Displaying publications 1 - 20 of 35 in total

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  1. Islam MR, Abdullah JM
    Malays J Med Sci, 2014 Dec;21(Spec Issue):34-40.
    PMID: 25941461 MyJurnal
    Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are a prognostic genetic model of absence epilepsy. This model displays the electro-clinical, behavioural, and pharmacological features of absence seizures. Although GAERS share typical characteristics, including spike-and-wave discharges (SWDs) in the electroencephalography (EEG), age-dependent studies with these animals have not yet been reported. The aim of the present study is to perform a systematic comparison contrasting the SWDs of young and older GAERS, in terms of the number, duration, frequency, and waveform morphology of the discharges, as well as the pre-SWD EEG characteristics, using identical measurement and analysis techniques. The number, cumulative total duration and mean duration of SWDs were significantly higher in young GAERS (4 to 6 months) compared to older GAERS (12 to 14 months). Furthermore, the SWD spectra and average SWD waveforms indicated that a single cycle of the SWD contains more energy in faster components, such as increased spikes and higher power, in the SWDs of the young GAERS. Additionally, older GAERS showed weak amplitude spikes in SWDs and higher power pre-SWDs. These clear morphological differences in the EEGs of young and older GAERS rats should be further examined in future studies that explore new dimensions of genetic absence epilepsy.
  2. Sharif O, Islam MR, Hasan MZ, Kabir MA, Hasan ME, AlQahtani SA, et al.
    J Healthc Inform Res, 2022;6(1):72-90.
    PMID: 34549163 DOI: 10.1007/s41666-021-00105-8
    The aim of this study is to analyse the coronavirus disease 2019 (COVID-19) outbreak in Bangladesh. This study investigates the impact of demographic variables on the spread of COVID-19 as well as tries to forecast the COVID-19 infected numbers. First of all, this study uses Fisher's Exact test to investigate the association between the infected groups of COVID-19 and demographical variables. Second, it exploits the ANOVA test to examine significant difference in the mean infected number of COVID-19 cases across the population density, literacy rate, and regions/divisions in Bangladesh. Third, this research predicts the number of infected cases in the epidemic peak region of Bangladesh for the year 2021. As a result, from the Fisher's Exact test, we find a very strong significant association between the population density groups and infected groups of COVID-19. And, from the ANOVA test, we observe a significant difference in the mean infected number of COVID-19 cases across the five different population density groups. Besides, the prediction model shows that the cumulative number of infected cases would be raised to around 500,000 in the most densely region of Bangladesh, Dhaka division.
  3. Islam MJ, Rahman M, Broidy L, Haque SE, Saw YM, Duc NH, et al.
    BMC Public Health, 2017 02 10;17(1):183.
    PMID: 28187721 DOI: 10.1186/s12889-017-4067-4
    BACKGROUND: We aimed to examine the influence of witnessing father-to-mother violence on: 1) perpetration of intimate partner violence (IPV); and 2) endorsement of attitudes justifying wife beating in Bangladesh.

    METHODS: This paper used data from the 2007 Bangladesh Demographic Health Survey. The analyses were based on the responses of 3374 ever-married men. Exposure to IPV was determined by men's self-reports of witnessing inter-parental violence in childhood. We used adjusted binary logistic regression models to assess the influence of exposure on husbands' perpetration of IPV and their endorsement of attitudes justifying wife beating.

    RESULTS: Nearly 60% of men reported violent behaviour towards an intimate partner and 35.7% endorsed attitudes justifying spousal abuse. Men who witnessed father-to-mother violence had higher odds of reporting any physical or sexual IPV (adjusted OR [AOR] = 3.26; 95% CI = 2.61, 4.06). Men who had witnessed father-to-mother violence were also 1.34 times (95% CI = 1.08, 1.65) more likely endorse attitudes justifying spousal abuse.

