Displaying publications 261 - 280 of 357 in total

Abstract:
Sort:
  1. Fulltext Antimicrobial activities of three different seed extracts of Lansium varieties
    Alimon, H, Abdullah Sani, A., Syed Abdul Azziz, S. S., Daud, N., Mohd Arriffin, N., Mhd Bakri, Y.
    Pertanika Journal of Science & Technology, 2014;22(2):529-540.
    MyJurnal
    Lansium domesticum Corr. is a fruit tree of the Meliaceae family, which is commonly found in SouthEast Asia with a wide range of varieties. This study investigated three varieties of L. domesticum; Duku, Langsat and Dokong for the phytochemical screening and antimicrobial activity. Seeds from the matured fruits were extracted using hexane, methanol and water. The crude extracts were screened for antimicrobial activities toward three bacteria, namely, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. The findings showed that Langsat seed extracts contained more groups of compounds compared with the other two varieties, and its methanol extract demonstrated the highest inhibition zones against the three bacteria. The crude methanol extract of Duku seeds showed inhibition zones only towards Bacillus subtilis at a high concentration (1.0 mgL-1), whilst the seed extracts of Dokong showed no inhibition zones towards any of the tested bacteria.
    Matched MeSH terms: Phytochemicals
  2. Fulltext Nutritional, phytochemical and pharmacological properties of Mikania micrantha Kunth
    Amirah Haziyah Ishak, Nurul Husna Shafie, Norhaizan Mohd Esa, Hasnah Bahari
    The Pertanika Journal of Scholarly Research Reviews, 2016;2(3):123-132.
    MyJurnal
    Mikania micrantha Kunth (Asteraceae) is a perennial creeping vine that can be found in South and North America, Africa, Pacific Islands and Southeast Asia, including Southern China and Malaysia. Previous studies have reported that this plant possesses several pharmacological properties which can be used to prevent and cure several diseases. Phytochemicals found from various parts of M. micrantha have been linked to beneficial medicinal properties such as antioxidant, antimicrobial, antitumour, anti-inflammatory, anti-stress, and also anti-diabetic activities. The primary aim of this paper is to review available scientific information on the nutritional, phytochemical and pharmacological properties of M. micrantha to provide baseline information for future studies.
    Matched MeSH terms: Phytochemicals
  3. Fulltext NiO nanoparticles induce cytotoxicity mediated through ROS generation and impairing the antioxidant defense in the human lung epithelial cells (A549): Preventive effect of Pistacia lentiscus essential oil
    Mohamed K, Zine K, Fahima K, Abdelfattah E, Sharifudin SM, Duduku K
    Toxicol Rep, 2018;5:480-488.
    PMID: 29854619 DOI: 10.1016/j.toxrep.2018.03.012
    Nickel oxide nanoparticles (NiO NPs) have attracted increasing attention owing to potential capacity to penetrate to several human cell systems and exert a toxic effect. Elsewhere, the use of medicinal plants today is the form of the most widespread medicine worldwide. Utilizing aromatic plants as interesting source of phytochemicals constitute one of the largest scientific concerns. Thus this study was focused to investigate antioxidant and cytoprotective effects of essential oil of a Mediterranean plant P. lentiscus (PLEO) on NiO NPs induced cytotoxicity and oxidative stress in human lung epithelial cells (A549). The obtained results showed that cell viability was reduced by NiO NPs, who's also found to induce oxidative stress in dose-dependent manner indicated by induction of reactive oxygen species and reduction of antioxidant enzymes activities. Our results also demonstrated that PLEO contains high amounts in terpinen-4-ol (11.49%), germacrene D (8.64%), α-pinene (5.97%), sabinene (5.19%), caryophyllene (5.10%) and δ-Cadinene (4.86%). PLEO exhibited a potent antioxidant capacity by cell viability improving, ROS scavenging and enhancing the endogenous antioxidant system against NiO NPs in this model of cells. The present work demonstrated, for the first time, the protective activity of PLEO against cell oxidative damage induced by NiO NPs. It was suggested that this plant essential oil could be use as a cells protector.
