Browse publications by year: 2025

  1. Mariyanti H, Yeo KJ, Klankhajhon S, Arifin H
    SAGE Open Nurs, 2025;11:23779608241312485.
    PMID: 39968386 DOI: 10.1177/23779608241312485
    BACKGROUND: Clinical education is crucial in nursing programs for preparing students to deliver compassionate, high-quality care. However, research on nursing students' perceptions and expressions of caring behaviors in clinical settings is limited, particularly in Indonesia. This study aims to explore Indonesian nursing students' views on caring behaviors in clinical settings, addressing a significant gap in nursing education research within the Indonesian context.

    METHODS: A descriptive phenomenology research design was employed in this study. Nursing students' views and perceptions of caring were obtained through telephone interviews with semistructured questions. The research participants comprised 20 undergraduate nursing students undergoing clinical education at nursing education institutions in Surabaya, Indonesia, obtained through purposive sampling. The recorded interviews were transcribed and analyzed using a phenomenological method. To ensure reliability and validity in the data analysis process, grounded in Husserlian phenomenology and Giorgi's phenomenological method were employed.

    RESULTS: Seven key themes related to the perceptions of caring behavior emerged from the phenomenological analysis: (1) Caring as trying one's best to meet patients' needs; (2) Caring as a central value of nursing practice; (3) Caring as compassion; (4) Caring as helping each other; (5) Caring as awareness of patients' individual needs; (6) Caring as professionalism; and (7) Caring as support.

    CONCLUSION: The findings of this study are expected to significantly improve nursing student application of caring behavior in the clinical setting. Increasing understanding and application of caring behavior in nursing students can have a positive impact on clinical practice. This study is useful as a guide for educators to help nursing students improve their caring practice in the clinical setting.

  2. Palanimuthu D, Yong E, Ramachandran K, Chen IHK
    Cureus, 2025 Jan;17(1):e77639.
    PMID: 39968434 DOI: 10.7759/cureus.77639
    Chickenpox is caused by the varicella-zoster virus (VZV), a DNA virus of the herpes virus family. While typically mild and self-limiting, it poses a high risk of contagion. A generalized pruritic rash is the common initial symptom among pediatric populations. Complications often include bacterial infections of skin lesions, predominantly staphylococcal or streptococcal, which may progress to cellulitis or bullous impetigo. Additionally, it may lead to more severe complications such as cerebellar ataxia, encephalitis, viral pneumonia, hemorrhagic conditions, and joint involvement. We present a case of a 17-month-old male diagnosed with varicella-zoster infection a week prior. His presentation included diffuse swelling in the left neck, accompanied by fever and reduced oral intake. Clinical and radiological assessments confirmed a left neck abscess with multiple cervical lymphadenitis. Following the incision and drainage of the abscess, the patient achieved complete resolution of symptoms with antimicrobial treatment. To the best of our knowledge, this is the first reported case of pediatric varicella-zoster infection complicated by a secondary bacterial skin infection leading to a neck abscess. It underscores the importance for clinicians to perform comprehensive evaluations in patients manifesting secondary skin lesion infections. Early referral to tertiary care facilities is imperative, as neck abscesses, albeit rare, necessitate prompt treatment to avert potential complications.
  3. Silva WFSM, Migliolo L, Silva PS, Lima GMS, Oliveira MDL, Andrade CAS
    Biotechnol Prog, 2025;41(1):e3510.
    PMID: 39324859 DOI: 10.1002/btpr.3510
    Healthcare-associated infections (HAIs) pose significant challenges to global health due to pathogen complexity and antimicrobial resistance. Biosensors utilizing antimicrobial peptides offer innovative solutions. Hylarana picturata Multiple Active Peptide 1 (Hp-MAP1), derived from Temporin-PTA, exhibits antibacterial properties sourced from the skin secretions of the Malaysian fire-bellied frog. An innovative sensing layer was developed for the electrochemical biorecognition of diverse pathogens: Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. Electrochemical impedance spectroscopy differentiated microorganisms based on distinct electrochemical responses. The sensor layer, composed of functionalized multi-walled carbon nanotubes (MWCNTs) associated with Hp-MAP1, exhibited varying levels of charge transfer resistance (RCT) for different microorganisms. Gram-negative species, especially P. aeruginosa, displayed higher RCT values, indicating better impedimetric responses. Excellent LODs were observed for P. aeruginosa (0.60), K. pneumoniae (0.42), E. coli (0.67), and S. aureus (0.59), highlighting the efficacy of the MWCNTs/Hp-MAP1 biosensor in microbial identification. The MWCNTs/Hp-MAP1 biosensor platform presents a promising and effective microbial identification strategy with potential healthcare applications to mitigate HAIs and enhance patient care.
    MeSH terms: Bacteria/isolation & purification; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; Staphylococcus aureus; Dielectric Spectroscopy
  4. Ghapar AAA, Abd Kadir KA, Chu GSE, Tai MLS, Idris MI, New RP, et al.
    Cerebrovasc Dis Extra, 2025;15(1):73-80.
    PMID: 39778533 DOI: 10.1159/000543418
    INTRODUCTION: This case report illustrates the complexities of arrhythmogenic right ventricular cardiomyopathy (ARVC) and its thromboembolic complications resulting in top-of-basilar artery syndrome. We discuss the case of a 37-year-old male with ARVC who presented with acute onset of dizziness, imbalance, and vomiting, leading to the diagnosis of a top-of-basilar artery occlusion (BAO) which was successfully treated.

