Displaying publications 441 - 460 of 5421 in total

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  1. Kuan GL, Tee AC
    MyJurnal
    To study the role of pulse oximetry in the assessment of acute asthma in children presenting to the A&E department, 360 children who presented themselves to the A&E department were enrolled into the study. Those admitted were found to have a lower mean Sa02 of 92% compared to those discharged with Sa02 of 94% (p < 0.001). After the initial treatment at the A&E, those admitted still have a lower mean Sa02 of 94% compared to those discharged with a mean Sa02 of 96% (p < 0.001). However taking Sa02 of 92% as a predictor of admission hada sensitivity of 39% and a specificity of 80% but it had a high negative predictive value of 92%. Hence pulse oximetry alone is not sensitive for predicting admission in acute asthma in children.
    Matched MeSH terms: Acute Disease
  2. Ahmad Kamil Arshad, Khairil Azman Masri, Juraidah Ahmad, Mohamad Saifullah Samsudin
    MyJurnal
    This paper presents the outcome of a laboratory investigation on mix design, resilient modulus, moisture susceptibility and rutting resistance of Stone Mastic Asphalt (SMA) and Dense Graded Asphalt (AC) that is incorporated with Nanosilica (NS) modified binder. Penetration Grade 60-70 (PEN60-70) types of binder were mixed with nanoparticles (NS) using concentration of 0wt%, 2wt%, 4wt% and 6wt% by weight of asphalt binder. The mixtures were tested for resilient modulus, indirect tensile strength and rutting, in order to evaluate the performance of NS-SMA and NS-AC. The results show that the existence of NS is capable of enhancing the performance of both asphalt mixtures, and the addition of NS decreases the susceptibility of moisture damage and provides better resistance against permanent deformation. Furthermore, the addition of 4wt% NS appears to be the most effective amount for the performance enhancement in AC and SMA mixtures.
    Matched MeSH terms: Disease Susceptibility
  3. Tang YH, Chong MC, Chua YP, Chui PL, Tang LY, Rahmat N
    J Clin Nurs, 2018 Dec;27(23-24):4311-4320.
    PMID: 29777560 DOI: 10.1111/jocn.14538
    AIMS: To determine the effect mobile messaging apps on coronary artery disease patient knowledge of and adherence to a healthy lifestyle.

    BACKGROUND: Due to the increasing incidence of coronary artery disease in recent years, interventions targeting coronary artery disease risk factors are urgent public priorities. The use of mobile technology in healthcare services and medical education is relatively new with promising future prospects.

    DESIGN: This study used a quasiexperimental design that included pre- and posttest for intervention and control groups.

    METHODS: The study was conducted from January-April 2017 with both intervention and control groups, in a teaching hospital in Klang Valley. Convenience sampling was used with inclusive criteria in choosing the 94 patients with coronary artery disease (intervention group: 47 patients; control group: 47 patients). The pretest was conducted as a baseline measurement for both groups before they were given standard care from a hospital. However, only the intervention group was given a daily information update via WhatsApp for 1 month. After 1 month, both groups were assessed with a posttest.

    RESULTS: The split-plot ANOVA analysis indicates that there is a significant and positive effect of the intervention on coronary artery disease patients' knowledge on coronary artery disease risk factors [F(1, 92) = 168.15, p 

