IPD) was performed in Hospital Universiti Sains Malaysia, a referral hospital situated in Northeast Malaysia. Over a 7- month period, a total of 126 acute IPD treatments were included involving 69 patients. The majority of patients suffered from chronic or end stage renal failure (92.7%) and nearly half (47.8%) have underlying diabetes mellitus. Peritonitis occured in 25 treatment sessions giving a frequency of 19.8% of procedures performed. The mean interval between starting dialysis and the first sign of peritonitis was 3.5 days, with 12% of peritonitis occuring before day 3 of treatment. Frequent catheter manipulation and/or leakages were identified as significant predisposing factors for peritonitis and the risk of peritonitis was increased with longer duration of IPD. Gram-negative infections were seen twice more commonly than gram-positive infections. We recommend the use of cloxacillin in combination with either an aminoglycoside or a cephalosporin as empirical antibiotic coverage until culture reports are available.
Recent Updates on the Phytochemistry, Pharmacological, and Toxicological Activities of Zingiber zerumbet (L.) Roscoe ex Sm

Haque MA, Jantan I

Curr Pharm Biotechnol, 2017;18(9):696-720.
PMID: 29141544 DOI: 10.2174/1389201018666171115115458

BACKGROUND: Zingiber zerumbet (L.) Roscoe ex Sm. (family, Zingiberaceae) is a potent medicinal herb widely known as shampoo ginger and its rhizome is used in numerous ethnomedicinal applications including antipyretic, anti-inflammatory, antibacterial, anti-diarrheal, antidiabetics, carminative, and diuretic. The aim of this review was to bring together all the scientific updates on the phytochemistry and pharmacological activities of this herb, including their toxicological studies, and critically analyzed the outcomes to provide directions for future research on the herb as potential source of bioactive metabolites for pharmaceutical and nutraceutical applications.
METHODS: A structured electronic search on worldwide accepted scientific databases (Web of Science, PubMed, Google Scholar, Science Direct, SciFinder, Wiley Online Library) was carried out to compile the relevant information. Some information was obtained from books and database on medicinal plants used in various countries.
RESULTS: About 60 metabolites, mainly polyphenols, and terpenoids have been isolated and identified. However, most of the reported pharmacological studies were based on crude extracts, and only a few of those isolated metabolites, particularly zerumbone have been investigated for biological and pharmacological activities. Many of the mechanistic studies to understand the pharmacological effects of the plant are limited by many considerations with regard to design, experimentation and interpretation.
CONCLUSION: The bioactive metabolites should be further investigated on their safety and more elaborate preclinical studies before clinical trials can be undertaken.
Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

Noor AAM

Chem Biodivers, 2024 Jun 27.
PMID: 38934531 DOI: 10.1002/cbdv.202400788

This review focus on the terpenoids as potential therapeutic agents for depression and anxiety disorders, which naturally found in a variety of plants and exhibit a wide range of biological activities. Among the terpenoids discussed in this review are α-pinene, β-caryophyllene, α-phellandrene, limonene, β-linalool, 1, 8-cineole, β-pinene, caryophyllene oxide, p-cymene, and eugenol. All of these compounds have been studied extensively regarding their pharmacological properties, such as neuroprotective effect, anti-inflammation, antibacterial, regulation of neurotransmitters and antioxidant effect. Preclinical evidence are reviewed to highlight their diverse mechanisms of action and therapeutic potential to support antidepressant and anxiolytic properties. Additionally, challenges and future directions are also discussed to emphasize therapeutic utility of terpenoids for mental health disorders. Overall, this review provides a promising role of terpenoids as novel therapeutic agents for depression and anxiety, with potential implications for the development of more effective and well-tolerated treatments in the field of psychopharmacology.
Fulltext Impacts of COVID-19 induced food insecurity among informal migrants: Insight from Dhaka, Bangladesh