    CASE PRESENTATION: This case highlights the diagnostic and acute treatment challenges in BAO due to its non-specific symptoms and emphasizes the critical role of CT angiography in detecting occlusive thrombi for timely intervention. With prompt endovascular thrombectomy and bridging intravenous thrombolysis, complete recanalization was achieved and the patient was discharged with modified Rankin Scale (mRS) of 1. Effective management strategies involve assessing ventricular function, detecting arrhythmias, identifying intracardiac thrombi, and implementing individualized stroke prevention measures, such as using direct oral anticoagulants.

    CONCLUSION: This study illustrates the necessity of a multidisciplinary approach in optimizing patient outcomes in acute stroke care. Focusing on the rare condition of ARVC and the specific challenge of top-of-BAOs in this case underscores the intricate interplay between cardiovascular and cerebrovascular pathology leading to improved understanding and management of these conditions.

    INTRODUCTION: This case report illustrates the complexities of arrhythmogenic right ventricular cardiomyopathy (ARVC) and its thromboembolic complications resulting in top-of-basilar artery syndrome. We discuss the case of a 37-year-old male with ARVC who presented with acute onset of dizziness, imbalance, and vomiting, leading to the diagnosis of a top-of-basilar artery occlusion (BAO) which was successfully treated.

    CASE PRESENTATION: This case highlights the diagnostic and acute treatment challenges in BAO due to its non-specific symptoms and emphasizes the critical role of CT angiography in detecting occlusive thrombi for timely intervention. With prompt endovascular thrombectomy and bridging intravenous thrombolysis, complete recanalization was achieved and the patient was discharged with modified Rankin Scale (mRS) of 1. Effective management strategies involve assessing ventricular function, detecting arrhythmias, identifying intracardiac thrombi, and implementing individualized stroke prevention measures, such as using direct oral anticoagulants.

    CONCLUSION: This study illustrates the necessity of a multidisciplinary approach in optimizing patient outcomes in acute stroke care. Focusing on the rare condition of ARVC and the specific challenge of top-of-BAOs in this case underscores the intricate interplay between cardiovascular and cerebrovascular pathology leading to improved understanding and management of these conditions.

    MeSH terms: Adult; Fibrinolytic Agents/administration & dosage; Humans; Male; Vertebrobasilar Insufficiency/complications; Vertebrobasilar Insufficiency/physiopathology; Vertebrobasilar Insufficiency/therapy; Thrombolytic Therapy*; Treatment Outcome; Thrombectomy*
  5. Habib GMM, Uzzaman N, Rabinovich R, Akhter S, Sultana M, Ali M, et al.
    J Glob Health, 2025 Feb 14;15:04002.
    PMID: 39946559 DOI: 10.7189/jogh.15.04002
    BACKGROUND: Pulmonary rehabilitation (PR) is an effective and essential component of care for the increasing number of individuals with chronic respiratory diseases (CRDs). Despite the benefits, it remains underutilised and poorly accessible in low- and middle-income countries (LMICs). We aimed to determine the feasibility of delivering PR in Bangladesh at home because of pandemic travel restrictions.