    CONCLUSIONS: Committing violence against an intimate partner is an all too frequent practice among men in Bangladesh. The study indicated that men who had witnessed father-to-mother violence were more likley to perpetrate IPV, suggesting an intergenerational transmission of violence. This transmission of violence may operate through the learning and modelling of attitudes favourable to spousal abuse. In support of this, witnnessing inter-parental violence was also associated with the endorsement of attitudes justifying spousal abuse. Our findings indicate the continued importance of efforts to identify and assist boys who have witnessed domestic violence and suggest such efforts should aim to change not just behaviours but also attitudes that facilitate such violence.

  4. Rahman M, Islam MJ, Haque SE, Saw YM, Haque MN, Duc NH, et al.
    Public Health Nutr, 2017 Feb;20(2):305-314.
    PMID: 27608854 DOI: 10.1017/S136898001600224X
    OBJECTIVE: To explore the association between high-risk fertility behaviours and the likelihood of chronic undernutrition, anaemia and the coexistence of anaemia and undernutrition among women of reproductive age.

    DESIGN: The 2011 Bangladesh Demographic and Health Survey, conducted from 8 July to 27 December 2011.

    SETTING: Selected urban and rural areas of Bangladesh.

    SUBJECTS: A total of 2197 ever-married women living with at least one child younger than 5 years. Exposure was determined from maternal reports of high-risk fertility behaviours. We considered three parameters, maternal age at the time of delivery, birth order and birth interval, to define the high-risk fertility behaviours. Chronic undernutrition, anaemia and the coexistence of anaemia and undernutrition among women were the outcome variables.

    RESULTS: A substantial percentage of women were exposed to have a high-risk fertility pattern (41·8 %); 33·0 % were at single high-risk and 8·8 % were at multiple high-risk. After adjusting for relevant covariates, high-risk fertility behaviours were associated with increased likelihood of chronic undernutrition (adjusted relative risk; 95 % CI: 1·22; 1·03, 1·44), anaemia (1·12; 1·00, 1·25) and the coexistence of anaemia and undernutrition (1·52; 1·17, 1·98). Furthermore, multiple high-risk fertility behaviours appeared to have more profound consequences on the outcome measured.

    CONCLUSIONS: Maternal high-risk fertility behaviours are shockingly frequent practices among women in Bangladesh. High-risk fertility behaviours are important predictors of the increased likelihood of women's chronic undernutrition, anaemia and the coexistence of anaemia and undernutrition.

  5. Islam MR, Chowdhury MR, Wakabayashi R, Tahara Y, Kamiya N, Moniruzzaman M, et al.
    Int J Pharm, 2020 May 30;582:119335.
    PMID: 32311469 DOI: 10.1016/j.ijpharm.2020.119335
    Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (IL-EtOH-IPM) systems consisting of biocompatible ILs, ethanol (EtOH), and isopropyl myristate (IPM) that can dissolve a significant amount of the sparingly soluble drug acyclovir (ACV). The ternary systems were optically transparent and thermodynamically stable with a wide range of IL pertinence. An in vitro drug permeation study showed that the ILs in the ternary systems dramatically enhanced ACV permeation into and across the skin. Fourier Transform Infrared spectroscopy of the stratum corneum (sc) after treatment with ternary systems showed that the skin barrier function was reduced by disturbance of the regularly ordered arrangement of corneocytes and modification of the surface properties of the sc during permeation. Histological analysis, and skin irritation studies using a reconstructed human epidermis model showed the safety profile of the ternary system, and there were no significant changes in the structures of the sc, epidermis, and dermis. Therefore, ternary systems containing biocompatible ILs are promising for transdermal delivery of insoluble or sparingly soluble drugs.
  6. Islam MR, Ali MM, Lai MH, Lim KS, Ahmad H
    Sensors (Basel), 2014;14(4):7451-88.