    Matched MeSH terms: Phytochemicals
  4. Fulltext Extraction and recovery of phytochemical components and antioxidative properties in fruit parts of Dacryodes rostrata influenced by different solvents
    Thavamoney N, Sivanadian L, Tee LH, Khoo HE, Prasad KN, Kong KW
    J Food Sci Technol, 2018 Jul;55(7):2523-2532.
    PMID: 30042568 DOI: 10.1007/s13197-018-3170-6
    This study investigated the recovery of phytochemical antioxidants in Dacryodes rostrata fruit using different extraction solvents. The effects of solvent of varying polarities with sequential extraction method on the recovery of phenolics, flavonoids, carotenoids and anthocyanins from different parts of the fruit (seed, pulp and peel) were determined. Their antioxidant activities were further determined using DPPH radical, ferric reducing antioxidant power (FRAP), hydroxyl radical scavenging, superoxide anion radical scavenging and phosphomolybdenum method. Dacryodes Rostrata seed had the highest total phenolic content with 50% ethanol as the most efficient extraction solvent. The highest total flavonoid content was obtained in ethyl acetate extract of fruit pulp, whereas peel extracted with hexane and 50% ethanol was the highest in total carotenoid content and total anthocyanin content, respectively. The seed extracted with 50% ethanol exhibited the strongest DPPH radical scavenging activity. Iron chelating activity measured by FRAP assay was the best in seed extracts, particularly in those polar extracts derived from water and 50% ethanol. Antioxidant activities of 50% ethanol extract of D. rostrata seed was the highest when determined by FRAP and phosphomolydenum assays. However, the influence of extraction solvents is not distinctly shown by hydroxyl radical and superoxide anion radical scavenging activities. This is the first report on the effect of various extraction solvents on the recovery of phytochemicals in D. rostrata fruit parts and the seed of D. rostrata is a potential source of polar antioxidants.
    Matched MeSH terms: Phytochemicals
  5. Fulltext Nutritional, phytochemical and pharmacological properties of Canarium odontophyllum miq. (Dabai) fruit
    Tan, Chin Xuan, Azrina Azlan
    The Pertanika Journal of Scholarly Research Reviews, 2016;2(1):80-94.
    MyJurnal
    Canarium odontophyllum Miq. fruit, popularly recognized as dabai fruit in Sarawak, is a
    seasonal fruit found in the tropical rainforest of East Malaysia. A dabai fruit can be divided into
    several anatomical parts, and different parts of the fruit have different valuable phytochemicals. Due
    to the lack of promotion, dabai fruit is viewed as nutritionally inferior fruit by the public. On the
    contrary, the fruit is rich in nutrients such as protein, fat, carbohydrates, sodium, calcium and iron.
    Many phytochemicals have been detected from different parts of dabai fruit, and these molecules have
    been linked to beneficial properties such as hypolipidemic, anti-atherosclerotic, anti-cholinesterase,
    antimicrobial and potentially anti-diabetic. The aim of this article is to review research studies on this
    fruit in order to provide adequate baseline information for commercial exploitation as well as for
    future studies.
    Matched MeSH terms: Phytochemicals
  6. Orthosiphon stamineus Benth. is an Outstanding Food Medicine: Review of Phytochemical and Pharmacological Activities
    Ashraf K, Sultan S, Adam A
    J Pharm Bioallied Sci, 2018 9 22;10(3):109-118.
    PMID: 30237681 DOI: 10.4103/jpbs.JPBS_253_17
    Orthosiphon stamineus Benth. (Lamiaceae) is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have demonstrated the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory activies. This review is a comprehensive summary of the presently available chemical, pharmacological investigations as well as the traditional and therapeutic uses of this plant. Important and different experimental data have been addressed along with a review of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils. O. stamineus has wide traditional and pharmacological uses in various pathophysiological conditions. Therefore, it is an attractive subject for further experimental and clinical investigations.
    Matched MeSH terms: Phytochemicals
  7. Fulltext Effect of various food processing and handling methods on preservation of natural antioxidants in fruits and vegetables
    Al-Juhaimi F, Ghafoor K, Özcan MM, Jahurul MHA, Babiker EE, Jinap S, et al.
    J Food Sci Technol, 2018 Oct;55(10):3872-3880.
