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Fulltext Neuroimaging findings are sensitive and specific in diagnosis of tuberculous meningitis

Mei-Ling Sharon TAI, Hazman MOHD NOR, Kartini Rahmat, Shanthi Viswanathan, Khairul Azmi Abdul Kadir, Norlisah Ramli, et al.

Neurology Asia, 2017;22(1):15-23.
MyJurnal

Objective: The primary objective of this study was to describe the neuroimaging changes of tuberculous meningitis (TBM), and to determine the role of neuroimaging in the diagnosis of TBM.
Methods: Between January 2009 and July 2015, we prospectively recruited TBM patients in two hospitals in Malaysia. Neuroimaging was performed and findings were recorded. The control consists of other types of meningo-encephalitis seen over the same period.
Results: Fifty four TBM patients were recruited. Leptomeningeal enhancement was seen in 39 (72.2%) patients, commonly at prepontine cistern and interpeduncular fossa. Hydrocephalus was observed in 38 (70.4%) patients, 25 (46.3%) patients had moderate and severe hydrocephalus. Thirty four patients (63.0%) had cerebral infarction. Tuberculoma were seen in 29 (53.7%) patients; 27 (50.0%) patients had classical tuberculoma, 2 (3.7%) patients
had “other” type of tuberculoma, 18 (33.3%) patients had ≥5 tuberculoma, and 11 (20.4%) patients had < 5 tuberculoma. Fifteen (37.2%) patients had vasculitis, 6 (11.1%) patients had vasospasm. Close to nine tenth (88.9%) of the patients had ≥1 classical neuroimaging features, 77.8% had ≥ 2 classical imaging features of TBM (basal enhancement, hydrocephalus, basal ganglia / thalamic infarct, classical tuberculoma, and vasculitis/vasospasm). Only 4% with other types of meningitis/encephalitis had ≥1 feature, and 1% had two or more classical TBM neuroimaging features. The sensitivity of the imaging features of the imaging features for diagnosis of TBM was 88.9% and the specificity was 95.6%.
Conclusion: The classic imaging features of basal enhancement, hydrocephalus, basal ganglia/thalamic infarct, classic tuberculoma, and vasculitis are sensitive and specific to diagnosis of TBM.

Matched MeSH terms: Humans
Fulltext Reliability, technical error of measurement and validity of height measurement using portable stadiometer

Azli Baharudin, Mohamad Hasnan Ahmad, Balkish Mahadir Naidu, Nurul Rufaidah Hamzah, Nor Azian Mohd Zaki, Ahmad Ali Zainuddin, et al.

Pertanika Journal of Science & Technology, 2017;25(3):675-686.
MyJurnal

This study sought to examine the reliability and validity of height measurements using a portable
stadiometer as compared to a mechanical scale. Samples from 142 adults aged 22 to 57 were taken during data collection in November 2014. There was a high degree of reliability for the inter-examiner, intraexaminer and inter-instrument aspects with regards to mean difference, the inter correlation coefficient (ICC) and Bland-Altman Plot. For the inter-examiner aspect, the height measurement taken by the first examiner was 0.01 cm higher than that by the second examiner with an ICC of 0.999. For the intraexaminer aspect, the difference was 0.1 cm; this was higher in the first measurement compared to the second. The ICC was also 0.999. For the inter-instrument aspect, measurement taken by stadiometer was 0.61 cm higher than the measurement taken by mechanical scale and the ICC was 0.997. The Bland-Altman plot showed a distribution of differences between measurements in the inter-examiner, intraexaminer and inter-instrument aspects that were close to zero within the narrow range of ±1.96SD. The technical error of measurement (TEM), coefficient of reliability (R) and coefficient of variation (CV) for the inter-examiner, intra-examiner and inter-instrument aspects were within the acceptable limits. This study suggests that the portable stadiometer is reliable and valid for use in community surveys.