    Matched MeSH terms: Coronary Artery Disease/etiology; Coronary Artery Disease/prevention & control; Coronary Artery Disease/psychology*
  4. Md S, Gan SY, Haw YH, Ho CL, Wong S, Choudhury H
    Int J Biol Macromol, 2018 Oct 15;118(Pt A):1211-1219.
    PMID: 30001606 DOI: 10.1016/j.ijbiomac.2018.06.190
    Alzheimer's disease (AD) is an increasingly prevalent neurological disorder of the central nervous system. There is growing evidence that amyloidogenesis is a pathological hallmark for AD; this leads to the formation of senile plaques. Naringenin is a bioflavonoid which has neuroprotective effects through its antioxidant and anti-inflammatory properties. However, its clinical usage is limited due to its inefficient transport across biological membranes. In the present study, a naringenin nanoemulsion was prepared and its neuroprotective effects were tested against β-amyloid induced neurotoxicity in a human neuroblastoma cell line (SH-SY5Y). The optimised, naringenin-loaded nanoemulsion formulation had a droplet size of 113.83 ± 3.35 nm and around 50 nm, as assessed respectively by photon correlation spectroscopy and transmission electron microscopy. The preparation showed a low polydispersity index (0.312 ± 0.003), a high zeta potential (12.4 ± 1.05) and a high percentage transmittance (97.01%). The neuroprotective activity of naringenin nanoemulsions was determined by assessing their ability to protect SH-SY5Y neuroblastoma cells against the neurotoxic effect of beta amyloid (Aβ). Aβ-induced production of reactive oxygen species (ROS), amyloid precursor protein (APP), β-secretase (BACE), total tau and phosphorylated tau (pT231) was also determined. The naringenin loaded nanoemulsion significantly alleviated the direct neurotoxic effects of Aβ on SH-SY5Y cells; this was associated with a down-regulation of APP and BACE expression, indicating reduced amyloidogenesis. Furthermore, it decreased the levels of phosphorylated tau in SH-SY5Y cells exposed to Aβ. These results suggest that a naringenin-loaded nanoemulsion could be a promising agent for the treatment of Alzheimer's disease.
    Matched MeSH terms: Alzheimer Disease/drug therapy*; Alzheimer Disease/metabolism; Alzheimer Disease/pathology
  5. Saifuddin, T.M., Amilin, N., Zafri, A.
    MyJurnal
    Huntington disease (HD) is a neurodegenerative disorder with psychiatric, cognitive, and motor symptoms. Psychiatric symptoms often manifest years before neurologic signs in HD patients. The present of psychiatric symptoms might increase risk of suicide in HD patient. We presented a case of HD who admitted to Psychiatry ward due to suicidal attempt and shows improvement with low dose of Olanzapine.
    Matched MeSH terms: Huntington Disease
  6. Baertling F, Sánchez-Caballero L, Timal S, van den Brand MA, Ngu LH, Distelmaier F, et al.
    Mol Genet Metab, 2017 03;120(3):243-246.
    PMID: 27986404 DOI: 10.1016/j.ymgme.2016.12.005
    NDUFAF3 is an assembly factor of mitochondrial respiratory chain complex I. Variants in NDUFAF3 have been identified as a cause of severe multisystem mitochondrial disease. In a patient presenting with Leigh syndrome, which has hitherto not been described as a clinical feature of NDUFAF3 deficiency, we identified a novel homozygous variant and confirmed its pathogenicity in patient fibroblasts studies. Furthermore, we present an analysis of complex I assembly routes representative of each functional module and, thereby, link NDUFAF3 to a specific step in complex I assembly. Therefore, our report expands the phenotype of NDUFAF3 deficiency and further characterizes the role of NDUFAF3 in complex I biogenesis.
    Matched MeSH terms: Leigh Disease/genetics*; Leigh Disease/pathology; Genetic Predisposition to Disease
  7. Mah SL, George P
    Malays Fam Physician, 2018;13(2):26-28.
    PMID: 30302180
    Dementia is typically characterized by the deterioration of cognitive abilities and is a common disorder among the elderly in Malaysia. However, behavioral and psychological symptoms are also present in approximately 90% of dementia patients.1 We report the manifestation of these symptoms in an elderly woman with dementia and the treatment thereof.
    Matched MeSH terms: Alzheimer Disease
  8. Takahashi S, Metcalf CJE, Arima Y, Fujimoto T, Shimizu H, Rogier van Doorn H, et al.
    J R Soc Interface, 2018 09 12;15(146).
    PMID: 30209044 DOI: 10.1098/rsif.2018.0507
    Outbreaks of hand, foot and mouth disease have been documented in Japan since 1963. This disease is primarily caused by the two closely related serotypes of Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16). Here, we analyse Japanese virologic and syndromic surveillance time-series data from 1982 to 2015. As in some other countries in the Asia Pacific region, EV-A71 in Japan has a 3 year cyclical component, whereas CV-A16 is predominantly annual. We observe empirical signatures of an inhibitory interaction between the serotypes; virologic lines of evidence suggest they may indeed interact immunologically. We fit the time series to mechanistic epidemiological models: as a first-order effect, we find the data consistent with single-serotype susceptible-infected-recovered dynamics. We then extend the modelling to incorporate an inhibitory interaction between serotypes. Our results suggest the existence of a transient cross-protection and possible asymmetry in its strength such that CV-A16 serves as a stronger forcing on EV-A71. Allowing for asymmetry yields accurate out-of-sample predictions and the directionality of this effect is consistent with the virologic literature. Confirmation of these hypothesized interactions would have important implications for understanding enterovirus epidemiology and informing vaccine development. Our results highlight the general implication that even subtle interactions could have qualitative impacts on epidemic dynamics and predictability.
    Matched MeSH terms: Disease Outbreaks; Hand, Foot and Mouth Disease/epidemiology*; Hand, Foot and Mouth Disease/virology*
  9. Supandi F, van Beek JHGM
    PLoS One, 2018;13(9):e0203687.
    PMID: 30208076 DOI: 10.1371/journal.pone.0203687
    BACKGROUND: Parkinson's disease is a widespread neurodegenerative disorder which affects brain metabolism. Although changes in gene expression during disease are often measured, it is difficult to predict metabolic fluxes from gene expression data. Here we explore the hypothesis that changes in gene expression for enzymes tend to parallel flux changes in biochemical reaction pathways in the brain metabolic network. This hypothesis is the basis of a computational method to predict metabolic flux changes from post-mortem gene expression measurements in Parkinson's disease (PD) brain.

