Displaying publications 21 - 40 of 71 in total

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  1. Techno-economic optimization and Nox emission reduction through steam injection in gas turbine combustion chamber for waste heat recovery and water production
    Hai T, El-Shafay AS, Goyal V, Alshahri AH, Almujibah HR
    Chemosphere, 2023 Sep 01.
    PMID: 37660791 DOI: 10.1016/j.chemosphere.2023.139782
    Considering the persistent human need for electricity and fresh water, cogeneration systems based on the production of these two products have attracted the attention of researchers. This study investigates a cogeneration system of electricity and fresh water based on gas turbine (GT) as the prime mover. The wasted energy of the GT exhaust gases is absorbed by a heat recovery steam generator (HRSG) and supplies the superheat steam required by the steam turbine (ST). In order to produce fresh water, a multi-effect desalination (MED) system is applied. The motive steam required is provided by extracting steam from the ST. In order to reduce the environmental pollution of this cogeneration system, the steam injection method is proposed in the GT's combustion chamber (CC). This system is optimized by a multi-objective optimization tool based on the Genetic Algorithm (GA). The design variables include pressure ratio of compressor (CPR), inlet temperature of gas turbine (TIT), steam injection mass flow rate in the CC, HRSG operating pressure, HRSG evaporator pinch point temperature difference (PPTD), steam pressure of the MED ejector, ejector motive steam flow rate, number of MED effects, and return effect. The goals are to minimize the total cost rate (TCR), which includes the cost of initial investment and maintenance of the system, the cost of consumed fuel, and the cost of disposing of CO and NO pollutants, as well as maximizing the exergy efficiency. In the end, it is observed that the steam injection in the CC leads to the reduction of the mentioned pollutant index, and it is proposed as a suitable solution to reduce the pollution of the proposed cogeneration system.
  2. Fulltext Anti-Candida activity of Quercus infectoria gall extracts against Candida species
    Baharuddin NS, Abdullah H, Abdul Wahab WN
    J Pharm Bioallied Sci, 2015 Jan-Mar;7(1):15-20.
    PMID: 25709331 DOI: 10.4103/0975-7406.148742
    Galls of Quercus infectoria have been traditionally used to treat common ailments, including yeast infections caused by Candida species.
  3. Integrated technologies for solid waste bin monitoring system
    Arebey M, Hannan MA, Basri H, Begum RA, Abdullah H
    Environ Monit Assess, 2011 Jun;177(1-4):399-408.
    PMID: 20703798 DOI: 10.1007/s10661-010-1642-x
    The integration of communication technologies such as radio frequency identification (RFID), global positioning system (GPS), general packet radio system (GPRS), and geographic information system (GIS) with a camera are constructed for solid waste monitoring system. The aim is to improve the way of responding to customer's inquiry and emergency cases and estimate the solid waste amount without any involvement of the truck driver. The proposed system consists of RFID tag mounted on the bin, RFID reader as in truck, GPRS/GSM as web server, and GIS as map server, database server, and control server. The tracking devices mounted in the trucks collect location information in real time via the GPS. This information is transferred continuously through GPRS to a central database. The users are able to view the current location of each truck in the collection stage via a web-based application and thereby manage the fleet. The trucks positions and trash bin information are displayed on a digital map, which is made available by a map server. Thus, the solid waste of the bin and the truck are being monitored using the developed system.
  4. Genotoxicity evaluation of locally produced dental porcelain--an in vitro study using the Ames and Comet assays
    Noushad M, Kannan TP, Husein A, Abdullah H, Ismail AR
    Toxicol In Vitro, 2009 Sep;23(6):1145-50.