Sohel MS, Hossain B, Sarker MNI, Horaira GA, Sifullah MK, Rahman MA

J Public Aff, 2021 Oct 29.
PMID: 34899062 DOI: 10.1002/pa.2770

Food insecurity is one of the rising problems in Bangladesh, and it is severely prevalent among informal migrant workers. In this case, the COVID-19 pandemic has multiplied the food insecurity of informal migrant workers. This study explores and synthesizes the COVID-19 induced food insecurity impact among informal migrants and recommends policy actions to tackle the COVID-19 led food crisis in Bangladesh. A qualitative research approach, including in-depth interviews, four FGDs, and participant observation, has been applied to data collection from different parts of Dhaka city. A thematic approach to interpretive phenomenological analysis is followed in this study. The results show that COVID-19 induced lockdown significantly affects informal migrants' household food security. Most participants report severe complications due to food insecurity like consuming less food, price hiking, no fish or meat, potato, and vegetable. Food insecurity leads to migrant's chronic food shortage, starvation, malnutrition of mother and children, and unhealthy food. As a result, the way of life of informal migrants has been directed to more fragility and vulnerability during the pandemic; even they are not affordable to maintain a minimal level of family affairs and necessity. The findings of this study would be essential guidelines for the governmental and non-governmental organizations and development practitioners to address the food insecurity situations.
Fulltext Coinfection, coepidemics of COVID-19, and dengue in dengue-endemic countries: A serious health concern

Miah MA, Husna A

J Med Virol, 2021 01;93(1):161-162.
PMID: 32633829 DOI: 10.1002/jmv.26269
A new genus and species of Peleopodidae Hodges, 1974 (Insecta: Lepidoptera) from South-East Asia

Rayhan MJ, Jahan S

Zootaxa, 2024 Oct 14;5523(1):128-138.
PMID: 39645948 DOI: 10.11646/zootaxa.5523.1.8

Paraxenoacria gen. nov., a new genus belonging to the family Peleopodidae is described to accommodate a new species Paraxenoacria spinosa sp. nov. from Bangladesh. This genus is peculiar and clearly distinct from the other genera of this family and others of the related families on the basis of external morphology as well as genitalia features of males such as having downwardly curved digitiform projections in the tegumen and distinct shape of the valva. Additionally, analysis of observations from different citizen science platforms reveals that this newly described genus is distributed throughout South-East Asia up to Malaysia. The biological aspects of this new species are also provided. The genus is tentatively being placed within the subfamily Acriinae due to its close resemblance to the genus Acria Stephens, 1834 pending further comprehensive taxonomic study.
Fulltext Harmonisation of food labelling regulations in Southeast Asia: benefits, challenges and implications

Kasapila W, Shaarani SM

Asia Pac J Clin Nutr, 2011;20(1):1-8.
PMID: 21393103

In the globalised world of the 21st century, issues of food and nutrition labelling are of pre-eminent importance. Several international bodies, including the World Health Organisation and World Trade Organisation, are encouraging countries to harmonise their food and nutrition regulations with international standards, guidelines and recommendations such as those for Codex Alimentarius. Through harmonisation, these organisations envisage fewer barriers to trade and freer movement of food products between countries, which would open doors to new markets and opportunities for the food industry. In turn, increased food trade would enhance economic development and allow consumers a greater choice of products. Inevitably, however, embracing harmonisation brings along cost implications and challenges that have to be overcome. Moreover, the harmonisation process is complex and sporadic in light of the tasks that countries have to undertake; for example, updating legislation, strengthening administrative capabilities and establishing analytical laboratories. This review discusses the legislation and regulations that govern food and nutrition labelling in Southeast Asia, and highlights the discrepancies that exist in this regard, their origin and consequences. It also gives an account of the current status of harmonising labelling of pre-packaged foodstuffs in the region and explains the subsequent benefits, challenges and implications for governments, the food industry and consumers.
Fulltext Molecular phylogeny of the bamboo sharks (Chiloscyllium spp.)

