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In vivo toxicity and antitumor activity of essential oils extract from agarwood (Aquilaria crassna)

Dahham SS 1 , Hassan LE 1 , Ahamed MB 1 , Majid AS 2 , Majid AM 3 , Zulkepli NN 4

Affiliations 

  • 1 EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, 11800, Malaysia
  • 2 Department of Pharmacology, School of Medical Sciences, Quest International University, Perak, Malaysia
  • 3 EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, 11800, Malaysia. aminmalikshah@gmail.com
  • 4 Center of Excellence Geopolymer and Green Technology (CEGeoGTech), Faculty of Engineering Technology (FETech), Universiti Malaysia Perlis (UniMAP), UniCITI Alam Campus, 02100, Padang Besar, Perlis, Malaysia. niknoriman@unimap.edu.my
BMC Complement Altern Med, 2016 Jul 22;16:236.
PMID: 27450078 DOI: 10.1186/s12906-016-1210-1

Abstract

Aquilaria crassna has been used in traditional Asian medicine to treat vomiting, rheumatism, asthma, and cough. Furthermore, earlier studies from our laboratory have revealed that the essential oil extract from agarwood inhibited colorectal carcinoma cells. Despite of the wide range of ethno-pharmacological uses of agarwood, its toxicity has not been previously evaluated through systematic toxicological studies. Therefore, the potential safety of essential oil extract and its in vivo anti-tumor activity had been investigated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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