    PMID: 19505568 DOI: 10.1016/j.tiv.2009.05.025
    The aim of this study was to determine the genotoxicity of a locally produced dental porcelain (Universiti Sains Malaysia, Malaysia) using the Ames and Comet assays. In the Ames assay, four genotypic variants of the Salmonella strains (TA98, TA100, TA1537 and TA1535) carrying mutations in several genes were used. The dental porcelain was incubated with these four strains in five different doses both in the presence and absence of metabolic activation (S9) and the result was assessed based on the number of revertant colonies. Concurrently, appropriate positive controls were used so as to validate the test. The average number of revertant colonies per plate treated with locally produced dental porcelain was less than double as compared to that of negative control. In the Comet assay, L929 (CCL-1 ATCC, USA) mouse fibroblast cells were treated with the dental porcelain in three different concentrations along with concurrent negative and positive controls. The tail moment which was used as a measurement of DNA damage was almost equal to that of the negative control, suggesting that the locally produced dental porcelain did not induce any DNA damage. The results indicated that the locally produced dental porcelain is non-genotoxic under the present test conditions.
  5. Fulltext Thermal Annealing Effect on Structural, Morphological, and Sensor Performance of PANI-Ag-Fe Based Electrochemical E. coli Sensor for Environmental Monitoring
    Mohammad Naim N, Abdullah H, Umar AA, Abdul Hamid A, Shaari S
    ScientificWorldJournal, 2015;2015:696521.
    PMID: 26078996 DOI: 10.1155/2015/696521
    PANI-Ag-Fe nanocomposite thin films based electrochemical E. coli sensor was developed with thermal annealing. PANI-Ag-Fe nanocomposite thin films were prepared by oxidative polymerization of aniline and the reduction process of Ag-Fe bimetallic compound with the presence of nitric acid and PVA. The films were deposited on glass substrate using spin-coating technique before they were annealed at 300 °C. The films were characterized using XRD, UV-Vis spectroscopy, and FESEM to study the structural and morphological properties. The electrochemical sensor performance was conducted using I-V measurement electrochemical impedance spectroscopy (EIS). The sensitivity upon the presence of E. coli was measured in clean water and E. coli solution. From XRD analysis, the crystallite sizes were found to become larger for the samples after annealing. UV-Vis absorption bands for samples before and after annealing show maximum absorbance peaks at around 422 nm-424 nm and 426 nm-464 nm, respectively. FESEM images show the diameter size for nanospherical Ag-Fe alloy particles increases after annealing. The sensor performance of PANI-Ag-Fe nanocomposite thin films upon E. coli cells in liquid medium indicates the sensitivity increases after annealing.
  6. Pathways to Youth Empowerment and Community Connectedness: A Study of Youth-Adult Partnership in Malaysian After-School, Co-Curricular Programs
    Zeldin S, Krauss SE, Kim T, Collura J, Abdullah H
    J Youth Adolesc, 2016 08;45(8):1638-51.
    PMID: 26092232 DOI: 10.1007/s10964-015-0320-2
    After-school programs are prevalent across the world, but there is a paucity of research that examines quality within the "black box" of programs at the point of service. Grounded in current theory, this research examined hypothesized pathways between the experience of youth-adult partnership (youth voice in decision-making; supportive adult relationships), the mediators of program safety and engagement, and the developmental outcomes of youth empowerment (leadership competence, policy control) and community connectedness (community connections, school attachment). Surveys were administered to 207 ethnically diverse (47.3 % female; 63.3 % Malay) youth, age 15-16, attending after-school co-curricular programs in Kuala Lumpur, Malaysia. Results showed that youth voice in program decision-making predicted both indicators of youth empowerment. Neither youth voice nor supportive adult relationships was directly associated with community connectedness, however. Program engagement mediated the associations between youth-adult partnership and empowerment. In contrast, program safety mediated the associations between youth-adult partnership and community connectedness. The findings indicate that the two core components of youth-adult partnership-youth voice and supportive adult relationships-may operate through different, yet complementary, pathways of program quality to predict developmental outcomes. Implications for future research are highlighted. For reasons of youth development and youth rights, the immediate challenge is to create opportunities for youth to speak on issues of program concern and to elevate those adults who are able and willing to help youth exercise their voice.
  7. Fulltext Breast Surgery International--breast cancer in developing countries
    Sandelin K, Apffelstaedt JP, Abdullah H, Murray EM, Ajuluchuku EU
    Scand J Surg, 2002;91(3):222-6.
