METHODS: A search was conducted on major databases, including PubMed, Web of Science, and ScienceDirect, to identify cases of isolated sixth cranial nerve palsy in patients with pituitary apoplexy. Only six cases were found in the available literature. Descriptive statistics were used to summarize the data, and relevant clinical features were compared between the cases.
RESULTS: Among the six identified cases, isolated sixth cranial nerve palsy in patients with pituitary apoplexy predominantly affected middle-aged adults, with a prominent male preponderance. Clinical manifestations included acute-onset diplopia and headache, with the most common radiologic finding being pituitary gland enlargement or hemorrhage. Laboratory investigations revealed hormonal dysregulation in some cases. Treatment approaches varied and included conservative management and surgical intervention. Outcomes were generally favorable, with most patients experiencing partial or complete resolution of their cranial nerve palsy.
CONCLUSION: Isolated sixth cranial nerve palsy in patients in the context of pituitary apoplexy is an exceptionally rare occurrence, with only six documented cases in the available literature. Further research and case reporting are essential to better understand this rare clinical entity and guide optimal management strategies.
METHOD: The study employed Walker and Avant's conceptual analysis method, which involves a systematic process comprising concept selection, setting objectives, exploring potential uses, defining attributes, constructing a model case, identifying contrary cases, determining antecedents and consequences, and examining empirical referents. A scoping review was conducted across multiple sources, including online dictionaries, scientific databases, and grey literature, with a focus on literature relevant to CFH.
RESULT: A total of 37 articles were reviewed, revealing diverse definitions and interpretations of CFH across various contexts. The concept was defined by five key attributes: (1) child interests-prioritized quality services, (2) child-friendly environments and spaces, (3) social interaction, (4) child participation, and (5) development facilitation. The study also identified the antecedents and consequences of CFH, developed model and contrary cases, and examined empirical referents to offer a comprehensive understanding of the concept.
CONCLUSION: This analysis effectively clarified the concept of CFH, highlighting its core attributes and providing valuable insights for clinical nursing practice. The findings suggest that CFH can be used as a framework to guide child-centered healthcare practices, thereby enhancing the quality of care provided to pediatric patients.
IMPLICATIONS: Conducting a concept analysis of CFH can significantly contribute to improving patient health outcomes, supporting institutional development, and fostering future research and practical applications in child healthcare settings.
OBJECTIVE: This study aims to explore how the experience of the Chinese Great Famine from 1959 to 1961 affects the risk of depressive symptoms among the elderly. Using a mechanism analysis, the study investigates the roles of social support, socioeconomic status, and intergenerational support in this process.
METHODS: Using micro-level individual data from the China Health and Retirement Longitudinal Survey (CHARLS), combined with province-level excess mortality data, this study employs a cohort-based difference-in-differences model to identify the causal effects of the famine experience on depression levels among the elderly.
RESULTS: The study reveals that experiencing the Great Famine significantly increases the risk of depression among the elderly. This effect is more pronounced among rural residents, those who experienced the famine during adolescence, and in regions less influenced by Confucian culture. The mechanism analysis indicates that diminished social support, lower socioeconomic status, and insufficient intergenerational support are the primary pathways through which the famine experience influences depression levels in the elderly.
CONCLUSIONS: The experience of the Great Famine has exerted a long-term and profound impact on the mental health of the elderly in China, particularly in terms of depression. The findings provide new perspectives on understanding the long-term effects of major historical events on health and offer important empirical evidence for the development of mental health intervention policies for the elderly.
AIMS OF STUDY: This review aims to provide a comprehensive overview of the mechanisms involved in wound healing, description of the attributes of ideal wound dressings, understanding of wound healing efficacy of collagen, exploring NPs-mediated drug delivery mechanisms in wound therapy, detailing the synthesis and fabrication techniques of collagen-based NPs, and delineating the applications of various collagen-based NPs infused wound dressings on wound healing.
METHODOLOGY: This review synthesizes relevant literature from reputable databases such as Scopus, Science Direct, Google Scholar, and PubMed.
RESULTS: A diverse array of collagen-based NPs, including nanopolymers, metal NPs, nanoemulsions, nanoliposomes, and nanofibers, demonstrate pronounced efficacy in promoting wound closure and tissue regeneration. The incorporation of collagen-based NPs has not only become an agent for the delivery of therapeutics but also actively contributes to the wound healing cascade.
CONCLUSION: In conclusion, In brief, the use of collagen-based NPs presents a compelling strategy for expediting wound healing processes.