Affiliations 

  • 1 School of Pharmacy, Monash University, Bandar Sunway, Jalan Lagoon Selatan, 46700 Selangor, Malaysia
  • 2 Director and Senior consultant, Aljaber Kidney and Dialysis Center, Alahsa, Eastern Province, Saudi Arabia
  • 3 School of Pharmaceutical Science, University Sains Malaysia Pulau Pinang, Malaysia
Sci Rep, 2016 11 08;6:36555.
PMID: 27824127 DOI: 10.1038/srep36555

Abstract

A prospective, observational, longitudinal study was conducted to assess the effectiveness of 75 mg pregabalin (PG) post-hemodialysis (pHD) for treatment-resistant uremic pruritus (UP). A total of forty-five patients completed the entire six week follow-up. At the baseline assessment, the majority of the patients were distressed by the UP frequency and intensity. Sleep (mean = 3.30 ± 1.1), leisure/social activities (mean = 2.90 ± 0.80) and distribution (mean = 2.92 ± 0.34) were the three domains that were primarily effected by the UP. Overall, further reduction in the 5D-itching scale (IS) was noted at day 42, which confirmed a sustained (B = -12.729, CI -13.257 to -12.201, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.