    RESULTS: We use a network model of central metabolism and optimize the correspondence between relative changes in fluxes and in gene expression. To this end we apply the Least-squares with Equalities and Inequalities algorithm integrated with Flux Balance Analysis (Lsei-FBA). We predict for PD (1) decreases in glycolytic rate and oxygen consumption and an increase in lactate production in brain cortex that correspond with measurements (2) relative flux decreases in ATP synthesis, in the malate-aspartate shuttle and midway in the TCA cycle that are substantially larger than relative changes in glucose uptake in the substantia nigra, dopaminergic neurons and most other brain regions (3) shifts in redox shuttles between cytosol and mitochondria (4) in contrast to Alzheimer's disease: little activation of the gamma-aminobutyric acid shunt pathway in compensation for decreased alpha-ketoglutarate dehydrogenase activity (5) in the globus pallidus internus, metabolic fluxes are increased, reflecting increased functional activity.

    CONCLUSION: Our method predicts metabolic changes from gene expression data that correspond in direction and order of magnitude with presently available experimental observations during Parkinson's disease, indicating that the hypothesis may be useful for some biochemical pathways. Lsei-FBA generates predictions of flux distributions in neurons and small brain regions for which accurate metabolic flux measurements are not yet possible.

    Matched MeSH terms: Parkinson Disease/genetics; Parkinson Disease/metabolism; Parkinson Disease/pathology*
  10. Zhu L, Kim Y, Yang Z
    J Acupunct Meridian Stud, 2018 Dec;11(6):343-354.
    PMID: 30195824 DOI: 10.1016/j.jams.2018.08.209
    Auriculotherapy has been extensively used for chronic spontaneous urticaria in China. However, the evidence of its effectiveness and safety for the treatment of chronic spontaneous urticaria is insufficient. Hence, we conducted this study to compare auriculotherapy or auriculotherapy joint treatment with Western medicine for the cure of chronic spontaneous urticaria. This meta-analysis of seven randomized controlled trials showed that auriculotherapy or auriculotherapy joint treatment was significantly superior to Western medicine in curing clinical signs and symptoms of chronic spontaneous urticaria [odds ration (OR), 2.61; 95% confidence interval (CI), 1.54-4.43; p = 0.0004) and also better in total effect rate (OR, 3.81; 95% CI, 2.07-7.01; p<0.0001). But, auriculotherapy or auriculotherapy joint treatment was similar to Western medicine in improving clinical signs and symptoms of chronic spontaneous urticaria (OR, 0.74; 95% CI, 0.35-1.56; p = 0.42). Auriculotherapy or auriculotherapy joint treatment was safer than Western medicine for curing chronic spontaneous urticaria (OR, 0.26; 95% CI, 0.09-0.80; p = 0.02). Auriculotherapy alone or auriculotherapy joint treatment appears to be more effective and safer than Western medicine that contains antihistamines in the treatment of chronic spontaneous urticaria. However, these findings should be interpreted with caution due to the unclear risk bias of methodological quality, and further studies with large-scale, better, and more rigorously designed protocol are necessary to prove these findings.
    Matched MeSH terms: Chronic Disease
  11. Siti Mariam Norrulashikin, Fadhilah Yusof, Kane, Ibrahim Lawal
    MATEMATIKA, 2018;34(1):73-85.
    MyJurnal
    Simulation is used to measure the robustness and the efficiency of the forecasting
    techniques performance over complex systems. A method for simulating multivariate
    time series was presented in this study using vector autoregressive base-process. By
    applying the methodology to the multivariable meteorological time series, a simulation
    study was carried out to check for the model performance. MAPE and MAE performance
    measurements were used and the results show that the proposed method that consider
    persistency in volatility gives better performance and the accuracy error is six time smaller
    than the normal hybrid model.
    Matched MeSH terms: Disease Vectors
  12. Naing C, Whittaker MA, Tanner M
    Malar J, 2018 Nov 16;17(1):430.
    PMID: 30445959 DOI: 10.1186/s12936-018-2562-4
    BACKGROUND: Malaria cases among mobile and migrant populations (MMPs) represent a large and important reservoir for transmission, if undetected or untreated. The objectives of this review were to identify which intersectoral actions have been taken and how they are applied to interventions targeted at the MMPs and also to assess the effect of interventions targeted to these special groups of population.

