Browse publications by year: 2024

  1. Yeoh ZY, Beh HC, Amirul Amzar Megat Hashim MM, Haireen AH, Chuan DR, Othman S
    PMID: 39534763 DOI: 10.51866/oa.653
    INTRODUCTION: Using quick response (QR) codes to disseminate information has become increasingly popular since the declaration of COVID-19 as a pandemic. We aimed to investigate the feasibility of implementing QR-based quality improvement projects in our clinic to improve patients' medical knowledge, experience and access to care.

    METHODS: We utilised systematic random sampling by recruiting every 25th patient registered in our clinic during data collection. Participants answered a self-administered printed questionnaire regarding their smartphone usage and familiarity with QR code scanning at the patients' waiting area. Data were analysed using the Statistical Package for the Social Sciences version 26.

    RESULTS: A total of 323 patients participated (response rate=100%). The participants' median age was 57 years (interquartile range=4l-67). Most participants were women (63.1%). Approximately 90.4% (n=282) used smartphones, with 83.7% (n=261) reporting average or good usage proficiency. More than half (58.0%) accessed medical information via their smartphones, and 67.0% were familiar with QR codes. Multiple logistic regression analyses revealed that familiarity with QR codes was linked to age of <65 years [adjusted odds ratio (AOR)=4.593, 95% confidence interval (CI)=2.351-8.976, P<0.001], tertiary education (AOR=2.385, 95% CI=1.170-4.863, P=0.017), smartphone proficiency (A0R=4.703, 95% CI= 1.624-13.623, P=0.004) and prior smartphone usage to access medical information (AOR=5.472, 95% CI=2.790-10.732, P<0.001).

    CONCLUSION: Since smartphones were accessible to most primary care patients, and more than half of the patients were familiar with QR code scanning, QR code-based quality improvement projects can be used to improve services in our setting.

  2. Sangaran LN, Kadir AA, Yaacob LH
    PMID: 39534764 DOI: 10.51866/oa.469
    INTRODUCTION: The study aimed to determine the prevalence and associated factors of internet addiction (IA) among early adolescents during the COVID-19 pandemic in Kota Bharu, Kelantan, Malaysia.

    METHODS: A cross-sectional online survey was conducted from February to April 2021 among adolescents in Kota Bharu, Kelantan. Participants completed the Malay Version of the Internet Addiction Test, the Depression, Anxiety and Stress Scale-21 and a sociodemographic information form. A multiple logistic regression analysis was performed to determine the associations between variables.

    RESULTS: A total of 535 adolescents participated in this study. Among them, 65.9% were girls. The prevalence of IA among the participants was 48.6%. Male sex [adjusted odds ratio (AOR)=2.15, 95% confidence interval (CI)=1.30-3.57], internet usage at home (AOR=6.17, 95% CI=1.94-19.58), internet usage to watch/download music (AOR=2.50, 95% CI= 1.52-4.12), internet usage to engage in social networking (AOR=2.29, 95% CI=1.19-4.40), inadequate parental/guardian bonding (AOR=2.19, 95% CI=1.31-3.65), depression (AOR=2.03, 95% CI=1.07-3.85), anxiety (AOR=2.79, 95% CI=1.64-4.76) and stress (AOR=4.67, 95% CI=2.00-10.91) were significantly associated with IA.

    CONCLUSION: IA was prevalent among Malaysian adolescents during the COVID-19 pandemic. Sex, internet usage profile and psychological factors were significant predictors of IA.

  3. Azwan Aziz M, Kunabal P
    PMID: 39534766 DOI: 10.51866/oa.632
    INTRODUCTION: Despite the wide range of injuries sustained by adolescents during karate, limited studies have investigated the type and frequency of sports injuries among adolescent karate athletes. This study would be the first to examine the epidemiology of injuries among adolescent karate athletes. Its objective was to describe the incidence of injuries throughout the 2023 season and the pattern of injuries among Malaysian adolescent karate athletes.

