Displaying publications 921 - 940 of 9998 in total

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  1. Ahmad Nasir S, Ramli R, Abd Jabar N
    PLoS One, 2018;13(10):e0204946.
    PMID: 30289909 DOI: 10.1371/journal.pone.0204946
    The aim of this study was to determine the predictors of post-traumatic enophthalmos (PE) in relation to the internal orbital changes following pure orbital blowout fractures. The design was a 10-year retrospective cross-sectional study analysing 629 medical records and computed tomography (CT) data of patients with orbital fractures from January 2008 to January 2017. Demographic, etiology, co-morbidity and clinical characteristics were obtained from the medical records. Assessment of the PE, fracture site and size, intraorbital structures and muscle change were performed using the Digital Imaging and Communications in Medicine (DICOM) viewer software, OsiriX v5.8.2. Of the 629 patients with orbital fractures, 87 were pure orbital blowout fractures. Demographic pattern showed that males outnumbered females in the series, with male: female ratio of 5.7:1. The mean age was 37.2 ± 14.7 and the main etiology was motor vehicle accident. Orbital floor fracture was the most common fracture location (67.8%). The involvement of the posterior ledge and inferior orbital fissure showed statistical significant difference with PE (Fisher's exact test, p = 0.03). Binary logistic regression showed that after controlling for age, patients with fracture size of more than 150 mm2 had three times the odds of sustaining a PE, (adjusted odds ratio (AOR) = 3.01 (95% CI 1.17-7.92). Fracture size larger than 150 mm2 was a radiological predictor of PE. Additional research investigating further on the role of concurrent fracture of the posterior ledge and inferior orbital fissure is advocated.
  2. Shah SA, Mahmood MI, Ahmad N
    Asian Pac J Cancer Prev, 2020 Nov 01;21(11):3137-3144.
    PMID: 33247668 DOI: 10.31557/APJCP.2020.21.11.3137
    BACKGROUND: The recent data shows reduced uptake on cancer screening where the Perception towards cancer screening by the public is one of the favorable factor might influence the screening uptake. Therefore, this study aims to determine the predictors of poor cancer screening perceptions among the population in Johor, Malaysia.

    METHODS: This was a cross sectional study of 1,312 respondents selected using a multistage design. Questionnaires relating to the demographic characteristics, socioeconomic profiles, social and physical environment, knowledge and perception of cancer screening were gathered. Multiple logistic regression models were used to examine the variables and their association with poor perceptions of cancer screening.

    RESULTS: Overall, 871(66.4%) respondents had poor perceptions of cancer screenings; 68.4% among males and 64.4% among females. In the multivariable analysis in the category of income, the bottom 40% and lower middle 40%, had not subscribed to health insurance, had poor social support, absence of any family history of cancer or comorbid illnesses, no previous attendance for cancer screening and poor knowledge of cancer, all of which were associated with their poor cancer screening perceptions.

    CONCLUSION: One way of developing cancer screening services to detect cancer in its early stage could include efforts to reach people with less awareness about cancer screening tests, lower socioeconomic status, and inadequate social support. Particular consideration should be taken to locate those who never had health insurance or attended cancer screening tests to provide the appropriate resources.