    PMID: 24763250 DOI: 10.3390/s140407451
    Optical fibers have been involved in the area of sensing applications for more than four decades. Moreover, interferometric optical fiber sensors have attracted broad interest for their prospective applications in sensing temperature, refractive index, strain measurement, pressure, acoustic wave, vibration, magnetic field, and voltage. During this time, numerous types of interferometers have been developed such as Fabry-Perot, Michelson, Mach-Zehnder, Sagnac Fiber, and Common-path interferometers. Fabry-Perot interferometer (FPI) fiber-optic sensors have been extensively investigated for their exceedingly effective, simple fabrication as well as low cost aspects. In this study, a wide variety of FPI sensors are reviewed in terms of fabrication methods, principle of operation and their sensing applications. The chronology of the development of FPI sensors and their implementation in various applications are discussed.
  7. Islam MR, Sheba NH, Islam MT, Rahman MM, Hossain S, Hussain MA, et al.
    J Community Health, 2022 Feb;47(1):136-142.
    PMID: 34491507 DOI: 10.1007/s10900-021-01025-9
    This study aimed to determine the seroprevalence and determinants of hepatitis B virus (HBV) infection among university students in Bangladesh. This cross-sectional study was conducted among 614 students from five universities in central Bangladesh. Data were collected on demographic information, immunization history, medical and blood transfusion history through the face-to-face interview. Blood samples were collected and screened for anti-HBsAg using ELISA, HBsAg Rapid Test-cassette, and immune chromatographic test. The overall seroprevalence of HBV infection was 5.0%, and vaccination coverage was 19.2% among the participants. Students having a history of surgery (OR 11.004, 95% CI 3.211-37.707), blood transfusion (OR 5.651, 95% CI 0.965-33.068), being married (OR 4.776, 95% CI 1.508-15.127), and not being vaccinated (OR 9.825, 95% CI 1.130-85.367) were at higher risk of being infected by HBV. This study showed the endemicity of HBV infection among the Bangladeshi population. Marriage, surgical or blood transfusion history, not being vaccinated were the determinants of HBV infection within the study population. Public health initiatives for preventing HBV infection at the university levels should be envisaged.
  8. Akash S, Baeza J, Mahmood S, Mukerjee N, Subramaniyan V, Islam MR, et al.
    Front Microbiol, 2023;14:1206872.
    PMID: 37497547 DOI: 10.3389/fmicb.2023.1206872
    The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or vaccines exist. Two crucial proteins, LASV glycoprotein and nucleoprotein, play vital roles in pathogenesis and are potential therapeutic targets. As effective treatments for many emerging infections remain elusive, cutting-edge drug development approaches are essential, such as identifying molecular targets, screening lead molecules, and repurposing existing drugs. Bioinformatics and computational biology expedite drug discovery pipelines, using data science to identify targets, predict structures, and model interactions. These techniques also facilitate screening leads with optimal drug-like properties, reducing time, cost, and complexities associated with traditional drug development. Researchers have employed advanced computational drug design methods such as molecular docking, pharmacokinetics, drug-likeness, and molecular dynamics simulation to investigate evodiamine derivatives as potential LASV inhibitors. The results revealed remarkable binding affinities, with many outperforming standard compounds. Additionally, molecular active simulation data suggest stability when bound to target receptors. These promising findings indicate that evodiamine derivatives may offer superior pharmacokinetics and drug-likeness properties, serving as a valuable resource for professionals developing synthetic drugs to combat the Lassa virus.
  9. Islam MR, Abdullah JM, Atoji Y
    Anat Histol Embryol, 2013 Aug;42(4):257-65.