    METHODS: Aligned with the Medical Research Council framework of development and evaluation of complex interventions, we recruited individuals with CRDs from the Community Respiratory Centre, Khulna, to a mixed-methods feasibility study. We assessed their functional exercise capacity and quality of life before and after an eight-week course of home PR, and conducted semi-structured interviews with PR providers and professional stakeholders by using a topic guide aligned with the normalisation process theory (NPT) and interpreting the findings within its constructs.

    RESULTS: We recruited 51 out of 61 referred patients with a range of CRDs, of whom 44 (86%) completed ≥70% of their home PR course. Functional exercise capacity, measured by the endurance shuttle walk test, improved in 78% of patients, with 48% exceeding the minimum clinically important difference (MCID). Health-related quality of life, measured by the Chronic Obstructive Pulmonary Disease Assessment Test, improved by more than the MCID in 83% of patients. Through the interviews, we found that PR providers encountered challenges in remote video supervision due to unstable internet connections, forcing them to resort to telephone calls. The strength of support for NPT constructs varied; many participants understood and appreciated the role of PR and could make sense of the innovation (NPT-1), and most were assessing the potential of a PR service in Bangladesh to decide if it was worthwhile (NPT-4). Participants were not yet ready to endorse or actively support (NPT-2) or operationalise (NPT-3) the roll-out of PR.

    CONCLUSIONS: A home PR programme, supported by remote supervision and monitoring, is feasible in Bangladesh, but local evidence will be needed to promote implementation.

    MeSH terms: Telerehabilitation; Adult; Aged; Bangladesh; Feasibility Studies*; Female; Humans; Male; Middle Aged; Quality of Life*; Pulmonary Disease, Chronic Obstructive/rehabilitation
  6. Surohedin IH, Ganes T, Yee A, Abd Rashid R, Lim PK
    J Ethn Subst Abuse, 2025 Feb 16.
    PMID: 39955636 DOI: 10.1080/15332640.2025.2457618
    BACKGROUND: The use of non-medical opioids has reached 60 million in 2021. Methadone-assisted treatment (MAT) is a widely used harm-reduction strategy for opioid addiction. However, methadone can cause cognitive impairment, which can impede treatment.

    METHODS: This cross-sectional study was conducted between July 1st and July 31, 2023. A total of 114 participants, comprising 76 MAT patients and 38 healthy subjects (controls), were recruited. Sociodemographic questionnaire, DSM-5 and neuropsychiatric cognitive (NUCOG) assessments were used. A general linear model was used to examine cognitive function between the MMT and control groups while controlling for all possible confounders.