    METHODS: From 1 January to 31 December 2023, this cross-sectional study examined 119 Malaysian adolescent karate athletes aged 13-19 years. Data on demographic characteristics and patterns of injuries were collected using a standardised form and analysed using SPSS version 26.

    RESULTS: The incidence of injuries was 22.3 injuries per 1000 athlete exposures. Specifically, the incidence of injuries during training was 15.34 injuries per 1000 athlete exposures, while that during competition was 106.6 injuries per 1000 athlete exposures. The majority of the injuries were mild (n=113, 87.6%), while the minority were severe (n=6, 4.7%). The injuries most commonly occurred in the head and neck (n=31, 24%), followed by the ankle (n=13, 10.1%) and foot (n=14, 10.9%).

    CONCLUSION: There is a need to explore the extrinsic and intrinsic risk factors of injuries among adolescent karate athletes in Malaysia, as the incidence of injuries is high during competition. Additionally, it is important to educate athletes and supporting sports science members about injury prevention programmes.

  4. Fernando G, Perdamaian TK
    PMID: 39534767 DOI: 10.51866/cm0007
    Palliative care is a vital component of primary healthcare systems, especially in Asia, where the ageing population is expected to increase significantly in the coming years. Integrating palliative care into primary healthcare systems is a crucial strategy for achieving universal access to palliative care. It is necessary to take concurrent actions to achieve this integration, including integrating palliative care into public health policies, educating primary healthcare workers, establishing appropriate service structures and ensuring the availability of controlled medications. Healthcare professionals involved with primary care, often led by physicians, play a significant role in driving the implementation of primary palliative care in Asia, as evidenced by their involvement in community- and home-based palliative care in India and primary palliative care for patients with cancer in Indonesia. However, there are challenges associated with implementing these actions in each country. Therefore, it is crucial to examine the ongoing advocacy efforts, milestones, obstacles and strategies that shape this process in the Asian context.
  5. Abrar SS, Azmel Mohd Isa S, Mohd Hairon S, Yaacob NM, Ismail MP
    Cureus, 2024 Oct;16(10):e71359.
    PMID: 39534844 DOI: 10.7759/cureus.71359
    Cervical cancer is the fourth most common cancer among women worldwide, with particularly high incidence and mortality rates in low- and middle-income countries, with Asia reporting the highest number of cases in 2022. Despite this significant burden, the prognostic factors specific to Asian populations remain underexplored. This scoping review aimed to identify and evaluate prognostic factors associated with cervical cancer outcomes in Asia, focusing on clinical, socio-demographic, and treatment-related variables. The review followed the Arksey and O'Malley framework and included 44 studies published between 2013 and 2023. The majority of research was concentrated in East Asia, particularly in China, Japan, and South Korea. Key prognostic factors affecting overall survival and disease-free survival included tumor size, histology, age, lymphovascular invasion, and lymph node metastasis. Non-squamous cell carcinoma histology, especially adenocarcinoma, was consistently linked to poorer outcomes. Older age and medical comorbidities, such as anemia and diabetes, also negatively impacted survival. Treatment-related factors, though less frequently reported, demonstrated the significance of adjuvant therapy, chemotherapy, and treatment intensity in improving outcomes. This review underscores the complexity of cervical cancer prognosis in Asian populations and highlights the need for targeted research and region-specific interventions to address the rising incidence of cervical cancer. It also highlights the scarcity of research on cervical cancer prognostic factors in West, Central, and South Asian countries. Future research should aim to address the gaps in understanding treatment-related factors and explore the potential for region-specific interventions to improve outcomes in cervical cancer across Asia.
  6. Pratama JH, Rahmawati Z, Widyanto AR, Gunawan T, Wan Abdullah WN, Azua Jamari NL, et al.
    RSC Adv, 2024 Nov 04;14(48):36040-36062.
    PMID: 39534849 DOI: 10.1039/d4ra06262k