    PMID: 12449462
    Breast Surgery International (BSI) was formed in 1999 as an integrated society within the International Surgical Society ISS/SIC. One goal is to promote breast surgery world wide and focus on the situation in the developing countries. An edited summary of a symposium on locally advanced breast cancer (LABC) and the current situation in two African countries and in Malaysia is reported. Diagnosis, management and treatment options differ from recommendations that prevail due to lack of resources, lack of access to facilities and cultural and socioeconomic barriers. Younger age at onset, more men are affected and locally advanced breast cancer dominates the clinical panorama. A rational treatment plan for LABC should have chemotherapy, surgery, radiotherapy and hormonal therapy as armaments. A unique opportunity exists for international interchange within a professional organization such as BSI, for providing training opportunities, for clinical and experimental studies of the world' s most common female malignancy.
  8. Fulltext Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus
    Abd Rashid N, Hapidin H, Abdullah H, Ismail Z, Long I
    Brain Behav, 2017 06;7(6):e00704.
    PMID: 28638710 DOI: 10.1002/brb3.704
    INTRODUCTION: REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment.

    METHODS: Male Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr. During this procedure, saline or nicotine (1 mg/kg) was given subcutaneously twice a day. Then, Morris water maze (MWM) test was used to assess learning and memory performance of the rats. The rats were sacrificed and the brain was harvested for immunohistochemistry and Western blot analysis.

    RESULTS: MWM test found that REM sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM protein expression in CA1, CA2, CA3, and DG regions and the mean relative level of DREAM protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM protein.

    CONCLUSION: This study suggests that changes in DREAM protein expression in CA1, CA2, CA3, and DG regions of rat's hippocampus and mean relative level of DREAM protein may involve in the mechanism of nicotine treatment-prevented REM sleep deprivation-induced learning and memory impairment in rats.

  9. Fulltext Immunomodulatory Effects of Asiaticoside Against Shigella flexneri-Infected Macrophages
    Michael S, Zakaria NM, Abbas MA, Abdullah H, Suppian R
    Trop Life Sci Res, 2021 Jun;32(2):29-44.
    PMID: 34367513 DOI: 10.21315/tlsr2021.32.2.3
    Macrophages provide the first line of defense against Shigella flexneri infection in the gastrointestinal tract by inducing a variety of inflammatory and antimicrobial responses. Secondary metabolites of plants are used as drugs against infections that are resistant to common antibiotics. In this study, the innate effects of asiaticoside on the proinflammatory activity of mouse macrophages infected with S. flexneri were investigated. The viability of the infected mouse macrophages were examined using viability assay, while the pro-inflammatory cytokines productions were determined using the enzyme-linked immunosorbent assay (ELISA) for determination of IL-1β, IL-12 p40 and TNF-α levels. The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) protein were determined using the Griess assay and western blot, respectively. Statistical analyses were performed using the Statistical Package of Social Sciences (SPSS) software, version 20. The data obtained from independent experiments (n = 3) were presented as the mean ± standard error of mean (SEM). The results showed that, asiaticoside stimulated the infected macrophages by stimulating increased production of TNF-α, IL-12 p40 and NO as well as increased expression of iNOS in a dose-dependent manner. In contrast the viability of the cells and the production of IL-1β and were reduced also in a dose-dependent manner when compared to untreated cells. These results indicate that asiaticoside has immunomodulatory effects on the innate immune function of infected macrophages, showing the potential use of this compound to reduce the clinical symptoms of the infections.
  10. A Neonate with Hypocalcemia and Cardiac Anomaly
    Arifin A, Thambiah SC, Abdullah H, Samsudin IN
    Clin Chem, 2021 06 01;67(6):823-826.
    PMID: 34059896 DOI: 10.1093/clinchem/hvab031
  11. Fulltext Mutation analysis of the BRCA1 gene in Malaysian breast cancer patients
    Balraj P, Khoo AS, Volpi L, Tan JA, Nair S, Abdullah H
    Singapore Med J, 2002 Apr;43(4):194-7.
    PMID: 12188064
    Thirty patients with early onset breast cancer or familial breast cancer from Malaysia were analysed for germline mutation in the early onset breast cancer I gene (BRCA1). Direct sequencing of the entire coding region of BRCA1 identified a frameshift mutation, c.5447-5448insC (insC5447) (codon 1776 of exon 21) in a patient aged 32 of the Malay ethnic origin, who had no family history of breast and/or ovarian cancer. Eight polymorphisms (2201C > T, 2430T > C, P871L, E1038G, K1183R, 4427T > C, S1613G and IVS8-57delT) were identified in the samples tested.