    RESULTS: The MAT group performed significantly lower on the NUCOG total score (p 

  7. Zou A
    J Lesbian Stud, 2025 Feb 16.
    PMID: 39955655 DOI: 10.1080/10894160.2025.2461902
    This article explores The Island of the Lost Plane, a novella written by Li Zishu during her time in Europe that has largely gone unnoticed. Through an analysis of the novella's portrayal of queer intimacy between two immigrant women-one a Sinophone Malaysian and the other a Jewish Israeli-this article examines their healing relationship and how it intertwines with the MH370 accident and the novella's use of the ocean as an ecological trope. This analysis highlights Li Zishu's literary intention to address themes of healing violence, and transnationalism, marking a significant departure from the canonized Sinophone Malaysian literature, which predominantly focuses on violence, rainforests, and heteronormative local experiences. My reading draws from the frameworks of queer Sinophone studies while incorporating perspectives from queer ecology, queer intimacy, and queer world-making. I first analyze how the nationalism and patriarchy tied to each character's origins contribute to their marginalization as "others" in Europe, and how their bond forms despite differences in nationality and ethnicity. This dynamic is metaphorically reflected in their first encounter in the UK. I pay particular attention to the narrator's experiences of discrimination in Germany, which are tied to her Sinophone Malaysian identity, particularly in the aftermath of the MH370 disappearance. These experiences reveal how nationalism, shaped by global power dynamics and rooted in origin narratives, subtly manifests as a form of violence imposed upon her. I then further examine the intimacy between the characters within the imagined oceanic space-an alternative realm that holds the potential to address the colonial violence tied to their respective origins and facilitate the healing of their traumas. By highlighting the peaceful and restorative interactions between the two characters, I argue that this imagined space offers a vision of queer world-making: one that envisions sensory, nonhierarchical, and non-patriarchal worlds that challenge heteronormative structures and dominant power relations.
  8. Ariestanti DM, Mun'im A, Hartrianti P, Nadia B, Chriscensia E, Rattu SA, et al.
    Ultrason Sonochem, 2025 Feb 12;114:107271.
    PMID: 39955874 DOI: 10.1016/j.ultsonch.2025.107271
    Javanese turmeric (Curcuma xanthorrhiza Roxb.) is known for its diverse pharmacological activities due to its rich phytoconstituents, including curcuminoids and xanthorrhizol. Typically, these compounds are extracted using organic solvents, which pose health and environmental risks. Therefore, safer and more environmentally friendly green extraction methods are being developed. This study investigated the effect of ultrasound-assisted extraction (UAE) combined with natural deep eutectic solvents (NADES) based on choline chloride and organic acids (lactic, malic, and citric acid) to find the best combination for extracting curcuminoids and xanthorrhizol from Javanese turmeric. Results showed that UAE using choline chloride and malic acid (1:1) (ChCl-MA) yielded the best results. The Box-Behnken Design optimized water addition, solvent-to-powder ratio, and extraction time, with optimal conditions being 25 % water addition, a 20 mL/g ratio, and a 15-minute extraction time. This method yielded 4.58 mg/g of curcuminoids and 12.93 mg/g of xanthorrhizol. Furthermore, the ChCl-MA NADES with UAE extraction showed more cytoselective activity towards the HeLa cancer cell line compared to the non-cancer HaCaT cell line. In contrast, traditional ethanol extraction was non-selective, as indicated by similar cell viability reductions in both HeLa and HaCaT cells at 6.25 ppm. Collectively, this study is the first to report the optimal NADES combination with UAE, based on salts and organic acids, for the extraction of Javanese turmeric rhizomes with selective cytotoxic effects against cancer cells. These findings may contribute to the development of novel, naturally derived anticancer agents using green extraction techniques.
  9. Bushi G, Gaidhane S, Balaraman AK, Padmapriya G, Kaur I, Lal M, et al.
    J Geriatr Oncol, 2025 Feb 15;16(3):102202.
    PMID: 39955892 DOI: 10.1016/j.jgo.2025.102202
    INTRODUCTION: Falls are a significant health concern among older adults, particularly those with cancer, due to aging-related frailty, treatment-related adverse effects, and comorbidities. Existing reviews have highlighted the burden of falls in this population; however, the absence of a comprehensive meta-analysis to synthesize pooled results from relevant studies has limited the generalizability of their findings. This systematic review and meta-analysis aimed to estimate the global prevalence of falls among older adults with cancer and provide evidence to guide prevention efforts.

    MATERIALS AND METHODS: A systematic search of PubMed, Embase, and Web of Science databases was conducted through October 2024, following PRISMA 2020 guidelines. Studies reporting fall prevalence in patients with cancer aged 65 years or older were included. Pooled prevalence estimates were calculated using a random-effects meta-analysis.

    RESULTS: Seventy-six studies, including 177,212 participants, met the inclusion criteria. The pooled prevalence of falls was 24 % (95 % confidence interval [CI], 20; 28), with significant heterogeneity (I2 = 100 %). Fall prevalence increased with follow-up duration: short-term 12 % (95 % CI, 5.2; 28.4), medium-term 23 % (95 % CI, 18.9; 29.5), and long-term 54 % (95 % CI, 14.9; 89.1) studies (p = 0.13). Older adults with breast cancer had the highest prevalence of falls at 31 % (95 % CI, 17; 48), while patients with colorectal cancer had the lowest at 15 % (95 % CI, 1; 78) (P ≤0.001). Fall prevalence ranged from 19 % in Australia to 24 % in North America (p = 0.89).

    DISCUSSION: Falls are frequent among older adults with cancer, with prevalence varying by cancer type, geographic region, and follow-up duration.