Matched MeSH terms: Humans
Fulltext Cardiovascular endurance fitness performance among Kedah Rugby Agong Cup’s players based on 20-meter multistage shuttle run pacer test

Syed Ahmad Ezahar Syed Ambon, Mohd. Foazi Md Nor, Syed Idrus Syed Mudayah, Junaidy Mohamad Hashim

Jurnal Sains Sukan & Pendidikan Jasmani, 2017;6(2):55-64.
MyJurnal

The study was conducted to determine the level of cardiovascular performance for Kedah team rugby players who will participate in the national Agong Cup's rugby championship. The test instrument used was the 20-meter multistage shuttle run pacer test. The total sample of the study was 40 (n = 40) consisted of players between the ages of 19 and 39. Assessment of cardiovascular endurance levels can be performed with measurements of VO2max (ml • kg-1 • min-1) as the most accurate score can be obtained to measure the fitness level of individual cardiovascular endurance. Therefore min VO2max (ml • kg-1 • min-1) obtained from the 20- meter multistage shuttle run pacer test shows that the VO2max (ml • kg-1 • min-1) level of the study sample is good and is at high level.

Matched MeSH terms: Humans
Fulltext Letter to the Editor: Colonic Perforation

Devaraj NK

Acta Med Port, 2017 12 29;30(12):891.
PMID: 29364805 DOI: 10.20344/amp.9556
Matched MeSH terms: Humans
Intra-Operative Frozen Sections for Ovarian Tumors – A Tertiary Center Experience

Md Arshad NZ, Ng BK, Md Paiman NA, Abdullah Mahdy Z, Mohd Noor R

Asian Pac J Cancer Prev, 2018 Jan 27;19(1):213-218.
PMID: 29373916

Background: Accuracy of diagnosis with intra-operative frozen sections is extremely important in the evaluation of ovarian tumors so that appropriate surgical procedures can be selected. Study design: All patients who with intra-operative frozen sections for ovarian masses in a tertiary center over nine years from June 2008 until April 2017 were reviewed. Frozen section diagnosis and final histopathological reports were compared. Main outcome measures: Sensitivity, specificity, positive and negative predictive values of intra-operative frozen section as compared to final histopathological results for ovarian tumors. Results: A total of 92 cases were recruited for final evaluation. The frozen section diagnoses were comparable with the final histopathological reports in 83.7% of cases. The sensitivity, specificity, positive predictive value and negative predictive value for benign and malignant ovarian tumors were 95.6%, 85.1%, 86.0% and 95.2% and 69.2%, 100%, 100% and 89.2% respectively. For borderline ovarian tumors, the sensitivity and specificity were 76.2% and 88.7%, respectively; the positive predictive value was 66.7% and the negative predictive value was 92.7%. Conclusion: The accuracy of intra-operative frozen section diagnoses for ovarian tumors is high and this approach remains a reliable option in assessing ovarian masses intra-operatively.

Matched MeSH terms: Humans
Trends in Vaccination Refusal in Children Under 2 Years of Age in Kedah, Malaysia: A 4-Year Review From 2013 to 2016

Chan HK, Soelar SA, Md Ali SM, Ahmad F, Abu Hassan MR

Asia Pac J Public Health, 2018 03;30(2):137-146.
PMID: 29292654 DOI: 10.1177/1010539517751312

The current study examined how the trends in childhood vaccination refusal in Kedah, Malaysia, changed over a 4-year period (2013-2016). Data contributed by 60 public health centers were used to determine the annual incidence rates (per 1000 newborns) of vaccination refusal, and to identify the reasons for refusal among the mothers. The trend analysis revealed a 2.2-times increment in the incidence rates of vaccination refusal from 4.72 in 2013 to 10.51 in 2015, followed by a 52.2% reduction to 5.02 in 2016 ( P = .046). Besides, the proportion of mothers who refused vaccination because of religious belief reduced from 78% between 2013 and 2015 to 67.1% in 2016 ( P = .005). Overall, the finding confirms the positive impact of the educational and religious interventions introduced by the State Health Department of Kedah since January 2016; nonetheless, efforts to strengthen the existing strategies and thereby to maximize the vaccination coverage in Kedah are warranted.

Matched MeSH terms: Humans
Fulltext Osteoradionecrosis in Subaxial Cervical Spine - a Rare and Devastating Complication: A Case Report

Rashid MZ, Ariffin MH, Rhani SA, Baharudin A, Ibrahim K

Malays Orthop J, 2017 Nov;11(3):53-55.
PMID: 29326769 MyJurnal DOI: 10.5704/MOJ.1711.005

Osteoradionecrosis, a rare complication of radiation therapy, is a slow progression disease which affects the surrounding structures of spinal components. It essentially weakens the soft tissue and bony configuration and can cause nerve impingement or cord compression. We describe a patient who underwent radiotherapy for thyroid cancer and presented with cervical kyphosis with anterolisthesis of C3/C4 and C4/C5 some 32 years later. We explore the role of anterior and posterior fusion, as well as hyperbaric oxygen therapy in promoting healing.