  12. The impact of CO2 emissions on economic growth: evidence from selected higher CO2 emissions economies
    Azam M, Khan AQ, Bin Abdullah H, Qureshi ME
    Environ Sci Pollut Res Int, 2016 Apr;23(7):6376-89.
    PMID: 26620862 DOI: 10.1007/s11356-015-5817-4
    The main purpose of this work is to analyze the impact of environmental degradation proxied by CO2 emissions per capita along with some other explanatory variables namely energy use, trade, and human capital on economic growth in selected higher CO2 emissions economies namely China, the USA, India, and Japan. For empirical analysis, annual data over the period spanning between 1971 and 2013 are used. After using relevant and suitable tests for checking data properties, the panel fully modified ordinary least squares (FMOLS) method is employed as an analytical technique for parameter estimation. The panel group FMOLS results reveal that almost all variables are statistically significant, whereby test rejects the null hypotheses of non cointegration, demonstrating that all variables play an important role in affecting the economic growth role across countries. Where two regressors namely CO2 emissions and energy use show significantly negative impacts on economic growth, for trade and human capital, they tend to show the significantly positive impact on economic growth. However, for the individual analysis across countries, the panel estimate suggests that CO2 emissions have a significant positive relationship with economic growth for China, Japan, and the USA, while it is found significantly negative in case of India. The empirical findings of the study suggest that appropriate and prudent policies are required in order to control pollution emerging from areas other than liquefied fuel consumption. The ultimate impact of shrinking pollution will help in supporting sustainable economic growth and maturation as well as largely improve society welfare.
  13. Fulltext Natural Gallic Acid and Methyl Gallate Induces Apoptosis in Hela Cells through Regulation of Intrinsic and Extrinsic Protein Expression
    Abdullah H, Ismail I, Suppian R, Zakaria NM
    Int J Mol Sci, 2023 May 09;24(10).
    PMID: 37239840 DOI: 10.3390/ijms24108495
    Induction of apoptosis is one of the targeted approaches in cancer therapies. As previously reported, natural products can induce apoptosis in in vitro cancer treatments. However, the underlying mechanisms of cancer cell death are poorly understood. The present study aimed to elucidate cell death mechanisms of gallic acid (GA) and methyl gallate (MG) from Quercus infectoria toward human cervical cancer cell lines (HeLa). The antiproliferative activity of GA and MG was characterised by an inhibitory concentration using 50% cell populations (IC50) by an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. Cervical cancer cells, HeLa, were treated with GA and MG for 72 h and calculated for IC50 values. The IC50 concentration of both compounds was used to elucidate the apoptotic mechanism using acridine orange/propidium iodide (AO/PI) staining, cell cycle analysis, the Annexin-V FITC dual staining assay, apoptotic proteins expressions (p53, Bax and Bcl-2) and caspase activation analysis. GA and MG inhibited the growth of HeLa cells with an IC50 value of 10.00 ± 0.67 µg/mL and 11.00 ± 0.58 µg/mL, respectively. AO/PI staining revealed incremental apoptotic cells. Cell cycle analysis revealed an accumulation of cells at the sub-G1 phase. The Annexin-V FITC assay showed that cell populations shifted from the viable to apoptotic quadrant. Moreover, p53 and Bax were upregulated, whereas Bcl-2 was markedly downregulated. Activation of caspase 8 and 9 showed an ultimate apoptotic event in HeLa cells treated with GA and MG. In conclusion, GA and MG significantly inhibited HeLa cell growth through apoptosis induction by the activation of the cell death mechanism via extrinsic and extrinsic pathways.
  14. Recent advances in advanced oxidation processes (AOPs) for the treatment of nitro- and alkyl-phenolic compounds
    Arifin MN, Jusoh R, Abdullah H, Ainirazali N, Setiabudi HD
    Environ Res, 2023 Jul 15;229:115936.