    PMID: 22994540 DOI: 10.1111/ahe.12009
    Bioassay and immunohistochemical studies have detected the presence of prosaposin in the central nervous system (CNS) of mammals. Here, first time, we have determined the partial cDNA sequence of pigeon prosaposin and mapped the distribution of its mRNA in the pigeon CNS. The predicted amino acid sequence of pigeon prosaposin showed 93 and 60% identity to chicken and human prosaposin, respectively. In situ hybridization, autoradiograms showed that the prosaposin mRNA expression was found in the olfactory bulb, prepiriform cortex, Wulst, mesopallium, nidopallium, hippocampal formation, thalamus, tuberis nucleus, pre-tectal nucleus, nucleus mesencephalicus lateralis, pars dorsalis, nucleus isthmi, pars parvocellularis and magnocellularis, Edinger-Westphal nucleus, optic tectum, cerebellar cortex and nuclei, vestibular nuclei and gray matter of the spinal cord. These results suggest that the cDNA sequence of pigeon prosaposin is comparable to other vertebrates, and the general distribution pattern of prosaposin mRNA resembles those are found in mammals.
  10. Haddad A, Habaebi MH, Elsheikh EAA, Islam MR, Zabidi SA, Suliman FEM
    PLoS One, 2024;19(4):e0301371.
    PMID: 38557695 DOI: 10.1371/journal.pone.0301371
    To secure sensitive medical records in the healthcare clouds, this paper proposes an End-to-End Encryption (E2EE) to enhance a patient-centric blockchain-based system for electronic health record (EHR) management. The suggested system with a focus on the patient enables individuals to oversee their medical records within various involved parties by authorizing or withdrawing permission for access to their records. Utilizing the inter-planetary file system (IPFS) for record storage is chosen due to its decentralized nature and its ability to guarantee the unchangeability of records. Then an E2EE enhancement maintains the medical data integrity using dual level-Hybrid encryption: symmetric Advanced Encryption Standard (AES) and asymmetric Elliptic Curve Cryptography (ECC) cryptographic techniques. The proposed system is implemented using the Ethereum blockchain system for EHR data sharing and integration utilizing a web-based interface for the patient and all users to initiate the EHR sharing transactions over the IPFS cloud. The proposed system performance is evaluated in a working system prototype. For different file sizes between 512 KB to 100 MB, the performance metrics used to evaluate the proposed system were the time consumed for generating key, encryption, and decryption. The results demonstrate the proposed system's superiority over other cutting-edge systems and its practical ability to share secure health data in cloud environments.
  11. Hossain MJ, Ahmmed F, Sarker MMR, Sarwar S, Bari MS, Khan MR, et al.
    Front Public Health, 2021;9:807474.
    PMID: 35223762 DOI: 10.3389/fpubh.2021.807474
    Severe session jam phobia (SJP), the extent of underprivileged online education, and subsequent mental health disorders among students have emerged as distinguished global problems due to the overwhelming effects of coronavirus disease 2019 (COVID-19). The purpose of this research was to evaluate the impact of extended COVID-19 lockdown and its mediating factors on current e-Learning activities, the prevalence of severe SJP and psychological distress among university students in Bangladesh. A web-based cross-sectional study was conducted to assemble responses through Google Form by applying a simple snowball sampling technique among university students aged 18 years or above in Bangladesh. All ethical considerations were maintained, and univariate, bivariate, and multivariate analyses were employed to analyze the acquired data set. Among the total analyzed data (n = 1,122), the male and female ratio was almost 1:1, and a remarkable segment (63.7%) was aged between 21-24 years. Alarmingly, around 50-60% of the students were suffering from severe SJP, prevailing underprivileged education in the e-Learning platform, and severe mental distress. Logistic regression analyses demonstrated that the students from public universities, lower- and mid-income families, lower-aged, and junior years education groups were significantly (p < 0.05) more underprivileged than their counter groups. Besides, the monthly family income and university type significantly influenced the extent of severe SJP. Finally, the students who were female, rustic, come from low-income families (below 25,000 BDT), who had academic uncertainty, job insecurity, online exam phobia, and dissatisfaction with e-Learning education, were significantly suffering from moderate to severe mental distress. The current evidence demonstrates that a substantial number of Bangladeshi university students are struggling with extreme session jam phobia, underprivileged e-Learning education, and subsequent psychological distress, which need to be immediately addressed through concerted efforts by the government, parents, and university authorities.