    Green diesel as a second-generation biofuel has received enormous attention owing to the huge demand for renewable fuel for addressing the net zero target in 2050. This study examines the development of green diesel research through a bibliometric analysis. The state-of-the-art green diesel research is studied based upon 1285 documents (1153 articles and 132 reviews) retrieved from the Scopus database related to the used keywords. The analysis focused on three categories: publication outcomes, most cited papers, and research area identification. The VOSviewer and RStudio (bibliometrix) were applied to analyse the data, rationalized within the framework of author, affiliation, country, citation analysis, cross-dimensional keyword analysis, research streams, and research gaps. The general result of the study highlighted a continuous incline in article numbers classified into three stages: initiation, exploration, and elevation. Those articles were mainly published in bioenergy-themed journals, including Fuel, Energy & Fuels, and Renewable and Sustainable Energy Reviews. Taufiq-Yap Yun Hin is the highest contributor with 41 articles, and Fuel published 110 articles. The rapid growth of green diesel was also inferred by the extensive spread of research maps worldwide. Amid those swift developments, the state of the art on green diesel through bibliometric analysis is not available to the best of our knowledge as far. Subsequently, this review aims to display the state of the art, research gap, and future forecast of green diesel research.
  7. Salman AM, Mohd MH
    PMID: 39534924 DOI: 10.1080/10255842.2024.2423879
    We examine an SIRS reaction-diffusion model with local dispersal and spatial heterogeneity to study COVID-19 dynamics. Using the operator semigroup approach, we establish the existence of disease-free equilibrium (DFE) and endemic equilibrium (EE), and derive the basic reproduction number, R0. Simulations show that without dispersal, reinfection and limited medical resources problems can cause a plateau in cases. Dispersal and spatial heterogeneity intensify localised outbreaks, while integrated control strategies (vaccination and treatment) effectively reduce infection numbers and epidemic duration. The possibility of reinfection demonstrates the need for adaptable health measures. These insights can guide optimised control strategies for enhanced public health preparedness.
  8. Azra MN, Wong LL, Aouissi HA, Zekker I, Amin MA, Adnan WNW, et al.
    Animals (Basel), 2024 Nov 13;14(22).
    PMID: 39535122 DOI: 10.3390/ani14223259
    The journal retracts the article titled "Crayfish Research: A Global Scientometric Analysis Using CiteSpace" [...].
  9. Jamma A, Vennapoosa CS, Annadata HV, Ghosh B, Govu R, Aggarwal H, et al.
    ACS Appl Mater Interfaces, 2024 Nov 27;16(47):64681-64690.
    PMID: 39535905 DOI: 10.1021/acsami.4c11732
    In this study, we developed a solid-state atomic replacement method for metal catalysts, enabling the exchange of metal atoms between single atoms and nanoalloys to create new combinations of nanoalloys and single atoms. We observed that partial metal interchange occurred between the RuNi nanoalloy and Zn from the zeolitic imidazolate framework-8 (ZIF-8) on a carbon-nitrogen framework (CNF) at a high temperature of 900 °C, leading to the creation of RuZn nanoparticles and single nickel atoms (Ni-CN). Extended X-ray absorption fine structure (EXAFS) and X-ray absorption near edge structure (XANES) analyses revealed that Ni is atomically dispersed within (RuZn)/Ni-CN. This finding confirms the migration of Zn and Ni during the pyrolysis of the RuNi@ZIF-8 precursor, providing definitive evidence of atomic replacement. Due to the synergistic influence of RuZn nanocrystals and Ni-CN, the resulting (RuZn)/Ni-CN multisite catalyst exhibited superior hydrogen evolution reaction (HER) ability compared to the conventional nanoalloy-based catalysts. Density functional theory calculations revealed that the integration of the (RuZn)n cluster on Ni surrounded with different N-coordinated carbon structures enhanced HER activity with the optimized (RuZn)n/NiN2C2 catalyst exhibiting a low ΔGH and improved electron charge redistribution, thereby promoting favorable hydrogen adsorption. Our findings provide valuable insights into the design and optimization of photocatalysts through atomic-level engineering, opening new avenues for efficient and sustainable energy conversion technologies.
  10. Yuan Y, Soh KG, Qi F, Bashir M, Zhao N
    PLoS One, 2024;19(11):e0310955.
    PMID: 39536016 DOI: 10.1371/journal.pone.0310955
    BACKGROUND: Superior physical fitness and performance are essential in male team sports. Among a myriad of training methodologies, high-intensity interval training (HIIT) has gained popularity owing to its unparalleled efficiency and effectiveness. Previous studies have established that HIIT is a proven and effective approach for enhancing various physiological performance outcomes, particularly oxygen consumption capacity, in individual sports. Despite potential differences in training practices between male and female athletes, HIIT is recognized as an anaerobic training approach for team-sport athletes. This systematic review aimed to comprehensively and innovatively analyze the existing literature to examine the effectiveness of HIIT on oxygen consumption performance among male team-sport athletes.

