Displaying publications 1 - 20 of 38 in total

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  1. Fulltext Posterior capsule rupture-causes, associations and outcomes: eight year analysis in a Malaysian General Hospital
    Thevi T, Zin MM
    International Eye Science, 2016;16:600-606.
    AIM: To see the causative factors, associations and outcomes of posterior capsule rupture (PCR). METHODS: A retrospective cohort study was done of all patients with PCR from 2007 to 2014 in Melaka Hospital. Associations between ocular comorbidities, lens related complications, surgeon grade, type of cataract surgery, whether done alone or in combination, with the occurrences of PCR were studied. The final visual outcome of cases with PCR was studied. RESULTS: PCR was the commonest intraoperative complication (n=623, 4.8%) among 12 846 patients. Ocular comorbidities and status of the lens did not cause PCR. Experience and seniority of surgeons were significantly associated with PCR. Medical officers had more PCRs than gazetting specialists (P=0.0000), who inturn had more PCRs than specialists (P=0.000). Each type of cataract surgery done was also significantly associated with PCR-phacoemulsification (phaco), phaco convert to extracapsular cataract extraction (ECCE) and intracapsular cataract extraction (ICCE) (P=0.000), lens aspiration (P=0.020), and ECCE (P=0.003). Specialists got good outcomes compared to trainees without PCR occurring (P=0.001) and also with PCR occurring (P=0.013). However, no difference was observed in the occurrence of PCR in complicated cases between specialists and trainees. Vision was compromised mainly by astigmatism following PCR. Impaired vision (P=0.000) and poor vision (P=0.000) were more than good vision. Poor vision was more in PCR compared to other complications.(P=0.000). CONCLUSION: PCR occurs in all types of cataract surgeries and is the main intraoperative complication causing poor vision. Good outcomes were significantly more when specialists got PCR compared to trainees. Junior surgeons should practice in wet labs and be given more cases. Copyright 2016 by the IJO Press.
    Matched MeSH terms: Vision, Low
  2. Fulltext The causes of low vision and pattern of prescribing at UKM low vision clinic
    Rokiah Omar, Knight, Victor Feizal, Zainora Mohammed
    Jurnal Sains Kesihatan Malaysia, 2008;6(2):55-64.
    MyJurnal
    When medical and surgical intervention cannot alleviate all of the impairments resulting from diseases of the eye, visual rehabilitation can help reduce the disability and increase the quality of life. Data from 169 patients seen at the UKM Low Vision Clinic (UKM LVC) over the past 2 years were examined and analysed. The age ranged from 6 to 87 years of age. The main cause of ocular pathological categories was conduction (63.9%), media (24.9%) and congenital (11.2%) related problems. The main causes of low vision at UKM LVC were congenital cataract, retinitis pigmentosa, glaucoma, cataract and diabetic retinopathy. 84% of these patients received low vision devices to improve their near or/and distance vision. The most common optical devices dispensed at UKM LVC were near high addition spectacle, hand magnifiers and stand magnifiers. Medical, vision care and rehabilitation professionals working together can offer a comprehensive treatment plan for the visually impaired, offering these patients the very best services to increase their quality of life.
    Matched MeSH terms: Vision, Low
  3. Effectiveness of low vision devices in a special education school. [Keberkesanan penggunaan alat bantuan penglihatan terhad]
    Rokiah Omar, Knight VF, Zainora Mohammed
    Sains Malaysiana, 2009;38.
    The purpose of this study is to determine the visual status and effectiveness of low vision devices among visually impaired school children. One hundred and thirteen students from the special education schools took part in this study. Distance and near visual acuity were measured both with and without low vision devices. Students needing further assessment were referred to the Low Vision Clinic (LVC) Universiti Kebangsaan Malaysia. On presentation, 31% of the students were catagorised as low vision with distance acuity between 6/18 and 6/95 whereas 67% were blind. 2% were found to have distance acuity better than 6/18. The range of near visual acuity of these students was between N4 and N64. Low vision devices such as hand held magnifier, stand magnifier and telescope, were owned by only 17% of low vision students. This study showed that 85% of the students that were referred to the LVC benefited from low vision devices. Access to visual examinations and eye care for students with needs to be provided so that these students can be identified early and suitable low vision devices prescribed. This study emphasises the importance of the role played by parents, teachers and optometrists in the management of vision impairment in school children so that their visual impairment can be rehabilitated effectively.