    PMID: 30228385 DOI: 10.1007/s13197-018-3370-0
    Bioactive compounds from plant sources are generally categorized as natural antioxidants with well-known health benefits. The health-promoting characteristics of natural antioxidants include anti-inflammatory, anti-diabetic, and hepatic effects as well as free radical scavenging. Herein, a comprehensive and comparative review are presented about the effects of conventional (thermal and mechanical) and relatively new (non-thermal) processing methods on phytochemicals and discussed the importance of implementing the use of those methods that could be of very helpful retaining the quality of the bioactive compounds in plant-based foods. Plant-based foods rich in phenolics, vitamin C, carotenoids, and other compounds undergo a range of processing operations before they are consumed. Most of these methods involve thermal treatments of fruits, stems, leaves, and roots. These techniques have varying effects on bioactive compounds and their activities, and the magnitude of these effects depends on process parameters such as temperature, time, and the food matrix. Thermal processing can be detrimental to bioactive compounds while nonthermal procedures may not cause significant deterioration of important health-promoting phytochemicals and in some cases can improve their bio-activity and bio-availability. The detrimental effects of conventional processing on the quality of natural antioxidants have been compared to the effects of innovative nonthermal food treatments such as gamma and ultraviolet irradiation, ultraviolet light, pulsed electric fields, and high hydrostatic pressure.
    Matched MeSH terms: Phytochemicals
  8. Fulltext Oral toxicity of arjunolic acid on hematological, biochemical and histopathological investigations in female Sprague Dawley rats
    Aamir K, Khan HU, Hossain CF, Afrin MR, Shaik I, Salleh N, et al.
    PeerJ, 2019;7:e8045.
    PMID: 31772835 DOI: 10.7717/peerj.8045
    Background: Arjunolic acid (AA) is a potent phytochemical with wider pharmacological activities. Despite potential medicinal properties on various in vitro and in vivo studies, there is still a dearth of scientific data related to its safety profile and toxicological parameters. The current study aimed to investigate acute toxicity of AA in normal female Sprague Dawley rats.

    Methods: In this study, AA was administered orally at an individual dose of 300 and 2000 mg/kg body weight to group 1 and 2 respectively, while group 3 served as normal control. All the animals were observed for 2 weeks to determine any behavioral and physical changes. On day 15, blood was collected for hematological and biochemical investigation, later animals from all the three groups were euthanized to harvest and store essential organs for histopathological analysis. Four different staining techniques; hematoxylin and eosin, Masson trichrome, Periodic acid Schiff and Oil O Red were used to investigate any alterations in different tissues through microscopical observation.

    Results: The results of the study showed no morbidity and mortality at two different dosage of AA treatment. Daily food & water intake, body weight, relative organ weight, hematological and biochemical parameters were detected to be normal with no severe alteration seen through microscopical investigation in the structure of harvested tissues. Our findings support the safety profile of AA, which was well tolerated at higher dose. Thus, an in-detail study on the subacute disease model is warranted.

    Matched MeSH terms: Phytochemicals
  9. Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
    Chunglok W, Utaipan T, Somchit N, Lertcanawanichakul M, Sudjaroen Y
    Sains Malaysiana, 2014;43:689-696.
    It is of interest that seeds and pericarps of tropical fruits contain phytochemicals being the components of various biological activities for beneficial health effects. This study was aimed to evaluate antioxidant and anticancer activities of the methanolic extracts from seeds and pericarps of three selected tropical fruits including Rambutan (Nephelium lappaceum L.), Litchi (Litchi chinensis Sonn.) and Tamarind (Tamarindus indica L.). Total phenolic content was determined by using the Folin-Ciocalteu method. Antioxidant capacity was evaluated based on the ability of the fruit extracts to scavenge ABTS and DPPH radicals. MTT reduction assay and Annexin V-FITC/PI staining were carried out for cytotoxicity and apoptosis induction, respectively. Total phenolic contents of the seeds and pericarps of the tropical fruits ranged from 104.60 to 501.95 mg/g DW. All extracts were found to have significant antioxidant activities. Among them, tamarind seed extract contained the highest total phenolic contents and possessed the highest antioxidant capacities. Tamarind seed extract showed the highest cytotoxicity to human mouth carcinoma (CLS-354) cells and had no toxicity to PBMCs. Staining with annexin V-FITC/PI showed that this apoptosis occurred early in this cell type with 10.0% of the cells undergoing apoptosis. Tamarind seed extract might have potential anticancer activity which could be attributed, in part, to selectively inhibit the growth of CLS-354 cells and induce apoptosis. This research finding would be valuable information to identify major constituents of the extracts and mechanisms underlying anticancer activity which could be attributed to dietary health supplements or cancer chemoprevention from fruits.