    METHODS: A comprehensive literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines across the PubMed, SCOPUS, Web of Science, and SPORTDiscus databases until December 31, 2023. The inclusion criteria for this review encompassed research articles published in peer-reviewed journals that specifically focused on the impact of HIIT on the oxygen consumption performance of male players engaged in team sports. The study population exclusively consisted of male participants. The collected data included study characteristics, participant demographics, intervention details, and outcomes. Methodological quality assessment was performed using standardized criteria. The effect sizes (ESs) were calculated, and a meta-analysis was conducted using a random-effects model.

    RESULTS: The literature search yielded 13 eligible studies encompassing 286 athletes aged 14-26 years. The meta-analysis showed statistically significant enhancements in maximal oxygen uptake (VO2max) in six studies (ES, 0.19-0.74; p < 0.005), Yo-Yo Intermittent Recovery Test (YYIRT) performance in six studies (ES, 0.20-2.07; p = 0.009), repeated-sprint ability total time (RSAtotal) in five studies (ES, 0.18-1.33; p < 0.001), and the best and average times for repeated-sprint ability (RSAbest and RSAmean, respectively) in four studies (ES, 0.47-1.50; p < 0.001). However, two studies did not report any significant differences in the outcomes of the Velocity in 30-15 Intermittent Fitness Test (VIFT) between the experimental and control groups (ES, -0.08 and -0.27; p = 0.87 and 0.443, respectively). Moreover, one study did not report any significant differences in the maximal aerobic speed (MAS) (ES, 0.41, p = 0.403).

    CONCLUSIONS: HIIT significantly improved VO2max, YYIRT, and RSA; however, it did not appear to enhance VIFT and MAS performance, irrespective of age or competition level. These findings indicate that HIIT could serve as a valuable method for improving oxygen consumption performance (VO2max, YYIRT, and RSA) in male team-sport athletes, offering a time-efficient alternative to the traditional training methods. Further research is warranted to investigate its impact on performance outcomes in competitive settings and identify optimal HIIT protocols tailored to specific team sports.