    Keywords: Low vision assessment; low vision devices
    Matched MeSH terms: Vision, Low*
  4. Effects of annealing temperature on the optical properties and device performance of Ag / n-Si / CuPc / Ag solar cell prepared via spin coating method
    Hanashriah Hassan, Noor Baa'yah Ibrahim, Zahari Ibarahim
    Sains Malaysiana, 2010;39.
    Copper phthalocyanine (CuPc) thin films have been prepared using a simple spin coating method. The films were annealed at 5 different temperatures (323, 373, 473, 523 and 573 K) for one hour in air. Optical properties study using the UV-Vis spectrophotometer showed that in the range of wavelength of 300-800 nm, all of the films have identical absorption coefficient patterns and there was no systematic changes with respect to annealing temperature. The film annealed at 373 K showed the highest absorbance while the lowest absorbance was shown by the film annealed at 323 K. The results showed that the optical band gaps depended on the temperature. The film annealed at 373 K has the lowest optical energy gap. Using the five annealed films, solar cell with the configuration of Ag / n-Si / CuPc / Ag were fabricated. Under the 50 W/cm2 light illumination, the current voltage measurements at room temperature were carried out on the device. The device which consists of film annealed at 373 K exhibited the best photovoltaic characteristics. The different annealing temperature also affect the photovoltaic behavior of the devices in a non-systematic way.
    Matched MeSH terms: Vision, Low
  5. Profile of a low vision clinic population
    Mohidin N, Yusoff S
    Clin Exp Optom, 2002 12 17;81(5):198-202.
    PMID: 12482319
    BACKGROUND: Causes of low vision and types of low vision devices (LVDs) prescribed in other low vision clinics have been studied extensively. Similar studies have not been conducted in Malaysia. This paper reports the results of a retrospective study of 573 patients seen at the Universiti Kebangsaan Malaysia-Malaysian Association for the Blind (UKM-MAB) low vision clinic in Kuala Lumpur. METHODS: The record cards of 573 patients seen at the UKM-MAB clinic over 10 years were examined and the following information extracted: date of first consultation, age, sex, cause of visual impairment as diagnosed by an ophthalmologist and types of low vision devices (LVDs) prescribed. RESULTS: The majority of patients were from the younger age groups with 423 (73.8 per cent) less than 50 years of age. Three hundred and ninety-five (68.9 per cent) of the subjects were males and 178 (31.1 per cent) female. The main causes of low vision were congenital structural defects including nystagmus among patients in the zero to 29 years age group, retinitis pigmentosa among the 30 to 59 years age group and age-related macular degeneration (ARM) among those over 60 years of age. CONCLUSIONS: Since the majority of the patients were from the younger age group the main causes of low vision were congenital and hereditary diseases. Three hundred and forty-one (59.5 per cent) patients seen at the low vision clinic accepted the use of LVDs.
    Matched MeSH terms: Vision, Low
  6. Fulltext Review of elderly driver visual perception simulation system for vehicle design
    Ghazilla, R. A. R., Yap, H. J.
    Malaysian Journal of Public Health Medicine, 2016;16(20):113-120.
    MyJurnal
    The number of people above 60 years of age will increases due to the growth of the population in the first half of the 21st century, particularly in Malaysia. This has led to the growing number of older drivers which is often unavoidable as driving is a necessary task that not only achieves mobility but also shows a sign of independence and improves self-esteem, which are essential towards effecting the lifestyle. This paper briefly looks at common elderly related visual impairment, reviews design approaches and tools that tackle or include these issues in the design process and further outlines new research needs. It is the intention of this paper to steer the research direction of the development of future design approach and tools that would enhance the capabilities of designers to be well prepared to cater for inclusive design for the elderly, more specifically for visual impairments issues.
    Matched MeSH terms: Vision, Low
  7. Independent impact of area-level socioeconomic measures on visual impairment
    Zheng Y, Lamoureux E, Finkelstein E, Wu R, Lavanya R, Chua D, et al.
    Invest Ophthalmol Vis Sci, 2011;52(12):8799-805.
    PMID: 21969296 DOI: 10.1167/iovs.11-7700
    It is known that a person's socioeconomic status (SES; individual-level SES) is closely correlated with his or her degree of visual impairment. Whether there is an independent relationship between area-level measures of SES (e.g., living in a lower SES environment) and visual impairment is unclear. This study describes the associations of area-level SES with visual impairment.
