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Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers

Navaratnam V 1 , Ramanathan S , Wahab MS , Siew Hua G , Mansor SM , Kiechel JR Show all authors , Vaillant M , Taylor WR , Olliaro P

Affiliations 

  • 1 National Center for Drug Research (CRD), Universiti Sains Malaysia (USM), 11800 Minden, Pulau Pinang, Penang, Malaysia
Eur J Clin Pharmacol, 2009 Aug;65(8):809-21.
PMID: 19404632 DOI: 10.1007/s00228-009-0656-1

Abstract

There is limited pharmacokinetic data available for the combination artesunate + amodiaquine, which is used widely to treat uncomplicated malaria. This study examines the bioavailability and tolerability of a fixed (200 mg artesunate + 540 mg amodiaquine) and loose (200 mg + 612 mg) combination with a 2x2 cross-over design in 24 healthy volunteers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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