    MeSH terms: Humans; Male; Athletes*
  11. Uthumange SS, Liew AJH, Chee XW, Yeong KY
    Bioorg Med Chem, 2024 Dec 15;116:117980.
    PMID: 39536361 DOI: 10.1016/j.bmc.2024.117980
    Scaffold-based drug design has become increasingly prominent in the pharmaceutical field due to the systematic and effective approach through which it facilitates the development of novel drugs. The identification of key scaffolds provides medicinal chemists with a fundamental framework for subsequent research. With mounting evidence suggesting that increased aromaticity could impede the chances of developmental success for oral drug candidates, there is an imperative need for a more thorough exploration of alternative ring systems to mitigate attrition risks. The unique characteristics exhibited by three-membered rings have led to their application in medicinal chemistry. This review explores the use of cyclopropane-, aziridine-, thiirane-, and epoxide-containing compounds in drug discovery, focusing on their roles in approved medicines and drug candidates. Specifically, the importance of the three-membered ring systems in rending biological activity for each drug molecule was highlighted. The undeniable therapeutic value and intriguing features presented by these compounds suggest significant pharmacological potential, providing justification for their incorporation into the design of novel drug candidates.
    MeSH terms: Aziridines/chemistry; Chemistry, Pharmaceutical*; Cyclopropanes/chemical synthesis; Cyclopropanes/pharmacology; Cyclopropanes/chemistry; Epoxy Compounds/chemical synthesis; Epoxy Compounds/pharmacology; Epoxy Compounds/chemistry; Humans; Drug Design; Molecular Structure; Drug Discovery*
  12. Martin MB, Chakona A, Kadye WT, Scheepers M
    J Fish Biol, 2024 Nov 13.
    PMID: 39537578 DOI: 10.1111/jfb.15987
    The chubbyhead barbs, a distinct group of fishes endemic to southern Africa, currently include eight valid species. Historically, Enteromius anoplus was the most widespread freshwater fish in South Africa due to synonymizations in the 1960s. It occurred in nearly every river system except coastal systems in the Cape Fold Ecoregion and the lower Orange River. However, a recent revision utilizing molecular and morphological analyses has led to significant taxonomic updates. Enteromius anoplus is restricted to the Gouritz River system, whereas Enteromius cernuus and Enteromius oraniensis have been revalidated and respectively confined to the Olifants and Orange River systems. Additionally, a new species Enteromius mandelai was described, with its range currently considered to encompass several river systems in the Eastern Cape. Despite these advances, the taxonomic status of fish previously assigned to E. anoplus from KwaZulu-Natal remained uncertain. In this study, an integrative approach, combining genetic analysis, morphological characteristics, and geographic data, was employed to resurrect Enteromius karkensis as a distinct species from E. anoplus. Enteromius karkensis is deeply genetically differentiated (3.99%-8.07% p-distance) from its congeners within the chubbyhead group. Morphologically, E. karkensis is easily distinguishable from its counterparts due to possession of a terminal mouth (vs. inferior in E. amatolicus), one pair of maxillary barbels (vs. two conspicuous pairs in E. motebensis, E. treurensis, and E. gurneyi), and a complete lateral line (vs. incomplete in E. anoplus and E. oraniensis). Furthermore, E. karkensis is differentiated from E. mandelai and E. cernuus by its long maxillary barbels that extend beyond the midpoint of the orbit. These findings highlight a consistent pattern from previous studies that show many freshwater fishes in South Africa have narrow geographic ranges. This emphasizes the importance of targeted conservation and management efforts, and our understanding of the biogeographic and evolutionary history of freshwater fishes in southern Africa.