  10. Liao C, Wang F, Li S, Zhao P, Wu W, Zheng Z, et al.
    Acta Psychol (Amst), 2025 Feb 14;254:104799.
    PMID: 39955923 DOI: 10.1016/j.actpsy.2025.104799
    In the increasingly competitive service industry, organizations require frontline employees to deliver customer service while simultaneously driving sales to enhance overall performance. However, employees face significant challenges in balancing these dual tasks. Grounded in social exchange theory, this study adopts a cross-level analysis to examine how group-level self-sacrificial leadership fosters employees' service-sales ambidextrous behavior through leader-member exchange (LMX), harmonious passion and shared vision. Employing structural equation modeling on data collected from 312 employees and their leaders across 20 companies, the findings reveal that self-sacrificial leadership directly promotes service-sales ambidextrous behavior and exerts an indirect influence through LMX and harmonious passion. Moreover, a shared vision within groups significantly enhances the positive effects of LMX and harmonious passion on employees' ambidextrous behavior. These findings highlight key mechanisms underlying the development of service-sales ambidextrous behavior and offer practical insights for organizations to foster flexibility and improve performance in dynamic and high-pressure environments.
  11. Rahman F, Ismail A, Abdullah SA, Amir A, Majid NA
    Mar Pollut Bull, 2025 Feb 15;213:117690.
    PMID: 39955980 DOI: 10.1016/j.marpolbul.2025.117690
    Birds are an excellent bio-indicator of biodiversity changes. Migratory shorebirds in particular cover a large distances traversing different types of habitats, from the tundra region in the most northern part of the world, to tropical and temperate areas in the southern most area. Kuala Gula, a sanctuary for more than 200 bird species is part of an Important Bird and Biodiversity Areas (IBAs) along the East-Asian Australian Flyway. Despite its importance, the area including its coastline is continuously pressured by anthropogenic activity. As such, there is a need to critically review Kuala Gula's environmental status to highlight its potential, along with understanding the issues and threats particularly to the migratory shorebirds population in the long run. This is important not just to maintain Kuala Gula's relevance as part of the important IBA in the Southeast Asia, but also to ascertain its qualification to meet its recognition's goal. Throughout this review, we found that there are several issues that need to be addressed urgently, particularly ones related to pollution activity. Furthermore, the studies done so far are not coordinated well enough and lack continuity. As such, certain important information is still lacking making the protection and conservation of the area a big challenge. It is concluded that, the stability and sustainability of Kuala Gula's habitats and its coastline is at stake, and there is a hope that this review will help related stakeholders to understand the current issues, and work together effectively to conserve the area.
  12. Xie P, Lai J, Lee YY, Xie R, He T, Tan CP, et al.
    Food Chem, 2025 Feb 12;475:143390.
    PMID: 39956073 DOI: 10.1016/j.foodchem.2025.143390
    With the development of the new tea drink market and increasing public attention to health, low-saturated fat aerated emulsions are becoming more popular. However, low saturation levels can easily lead to poor whipping capabilities. This study systematically investigated the mechanisms by which multiple enzyme-modified palm olein, used as a low-saturated fat base in aerated emulsions. After enzyme-catalyzed interesterification, fat crystallization properties were significantly enhanced, primarily through the promotion of fat crystal-membrane interaction effects between fat globules, which in turn, improved whipping capabilities. Additionally, it was found that the DAG form of palm olein easily adsorbed casein, resulting in a significant decrease in serum protein concentration, which weakened overrun due to insufficient air encapsulation. However, the whipping time was significantly reduced. Finally, by combining interesterified fats with DAG, the foam properties were greatly improved. This study provides important guidance for the industrial application of interesterified fats and DAG in aerated emulsions.
  13. Ali M
    Clin Teach, 2025 Apr;22(2):e70040.
    PMID: 39956546 DOI: 10.1111/tct.70040
    Artificial intelligence (AI) is redefining medical education, bringing new dimensions of personalized learning, enhanced visualization and simulation-based clinical training to the forefront. Additionally, AI-powered simulations offer realistic, immersive training opportunities, preparing students for complex clinical situations and fostering interprofessional collaboration skills essential for modern healthcare. However, the integration of AI into medical education presents challenges, particularly around ethical considerations, skill atrophy due to overreliance and the exacerbation of the digital divide among educational institutions. Addressing these challenges demands a balanced approach that includes blended learning models, digital literacy and faculty development to ensure AI serves as a supplement to, rather than a replacement for, core medical competencies. As medical education evolves alongside AI, institutions must prioritize strategies that preserve human-centred skills while advancing technological innovation to prepare future healthcare professionals for an AI-enhanced landscape.