  3. Wan Ishak WH, Rosli NA, Ahmad I
    Sci Rep, 2020 Jul 09;10(1):11342.
    PMID: 32647369 DOI: 10.1038/s41598-020-68274-x
    Eco-friendly materials such as poly(lactic acid) (PLA) and cellulose are gaining considerable interest as suitable substitutes for petroleum-based plastics. Therefore, amorphous cellulose (AC) was fabricated as a new reinforcing material for PLA biocomposites by modifying a microcrystalline cellulose (MCC) structure via milling. In this study, the mechanical properties, thermal properties, and degradability of PLA were analysed to compare the effects of both MCC and AC on PLA. The tensile and impact properties improved at an optimum value with AC at 8 wt% and 4 wt% fibre loading, respectively. Notably, a scanning electron micrograph analysis revealed improved AC fibre-matrix adhesion, compared with MCC fibre-matrix adhesion, as well as excellent interaction between AC and PLA. Both MCC and AC improved the hydrolytic degradation of PLA. Moreover, the biocomposites with AC exhibited superior degradation when the incorporation of AC improved the water absorption efficiency of PLA. These findings can expand AC applications and improve sustainability.
  4. Ahmad SS, Rahim AA, Ghani SA
    Digit J Ophthalmol, 2011;17(1):3-5.
    PMID: 23362385 DOI: 10.5693/djo.02.2011.01.002
    Spontaneous absorption of lenses or cataracts is rare. We report a case of bilateral spontaneous lens absorption in a 36-year-old woman for which no cause could be determined despite extensive laboratory testing.
  5. Fazwi R, Chandran PA, Ahmad TS
    Malays Orthop J, 2011 Nov;5(3):8-12.
    PMID: 25279028 MyJurnal DOI: 10.5704/MOJ.1111.007
    ABSTRACT: Glomus tumours (GT), neoplasms of the glomus body comprise 4.5% of upper limb tumours. Seventy-five per cent of these occur in the hand, and most are subungual (50%). We performed a literature review and retrospective search of histopathologically confirmed GT seen from 1995 to 2009. Fifteen patients were identified, with an average age of 49.6 years. Eight were in the hand, 2 in the upper limb, 2 lower limb and 3 in the ear. Eighty-six per cent presented with pain and 50% underwent radiological investigation. Most diagnoses followed biopsy findings. Surgical excision resulted in a recurrence rate of 13%. The average time to diagnosis was 3.3 years. The average duration of symptoms was 7 to 11 years with an average of 2 to 3 consultations prediagnosis. MRI remains the most useful imaging modality (82 to 90% sensitivity). Excision biopsy is the most common treatment. Greater awareness is needed for quicker diagnosis.

    KEY WORDS: Glomus Tumour, Presentation, Imaging, Recurrence.

