Autophagy in Helicobacter pylori Infection and Related Gastric Cancer

Castaño-Rodríguez N 1 , Kaakoush NO 1 , Goh KL 2 , Fock KM 3 , Mitchell HM 1

Affiliations 

  • 1 School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia
  • 2 Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore City, Singapore
Helicobacter, 2015 Oct;20(5):353-69.
PMID: 25664588 DOI: 10.1111/hel.12211

Abstract

Autophagy, a degradation pathway in which cytoplasmic content is engulfed and degraded by lysosomal hydrolases, plays a pivotal role in infection and inflammation. Given that defects in autophagy lead to increased susceptibility to infection, we investigated the role of autophagy in Helicobacter pylori-related gastric cancer (GC).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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