    Matched MeSH terms: Vision, Low/diagnosis*; Vision, Low/epidemiology*
  8. Fulltext Arteriovenous malformation in temporal lobe presenting as contralateral ocular symptoms mimicking carotid-cavernous fistula
    Mohd-Tahir F, Siti-Raihan I, Wan Hazabbah WH
    Case Rep Ophthalmol Med, 2013;2013:158961.
    PMID: 23533876 DOI: 10.1155/2013/158961
    Aim. To report a rare case of arteriovenous malformation in temporal lobe presenting as contralateral orbital symptoms mimicking carotid-cavernous fistula. Method. Interventional case report. Results. A 31-year-old Malay gentleman presented with 2-month history of painful progressive exophthalmos of his left eye associated with recurrent headache, diplopia, and reduced vision. Ocular examination revealed congestive nonpulsating 7 mm exophthalmos of the left eye with no restriction of movements in all direction. There was diplopia in left lateral gaze. Left IOP was elevated at 29 mmHg. Left eye retinal vessels were slightly dilated and tortuous. CT scan was performed and showed right temporal arteriovenous malformation with a nidus of 3.8 cm × 2.5 cm with right middle cerebral artery as feeding artery. There was dilated left superior ophthalmic vein of 0.9 mm in diameter with enlarged left cavernous sinus. MRA and carotid angiogram confirmed right temporal arteriovenous malformation with no carotid-cavernous fistula. Most of the intracranial drainage was via left cavernous sinus. His signs and symptoms dramatically improved following successful embolisation, completely resolved after one year. Conclusion. Intracranial arteriovenous malformation is rarely presented with primary ocular presentation. Early intervention would salvage the eyes and prevent patients from more disaster morbidity or fatality commonly due to intracranial haemorrhage.
    Matched MeSH terms: Vision, Low
  9. Fulltext Oral health status of a group of visually impaired school children in Kuala Lumpur
    Afsary Jahan Khan, Mas Suryalis Ahmad, Ahmad Shuhud Irfani Zakaria, Universiti Kebangsaan Malaysia, Tanti Irawati Rosli
    Malaysian Journal of Medicine and Health Sciences, 2020;16(1):100-105.
    MyJurnal
    Introduction: Children with visual impairment are reported to be at higher risk of poor oral health. They faced dif- ficulties in basic skills including oral care. For this reason, they may develop dental caries and periodontal disease. The aim of this study was to assess the oral health status of a group of visually impaired school children in Kuala Lumpur. Methods: A cross-sectional study was carried out on students from a Special Education School in Kuala Lumpur. Oral examination was conducted to determine caries experience and oral hygiene status. Caries was mea- sured using DMFT index and simplified oral hygiene index (OHI-S) for oral hygiene status. Oral examination was based on modified World Health Organization (WHO) oral health assessment criteria for children. Chi-square test was used to determine associations between demographic variables and oral health status. Results: A total of 91 visually impaired students (41 blind, 50 low vision) within the age group of 13 to 17 years old participated in this study. The mean OHI-S score was 1.68 (SD 0.87) with majority of students had fair oral hygiene (39.6%) and 29.7% with poor and very poor oral hygiene. The mean DMFT score of total students were 0.80 (SD 1.62). Male students demonstrated significantly better oral health status than female in relation to prevalence and mean score of dental caries. Conclusion: Most of the visually impaired children in this study showed fair oral health status. Regular oral health education is recommended to improve the oral hygiene especially in the totally blind group.
    Matched MeSH terms: Vision, Low
  10. Fulltext Childhood blindness and severe visual impairment in Malaysia: a nationwide study
    Patel DK, Tajunisah I, Gilbert C, Subrayan V
    Eye (Lond), 2011 Apr;25(4):436-42.
    PMID: 21350565 DOI: 10.1038/eye.2011.19
    To determine the causes of childhood blindness and severe visual impairment (BL/SVI) in schools for the blind in Malaysia.
    Matched MeSH terms: Vision, Low/etiology*
  11. Fulltext Prevalence of retinopathy of prematurity and refractive status in premature infants in Sabah Women and Children Hospital (SWACH)
    Linggam, Rachel Clarice, Mohammed Danial A. Razak, Israk Mohd Isa, Hanisah Abdul Hamid, Shuaibah Abdul Ghani
    Borneo Journal of Medical Sciences, 2020;3(101):13-14.
    MyJurnal
    Introduction: Myopia has been regarded as an important cause of blindness and visual impairment by WHO. Due to higher incidence of myopia in a preterm baby with ROP, early detection and visual rehabilitation need to commence as soon as possible to give the children better quality of life and prevent blindness in this population. To determine the prevalence of ROP and refractive status in premature infants in Sabah Women and Children Hospital, Kota Kinabalu in 2018. To establish the relationship between low BW and GA with the presentation of ROP.