Masstor NH, Samat A, Nor SM, Md-Zain BM

Biomed Res Int, 2014;2014:213896.
PMID: 25013766 DOI: 10.1155/2014/213896

Chiloscyllium, commonly called bamboo shark, can be found inhabiting the waters of the Indo-West Pacific around East Asian countries such as Malaysia, Myanmar, Thailand, Singapore, and Indonesia. The International Union for Conservation of Nature (IUCN) Red List has categorized them as nearly threatened sharks out of their declining population status due to overexploitation. A molecular study was carried out to portray the systematic relationships within Chiloscyllium species using 12S rRNA and cytochrome b gene sequences. Maximum parsimony and Bayesian were used to reconstruct their phylogeny trees. A total of 381 bp sequences' lengths were successfully aligned in the 12S rRNA region, with 41 bp sites being parsimony-informative. In the cytochrome b region, a total of 1120 bp sites were aligned, with 352 parsimony-informative characters. All analyses yield phylogeny trees on which C. indicum has close relationships with C. plagiosum. C. punctatum is sister taxon to both C. indicum and C. plagiosum while C. griseum and C. hasseltii formed their own clade as sister taxa. These Chiloscyllium classifications can be supported by some morphological characters (lateral dermal ridges on the body, coloring patterns, and appearance of hypobranchials and basibranchial plate) that can clearly be used to differentiate each species.
Fulltext Hurthle cells in fine needle aspiration cytology of the thyroid: a potential diagnostic dilemma?

Wong YP, Md Isa N, Md Zin RR, Noor Akmal S

Malays J Pathol, 2015 Apr;37(1):49-52.
PMID: 25890614 MyJurnal

Hurthle cells are not uncommonly encountered in thyroid fine needle aspiration cytology (FNAC) smears. They are easily recognized by their distinct cytomorphology in cytological preparations, i.e. large, polygonal cells displaying uniform, rounded nuclei, often prominent nucleoli and abundant granular cytoplasm. Hurthle cells can be seen in both non-neoplastic and neoplastic thyroid lesions which can pose diagnostic dilemma to cytopathologists, especially when the lesions are focally sampled. We describe a case of solitary thyroid nodule in a 46-year-old male, whose aspirates comprised predominantly of Hurthle cells exhibiting nuclear features suspicious of papillary carcinoma, which turned out to be Hurthle cell carcinoma on subsequent histological sections. The potential diagnostic pitfalls of Hurthle cell lesions and associated conditions in thyroid FNA are discussed. The presence of Hurthle cell change in a wide variety of thyroid lesions can be diagnostically challenging. However, accurate diagnosis can still be made with careful observation of the predominant cell population, nuclear features and whether there is abundant colloid or lymphocytes in the background.
Fulltext Management of otitis media with effusion in children

Zulkiflee S, Siti Sabzah MH, Philip R, Md Aminuddin MY

Malays Fam Physician, 2013;8(2):32-35.
PMID: 25606279 MyJurnal

Otitis media with effusion (OME) is a condition characterised by a collection of fluid within the middle ear without signs of acute inflammation. It is common in young children, with a bimodal peak at two and five years of age. Eighty percent of children have at least one episode of OME by the age of 10 years. This disease is a common ear problem among children with craniofacial anomalies including cleft palate and Down syndrome (DS).
Fulltext Cognitive Reactivity: Cultural Adaptation and Psychometric Testing of the Persian Version of the Leiden Index of Depression Sensitivity Revised (LEIDS-R) in an Iranian Sample

Ostovar S, Md Nor MB, Griffiths MD, Chermahini SA

Int J Ment Health Addict, 2017;15(3):621-638.
PMID: 28596716 DOI: 10.1007/s11469-016-9713-z