Matched MeSH terms: Humans
Newer drugs to treat prostate symptoms are associated with increased risk of falls

Tan MP, Abdul Razack AH

Evid Based Nurs, 2017 01;20(1):14.
PMID: 27974401 DOI: 10.1136/eb-2016-102315
Matched MeSH terms: Humans
Automated localization and segmentation techniques for B-mode ultrasound images: A review

Meiburger KM, Acharya UR, Molinari F

Comput Biol Med, 2018 01 01;92:210-235.
PMID: 29247890 DOI: 10.1016/j.compbiomed.2017.11.018

B-mode ultrasound imaging is used extensively in medicine. Hence, there is a need to have efficient segmentation tools to aid in computer-aided diagnosis, image-guided interventions, and therapy. This paper presents a comprehensive review on automated localization and segmentation techniques for B-mode ultrasound images. The paper first describes the general characteristics of B-mode ultrasound images. Then insight on the localization and segmentation of tissues is provided, both in the case in which the organ/tissue localization provides the final segmentation and in the case in which a two-step segmentation process is needed, due to the desired boundaries being too fine to locate from within the entire ultrasound frame. Subsequenly, examples of some main techniques found in literature are shown, including but not limited to shape priors, superpixel and classification, local pixel statistics, active contours, edge-tracking, dynamic programming, and data mining. Ten selected applications (abdomen/kidney, breast, cardiology, thyroid, liver, vascular, musculoskeletal, obstetrics, gynecology, prostate) are then investigated in depth, and the performances of a few specific applications are compared. In conclusion, future perspectives for B-mode based segmentation, such as the integration of RF information, the employment of higher frequency probes when possible, the focus on completely automatic algorithms, and the increase in available data are discussed.

Matched MeSH terms: Humans
Fulltext Development and validation of a Database Forensic Metamodel (DBFM)

Al-Dhaqm A, Razak S, Othman SH, Ngadi A, Ahmed MN, Ali Mohammed A

PLoS One, 2017;12(2):e0170793.
PMID: 28146585 DOI: 10.1371/journal.pone.0170793

Database Forensics (DBF) is a widespread area of knowledge. It has many complex features and is well known amongst database investigators and practitioners. Several models and frameworks have been created specifically to allow knowledge-sharing and effective DBF activities. However, these are often narrow in focus and address specified database incident types. We have analysed 60 such models in an attempt to uncover how numerous DBF activities are really public even when the actions vary. We then generate a unified abstract view of DBF in the form of a metamodel. We identified, extracted, and proposed a common concept and reconciled concept definitions to propose a metamodel. We have applied a metamodelling process to guarantee that this metamodel is comprehensive and consistent.

Matched MeSH terms: Humans
Editorial: NAFLD in Asia-clinical associations with advanced disease become clearer. Authors' reply

Chan WK, Dan YY, Wong VW, GO ASIA Initiative

Aliment Pharmacol Ther, 2018 04;47(7):1037-1038.
PMID: 29512909 DOI: 10.1111/apt.14572
Matched MeSH terms: Humans
Paediatric middle aortic syndrome with endovascular treatment in East Malaysia

Hong Ong G, Benjamin Leong DK

Med J Malaysia, 2018 02;73(1):57-59.
PMID: 29531207 MyJurnal

Middle-aortic syndrome is a surgically curable cause of childhood hypertension. Open surgery is traditionally offered but with the advance of medical technology, endovascular approached is available in many country. Failure to control BP in open surgery is as low as 4.1% compares to 13% in endovascular approaches. However, mortality is 4% in open surgery almost 2 times higher than 2.3% in endovascular approach. This article presents a case of 10 years old child treated successfully without complication with endovascular balloon dilatation, as a first case of such disease in East Malaysia.