    Matched MeSH terms: Vision, Low
  12. Visual Presentation and Factors Affecting Visual Outcome in Children with Craniopharyngioma in East Coast States of Peninsular Malaysia: A Five-year Review
    Mohd-Ilham IM, Ahmad-Kamal GR, Wan Hitam WH, Shatriah I
    Cureus, 2019 Apr 08;11(4):e4407.
    PMID: 31205829 DOI: 10.7759/cureus.4407
    Purpose To describe the visual presentation and factors affecting visual outcome in pediatric patients treated for craniopharyngioma at a referral center in the East Coast states of Peninsular Malaysia. Methodology A retrospective review of medical records of children aged 17 years and below who had been treated for craniopharyngioma in Hospital Universiti Sains Malaysia from January 2014 to December 2018. The data collected included age, gender, presenting symptoms and duration, visual acuity, visual fields, color vision, light brightness, relative afferent pupillary defects, fundus examination and cranial nerves examination. The best corrected visual acuity during presentation, and after a one-year post-operative period, was documented. Records on investigations, surgical procedures, therapeutic modalities and recurrences were also reviewed. Results A total of 11 pediatric patients (22 eyes) were recruited. Fifty percent presented with optic atrophy. The mean duration of the onset of symptoms before consultation was 22.3 (24.5) months. A final best corrected visual acuity of 6/12 (20/40) or better was observed in 50% of the patients. There was a statistically significant association between presenting visual acuity, optic nerve function and visual field defects, and the final visual outcome. Conclusions Visual presentations in our study were fairly similar to previous reported studies. One-third presented late with permanent visual loss. Almost half had significant visual impairment after one-year post-operative period. Significant associations were observed between presenting visual acuity, duration of symptoms, impairment of optic nerve function tests, and visual field defects during presentation, and final visual acuity at one year after treatment.
    Matched MeSH terms: Vision, Low
  13. Prevalence and causes of functional low vision in school-age children: results from standardized population surveys in Asia, Africa, and Latin America
    Gilbert CE, Ellwein LB, Refractive Error Study in Children Study Group
    Invest Ophthalmol Vis Sci, 2008 Mar;49(3):877-81.
    PMID: 18326706 DOI: 10.1167/iovs.07-0973
    Data on the prevalence and causes of functional low vision (FLV) in adults and children are lacking but are important for planning low-vision services. This study was conducted to determine the prevalence and causes of FLV among children recruited in eight population-based prevalence surveys of visual impairment and refractive error from six countries (India [2 locations]; China [2 locations]; Malaysia, Chile, Nepal, and South Africa).
    Matched MeSH terms: Vision, Low/etiology*; Vision, Low/epidemiology*
  14. Fulltext Oral hygiene practices among the visually impaired adolescents
    Azrina, A.N., Norzuliza, G., R. Saub, R.
    Ann Dent, 2007;14(1):1-6.
    MyJurnal
    The purpose of this study was to gather information on the oral hygiene behaviour among the visually impaired adolescents. Interview and observation methods were used to collect data. A total of 114 visually impaired adolescents were interviewed and 10 of the interviewees were selected for observation on the actual oral hygiene practices. The mean age of the sample was 16 years old. The sample comprised of 53.5% female, majority were Malays (86.8%) and most of them were from the lower income group. Fifty four percent of the sample had low vision and 45.6% were blind. All of the participants reported that they brushed their teeth daily and most of them brushed twice a day or more. Flossing (6.1%) was not common practice among this group. It was observed that they encountered some difficulties, especially when putting the toothpaste on the toothbrush and also the way that they brushed their teeth could cause detrimental effect to the oral cavity. Thus, they need to be taught on proper oral hygiene care so that they can practice safe oral hygiene care and maintain their own oral health.
    Matched MeSH terms: Vision, Low
  15. Fulltext Full thickness macular hole: Early intervention is an important factor in visual prognosis
    Ng HK, Yaakub A, Ong LB
    Malays Fam Physician, 2014;9(3):42-8.