  12. Islam MJ, Ahmad S, Haque F, Reaz MBI, Bhuiyan MAS, Islam MR
    Diagnostics (Basel), 2021 May 07;11(5).
    PMID: 34067203 DOI: 10.3390/diagnostics11050843
    A force-invariant feature extraction method derives identical information for all force levels. However, the physiology of muscles makes it hard to extract this unique information. In this context, we propose an improved force-invariant feature extraction method based on nonlinear transformation of the power spectral moments, changes in amplitude, and the signal amplitude along with spatial correlation coefficients between channels. Nonlinear transformation balances the forces and increases the margin among the gestures. Additionally, the correlation coefficient between channels evaluates the amount of spatial correlation; however, it does not evaluate the strength of the electromyogram signal. To evaluate the robustness of the proposed method, we use the electromyogram dataset containing nine transradial amputees. In this study, the performance is evaluated using three classifiers with six existing feature extraction methods. The proposed feature extraction method yields a higher pattern recognition performance, and significant improvements in accuracy, sensitivity, specificity, precision, and F1 score are found. In addition, the proposed method requires comparatively less computational time and memory, which makes it more robust than other well-known feature extraction methods.
  13. Islam MR, Uddin S, Chowdhury MR, Wakabayashi R, Moniruzzaman M, Goto M
    ACS Appl Mater Interfaces, 2021 Sep 15;13(36):42461-42472.
    PMID: 34460218 DOI: 10.1021/acsami.1c11533
    Since injection administration for diabetes is invasive, it is important to develop an effective transdermal method for insulin. However, transdermal delivery remains challenging owing to the strong barrier function of the stratum corneum (SC) of the skin. Here, we developed ionic liquid (IL)-in-oil microemulsion formulations (MEFs) for transdermal insulin delivery using choline-fatty acids ([Chl][FAs])-comprising three different FAs (C18:0, C18:1, and C18:2)-as biocompatible surface-active ILs (SAILs). The MEFs were successfully developed using [Chl][FAs] as surfactants, sorbitan monolaurate (Span-20) as a cosurfactant, choline propionate IL as an internal polar phase, and isopropyl myristate as a continuous oil phase. Ternary phase behavior, dynamic light scattering, and transmission electron microscopy studies revealed that MEFs were thermodynamically stable with nanoparticle size. The MEFs significantly enhanced the transdermal permeation of insulin via the intercellular route by compromising the tight lamellar structure of SC lipids through a fluidity-enhancing mechanism. In vivo transdermal administration of low insulin doses (50 IU/kg) to diabetic mice showed that MEFs reduced blood glucose levels (BGLs) significantly compared with a commercial surfactant-based formulation by increasing the bioavailability of insulin in the systemic circulation and sustained the insulin level for a much longer period (half-life > 24 h) than subcutaneous injection (half-life 1.32 h). When [Chl][C18:2] SAIL-based MEF was transdermally administered, it reduced the BGL by 56% of its initial value. The MEFs were biocompatible and nontoxic (cell viability > 90%). They remained stable at room temperature for 3 months and their biological activity was retained for 4 months at 4 °C. We believe SAIL-based MEFs will alter current approaches to insulin therapy and may be a potential transdermal nanocarrier for protein and peptide delivery.
  14. Hossain MK, Islam MR, Sundaram RM, Bhuiyan MAR, Wickneswari R
    Front Plant Sci, 2022;13:981345.
    PMID: 36699836 DOI: 10.3389/fpls.2022.981345
    INTRODUCTION: Sheath blight (SB) is the most damaging fungal disease in rice caused by a soil-borne pathogenic fungus, Rhizoctonia solani Kuhn (R. solani). The disease resistance in rice is a complex quantitative trait controlled by a few major genes. UKMRC2 is a newly developed elite rice variety that possesses high yield potential but is susceptible to sheath blight disease indicating a huge risk of varietal promotion, mass cultivation, and large-scale adoption. The aim of our present study was the development of varietal resistance against R. solani in UKMRC2 to enhance its stability and durability in a wide range of environments and to validate the effects of an SB-resistance QTL on the new genetic background.

