Affiliations 

  • 1 Faculty of Medicine and Defence Health, National University of Defence, Malaysia
  • 2 Faculty of Medicine, University Teknologi MARA, Sungai Buloh, Selangor, Malaysia
  • 3 Faculty of Medicine, Management Science University, Shah Alam, Selangor, Malaysia
  • 4 Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia
  • 5 Department of Community Health, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia
Korean J. Parasitol., 2015 Feb;53(1):29-34.
PMID: 25748706 DOI: 10.3347/kjp.2015.53.1.29

Abstract

The aim of this cross sectional case control study was to examine the serofrequency and serointensity of Toxoplasma gondii (Tg) IgG, IgM, and DNA among patients with schizophrenia. A total of 101 patients with schizophrenia and 55 healthy controls from Sungai Buloh Hospital, Selangor, Malaysia and University Malaya Medical Center (UMMC) were included in this study. The diagnosis of schizophrenia was made based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The presence of Tg infection was examined using both indirect (ELISA) and direct (quantitative real-time PCR) detection methods by measuring Tg IgG and IgM and DNA, respectively. The serofrequency of Tg IgG antibodies (51.5%, 52/101) and DNA (32.67%, 33/101) among patients with schizophrenia was significantly higher than IgG (18.2%, 10/55) and DNA (3.64%, 2/55) of the controls (IgG, P=0.000, OD=4.8, CI=2.2-10.5; DNA, P=0.000, OD=12.9, CI=2.17-10.51). However, the Tg IgM antibody between patients with schizophrenia and controls was not significant (P>0.005). There was no significant difference (P>0.005) in both serointensity of Tg IgG and DNA between patients with schizophrenia and controls. These findings have further demonstrated the strong association between the active Tg infection and schizophrenia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.