    PMID: 26425305 MyJurnal
    Full thickness macular hole is an eye disease, which can cause permanent visual impairment. Current advancement in vitreoretinal surgery has high success rates in repairing them, leading to a significant visual improvement, especially if patient presents early. In this article, three cases of idiopathic full thickness macular hole with different visual outcomes have been presented. All cases were referred by the primary care practitioners and had undergone macular hole surgery with the same vitreoretinal surgeon. The visual outcome was best in the patient who had the earliest presentation and referral. Early detection and referral of these patients is vital so that early surgical intervention can be carried out to improve their vision.
    Matched MeSH terms: Vision, Low
  16. Fulltext The status of Malaysian school children’s visual acuity from year 1990 to 2017
    Saidatul Norbaya Buang, Abdul Shukor Salha, Marhaida Mahmood, Noor Haire Sumarlie Nordin
    Malaysian Journal of Medicine and Health Sciences, 2019;15(104):100-100.
    MyJurnal
    Introduction: Refractive error is the most common cause of visual impairment among the school children. The visual acuity screening has long been administered through the school health service in Malaysia. The objective of this study was to examine the status of refractive error in the school health screening from year 1990 to 2017. Methods: Every year an average of 1.2 million students were screened for refractive errors through school health service. Stu-dents with visual acuity reading of 6/9 or worst based on 6-meter Snellen chart ware referred for confirmation of refractive error. Secondary data on school visual acuity screening from the Health Informatics for the period of 1990 to 2017 were used to describe the changing pattern of refractive errors. Results: It was observed that the prevalent of suspected refractive errors amongst the Standard 1 student increased from 7 per 1,000 students examined in 1990 to 44.4 per 1,000 students in the 2000 and further increased to 74 per 1,000 students before slow decline to 55 per 1,000 students from year 2015 to 2017. A higher level of detection was observed for students in standard 6 and form 3 between the period of 1990 to 2009 (78/1,000 and 65/1,000 respectively) and further decline thereafter to lowest level in 2017 (33/1,000 to 21.5/1,000 respectively). Conclusion: The Standard 1 students in the 21st century have higher rate of suspected refractive errors compared to their counterpart that lived in the 20th century. Community awareness program need to be introduce for early detection of visual acuity problem.
    Matched MeSH terms: Vision, Low
  17. Fulltext Visual status and prevalence of refractive error among preschool children from amblyopia and vision impairment screening (AVIS) programme in Kota Kinabalu [Abstract]
    Linggam, Rachel Clarice, Arifah Nur Bt Yahya, Muhassanah Aliah Bt Baharum
    Borneo Journal of Medical Sciences, 2019;2(101):15-16.
    MyJurnal
    Introduction: Vision is an important requirement for learning and plays a critical role in the development of a child during the first three years of life. Little is known regarding the extent of visual impairment amongst preschool children in Sabah.
    Objective: To determine visual status among preschool children in Kota Kinabalu and to determine prevalence of refractive error among children who were referred by the programme.
    Methodology: A retrospective cohort study of clinical records was conducted at Department of Ophthalmology, Hospital Queen Elizabeth, Kota Kinabalu, Sabah from May to September 2017. Criteria for failed vision were VA 6/12 (0.3 LogMar) or worse. All records of referred children were selected for prevalence of refractive error. Data collected include basic demographic data, visual acuity and refractive error. Myopia was defined as spherical equivalent (SE) ≥−1.00 DS, hyperopia SE ≥+3.00 DS and astigmatism ≥−1.50 DC.
    Results: A total of 192 children age 4 to 6 years old were screened, comprised of 102 (53.1%) male and 90 (46.9%) female (mean age: 5.81 ± 0.41 years). Of the 192 students, 39 (20.3%) of them failed vision screening. Among the 39 children, only 17 children came for further eye assessment. Twelve (70.6%) of them had a binocular visual impairment (VI) while 5 (29.4%) children had monocular VI. Six years old children were found to have VI more compared to other age groups (n= 14, 82.4%) and majority of this age group having binocular VI (n=10, 83.3%). Mean SE was −0.60 ± 0.94. Astigmatism is the commonest type of refractive error found with a prevalence of 41.4% followed by myopia, 27.6%.
    Conclusion: This study was the first attempt to investigate the visual status among preschool in Kota Kinabalu. As most children were found with astigmatism, early detection of significant refractive error could help to minimize the effect of VI.
    Matched MeSH terms: Vision, Low
  18. Fulltext Mental health state and quality of life questionnaire in low vision assessment: a case report
    Omar R, Rahman MH, Knight VF, Mustaphal M, Mohammed Z
    BMC Res Notes, 2014;7:667.