    METHODS: In our study, we developed 290 BC1F1 backcross progenies from a cross between UKMRC2 and Tetep to introgress the QTL qSBR11-1TT into the UKMRC2 genetic background. Validation of the introgressed QTL region was performed via QTL analysis based on QTL-linked SSR marker genotyping and phenotyping against R. solani artificial field inoculation techniques.

    RESULTS AND DISCUSSION: The QTL qSBR11-1TT was then authenticated with the results of LOD score (3.25) derived from composite interval mapping, percent phenotypic variance explained (14.6%), and additive effect (1.1) of the QTLs. The QTL region was accurately defined by a pair of flanking markers K39512 and RM7443 with a peak marker RM27360. We found that the presence of combination of alleles, RM224, RM27360 and K39512 demonstrate an improved resistance against the disease rather than any of the single allele. Thus, the presence of the QTL qSBR11-1TT has been validated and confirmed in the URMRC2 genetic background which reveals an opportunity to use the QTL linked with these resistance alleles opens an avenue to resume sheath blight resistance breeding in the future with marker-assisted selection program to boost up resistance in rice varieties.

  15. Islam MR, Chowdhury MR, Wakabayashi R, Kamiya N, Moniruzzaman M, Goto M
    Pharmaceutics, 2020 Apr 24;12(4).
    PMID: 32344768 DOI: 10.3390/pharmaceutics12040392
    The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed to enhance the solubility and transdermal delivery of the sparingly soluble drug, acyclovir. The prepared MEs were composed of a hydrophilic IL (choline formate, choline lactate, or choline propionate) as the non-aqueous polar phase and a surface-active IL (choline oleate) as the surfactant in combination with sorbitan laurate in a continuous oil phase. The selected ILs were all biologically active ions. Optimized pseudo ternary phase diagrams indicated the MEs formed thermodynamically stable, spherically shaped, and nano-sized (<100 nm) droplets. An in vitro drug permeation study, using pig skin, showed the significantly enhanced permeation of acyclovir using the ME. A Fourier transform infrared spectroscopy study showed a reduction of the skin barrier function with the ME. Finally, a skin irritation study showed a high cell survival rate (>90%) with the ME compared with Dulbecco's phosphate-buffered saline, indicates the biocompatibility of the ME. Therefore, we conclude that IL/O ME may be a promising nano-carrier for the transdermal delivery of sparingly soluble drugs.
  16. Ashraf QM, Habaebi MH, Islam MR
    PLoS One, 2016;11(9):e0160311.
    PMID: 27583378 DOI: 10.1371/journal.pone.0160311
    Communication abilities of a wireless network decrease significantly in the presence of a jammer. This paper presents a reactive technique, to detect and locate the position of a jammer using a distributed collection of wireless sensor devices. We employ the theory of autonomic computing as a framework to design the same. Upon detection of a jammer, the affected nodes self-configure their power consumption which stops unnecessary waste of battery resources. The scheme then proceeds to determine the approximate location of the jammer by analysing the location of active nodes as well as the affected nodes. This is done by employing a circular curve fitting algorithm. Results indicate a high degree of accuracy in localizing a jammer has been achieved.
  17. Bari MS, Hossain MJ, Ahmmed F, Sarker MMR, Khandokar L, Chaithy AP, et al.
    Vaccines (Basel), 2021 Dec 07;9(12).