    PMID: 37080279 DOI: 10.1016/j.envres.2023.115936
    The presence of phenolic compounds in the aquatic environment has posed severe risks due to their toxicity. Among the phenolic families, nitro- and alkyl-phenolic compounds have been categorized as precedence contaminants by the United States Environmental Protection Agency (US EPA). Therefore, efficient treatment methods for wastewater containing nitro- and alkyl-phenolic compounds are urgently needed. Due to the advantages of creating reactive species and generating efficient degradation of hazardous contaminants in wastewater, advanced oxidation processes (AOPs) are well-known in the field of treating toxic contaminants. In this review paper, the recent directions in AOPs, catalysts, mechanisms, and kinetics of AOPs are comprehensively reviewed. Furthermore, the conclusion summarizes the research findings, future prospects, and opportunities for this study. The main direction of AOPs lies on the optimization of catalyst and operating parameters, with industrial applications remain as the main challenge. This review article is expected to present a summary and in-depth understanding of AOPs development; and thus, inspiring scientists to accelerate the evolution of AOPs in industrial applications.
  15. Fulltext Evolution of anodised titanium for implant applications
    Alipal J, Lee TC, Koshy P, Abdullah HZ, Idris MI
    Heliyon, 2021 Jul;7(7):e07408.
    PMID: 34296002 DOI: 10.1016/j.heliyon.2021.e07408
    Anodised titanium has a long history as a coating structure for implants due to its bioactive and ossified surface, which promotes rapid bone integration. In response to the growing literature on anodised titanium, this article is the first to revisit the evolution of anodised titanium as an implant coating. The review reports the process and mechanisms for the engineering of distinctive anodised titanium structures, the significant factors influencing the mechanisms of its formation, bioactivity, as well as recent pre- and post-surface treatments proposed to improve the performance of anodised titanium. The review then broadens the discussion to include future functional trends of anodised titanium, ranging from the provision of higher surface energy interactions in the design of biocomposite coatings (template stencil interface for mechanical interlock) to techniques for measuring the bone-to-implant contact (BIC), each with their own challenges. Overall, this paper provides up-to-date information on the impacts of the structure and function of anodised titanium as an implant coating in vitro and in/ex vivo tests, as well as the four key future challenges that are important for its clinical translations, namely (i) techniques to enhance the mechanical stability and (ii) testing techniques to measure the mechanical stability of anodised titanium, (iii) real-time/in-situ detection methods for surface reactions, and (iv) cost-effectiveness for anodised titanium and its safety as a bone implant coating.
  16. Fulltext Exploration of vulnerability factors of digital hoarding behavior among university students and the moderating role of maladaptive perfectionism
    Zaremohzzabieh Z, Abdullah H, Ahrari S, Abdullah R, Md Nor SM
    Digit Health, 2024;10:20552076241226962.
    PMID: 38298527 DOI: 10.1177/20552076241226962
    In light of the rapidly evolving digital landscape, there is an increasing need to explore digital hoarding behavior. This need is driven by concerns regarding its intricate psychological foundations and its impact on individuals within our technology-centric society. This research investigates the influence of various factors, including the fear of missing out, emotional attachment, information overload, and decision fatigue, on digital hoarding behaviors among university students in Iran. Additionally, the study examines the moderating role of maladaptive perfectionism in these relationships. The study involved 275 university students (mean age = 21.62 years; standard deviation = 2.28 years; 65.6% female) selected from four universities in Iran. The data were analyzed using partial least squares structural equation modeling (PLS-SEM). The results revealed that the fear of missing out, emotional attachment, information overload, and decision fatigue significantly predict university students' digital hoarding behavior. Moreover, the findings highlighted the moderating effect of maladaptive perfectionism on the association between emotional attachment and digital hoarding behavior. This suggests that individuals with higher levels of maladaptive perfectionism exhibit amplified digital hoarding tendencies when emotionally attached to their digital data. This study provides a deeper understanding of the relationship between psychological factors and digital hoarding tendencies. These findings have practical implications for educational institutions and mental health professionals, as they can help in developing targeted strategies and interventions to manage digital hoarding behavior in university freshmen and promote healthier digital habits.