Cognitive reactivity (CR) to the experimental induction of sad mood has been found to predict relapse in recovered depressed patients. The Leiden Index of Depression Sensitivity Revised (LEIDS-R) is a self-report measure of CR. The aim of the present study was to establish the validity and reliability of the Persian version of the LEIDS-R. The participants were recovered depressed and non-depressed Iranian individuals (n = 833). The analyses included content validation, factor analysis, construct validity, and reliability testing. Preliminary construct validation analysis confirmed that factor analysis was appropriate for the Persian version of the LEIDS-R. Factor analysis displayed similar factor loadings to the original English version. The total internal consistency of the translated version, which was assessed using Cronbach's alpha coefficient, was equal to 0.90. The test-retest reliability of the total score was equal to that of the test-retest conducted after a two-week interval at 0.94. Content validity, face validity, and construct validity, as well as reliability analysis were all found to be satisfactory for the Persian version of the LEIDS-R. The Persian version of the LEIDS-R appears to be valid and reliable for use in future studies, and has properties comparable to the original version and to that obtained in previous studies.
Immune-mediated Pathogenesis and Therapies for Inflammatory Autoimmune Diseases

Islam MA, Kamal MA, Md Zulfiker AH, Gan SH

Curr Pharm Des, 2019;25(27):2907-2908.
PMID: 31621552 DOI: 10.2174/138161282527191007151037
Fulltext Clinicopathological and Prognostic Characteristics of Malaysian Triple Negative Breast Cancer Patients Undergoing TAC Chemotherapy Regimen

Abdul Aziz AA, Md Salleh MS, Ankathil R

Int J Breast Cancer, 2020;2020:8424365.
PMID: 32308997 DOI: 10.1155/2020/8424365

Triple negative breast cancer (TNBC) is associated with aggressive tumour phenotype and early tumour relapse following diagnosis. Generally, clinicopathological features such as tumour size, patient's age at diagnosis, tumour histology subtypes, grade and stage, involvement of lymph nodes, and menopausal status are commonly used for predicting disease progression, prospects of recurrence, and treatment response. Prognostic value of clinicopathological features on Malaysian TNBC patients is limited. Thus, this study is aimed at investigating the association of clinicopathological features on disease-free survival (DFS) and overall survival (OS) of Malaysian TNBC patients undergoing TAC chemotherapy. Seventy-six (76) immunohistochemistry-confirmed TNBC patients were recruited. The clinicopathological features of TNBC patients were collected and recorded. Kaplan-Meier and log-rank followed by a Cox proportional hazard regression model were performed to evaluate the TNBC patients' survival. Out of 76 TNBC patients, 25 were chemoresistant and 51 were chemoresponders to the TAC chemotherapy regimen. The overall 5-year cumulative DFS and OS of TNBC patients were 63.5% and 76.3%, respectively. Multivariate Cox analysis demonstrated that medullary and metaplastic histology subtypes and positive axillary lymph node metastasis were significant prognostic factors associated with relapse with adjusted HR: 5.76, 95% CI: 2.35, 14.08 and adjusted HR: 3.55, 95% CI: 1.44, 8.74, respectively. Moreover, TNBC patients with medullary and metaplastic histology subtypes and positive axillary lymph node metastases had a higher risk to death than patients who had infiltrating ductal carcinoma and negative axillary lymph node metastasis (adjusted HR: 8.30, 95% CI: 2.38, 28.96 and adjusted HR: 6.12, 95% CI: 1.32, 28.42, respectively). Our results demonstrate the potential use of medullary and metaplastic histology subtype and positive axillary lymph node metastasis as a potential biomarker in predicting relapse and survival of the TNBC patients. This warrants further studies on intensification of chemotherapy and also identification and development of targeted therapy to reduce relapses and improve survival of TNBC patients.
Fulltext Penta band single negative meta-atom absorber designed on square enclosed star-shaped modified split ring resonator for S-, C-, X- and Ku- bands microwave applications