    MeSH terms: Artificial Intelligence*; Clinical Competence; Humans
  14. Doshi M, Rabari V, Trivedi J
    Water Environ Res, 2025 Feb;97(2):e70042.
    PMID: 39956909 DOI: 10.1002/wer.70042
    Microplastics (MPs) are ubiquitous in the marine environment and harmful for biodiversity. This review was based on 311 studies published on various online platforms published between 2006 and 2024 on MP contamination in marine sediment and water in different countries of Asia. The research highlights an increasing trend in MP contamination studies, with China and India. Analytical techniques for sample collection, digestion, flotation, and polymer identification are discussed. Fourier transform infrared spectroscopy (FTIR) emerged as the preferred method for polymer identification. The maximum MP contamination in marine sediments was recorded at Taiwan and Indonesia, while the maximum MP contamination in marine water was recorded in China, Malaysia, and India. The fiber was the most dominant shape. The 1-2 mm and 500 μ-1 mm-sized MPs having blue color were found dominantly. The pollution indices revealed a very high risk of MP contamination in all the Asian countries. PRACTITIONER POINTS: China and India are the leading in publications on MP contamination studies. Common tools used are steel scoop/spatula/shovel for sediment, nets for water. FTIR is the preferred method for polymer identification. Highest MP in sediment of Indonesia and in water of China, Malaysia, and India. Dominant MP shape: fiber; size 1-2 mm and 500 μ-1 mm, blue color.
    MeSH terms: Asia; Seawater/chemistry; Risk Assessment
  15. Govarthnapany N, Gabrhelik R, Singh D
    J Psychoactive Drugs, 2025 Feb 16.
    PMID: 39956995 DOI: 10.1080/02791072.2025.2465797
    Kratom (Mitragyna speciosa) is a medicinal plant in Southeast Asia. While studies continue to highlight kratom's utility among poly-drug users, its context of use and therapeutic relevance appears opaque. This review evaluated studies reporting the therapeutic benefits of kratom use among poly-drug users in Southeast Asia, as perceived by the users. A literature search was conducted and only articles that narrated kratom use in poly-drug users in Southeast Asia were selected. A total of nine articles were reviewed. All the surveys were designed as cross-sectional studies and most (n = 7/9) originated from Malaysia. There were no significant differences in the context and motives of kratom use among poly-drug users in Southeast Asia. Kratom was reportedly ingested for a variety of purposes, but largely as an affordable substitute to opiates and amphetamine-type stimulants. Poly-drug users commonly use kratom to self-manage substance use disorder or drug dependence, decrease drug intake, alleviate withdrawal, and for its rejuvenating effects. Co-consumption was not associated with health issues. While these preliminary studies provided important empirical insights, the limitations in their design, sample selection, and focus underscore the need for further studies, including clinical studies, to establish the safety and claimed therapeutic value of kratom in poly-drug users.
  16. Prabhu D, Dharshini MKD, Rajamanikandan S, Padmavathi AR, Velusamy P, Gopinath SCB
    PMID: 39957355 DOI: 10.1002/bab.2727
    Lymphatic filariasis (LF) is a mosquito-borne disease caused by parasitic nematodes Brugia malayi, Brugia timori, and Wuchereria bancrofti. The drugs available are effective in several cases, and the absence of vaccination is the crucial factor hindering the elimination of LF. The UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase (MurE) plays an important role in the peptidoglycan biosynthesis of Wolbachia endosymbiont B. malayi, which are reported to be a vital drug target for bacterial and endosymbiotic hosts. Thus, we selected the ATP binding cavity of MurE as the potential site to screen inhibitors. The MurE structure was modeled using AlphaFold due to the absence of an experimental structure. Structure-based screening identified five potent phytochemicals targeting the ATP binding site with higher Glide scores and affinity. The top five phytochemicals CID 311, CID 445713, CID 441626, CID 39077, and CID 10814 showed a docking score of -16.812, -16.117, -15.668, -15.324, and -13.442 kcal/mol, respectively. Further, the molecular dynamics simulations depicted the binding stability of the phytochemical inhibitors bound to the MurE complex. Moreover, ADME assessment and Density Functional Theory analyses of the predicted compounds have shown acceptable pharmacokinetic properties and high reactivity with the drug target of MurE.
  17. Perişanoğlu U, Kavaz Perişanoğlu E, Kudaş Z, Ekinci D, Ismail I, Gür E
    Nanoscale, 2025 Feb 17.
    PMID: 39957422 DOI: 10.1039/d5nr00329f