  13. Tang J, Li T, Wang X, Xue H, Zhang D, Liu X, et al.
    Sci Rep, 2024 Nov 13;14(1):27862.
    PMID: 39537656 DOI: 10.1038/s41598-024-76510-x
    To investigate the difference in preoperative retinal function in patients with type 2 diabetes cataract (DC) without obvious retinopathy and to explore the clinical application of full blood glucose management for improving the postoperative vision in DC patients. This was a retrospective analysis in which we estimated the changes in visual electrophysiology (N75, P100, photopic flash electroretinogram(FERG), and scotopic FERG, paraoptic retinal nerve fibre layer thickness (pRNFL) and paraoptic radial capillary network blood flow density (ppVD) of type 2 diabetes (T2DM) patients at different phases of disease progression along with fasting blood glucose (FBG) and glycosylated haemoglobin (HbAlC) levels before and after DC surgery at Ziyang Central Hospital from January 2020 to December 2022. Additionally, trends in the above data throughout the entire process of glucose management intervention were examined. As the course of T2DM progressed, FBG and HbA1c increased, the N75 and P100 latency periods of patients gradually increased, and the values of photopic FERG, scotopic FERG, pRNFL, and ppVD gradually decreased at each postoperative time point. Moreover, the best corrected visual acuity(BCVA) of patients after surgery gradually decreased (P 
    MeSH terms: Aged; Cataract Extraction/methods; Female; Hemoglobin A, Glycosylated/analysis; Hemoglobin A, Glycosylated/metabolism; Humans; Male; Middle Aged; Retina/physiopathology; Retrospective Studies; Visual Acuity*; Tomography, Optical Coherence*
  14. Al-Zubi MA, Ahmad M, Abdullah S, Khan BJ, Qamar W, Abdullah GMS, et al.
    Sci Rep, 2024 Nov 13;14(1):27928.
    PMID: 39537833 DOI: 10.1038/s41598-024-79588-5
    The resilient modulus (MR) of different pavement materials is one of the most important input parameters for the mechanistic-empirical pavement design approach. The dynamic triaxial test is the most often used method for evaluating the MR, although it is expensive, time-consuming, and requires specialized lab facilities. The purpose of this study is to establish a new model based on Long Short-Term Memory (LSTM) networks for predicting the MR of stabilized base materials with various additives during wet-dry cycles (WDC). A laboratory dataset of 704 records has been used using input parameters, including WDC, ratio of calcium oxide to silica, alumina, and ferric oxide compound, Maximum dry density to the optimal moisture content ratio (DMR), deviator stress (σd), and confining stress (σ3). The results demonstrate that the LSTM technique is very accurate, with coefficients of determination of 0.995 and 0.980 for the training and testing datasets, respectively. The LSTM model outperforms other developed models, such as support vector regression and least squares approaches, in the literature. A sensitivity analysis study has determined that the DMR parameter is the most significant factor, while the σd parameter is the least significant factor in predicting the MR of the stabilized base material under WDC. Furthermore, the SHapley Additive exPlanations approach is employed to elucidate the optimal model and examine the impact of its features on the final result.
  15. Bushi G, Gaidhane S, Ballal S, Kumar S, Bhat M, Sharma S, et al.
    BMC Cardiovasc Disord, 2024 Nov 13;24(1):643.
    PMID: 39538129 DOI: 10.1186/s12872-024-04315-x
    BACKGROUND: The global COVID-19 vaccination campaign, with 13.53 billion doses administered by early 2024, has significantly reduced severe illness and mortality. However, potential adverse effects, such as Postural Orthostatic Tachycardia Syndrome (POTS), have raised concerns. This systematic review evaluates the incidence, mechanisms, and clinical implications of POTS following COVID-19 vaccination.