Matched MeSH terms: Humans
Acquired lung cysts in post primary tuberculosis: An uncommon radiological finding in a common disease

Tan LS, Tan S

Med J Malaysia, 2018 02;73(1):54-56.
PMID: 29531206 MyJurnal

Tuberculosis (TB) is still an endemic disease in Malaysia. Cystic lung disease in post primary tuberculosis is not common. It can occur before, during or after completion of anti-TB treatment. Clinical history and review of serial chest radiograph is paramount to make the diagnosis. This case report highlights an interesting case of a young female patient who developed extensive cystic lung disease during the course of anti-TB treatment and the importance of recognizing this unusual manifestation.

Matched MeSH terms: Humans
Fulltext Differential effects of dietary flavonoids on adipogenesis

Khalilpourfarshbafi M, Gholami K, Murugan DD, Abdul Sattar MZ, Abdullah NA

Eur J Nutr, 2019 Feb;58(1):5-25.
PMID: 29541908 DOI: 10.1007/s00394-018-1663-8

PROPOSE: Obesity is a fast growing epidemic worldwide. During obesity, the increase in adipose tissue mass arise from two different mechanisms, namely, hyperplasia and hypertrophy. Hyperplasia which is the increase in adipocyte number is characteristic of severe obese patients. Recently, there has been much interest in targeting adipogenesis as therapeutic strategy against obesity. Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development.
METHODS: Presently, we provide a review of key studies evaluating the effects of dietary flavonoids in different stages of adipocyte development with a particular emphasis on the investigations that explore the underlying mechanisms of action of these compounds in human or animal cell lines as well as animal models.
RESULTS: Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Although most of the studies reveal anti-adipogenic effect of flavonoids, some flavonoids demonstrated proadipogenic effect in mesenchymal stem cells or preadipocytes.
CONCLUSION: The anti-adipogenic effect of flavonoids is mainly via their effect on regulation of several pathways such as induction of apoptosis, suppression of key adipogenic transcription factors, activation of AMPK and Wnt pathways, inhibition of clonal expansion, and cell-cycle arrest.

Matched MeSH terms: Humans
Fulltext Implementation of maximum surgical blood ordering schedule in a tertiary hospital in Malaysia during COVID-19 pandemic

Tan PP, Abdul Rahman J, Mat Noh S, Mohd Yasin I, Mohd Noor S

Transfus Apher Sci, 2021 Dec;60(6):103280.
PMID: 34593332 DOI: 10.1016/j.transci.2021.103280
Matched MeSH terms: Humans
Fulltext Experiences and challenges in mental health research and practice during COVID-19: Perspectives from emerging psychologists across five countries

Simon PD, Adams C, Goh MCW, Suhaimi AF, Hassem T

Asian J Psychiatr, 2021 Nov;65:102813.
PMID: 34419720 DOI: 10.1016/j.ajp.2021.102813
Matched MeSH terms: Humans
Fulltext Interactive virtual medication counselling in outpatient pharmacy: An accessible and safe patient counselling method during the COVID-19 pandemic

Yong WY, Chang CT, Chew CC, Khoo TE

Res Social Adm Pharm, 2021 Oct;17(10):1860-1862.
PMID: 34272201 DOI: 10.1016/j.sapharm.2021.07.002
Matched MeSH terms: Humans
Mini Nutritional Assessment for Adult Cancer Patients: A Systematic Review and Meta-Analysis

Wang P, Jiang L, Soh KL, Ying Y, Liu Y, Huang X, et al.

Nutr Cancer, 2023;75(1):61-72.
PMID: 35903897 DOI: 10.1080/01635581.2022.2104877

Early assessment of malnutrition in cancer patients is very important. The Mini Nutritional Assessment (MNA) is often used to assess malnutrition in adult cancer patients. However, the diagnostic values of MNA are controversial. We aimed to analyze the diagnostic values of MNA in assessing malnutrition in adult cancer patients. A systematic search was performed using Embase, Web of Science, PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, and China Science and Technology Journal Database (VIP). Studies comparing MNA with other tools or criteria in cancer patients were included. The quality of the included studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The pooled sensitivity, specificity, the area under the receiver-operating characteristic curve (AUC), and the diagnostic odds ratio (DOR) were calculated using Stata 17.0 and Meta-DiSc1.4. In addition, sensitivity, subgroup, meta-regression, and publication bias analyses were conducted. In total, 11 studies involving 1367 patients involving MNA were included. The pooled sensitivity, specificity, ROC, and DOR were 0.84 (95% CI: 0.81-0.87), 0.66 (95% CI: 0.63-0.69), 0.84 (95% CI: 0.81-0.87), and 16.11 (95% CI: 7.16-36.27), respectively. In the assessment of malnutrition in adult cancer patients, MNA has high sensitivity and moderate specificity.