    Matched MeSH terms: Phytochemicals
  10. Chemical constituents from the fruit peel of Goniothalamus scortechinii
    Aryanti Abdullah, Zuriati Zakaria, Fasihuddin Ahmad, Mat-Salleh K, Laily B. Din
    Sains Malaysiana, 2009;38.
    The phytochemical investigation on the fruit peel of Goniothalamus scortechinii (Selayar Raja Ubat) obtained from Gunung Stong, Kelantan has resulted in the isolation of five compounds namely pinocembrine, altholactone, goniofufurone, goniotriol and goniopypyrone. Their structures were determined by extensive ultra violet (UV), infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and gas chromatography-mass spectrum (GCMS) analysis.
    Matched MeSH terms: Phytochemicals
  11. Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor
    Yeong KY, Khaw KY, Takahashi Y, Itoh Y, Murugaiyah V, Suzuki T
    Bioorg Chem, 2020 01;94:103403.
    PMID: 31711765 DOI: 10.1016/j.bioorg.2019.103403
    Studies have suggested that sirtuin inhibition may have beneficial effects on several age-related diseases such as neurodegenerative disorders and cancer. Garcinia mangostana is a well-known tropical plant found mostly in South East Asia with several positive health effects. Some of its phytochemicals such as α-mangostin was found to be able to modulate sirtuin activity in mice and was implicated with inflammation, diabetes and obesity. However, comprehensive studies on sirtuin activity by the prenylated xanthones extracted from Garcinia mangostana have yet to be reported. The present study led to the discovery and identification of γ-mangostin as a potent and selective SIRT2 inhibitor. It was demonstrated that γ-mangostin was able to increase the α-tubulin acetylation in MDA-MD-231 and MCF-7 breast cancer cells. It was also found to possess potent antiproliferative activity against both cell lines. In addition, it was able to induce neurite outgrowth in the N2a cells.
    Matched MeSH terms: Phytochemicals
  12. Differentiation of Ficus deltoidea varieties and chemical marker determination by UHPLC-TOFMS metabolomics for establishing quality control criteria of this popular Malaysian medicinal herb
    Afzan A, Kasim N, Ismail NH, Azmi N, Ali AM, Mat N, et al.
    Metabolomics, 2019 Mar 04;15(3):35.
    PMID: 30830457 DOI: 10.1007/s11306-019-1489-2
    BACKGROUND: Ficus deltoidea Jack (Moraceae) is a plant used in Malaysia for various diseases including as a supplement in diabetes management. Morphology distinction of the 7 main varieties (var. angustifolia, var. bilobata, var. deltoidea, var. intermedia, var. kunstleri, var. motleyana and var. trengganuensis) is challenging due to the extreme leaf heterophylly and unclear varietal boundaries, making it difficult for quality control of F. deltoidea products.

    OBJECTIVE: We aimed to compare the phytochemical composition of 7 varieties growing in different conditions at various geographical locations. We also aimed to establish the quality control markers for the authentication of these varieties.

    METHODS: We applied untargeted UHPLC-TOFMS metabolomics to discriminate 100 leaf samples of F. deltoidea collected from 6 locations in Malaysia. A genetic analysis on 21 leaf samples was also performed to validate the chemotaxonomy differentiation.

    RESULTS: The PCA and HCA analysis revealed the existence of 3 chemotypes based on the differentiation in the flavonoid content. The PLS-DA analysis identified 15 glycosylated flavone markers together with 1 furanocoumarin. These markers were always consistent for the respective varieties, regardless of the geographical locations and growing conditions. The chemotaxonomy differentiation was in agreement with the DNA sequencing. In particular, var. bilobata accession which showed divergent morphology was also differentiated by the chemical fingerprints and genotype.

    CONCLUSION: Chemotype differentiation based on the flavonoid fingerprints along with the proposed markers provide a powerful identification tool to complement morphology and genetic analyses for the quality control of raw materials and products from F. deltoidea.