    RESULTS: A total of 36 studies met the inclusion criteria for this review. Numerous stakeholders were identified as involved in the intersectoral actions to defeat malaria amongst MMPs. Almost all studies discussed the involvement of Ministry of Health/Public Health (MOH/MOPH). The most frequently assessed intervention among the studies that were included was the coverage and utilization of insecticide-treated nets as personal protective measures (40.5%), followed by the intervention of early diagnoses and treatment of malaria (33.3%), the surveillance and response activities (13.9%) and the behaviour change communication (8.3%). There is a dearth of information on how these stakeholders shared roles and responsibilities for implementation, and about the channels of communication between-and-within the partners and with the MOH/MOPH. Despite limited details in the studies, the intermediate outcomes showed some evidence that the intersectoral collaborations contributed to improvement in knowledge about malaria, initiation and promotion of bed nets utilization, increased access to diagnosis and treatment in a surveillance context and contributed towards a reduction in malaria transmission. Overall, a high proportion of the targeted MMPs was equipped with correct knowledge about malaria transmission (70%, 95% CI 57-83%). Interventions targeting the use of bed nets utilization were two times more likely to reduce malaria incidence amongst the targeted MMPs (summary OR 2.01, 95% CI 1.43-2.6) than the non-users. The various intersectoral actions were often more vertically organized and not fully integrated in a systemic way within a given country or sub-national administrative setting.

    CONCLUSION: Findings suggest that interventions supported by the multiple stakeholders had a significant impact on the reduction of malaria transmission amongst the targeted MMPs. Well-designed studies from different countries are recommended to robustly assess the role of intersectoral interventions targeted to MMPs and their impact on the reduction of transmission.

    Matched MeSH terms: Communicable Disease Control/methods*; Disease Transmission, Infectious/prevention & control*
  13. Hosseini S, Oliva-Ramírez J, Vázquez-Villegas P, García AR, Muñoz-Soto RB, Aghamohammadi N, et al.
    Curr Top Med Chem, 2018 Nov 05.
    PMID: 30394209 DOI: 10.2174/1568026618666181105130000
    Current review article focuses on Dengue, which is one of the most fatal infectious illnesses and is considered to be a worldwide threat. The paper covers essential topics including an overview on neglected tropical diseases with specific emphasis on Dengue fever, mosquito's cycle of life and mechanism of infection, adaptive response, and different stages in Dengue immunopathogenesis. The current work is also dedicated to the thorough study of Dengue outbreak across the globe with narrowed study to tropical and subtropical regions. Moreover, this review article demonstrates the correlation between the climate factors and Dengue incidence. Furthermore, we present an overview on the detection strategies of Dengue including the latest developments in commercial and non-commercial platforms. Several attempts in developing effective vaccine to protect individuals from Dengue infection and the stage of clinical trails are gathered in the present work as well. Future directions including bio-control are also discussed in this review article. In an overall view, effective management of Dengue is a multidisciplinary task that requires international involvement from different backgrounds and expertise to address this global concern. This review article briefly portrays some of these connecting areas across the disciplines while many other perspectives remain uncovered.
    Matched MeSH terms: Disease Outbreaks
  14. Green R, Mankikar DS
    Matched MeSH terms: Disease Outbreaks
  15. Suwanda Idris
    Total Variance (TV) and Generalized Variance (GV) are commonly used as a measure multivariate dispersion. However, these two statistics has some drawbacks. This paper proposes a new measure of multivariate dispersion, named Vectorial Variance (VV) an inner product for set of operators defined on a Hilbert-Smith space. Since, the exact sampling distribution of VV is difficult to find, therefore the asymptotic sampling distribution is obtained.
    [Jumlah Varians dan Varians Teritlak kebiasaannya digunakan sebagai ukuran dispersi multivariate. Namun begitu, kedua-dua statistik ini mempunyai beberapa kelemahan. Dalam tulisan ini akan dicadankgan satu ukuran dispersi multivariate yang baru, dikenali sebagai varians bervektor (VV) yang merupakan suatu hasil darab terkedalam bagi set pengoperasi yang tertakrif ke atas suatu ruang Hilbert-Smith. Oleh kerana taburan pensampilan tepat dari statistik vv tersebut sangat sukar untuk ditentukan, maka taburan pensampilan asimtot telah diperolehi].
    Matched MeSH terms: Disease Vectors
  16. Taufik N, Hanafiah MH
    Heliyon, 2019 Dec;5(12):e02960.
    PMID: 31890945 DOI: 10.1016/j.heliyon.2019.e02960
    Purpose: The purpose of this paper is to examine the factors influencing passenger adoption and behaviour of self-service technology (SST) in airports. This study adopted the Theory Acceptance Model (TAM) and extended the model by including the need for human interaction (NI) construct in the study framework.

