Overexpression of DNA methyltransferase 1 (DNMT1) protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase (MGMT) expression

Rahman WF 1 , Rahman KS 1 , Nafi SN 1 , Fauzi MH 2 , Jaafar H 1

Affiliations 

  • 1 Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus Kota Bharu 16150, Kelantan, Malaysia
  • 2 Department of Emergency Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus Kota Bharu 16150, Kelantan, Malaysia
Int J Clin Exp Pathol, 2015;8(6):6095-106.
PMID: 26261487

Abstract

The relationship between DNA methyltransferase (DNMT) and O6-methylguanine-DNA methyltransferase (MGMT) in mediating tumorigenesis is still poorly understood. This study was carried out to investigate a correlation between DNMT1 and MGMT immunoexpression in astrocytic tumour samples.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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