    Matched MeSH terms: Phytochemicals
  13. Fulltext HPLC-PDA Polyphenolic Quantification, UHPLC-MS Secondary Metabolite Composition, and In Vitro Enzyme Inhibition Potential of Bougainvillea glabra
    Saleem H, Htar TT, Naidu R, Anwar S, Zengin G, Locatelli M, et al.
    Plants (Basel), 2020 Mar 20;9(3).
    PMID: 32245104 DOI: 10.3390/plants9030388
    The plants of the Bougainvillea genus are widely explored regarding nutritive and medicinal purposes. In this study, dichloromethane (DCM) and methanol (MeOH) extracts of Bougainvillea glabra (Choisy.) aerial and flower parts were analyzed for high-performance liquid chromatography with photodiode array detection (HPLC-PDA), ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) phytochemical composition, and enzyme inhibition potential against key enzymes involved in diabetes (α-amylase), skin problems (tyrosinase), and inflammatory disorders (lipoxygenase (LOX)). HPLC-PDA quantification revealed the identification of nine different polyphenolics, amongst which both flower extracts were richest. The flower MeOH extract contained the highest amount of catechin (6.31 μg/g), gallic acid (2.39 μg/g), and rutin (1.26 μg/g). However, none of the quantified compounds were detected in the aerial DCM extract. UHPLC-MS analysis of DCM extracts revealed the tentative identification of 27 secondary metabolites, where the most common belonged to terpenoid, alkaloid, and phenolic derivatives. Similarly, for enzyme inhibition, all the extracts presented moderate activity against tyrosinase and α-amylases, whereas, for LOX, both methanolic extracts showed higher percentage inhibition compared with DCM extracts. Based on our findings, B. glabra could be regarded as a perspective starting material for designing novel pharmaceuticals.
    Matched MeSH terms: Phytochemicals
  14. Comparative analysis of metabolites and antioxidant potentials from different plant parts of curcuma aeruginosa roxb.
    Sanimah Simoh, Sew YS, Fazri Abd Rahim, Muhammad Aizuddin Ahmad, Alizah Zainal
    Sains Malaysiana, 2018;47:3031-3041.
    A comparative analysis of metabolites from different parts of Curcuma aeruginosa, i.e. leaves, stems, adventitious
    roots and rhizomes was performed by GC-MS/MS coupled with multivariate statistical analysis. The GC-MS/MS analysis
    confirmed the occurrence of 26 metabolites belonged to terpenoids in almost all the samples. The Principal Component
    Analysis (PCA) indicated that there was a clear distinction between rhizomes and other plant parts, i.e. stems, leaves,
    and adventitious roots that could be explained by relatively higher contents of terpenoids including curzerene, alphafarnesen, furanocoumarin, velleral, germacrone cineole, borneol, beta- and gamma- elemene and methenolone. The
    results of Hierarchical Clustering Analyses (HCA) corresponded with the PCA results where many terpenoids found
    abundantly high in rhizome were clustered together. This was supported by the Pearson correlation analysis that
    showed a significantly good relationship between those terpenoids. The adventitious roots demonstrated the strongest
    antioxidant activity as compared to the other plant parts which could be attributed to its highest Total Phenolic
    Contents (TPC). Total phenolic contents of all the plant parts were positively correlated with their antioxidant activities
    which indicate that phenolic compounds may play a role in the overall antioxidant activities of the plants. The results
    of the study highlighted the potential of this underexploited Curcuma species which could serve as a new source of
    important phytochemicals and natural antioxidant that could be incorporated in functional foods and nutraceuticals.
    In addition, chemical and biological evidence shown in the present work has rationalised the different uses of various
    plant parts of C. aeruginosa.
    Matched MeSH terms: Phytochemicals
  15. Skin and Eye Irritation Assessment of Oil Palm ( Elaeis guineensis) Leaf Extract for Topical Application
    Yusof NZ, Abd Gani SS, Azizul Hasan ZA, Idris Z
    Int J Toxicol, 2018 05 07;37(4):335-343.