  17. Fulltext A natural compound from Hydnophytum formicarium induces apoptosis of MCF-7 cells via up-regulation of Bax
    Abdullah H, Pihie AHL, Hohmann J, Molnár J
    Cancer Cell Int, 2010 May 04;10:14.
    PMID: 20441573 DOI: 10.1186/1475-2867-10-14
    BACKGROUND: Hydnophytum formicarium Jack is an epyphytic shrub that belongs to the family of Rubiaceae and is native to the tropical rain forests of the Asean region, which includes Malaysia. A flavanoid derivative, 7, 3', 5'-trihydroxyflavanone (3HFD), isolated from H. formicarium has been reported to have cytotoxic effects on the human breast carcinoma cell line MCF-7. The aim of the current study was to investigate the mode of cell death in MCF-7 cells treated with 3HFD. A DNA fragmentation assay was conducted on isolated genomic DNA, a TUNEL assay was used to determine the mode of cell death and Western blotting was used to evaluate the expression levels of Bax and Bcl-2. Immunofluorescence staining of MCF-7 cells was also performed to confirm the up-regulation of the Bax protein.

    RESULTS: The ladder pattern resulting from the DNA fragmentation assay was a multimer of 180 kb. The morphological changes of cells undergoing apoptosis were visualised by a TUNEL assay over time. The percentage of apoptotic cells increased as early as 6 hours post treatment compared to untreated cells. Western blotting revealed up-regulation of the pro-apoptotic protein Bax. However, 3HFD did not affect expression of the anti-apoptotic protein Bcl-2.

    CONCLUSIONS: Our results provide evidence that plant-derived 3HFD was able to induce the apoptotic cell death of MCF-7 cells by increasing Bax expression level and makes 3HFD a promising agent for chemotherapy, which merits further study.

  18. Current solid waste management strategies and energy recovery in developing countries - State of art review
    Khan AH, López-Maldonado EA, Khan NA, Villarreal-Gómez LJ, Munshi FM, Alsabhan AH, et al.
    Chemosphere, 2022 Mar;291(Pt 3):133088.
    PMID: 34856242 DOI: 10.1016/j.chemosphere.2021.133088
    Solid waste generation has rapidly increased due to the worldwide population, urbanization, and industrialization. Solid waste management (SWM) is a significant challenge for a society that arises local issues with global consequences. Thus, solid waste management strategies to recycle waste products are promising practices that positively impact sustainable goals. Several developed countries possess excellent solid waste management strategies to recycle waste products. Developing countries face many challenges, such as municipal solid waste (MSW) sorting and handling due to high population density and economic instability. This mismanagement could further expedite harmful environmental and socioeconomic concerns. This review discusses the current solid waste management and energy recovery production in developing countries; with statistics, this review provides a comprehensive revision on energy recovery technologies such as the thermochemical and biochemical conversion of waste with economic considerations. Furthermore, the paper discusses the challenges of SWM in developing countries, including several immediate actions and future policy recommendations for improving the current status of SWM via harnessing technology. This review has the potential of helping municipalities, government authorities, researchers, and stakeholders working on MSW management to make effective decisions for improved SWM for achieving sustainable development.
  19. Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition
    Dabbagh A, Mahmoodian R, Abdullah BJ, Abdullah H, Hamdi M, Abu Kasim NH
    Int J Hyperthermia, 2015;31(8):920-9.
    PMID: 26670340 DOI: 10.3109/02656736.2015.1094147
    The aim of this paper was to synthesise core-shell nanostructures comprised of mesoporous silica core and a low melting-point polyethylene glycol (PEG) nanoshell with a sharp gel-liquid phase transition for rapid drug release at hyperthermia temperature range.
  20. A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
    Dabbagh A, Abdullah BJ, Abu Kasim NH, Abdullah H, Hamdi M
    Int J Hyperthermia, 2015 Jun;31(4):375-85.
    PMID: 25716769 DOI: 10.3109/02656736.2015.1006268
    The aim of this paper was to introduce a new mechanism of thermal sensitivity in nanocarriers that results in a relatively low drug release at physiological temperature and rapid release of the encapsulated drug at hyperthermia and thermal ablation temperature range (40-60 °C).
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