    Flexible supercapacitors (SCs), which are mostly produced from carbon-based materials, are emerging devices for lightweight, portable, miniaturized, and wearable electronic products. However, it is important to improve the energy density, power density and durability of flexible SCs, for which newly developed materials and composites are required. In this study, we developed flexible SCs with enhanced capacitance and stability using the advantages of high volume/surface ratio of vertical two-dimensional MoS2 and WS2 structures. Electrodes were grown on graphenated carbon nanotube (G-CNT) cotton using Radio Frequency (RF) magnetron sputtering in a time varying manner to investigate the impact on the vertical structure densities on the performance of the as-developed SCs. Galvanostatic charge-discharge (GCD) measurements revealed a maximum aerial capacitance value of 131.2 mF cm-2 for the best WS2 electrode and a value of 97.60 mF cm-2 for the best MoS2 electrode. The flexibilities of the SC devices were examined using angle-dependent CV measurements, which revealed almost no change. Stability tests for 10 000 cycles showed a retention rate of over 96% capacitance for both electrodes. This research demonstrates the potential of integrating the conductivity, large surface/volume ratio, and processability of G-CNTs with the unique features of transition metal dichalcogenides to develop SCs with improved efficiencies and flexibilities.
  18. Lakshmipriya T, Gopinath SCB
    PMID: 39957699 DOI: 10.2174/0118715273372575250212091813
    Cerebral or brain infarction is a pathological process that restricts or blocks the supply of blood to the brain due to occlusion or narrowing of cerebral blood vessels. At present, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to image cerebral infarction. Along with imaging, numerous non-invasive external brain monitoring tools are being developed that use a variety of technologies to act as sensors for neurological disorders, including stroke. This review briefly discussed the recent biomarkers for cerebral infarction and its diagnostic system through different biosensors.
  19. Nasrin T, Selvanathan V, Islam MA, Haque MM, Rashid AW, Ahmad Ludin N, et al.
    RSC Adv, 2025 Feb 13;15(7):4892-4903.
    PMID: 39957833 DOI: 10.1039/d4ra06320a
    Cadmium sulfide (CdS) is one of the most important semiconductor materials in solar cells. In this study, different concentrations (0-0.118 M) of 1-butyl-3-methylimidazolium tetrafluoroborate (BMIMBF4) ionic liquid (IL) are introduced as a novel complexing agent in dilute chemical bath deposition of CdS thin films. To comprehend the effectiveness of different ionic liquid concentrations as the complexing agent, the structural, morphological, electrical, and optoelectronic properties of the films were investigated. X-ray diffractogram of the CdS thin film exhibited peaks attributed to wurtzite structure, with peak intensity enhanced dramatically after IL addition. From morphological studies, a pinhole-free and uniformly deposited CdS film with large grain size was observed upon inclusion of 0.069 M IL. Optical characterization has shown good transparency up to 85% from the UV-vis spectroscopy analysis. With the variation of the ionic liquid concentration, there was no major difference observed in the energy bandgap. However, an increment in carrier concentration and reduction in resistivity of the deposited thin films were observed. The film with 0.069 M IL showed the maximum carrier concentration value of 7.51 × 1014 cm-3 with the lowest resistivity. Incorporating the optoelectronic properties of the deposited CdS films, numerical simulations were performed to validate those as electron transport layers for perovskite solar cells with the device structure of FTO/CdS (CdS-0 to CdS-3)/CsSnBr3/P3HT/Ag. Simulation results demonstrated that the fabricated CdS thin film fabricated with 0.069 M BMIMBF4 would be a promising candidate in perovskite solar cells with an efficiency of around 16.5%.
  20. Mohammed M, Zainal H, Ong SC, Tangiisuran B, Aziz FA, Sidek NN, et al.
    Health Sci Rep, 2025 Feb;8(2):e70445.
    PMID: 39957974 DOI: 10.1002/hsr2.70445
    BACKGROUND AND AIMS: There is a lack of population-based studies focusing on guideline-based prognostic models for stroke. This study aimed to develop and validate a prognostic model that predicts mortality following a first-ever acute ischemic stroke.

    METHODS: The study included 899 adult patients ( ≥ 18 years) with confirmed diagnosis of first-ever acute ischemic stroke enrolled in the Malaysian National Stroke Registry (NSR) from January 2009 to December 2019. The primary outcome was mortality within 90 days post-stroke (266 events [29.6%]). The prognostic model was developed using logistic regression (75%, n = 674) and internally validated (25%, n = 225). Model performance was assessed using discrimination (area under the curve (AUC]) and calibration (Hosmer-Lemeshow test [HL]).

    RESULTS: The final model includes factors associated with increased risk of mortality, such as age (adjusted odds ratio, aOR 1.06 [95% confidence interval, CI 1.03, 1.10; p

External Links