  6. Ahmad M, Dhanasekar B, Aparna IN, Naim H
    J Indian Prosthodont Soc, 2014 Sep;14(3):297-300.
    PMID: 25183915 DOI: 10.1007/s13191-012-0188-8
    As more and more dental practitioners are focusing on implant-supported fixed restorations, some clinicians favor the use of cement retained restorations while others consider screw-retained prosthesis to be the best choice. As both types of prostheses have certain advantages and disadvantages, clinicians should be aware of the limitations of each type. Screw-retained implant restorations have an advantage of predictable retention, retrievability and lack of potentially retained sub-gingival cement. However, a few disadvantages exist such as precise placement of the implant for optimal and esthetic location of the screw access hole and obtaining passive fit. On the other hand, cement retained restorations eliminates unaesthetic screw access holes; have passive fit of castings; reduce stress to splinted implants because of minor misfit of the framework; reduced complexity of lab procedures; enhanced esthetics; reduced cost factors and non disrupted morphology of the occlusal table. This case report presents the replacement of missing left central incisor using screw-retained implant prosthesis due to palatal trajectory of the implant placement and inadequate abutment height for retention of cement retained prosthesis.
  7. Attiq A, Afzal S, Ahmad W, Kandeel M
    Eur J Pharmacol, 2024 Mar 05;966:176338.
    PMID: 38242225 DOI: 10.1016/j.ejphar.2024.176338
    Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein entry, retention, and oxidative modification cause endothelial damage, triggering innate and adaptive immune responses. Recruited immune cells orchestrate the early atherosclerotic lesions by releasing proinflammatory cytokines, expediting the foam cell formation, intraplaque haemorrhage, secretion of matrix-degrading enzymes, and lesion progression, eventually promoting coronary artery syndrome via various inflammatory cascades. In addition, soluble mediators disrupt the dynamic anti- and prothrombotic balance maintained by endothelial cells and pave the way for coronary artery disease such as angina pectoris. Recent studies have established a relationship between elevated levels of inflammatory markers, including C-reactive protein (CRP), interleukins (IL-6, IL-1β), and tumour necrosis factor-alpha (TNF-α) with the severity of CAD and the possibility of future cardiovascular events. High-sensitivity C-reactive protein (hs-CRP) is a marker for assessing systemic inflammation and predicting the risk of developing CAD based on its peak plasma levels. Hence, understanding cross-talk interactions of inflammation, atherogenesis, and CAD is highly warranted to recalculate the risk factors that activate and propagate arterial lesions and devise therapeutic strategies accordingly. Cholesterol-inflammation lowering agents (statins), monoclonal antibodies targeting IL-1 and IL-6 (canakinumab and tocilizumab), disease-modifying antirheumatic drugs (methotrexate), sodium-glucose transport protein-2 (SGLT2) inhibitors, colchicine and xanthene oxidase inhibitor (allopurinol) have shown promising results in reducing inflammation, regressing atherogenic plaque and modifying the course of CAD. Here, we review the complex interplay between inflammatory, endothelial, smooth muscle and foam cells. Moreover, the putative role of inflammation in atherosclerotic CAD, underlying mechanisms and potential therapeutic implications are also discussed herein.
  8. Ulagantheran V, Ahmad Fauzi MS, Reddy SC
    Int J Ophthalmol, 2010;3(3):272-6.
    PMID: 22553571 DOI: 10.3980/j.issn.2222-3959.2010.03.22
    To determine the causes, associated ocular findings and visual acuity on presentation, complications and visual outcome following treatment in patients of hyphema due to blunt injury
  9. Charbgoo F, Ahmad MB, Darroudi M
    Int J Nanomedicine, 2017;12:1401-1413.