Matched MeSH terms: Humans
Fulltext Proposal for development of a guideline in maintaining quality cancer care during and post-covid-19 in an upper middle-income country with universal health coverage

Teoh SP, Bustamam RS, Mustapha FI, Yip CH, Saad M, Somasundaram S, et al.

J Cancer Policy, 2021 Dec;30:100300.
PMID: 35559796 DOI: 10.1016/j.jcpo.2021.100300

BACKGROUND: During periods of high community transmission of COVID-19, the public hospitals in Malaysia, an upper middle-income country, have been forced to scale down elective surgeries, prioritize cancer treatments based on treatment benefits, and postpone non-emergency imaging procedures. These inevitably led to disruptions in cancer care delivery within the public health care system. This study aims to explore the facilitators and barriers faced by healthcare providers and cancer survivors in cancer care, and to co-design a guideline to maintain the delivery of cancer care amid the disaster situations.
METHOD: In-depth interviews (IDIs) will be conducted with Malaysian healthcare providers and cancer survivors and findings will be analysed thematically. The insights will be used in a subsequent phase to co-design a guideline to maintain the delivery of quality cancer care in Malaysia via a three-round modified Delphi survey with a broad range of cancer stakeholders.
EXPECTED RESULTS: Findings derived from IDIs and existing literature will be included for rating across three rounds by the expert panel. Feedback provided will be refined until consensus on the best practises for cancer care continuity during crises is achieved.
CONCLUSION: The output of the present study is not only expected to ensure the continuity of delivery of high-quality cancer care in Malaysia during the ongoing pandemic but also to be adapted during unforeseen crises in the near future.
POLICY SUMMARY STATEMENT: Collaborative work between policy makers, public health physicians, members of the multidisciplinary oncology team as well as cancer survivors is vital in developing an evidenced- based contingency plan for maintaining access to cancer care.

Matched MeSH terms: Humans
Research on the application effect of cognitive stimulation therapy in patients with Alzheimer's disease based on expert consultation and semistructured interviews

Shuzhen L, Hongyan G, Wei W, Ruiying W, Mulud ZA

J Popul Ther Clin Pharmacol, 2022;29(4):e97-e106.
PMID: 36441056 DOI: 10.47750/jptcp.2022.991

The awareness and utilization of psychological therapies for Alzheimer's disease have increased significantly in recent years. Limitations on the utilization of pharmacological therapy for Alzheimer's disease in China have corresponded with this surge in greater studies in the field. For individuals who have Alzheimer's disease, cognitive stimulation therapy (CST) is a quick self-help that is founded on the theories of quality and cognitive functioning. People with Alzheimer's disease often participate in cognitive behavioral programs; however, their expense has never been studied. Being part of a meta-analysis, we analyze the application effectiveness of a CST program that is based on recent research for Alzheimer's disease patients. A CST group therapy was given to 91 Alzheimer's patients, who resided in healthcare settings or the general public, multiple times per week for 8 weeks; the other 70 people with Alzheimer's disease got a medical therapy. Costs were computed, and resource utilization was tracked for 8 weeks both before and after the therapy. It was determined by a value study. In the value study, cognition and quality of life were the major and tertiary outcomes, respectively. Contours of cost-effectiveness and acceptance were drawn. It was driven based on expert consultation and semistructured interviews. In Alzheimer's disease, CST improves intelligence and standard of living, and there was no difference in implementation expenditures between the categories. Regarding both outcome metrics, there is a significant chance that CST seems to be more expensive than conventional therapy within realistic expectations. The efficacy of CST for Alzheimer's patients is superior to conventional treatment, and it could be the greater value. The outcomes contrast well with pharmacological studies for Alzheimer's. Many people with Alzheimer's disease may benefit significantly from CST groups.

Matched MeSH terms: Humans

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