Islam MR, Islam MT, Moniruzzaman M, Samsuzzaman M, Arshad H

Sci Rep, 2021 Apr 22;11(1):8784.
PMID: 33888759 DOI: 10.1038/s41598-021-87958-6

This paper represents a penta band square enclosed star-shaped modified split ring resonator (SRR) based single negative meta-atom absorber (MAA) for multi-band microwave regime applications. FR-4 low-cost material has been used as a substrate to make the MAA unit cell with 0.101λ0 × 0.101λ0 of electrical size, where λ0 is the wavelength calculated at the lower resonance frequency of 3.80 GHz. There are two outer square split ring and one inner star ring shape resonator of 0.035 mm thickness of copper placed on the one side, and another side of the substrate has full copper to construct the desired unit cell. The MAA unit cell provides five absorption peaks of 97.87%, 93.65%, 92.66%, 99.95%, and 99.86% at the frequencies of 3.80, 5.65, 8.45, 10.82, and 15.92 GHz, respectively, which covers S-, C-, X-, and Ku- bands. The properties of MAA have been investigated and analyzed in the E-, H-fields and surface current. The EMR and highest Q factor of the designed MAA is 9.87 and 30.41, respectively, and it shows a single negative (SNG) property. Different types of parametric analysis have been done to show the better performance of absorption. Advanced Designed System (ADS) software has been used for equivalent circuit to verify the simulated S11 result obtained from the CST-2019 software. Experimental outcomes of the MAA unit cell have a good deal with the simulated result and measured result of the 24 × 20 array of unit cells also shown. Since the unit cell provides superior EMR, excellent Q-factor, and highest absorption so the recommended MAA can be effectively used as a penta band absorber in microwave applications, like notch filtering, sensing, reducing the unintended noise generated with the copper component of the satellite and radar antennas.
Fulltext A case report of gastroschisis: Prenatal diagnosis in primary care settings matters

Said AH, Md Nor MZ, Che Yusof MD

Malays Fam Physician, 2023;18:53.
PMID: 37814671 DOI: 10.51866/cr.278

Gastroschisis may lead to serious congenital disability, as prolonged exposure to the amniotic fluid could compromise the mesenteric blood flow and irritate the foetal intestinal wall. The consequences of gastroschisis include spontaneous preterm birth, growth restriction and foetal demise. Awareness of this disease is essential, as a high mortality rate is linked to inadequate initial therapy. Early detection of the disease, mainly by primary care physicians as the initial point of contact, is crucial to improve the course of the condition through early monitoring and referral to tertiary care centres. With this case report, we hope to highlight the need of detecting gastroschisis before to the third trimester of pregnancy for better readiness, especially in primary care settings located far from tertiary centres.
Fulltext Comparison of decision tree and naïve Bayes algorithms in detecting trace residue of gasoline based on gas chromatography-mass spectrometry data

Md Ghazi MGB, Chuen Lee L, Samsudin AS, Sino H

Forensic Sci Res, 2023 Sep;8(3):249-255.
PMID: 38221967 DOI: 10.1093/fsr/owad031

Fire debris analysis aims to detect and identify any ignitable liquid residues in burnt residues collected at a fire scene. Typically, the burnt residues are analysed using gas chromatography-mass spectrometry (GC-MS) and are manually interpreted. The interpretation process can be laborious due to the complexity and high dimensionality of the GC-MS data. Therefore, this study aims to compare the potential of classification and regression tree (CART) and naïve Bayes (NB) algorithms in analysing the pixel-level GC-MS data of fire debris. The data comprise 14 positive (i.e. fire debris with traces of gasoline) and 24 negative (i.e. fire debris without traces of gasoline) samples. The differences between the positive and negative samples were first inspected based on the mean chromatograms and scores plots of the principal component analysis technique. Then, CART and NB algorithms were independently applied to the GC-MS data. Stratified random resampling was applied to prepare three sets of 200 pairs of training and testing samples (i.e. split ratio of 7:3, 8:2, and 9:1) for estimating the prediction accuracies. Although both the positive and negative samples were hardly differentiated based on the mean chromatograms and scores plots of principal component analysis, the respective NB and CART predictive models produced satisfactory performances with the normalized GC-MS data, i.e. majority achieved prediction accuracy >70%. NB consistently outperformed CART based on the prediction accuracies of testing samples and the corresponding risk of overfitting except when evaluated using only 10% of samples. The accuracy of CART was found to be inversely proportional to the number of testing samples; meanwhile, NB demonstrated rather consistent performances across the three split ratios. In conclusion, NB seems to be much better than CART based on the robustness against the number of testing samples and the consistent lower risk of overfitting.

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