    Design/methodology/approach: The research framework is based on the theoretical concepts of SST usage from the inter-disciplinary field. Four hundred two questionnaires were collected from passengers who used the self-check-in kiosks in Kuala Lumpur International Airport (KLIA and KLIA2). The collected data were analysed using the structural equation modelling (SEM) technique.

    Findings: Different factors determine passengers' willingness and adoption of SSTs. Perceived ease of use and perceived usefulness significantly affect passenger adoption and behaviour of SSTs in airports. However, the passenger was much comfortable with the SST as the moderating effect of need for human interaction shows a negative result.

    Practical implications: The findings contribute to an understanding of how and why passengers use SSTs, which is critical from a customer relationship management (CRM) perspective. Better strategies can be developed to manage and coordinate SSTs delivery in the airport by understanding the passengers' experience from the self-check-in kiosks.

    Originality/value: This paper goes beyond the basic SSTs usage and intentions study by highlighting the nonimportance of human interaction in SSTs usage specifically by airport passengers.

    Matched MeSH terms: Disease Management
  17. Jamal F, Abdullah N, Zambahari R
    Family Practitioner, 1988;11(1):46-47.
    Matched MeSH terms: Rheumatic Heart Disease
  18. Majid Y, Warade M, Sinha J, Kalyanpur A, Gupta T
    Biomed Imaging Interv J, 2011 01 01;7(1):e2.
    PMID: 21655111 DOI: 10.2349/biij.7.1.e2
    Noninvasive imaging of coronary artery disease is rapidly replacing angiography as the first line of investigation. Multislice CT is the non-invasive modality of choice for imaging coronary artery disease and provides high speed with good spatial resolution. CT coronary angiography in addition to detecting and characterising atherosclerotic coronary artery disease is also a good imaging tool for evaluating anomalies of coronary arteries. Superdominant right coronary artery with absent left circumflex artery is one such rare coronary artery anomaly which is well evaluated with multislice CT angiography. The authors report one such case of superdominant right coronary artery with absent left circumflex artery imaged with 64-slice MDCT.
    Matched MeSH terms: Coronary Artery Disease
  19. Simon N, de Roiste M, Crozier M, Abdul Ghani Rafek
    Sains Malaysiana, 2017;46:27-34.
    In the literatures, discussions on the accuracy of different models for landslide analysis have been discussed widely.
    However, to date, arguments on the type of input data (landslides in the form of point or polygon) and how they affect
    the accuracy of these models can hardly be found. This study assesses how different types of data (point or polygon)
    applied to the same model influence the accuracy of the model in determining areas susceptible to landsliding. A total
    of 137 landslides was digitised as polygon (areal) units and then transformed into points; forming two separate datasets
    both representing the same landslides within the study area. These datasets were later separated into training and
    validation datasets. The polygon unit dataset uses the area density technique reported as percentage, while the point
    data uses the landslide density technique, as means of assigning weighting to landslide factor maps to generate the
    landslide susceptibility map that is based on the analytical hierarchy process (AHP) model. Both data groups show striking
    differences in terms of mapping accuracy for both training and validation datasets. The final landslide susceptibility
    map using area density (polygon) as input only has 48% (training) and 35% (validation) accuracy. The accuracy for
    the susceptibility map using the landslide density as input data achieved 89% and 82% for both training and validation
    datasets, respectively. This result showed that the selection of the type of data for landslide analysis can be critical in
    producing an acceptable level of accuracy for the landslide susceptibility map. The authors hope that the finding of this
    research will assist landslide investigators to determine the appropriateness of the type of landslide data because it will
    influence the accuracy of the final landslide potential map.
    Matched MeSH terms: Disease Susceptibility
  20. Lee NY, Khoo WK, Adnan MA, Mahalingam TP, Fernandez AR, Jeevaratnam K
    J Pharm Pharmacol, 2016 Jun 10.
    PMID: 27283048 DOI: 10.1111/jphp.12565
    Phyllanthus niruri is a traditional shrub of the genus Phyllanthaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use.
    Matched MeSH terms: Disease Models, Animal
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