    PMID: 28260887 DOI: 10.2147/IJN.S124855
    CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO2-NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO2-NPs in biological and medical fields. Exploiting biocompatible CeO2-NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.
  10. Ahmad N, Hashim R, Mohd Noor A
    Int J Microbiol, 2013;2013:121845.
    PMID: 24194761 DOI: 10.1155/2013/121845
    Acute melioidosis may present as localised or septicaemic infections and can be fatal if left untreated. Burkholderia pseudomallei resistant to antibiotics used for the treatment of melioidosis had been reported. The aim of this study was to determine the in vitro antibiotic susceptibility patterns of Burkholderia pseudomallei isolated in Malaysia to a panel of antibiotics used for the treatment of melioidosis and also to potential alternative antibiotics such as tigecycline, ampicillin/sulbactam, and piperacillin/tazobactam. A total of 170 Burkholderia pseudomallei isolates were subjected to minimum inhibitory concentration determination using E-test method to eleven antibiotics. All isolates were sensitive to meropenem and piperacillin/tazobactam. For ceftazidime, imipenem, amoxicillin/clavulanic acid, and doxycycline resistance was observed in 1 isolate (0.6%) for each of the antibiotics. Trimethoprim/sulfamethoxazole resistance was observed in 17 (10%) isolates. For other antibiotics, ampicillin/sulbactam, chloramphenicol, tigecycline, and ciprofloxacin resistance were observed in 1 (0.6%), 6 (3.5%), 60 (35.3%) and 98 (57.7%) isolates respectively. One isolate B170/06 exhibited resistance to 4 antibiotics, namely, ciprofloxacin, chloramphenicol, trimethoprim/sulfamethoxazole, and tigecycline. In conclusion, the Malaysian isolates were highly susceptible to the current antibiotics used in the treatment of melioidosis in Malaysia. Multiple resistances to the antibiotics used in the maintenance therapy are the cause for a concern.
  11. Mohd Jenol NA, Ahmad Pazil NH
    J Relig Health, 2023 Aug;62(4):2933-2946.
    PMID: 36964281 DOI: 10.1007/s10943-023-01798-4
    Vaccine hesitancy is gaining attention due to the increasing spread of the COVID-19 pandemic in Malaysia. Malaysia is a majority Muslim country and religion has a significant influence on the acceptance or rejection of vaccines. This is clearly seen through the disagreement over the  halal status of vaccines. Social media has become a platform for discussion and dissemination of information and dis-information on vaccines. Thus, it has had a relatively significant influence on vaccine hesitancy among social media users. By analysing tweets from February 2020 to February 2021 using Twitter API, this paper highlights the discussion of COVID-19 vaccines' halal status on Twitter. This study focuses on the analysis of vaccination reluctancy among the Twitter users in Malaysia and found that the most prevalent theme from the discussion is the constructed religious narratives to justify scientifically misleading and false claims concerning vaccination represented on social media. This finding also calls for a deeper understanding of society's constructed knowledge concerning contemporary issues in the digital age on social media.
  12. Jane Ling MY, Ahmad N, Aizuddin AN
    PLoS One, 2023;18(6):e0286518.
    PMID: 37262079 DOI: 10.1371/journal.pone.0286518
    BACKGROUND: The burden of non-communicable diseases (NCDs) is increasing. Risk perception of NCDs is an important factor towards the uptake of preventive health interventions. There are various questionnaires assessing risk perception of NCDs, but no internationally standardized questionnaire has been available. Identification of factors associated with risk perception of NCDs may facilitate the development of targeted interventions. This systematic review aims to identify available questionnaire assessing risk perception of NCDs and the factors associated with risk perception of NCDs.