    PMID: 34960195 DOI: 10.3390/vaccines9121449
    Vaccine willingness among the mass populace, as well as their proper knowledge and perception regarding vaccines and the vaccination process, may contribute extensively towards attaining their anticipated vaccination rates. The current study endeavored to ascertain the Bangladeshi population's knowledge, perception, and willingness towards COVID-19 vaccination. Relevant information was collected from 1201 adults aged 18 years or older by employing an online-based survey from 1 to 30 July 2021. Descriptive statistics, the chi-square (χ2) test, and a binary logistic regression analysis were applied in order to compare the extent of knowledge and perception prevalent among different demographic groups and correlate such prevalence with respective vaccine willingness. The participants expressed mean (± standard deviation) knowledge and perception scores of 6.48 ± 1.13 out of 8 and 5.37 ± 1.22 out of 7, respectively. A multivariate analysis confirmed the significant association (p < 0.05) of gender, age, and family income with the knowledge score, whereas age and knowledge level significantly influenced perception. Current living area, family income, and age were considerable contributors to COVID-19 vaccine willingness. Overall vaccine willingness was found to be significantly curtailed by inadequate knowledge (AOR 0.514, CI 95% 0.401-0.658, p < 0.001) and perception (AOR 0.710, CI 95% 0.548-0.920, p = 0.010) among the participants. All of the concerned authorities' efforts are warranted in order to improve public understanding, perception, and inclination towards vaccination.
  18. Uddin S, Islam MR, Chowdhury MR, Wakabayashi R, Kamiya N, Moniruzzaman M, et al.
    ACS Appl Bio Mater, 2021 08 16;4(8):6256-6267.
    PMID: 35006923 DOI: 10.1021/acsabm.1c00563
    Lipid-based biocompatible ionic liquids (LBILs) have attracted attention as carriers in transdermal drug delivery systems (TDDSs) because of their lipophilic character. In this study, we report the formulation of a peptide-LBIL complex microencapsulated in an oil phase as a potential carrier for the transdermal delivery of leuprolide acetate as a model hydrophilic peptide. The peptide-LBIL complexes were prepared via a water-in-oil emulsion composed of 1,2-dimyristoyl-sn-glycerol-3-ethyl-phosphatidylcholine (EDMPC), a fatty acid (stearic, oleic, and linoleic acid)-based LBIL, and cyclohexane followed by freeze-drying to remove the water and cyclohexane. Then, the peptide-LBIL complexes were nanodispersed and stabilized in isopropyl myristate (IPM) using sorbitol laurate (Span-20). Ionic-liquid-in-oil nanodispersions (IL/O-NDs) were prepared with varying weight ratios of LBILs and Span-20 as the surfactant and the cosurfactant, respectively. Keeping the overall surfactant constant at 10 wt % in IPM, a 5:5 wt % ratio of surfactant (IL) and cosurfactant (Span-20) in the IL/O-NDs significantly (p < 0.0001) increased the physiochemical stability, drug-loading capacity, and drug encapsulation efficiency. The in vitro and in vivo peptide delivery across the skin was increased significantly (p < 0.0001) using IL/O-NDs, compared with non-IL-treated groups. Of all of the LBIL-based formulations, [EDMPC][Linoleate]/O-ND was considered the most preferable for a TDDS based on the pharmacokinetic parameters. The transdermal delivery flux with [EDMPC][Linoleate]/O-ND was increased 65-fold compared with the aqueous delivery vehicle. The IL/O-NDs were able to deform the lipid and protein arrangements of the skin layers to enhance the transdermal permeation of the peptide. In vitro and in vivo cytotoxicity studies of the IL/O-NDs revealed the biocompatibility of the LBIL-based formulations. These results indicated that IL/O-NDs are promising biocompatible carriers for lipid-peptide TDDSs.
  19. Hossain MA, Ahmad M, Islam MR, David Y
    Health Technol (Berl), 2020;10(2):547-561.