    PMID: 29734825 DOI: 10.1177/1091581818773979
    Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells with percentage viability more than 90% after 24 and 48 hours of incubation. Skin irritation potential of OPLE was evaluated using in vitro SkinEthic reconstructed human epidermis (RHE) model (Organization for Economic Cooperation and Development [OECD] Test Guideline 439, 2015), while eye irritation potential was evaluated using in vitro SkinEthic Human corneal epithelium (HCE) model (OECD test guideline 492, 2017). Hazard identification results showed that OPLE at 1%, 5%, and 10% (wt/wt) was classified as nonirritant to the skin and eye where mean tissue viabilities of SkinEthic RHE and SkinEthic HCE were more than 50% and 60%, respectively. Therefore, we recommend a further safety assessment, such as human patch testing, to confirm the nonirritant of OPLE.
    Matched MeSH terms: Phytochemicals
  16. The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition
    Khangholi S, Majid FA, Berwary NJ, Ahmad F, Aziz RB
    Planta Med, 2016 Jan;82(1-2):32-45.
    PMID: 26550791 DOI: 10.1055/s-0035-1558086
    Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.
    Matched MeSH terms: Phytochemicals
  17. Fulltext Phytochemical analysis and evaluation of antimicrobial, antioxidant, and antidiabetic activities of essential oils from Moroccan medicinal plants: Mentha suaveolens, Lavandula stoechas, and Ammi visnaga
    El Hachlafi N, Benkhaira N, Al-Mijalli SH, Mrabti HN, Abdnim R, Abdallah EM, et al.
    Biomed Pharmacother, 2023 Aug;164:114937.
    PMID: 37267633 DOI: 10.1016/j.biopha.2023.114937
    Mentha suaveolens, Lavandula stoechas, and Ammi visnaga are widely used in Moroccan folk medicine against several pathological disorders, including diabetes and infectious diseases. This work was designed to determine the chemical profile of M. suaveolens (MSEO), L. stoechas (LSEO), and A. visnaga (AVEO) essential oils and assess their antimicrobial, antioxidant, and antidiabetic effects. The volatile components of LSEO, AVEO, and MSEO were analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The in vitro antidiabetic activity was assessed using α-amylase and α-glucosidase enzymes, while DPPH, FRAP, and β-carotene/linoleic acid methods were used to determine the antioxidant capacity. The antimicrobial activities were investigated using disc diffusion and broth-microdilution assays. GC-MS investigation revealed that the main components were fenchone (29.77 %) and camphor (24.9 %) for LSEO, and linalool (38.29 %) for AVEO, while MSEO was mainly represented by piperitenone oxide (74.55 %). The results of the antimicrobial evaluation showed that all examined essential oils (EOs) had noticeable antimicrobial activity against both bacteria and yeast, especially Micrococcus luteus and Bacillus subtilis. The MIC, MBC, and MFC values were ranged from 0.015 % to 0.5 %. The MBC/MIC and MFC/MIC ratios were less than or equal to 4.0 % (v/v), indicating their noticeable bactericidal and candidacidal efficacy. Moreover, the three EOs showed significant inhibitory effects on α-amylase and α-glucosidase (p 
    Matched MeSH terms: Phytochemicals
  18. Fulltext Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats
    Mohamad Zaid SS, Kassim NM, Othman S
    Evid Based Complement Alternat Med, 2015;2015:202874.
    PMID: 26788107 DOI: 10.1155/2015/202874
    Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats. Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution. There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats. In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties.
    Matched MeSH terms: Phytochemicals
  19. Fulltext Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency
    Mohd Effendy N, Mohamed N, Muhammad N, Naina Mohamad I, Shuid AN
    Evid Based Complement Alternat Med, 2012;2012:125761.
    PMID: 22844328 DOI: 10.1155/2012/125761
    Osteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis.
    Matched MeSH terms: Phytochemicals
  20. Fulltext Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review
    Joffry SM, Yob NJ, Rofiee MS, Affandi MM, Suhaili Z, Othman F, et al.
    Evid Based Complement Alternat Med, 2012;2012:258434.
    PMID: 22242040 DOI: 10.1155/2012/258434
    Melastoma malabathricum L. (Melastomataceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese, and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds, and roots of M. malabathricum have been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic, and antioxidant activities. Various types of phytochemical constituents have also been isolated and identifed from different parts of M. malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents, and pharmacological activities of M. malabathricum.
    Matched MeSH terms: Phytochemicals
Related Terms
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links