    METHODS: The reporting of this systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We carried out a literature search through three databases (Scopus, PubMed, Web of Science) and targeted original article published in English between 2012 and 2021. Quality appraisal of the eligible articles was conducted using the Mixed Methods Appraisal Tool. Findings were synthesized using content analysis.

    RESULTS: A total of 86 studies were included. We found a variety of questionnaires assessing risk perception of NCDs, with many differences in their development, domains, items and validity. We also identified several personal, sociopsychological and structural factors associated with risk perception of NCDs.

    LIMITATIONS: Most of the included studies were of cross-sectional design, and therefore the quality of evidence was considered low and exhibit a high risk of bias. The role of publication bias within this systematic review should be acknowledged as we did not include grey literature. Additionally, language bias must be considered as we only included English-language publications.

    CONCLUSION: Further development and testing of available questionnaire is warranted to ensure their robustness and validity in measuring risk perception of NCDs. All the identified factors deserve further exploration in longitudinal and experimental studies.

  13. Chin JY, Ahmad AL, Low SC
    J Environ Manage, 2023 Oct 01;343:118231.
    PMID: 37247545 DOI: 10.1016/j.jenvman.2023.118231
    The surge in the use of antibiotics, especially in aquaculture, has led to development of antibiotic resistance genes, which will harm environmental and public health. One of the most commonly used antibiotics in aquaculture is oxytetracycline (OTC). Employing photocatalysis, this study compared OTC degradation efficiency of two different types of common photocatalysts, TiO2 and graphitic carbon nitride (GCN) in terms of their photochemical properties and underlying photocatalytic mechanism. For reference purpose, self-synthesized GCN from urea precursor (GCN-Urea) and commercial GCN (GCN-Commercial) were both examined. OTC adsorption-photocatalysis removal rates in pure OTC solution by TiO2, GCN-Urea and GCN-Commercial were attained at 95%, 60% and 40% respectively. Photochemical properties evaluated included light absorption, band gap, valence and conduction band positions, photoluminescence, cyclic voltammetry, BET surface area and adsorption capability of the photocatalysts. Through the evaluations, this study provides novel insights towards current state-of-the-art heterogeneous photocatalytic processes. The electron-hole recombination examined by photoluminescence is not the key factor influencing the photocatalytic efficacies as commonly discussed. On the contrary, the dominating factors governing the higher OTC degradation efficiency of TiO2 compared to GCN are the high mobility of electrons that leads to high redox capability and the high pollutant-photocatalyst affinity. These claims are proven by 86% and 40% more intense anodic and cathodic cyclic voltammetry curve peaks of TiO2 as compared to both GCNs. OTC also demonstrated 1.7 and 2.3 times higher affinity towards TiO2 than GCN-Urea and GCN-Commercial. OTC removal by TiO2 in real aquaculture wastewater only achieved 50%, due to significant inhibition effect by dissolved solids, dissolved organic matters and high ionic contents in the wastewater.
  14. Ahmad Fatan N, Sivajothy K, Yossa R
    Heliyon, 2023 Jun;9(6):e17221.
    PMID: 37360106 DOI: 10.1016/j.heliyon.2023.e17221
    A 3 × 2 factorial experiment was conducted to investigate the effects of dietary lysine on growth performance, body indices, feed intake, feed efficiency, whole body nutrient composition and amino acid deposition in two successive generations (16th and 17th) of GIFT (Oreochromis niloticus). Three diets containing different levels of lysine at 1.16%, 1.56% and 2.41% were prepared for the feeding trial. Triplicate groups of fish with an initial body weight of 155 g were fed to apparent satiation for 10 weeks in a recirculating aquaculture system. Apparent digestibility coefficients (ADC) of dry matter, crude protein, crude lipids, and total carbohydrates were measured in the experimental diets. At the end of the experiment, no interactions between dietary lysine levels in diet and fish generation were observed on all parameters except for the condition factor (CF) and ADC of crude protein. However, dietary lysine level significantly affected the final weight, weight gain, thermal unit growth coefficient (TGC), protein efficiency ratio (PER) and ADC of dry matter regardless of the fish generation. Final weight, weight gain and TGC of fish were the highest in fish fed 2.41% dietary lysine in diet or 6.52% lysine in the protein. PER was the lowest in fish fed 1.16% dietary lysine. The final weight and the body's accumulation of isoleucine, phenylalanine, and alanine were significantly affected by the fish generation, with the 17th generation having the best performance. Increase growth and higher lysine requirement observed in the improved generation (17th) compared to the (16th) generation at grow out phase indicating that genetic improvement may have changed the dietary lysine requirement.
  15. Noh AAM, Ahmad AH, Salim H
    Sci Rep, 2023 Feb 17;13(1):2854.
    PMID: 36808172 DOI: 10.1038/s41598-023-29499-8