    METHODS: A systematic search of PubMed, EMBASE, and Web of Science was conducted up to June 7, 2024, following PRISMA guidelines to identify studies related to COVID-19 vaccines and POTS. Eligible studies included randomized controlled trials, cohort studies, cross-sectional studies, case-control studies, case series, and case reports. Screening, data extraction, and quality assessment were independently performed by two reviewers using the Joanna Briggs Institute Checklists and the Newcastle-Ottawa Scale.

    RESULTS: Of the 1,531 articles identified, 10 met the inclusion criteria, encompassing a total of 284,678 participants. These studies included five case reports, two case series, one cross-sectional study, one prospective observational study, and one cohort study. The cohort study reported that the odds of new POTS diagnoses post-vaccination were 1.33 (95% CI: 1.25-1.41) compared to the 90 days prior. In contrast, the post-infection odds were 2.11 (95% CI: 1.70-2.63), and the risk of POTS was 5.35 times higher (95% CI: 5.05-5.68) post-infection compared to post-vaccination. Diagnostic findings across studies included elevated norepinephrine levels and reduced heart rate variability. Reported management strategies involved ivabradine, intravenous therapies, and lifestyle modifications.

    CONCLUSION: The risk of POTS following COVID-19 vaccination is lower than that observed post-SARS-CoV-2 infection; however, existing studies are limited by small sample sizes and methodological variability. Further research is needed to clarify the incidence, mechanisms, and long-term outcomes of vaccine-related POTS to inform effective clinical management strategies.

    MeSH terms: Adult; Aged; Female; Humans; Male; Middle Aged; Risk Factors; Vaccination/adverse effects; Incidence; Risk Assessment; Young Adult
  16. Tapaopong P, Chainarin S, Mala A, Rannarong A, Kangkasikorn N, Kusolsuk T, et al.
    Malar J, 2024 Nov 13;23(1):342.
    PMID: 39538241 DOI: 10.1186/s12936-024-05162-z
    BACKGROUND: Recent reports from Thailand reveal a substantial surge in Plasmodium knowlesi cases over the past decades, with a more than eightfold increase in incidence by 2023 compared to 2018. This study investigates temporal changes in genetic polymorphism associated with the escalating transmission of P. knowlesi malaria in Thailand over time using the prominent vaccine candidate, pkmsp1 as a marker.

    METHODS: Twenty-five P. knowlesi samples collected in 2018-2023 were sequenced for the 42-kDa region of pkmsp1 and compared with 24 retrieved sequences in 2000-2009, focusing on nucleotide diversity, natural selection, recombination rate, and population differentiation.

    RESULTS: Seven unique haplotypes were identified in recent samples, compared to 15 in earlier samples. Nucleotide and haplotype diversity were lower in recent samples (π = 0.016, Hd = 0.817) than in earlier samples (π = 0.018, Hd = 0.942). Significantly higher synonymous substitution rates were observed in both sample sets (dS-dN = 2.77 and 2.43, p 

    MeSH terms: Haplotypes; Humans; Polymorphism, Genetic*; Thailand/epidemiology
  17. Yu H, Deng Z, Zahidi I, Fai CM, Liang D, Madsen DØ
    Ecotoxicol Environ Saf, 2024 Nov 01;286:117164.
    PMID: 39396399 DOI: 10.1016/j.ecoenv.2024.117164
  18. Ali L, Alam A, Ali AM, Teoh WY, Altarawneh M
    Ecotoxicol Environ Saf, 2024 Nov 01;286:117196.
    PMID: 39426109 DOI: 10.1016/j.ecoenv.2024.117196
    Halogenated polycyclic aromatic hydrocarbons (HPAHs, H = F, Cl, Br) are a new class of PAHs derivatives that mainly originate from the incomplete combustion of halogen-laden materials and via metallurgical operations. These compounds circulate extensively in various environmental matrices. This survey provides a comprehensive review on governing synthesis routes of HPAHs, their environmental occurrence, and their health and ecological effects. The review comprehensively enlists and presents emission sources of these emerging organic pollutants into the air that serves as their main reservoir. The formation of HPAHs ensues through successive addition reactions of related precursors accompanied by ring cyclization steps; in addition to direct unimolecular fragmentation of parents halogenated. Halogenation of parent PAHs rapidly occurs in saline ecosystems, thus multiplying the availability of these notorious compounds in the environment. Certain HPAHs appear to be more carcinogenic than dioxins. Transmission routes of HPAHs from their emission sources to water bodies, soil, aquatic life, plants, terrestrial animals, and humans are well-documented. Later, the direct and indirect diffusion of HPAHs from air to the biotic (plants, animals, humans) and abiotic components (soil, water, sediments) are described in detail. The study concludes that HPAHs are permeable to the carbon matrices resulting in the alleviation of the source-to-sink interface. As a potential future perspective, understanding the transmission interfaces lays a foundation to intervene in the introduction of these toxicants into the food chain.
    MeSH terms: Animals; Biotransformation*; Environmental Monitoring*; Environmental Pollutants/chemistry; Humans; Hydrocarbons, Halogenated/chemistry; Ecosystem; Halogenation
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