    PMID: 32432021 DOI: 10.1007/s12553-019-00390-9
    At present, the patient care delivery system (PCDS) in a hospital/medical institute/clinic is absolutely medical technology-dependent and this tendency is found to increase day by day. To ensure the quality of patient care (QPC) appropriate implementation of the patient care technology management system (PCTMS) is necessary. Unfortunately, it is found to be absent in the healthcare delivery system in most of the countries in the world. The situation is very much severe, particularly, in medium- and low-income countries like Malaysia, India, Sri Lanka, Bangladesh, Pakistan, etc. The opposite scenario is found in high-income countries, specifically, in Japan where QPC has been improved significantly by adopting the clinical engineering approach (CEA) in their PCDS. Up to now, QPC is determined based on prediction as there are no mathematical ways to evaluate it properly. In this study, we for the first time, propose a mathematical model to evaluate the QPC quantitatively based on feedback control analogy taking into account of CEA in PCTMS, particularly, for clinical and surgical equipment. The model consists of three subsections: the clinical engineering department (CED), PCTMS, and health care engineering directorate (HCED). The correlation among the subsections and their performance parameters are defined and standardized. Multiple linear regression method is applied to derive the least square normal equations for each of the subsections and then the regression coefficients are solved by the standard data taken from 1000 beds hospitals of different countries. The model is applied to reveal the present status of QPC for 18 different countries including high-, middle-, and low-income countries of the world. The results obtained from the model demonstrate that the present status of QPC in Japan is 84.69% and in Pakistan, it is only 0.20%. This huge discrepancy is identified to be caused by the inclusion of CEA in PCDS of Japan. The proposed model can be applied to evaluate the QPC of a hospital/in a country and hence to take necessary steps accordingly for establishing the proposed research methodology. It is to be mentioned here that the proposed model cannot be applied to evaluate the QPC in some countries like Bangladesh, Bhutan, Nepal, etc. due to the unavailability of data related to the model parameters.
  20. Islam MR, Islam MT, Soliman MS, Baharuddin MH, Mat K, Moubark AM, et al.
    Sci Rep, 2021 Nov 05;11(1):21782.
    PMID: 34741089 DOI: 10.1038/s41598-021-01275-6
    In this research paper, an inverse double V loaded complementary square split ring resonator based double negative (DNG) metamaterial has been developed and examined numerically and experimentally. The electromagnetic (EM) properties of the proposed inverse double V-structure were calculated using computer simulation technology (CST-2019) and the finite integration technique (FIT). The designed metamaterial provides three resonance frequencies are 2.86, 5, and 8.30 GHz, covering S-, C-, and X-bands. The total size of the recommended unit cell is 8 [Formula: see text] 8 [Formula: see text] 1.524 mm3, and a high effective medium ratio (EMR) value of 13.11 was found from it. The - 10 dB bandwidths of this structure are 2.80 to 2.91, 4.76 to 5.17, and 8.05 to 8.42 GHz. The proposed structure's novelty is its small size, simple resonator structure, which provides double negative characteristics, high EMR, maximum coverage band, and required resonance frequencies. Wi-Fi network speeds are generally faster when frequencies in the 5 GHz band are used. Since the proposed structure provides a 5 GHz frequency band, hence the suggested metamaterial can be used in Wi-Fi for high bandwidth and high-speed applications. The marine radars operate in X-band, and weather radar works in S-band. Since the designed cell provides two more resonance frequencies, i.e., 2.86 GHz (S-band) and 8.30 GHz (X-band), the proposed metamaterial could be used in weather radar and marine radar. The design process and various parametric studies have been analyzed in this article. The equivalent circuit is authenticated using the advanced design system (ADS) software compared with CST simulated result. The surface current, E-field, and H-field distributions have also been analyzed. Different types of array structure, i.e., 1 [Formula: see text] 2, 2 [Formula: see text] 2, 3 [Formula: see text] 3, 4 [Formula: see text] 4, and 20 [Formula: see text] 25 is examined and validated by the measured result. The simulated and measured outcome is an excellent agreement for the inverse double V loaded CSSRR unit cell and array. We showed the overall performance of the suggested structure is better than the other structures mentioned in the paper. Since the recommended metamaterial unit cell size is small, provides desired resonance frequency, gives a large frequency band and high EMR value; hence the suggested metamaterial can be highly applicable for Radar and Wi-Fi.
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