    Studies were conducted on the potential use of cholecalciferol as an alternative to anticoagulant rodenticides to control common rat pest in oil palm plantations, i.e., wood rats, Rattus tiomanicus, and the secondary poisoning impact of cholecalciferol on barn owls, Tyto javanica javanica. The laboratory efficacy of cholecalciferol (0.075% a.i.) was compared with commonly used first-generation anticoagulant rodenticides (FGARs): chlorophacinone (0.005% a.i) and warfarin (0.05% a.i). The 6-day wild wood rat laboratory feeding trial showed cholecalciferol baits had the highest mortality rate at 71.39%. Similarly, the FGAR chlorophacinone recorded a mortality rate of 74.20%, while warfarin baits recorded the lowest mortality rate at 46.07%. The days-to-death of rat samples was in range of 6-8 days. The highest daily consumption of bait by rat samples was recorded for warfarin at 5.85 ± 1.34 g per day while the lowest was recorded in rat samples fed cholecalciferol, i.e., 3.03 ± 0.17 g per day. Chlorophacinone-treated and control rat samples recorded consumption of about 5 g per day. A secondary poisoning assessment on barn owls in captivity fed with cholecalciferol-poisoned rats showed after 7 days of alternate feeding, the barn owls appeared to remain healthy. All the barn owls fed with cholecalciferol-poisoned rats survived the 7-day alternate feeding test and throughout the study, up to 6 months after exposure. All the barn owls did not show any abnormal behavior or physical change. The barn owls were observed to be as healthy as the barn owls from the control group throughout the study.
  16. Yusuf AB, Lim HS, Ahmad Abir I
    Heliyon, 2023 Jun;9(6):e16310.
    PMID: 37274670 DOI: 10.1016/j.heliyon.2023.e16310
    An estimate of the radiogenic heat production (RHP) across the different petrologic units of northeastern, Nigeria was previously not performed. Hence, their geothermal potentials are not widely known. However, an airborne radiometric data of equivalent uranium, (eU), equivalent thorium (eTh,) and percentage potassium (% K) acquired by Nigerian geological survey agency (NGSA) in the year 2009 was deployed in the evaluation of the RHP across the major petrologic outcrops of northeastern, Nigeria. The objective of this study is to estimate the quantity of RHP across the 13 petrologic units of the northeastern Nigerian terrain via the use of an empirical equation (RHP=ρ(0.0952Cu+0.0256CTh+0.0348Ck)). The petrologic units studied are; medium-coarse grained biotite-hornblende granites (OGe), porphyritic biotite-hornblende granites (OGp), banded gneiss (bG), charnokytes (Ch), ignimbrites (JYG), migmatites-gneiss (MG), basalts (bb), Gombe sandstones (GS), Pindiga Formation (PS), Yolde Formation (YL), Bima sandstones (BS), Keri-Keri Formation (KK), and alluvium (AL). Basic/preliminary processing such as; signal integration, signal validation, and examination of spurious data were applied prior to the RHP computation. The results of the heat production analysis performed show the range of RHP to be from 1.11μW/m3 to 3.35μW/m3 Hence, the maximum heat production value of 3.35μW/m3 was recorded along porphyritic biotite-hornblende granites (OGp) rock block, while the least value of 1.11μW/m3 was recorded over alluvium (AL) rock outcrops. Furthermore, the spatial distribution of the RHP values over the study location shows a gradual increase from the middle, low heat production (sedimentary zones) to the high heat producing areas (granitic and metamorphic zones) around eastern and western parts. The petrologic units arranged in order of decreasing magnitude of radiogenic heat generation are; OGp > MG > OGe/bG > bb > GS > Ch > JYG > BS > PS/YL > KK > AL. On a general note, the petrologic units studied were classified as low in terms of geothermal character based on comparison with other previous global RHP studies.
  17. Hoe CYW, Ahmad B, Watterson J
    Diabetes Metab Res Rev, 2024 Feb;40(2):e3722.
    PMID: 37690072 DOI: 10.1002/dmrr.3722
    Diabetes prevalence is rising worldwide, calling for public health concerns and interventions to improve prevention and management. Self-care is an important component in reducing the incidence of complications from diabetes, but it must be taught. This systematic review aims to synthesise the evidence for education videos for people with diabetes. Electronic databases, including Ovid (Medline, Embase, EmCare), PsychInfo, CINAHL, Web of Science and Scopus, were searched for studies on educational videos for patients with diabetes that met the inclusion criteria. A total of 36 studies met the inclusion criteria. Data extracted were synthesised through narrative synthesis. Studies examined outcomes including biological (i.e., glycated haemoglobin (HbA1C), weight, BMI), non-biological (health literacy, self-efficacy) and subjective feedback (i.e., acceptability, cultural appropriateness). The most common length of video was ≤10 min. Online dissemination was the most common method of video distribution. A statistically significant decrease (ranging from -0.1% to -2.1%) in HbA1C was noted in 7 of 12 studies examining this outcome. Other studies also found evidence of improvement in health literacy, self-efficacy, physical activity, medication adherence and other outcomes. Feedback from participants was generally positive, and emphasis was placed on the need for cultural appropriateness and representation in the educational videos.
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