    PMID: 25245590 DOI: 10.1186/1756-0500-7-667
    BACKGROUND: Vision impairment associated with diabetic retinopathy, is well known and low vision rehabilitation is always recommended. In this report, the importance of objective measure of mental health and quality of life screening in diabetic retinopathy low-vision assessment is discussed.
    CASE PRESENTATION: We describe the case of a 43-year-old Asian female who has mild vision impairment due to tractional retinal detachment secondary to diabetic retinopathy and how mental health screening and quality of life screening during low vision rehabilitation can improve in the management of this patient.
    CONCLUSION: Although vision impairment was mild, the psychological impact was enormous and affected her quality of life substantially. This case report illustrates that recognition of the mental health and quality of life impact on visual impairment is critical to the rehabilitation management of low vision patients with diabetic retinopathy.
    Matched MeSH terms: Vision, Low/physiopathology*
  19. Use of technology by orientation and mobility professionals in Australia and Malaysia before COVID-19
    Deverell L, Bhowmik J, Lau BT, Al Mahmud A, Sukunesan S, Islam FMA, et al.
    Disabil Rehabil Assist Technol, 2020 Jul 09.
    PMID: 32643468 DOI: 10.1080/17483107.2020.1785565
    PURPOSE: Orientation and Mobility (O&M) professionals teach people with low vision or blindness to use specialist assistive technologies to support confident travel, but many O&M clients now prefer a smartphone. This study aimed to investigate what technology O&M professionals in Australia and Malaysia have, use, like, and want to support their client work, to inform the development of O&M technologies and build capacity in the international O&M profession.

    MATERIALS AND METHODS: A technology survey was completed by professionals (n = 36) attending O&M workshops in Malaysia. A revised survey was completed online by O&M specialists (n = 31) primarily in Australia. Qualitative data about technology use came from conferences, workshops and interviews with O&M professionals. Descriptive statistics were analysed together with free-text data.

    RESULTS: Limited awareness of apps used by clients, unaffordability of devices, and inadequate technology training discouraged many O&M professionals from employing existing technologies in client programmes or for broader professional purposes. Professionals needed to learn smartphone accessibility features and travel-related apps, and ways to use technology during O&M client programmes, initial professional training, ongoing professional development and research.

    CONCLUSIONS: Smartphones are now integral to travel with low vision or blindness and early-adopter O&M clients are the travel tech-experts. O&M professionals need better initial training and then regular upskilling in mainstream O&M technologies to expand clients' travel choices. COVID-19 has created an imperative for technology laggards to upskill for O&M tele-practice. O&M technology could support comprehensive O&M specialist training and practice in Malaysia, to better serve O&M clients with complex needs.Implications for rehabilitationMost orientation and mobility (O&M) clients are travelling with a smartphone, so O&M specialists need to be abreast of mainstream technologies, accessibility features and apps used by clients for orientation, mobility, visual efficiency and social engagement.O&M specialists who are technology laggards need human-guided support to develop confidence in using travel technologies, and O&M clients are the experts. COVID-19 has created an imperative to learn skills for O&M tele-practice.Affordability is a significant barrier to O&M professionals and clients accessing specialist travel technologies in Malaysia, and to O&M professionals upgrading technology in Australia.Comprehensive training for O&M specialists is needed in Malaysia to meet the travel needs of clients with low vision or blindness who also have physical, cognitive, sensory or mental health complications.

    Matched MeSH terms: Vision, Low
  20. Use of recombinant tissue plasminogen activator for treatment of recalcitrant anterior uveitis: A case series
    Patrick S, Hui-Tze C, Wan-Hazabbah WH, Zunaina E, Azhany Y, Liza-Sharmini AT
    J Taibah Univ Med Sci, 2018 Oct;13(5):483-487.
    PMID: 31435366 DOI: 10.1016/j.jtumed.2018.03.005
    Management of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt-Koyanagi-Harada disease, respectively. A 40-year-old woman presented with bilateral redness and vision reduction that had persisted 2 weeks. She also had bilateral anterior uveitis, vasculitis, retinitis, and optic disc swelling. Serology was positive for Bartonella henselae and Toxoplasma gondii. She was treated using long-term systemic corticosteroids and appropriate antibiotics. Our second case; a healthy 30-year-old man with bilateral eye redness and reduced vision without pain, and associated with headache and tinnitus for 1 weeks. He showed bilateral granulomatous inflammation with vitritis, choroiditis, retinitis, and hyperemic optic disc. The patient was diagnosed with Vogt-Koyanagi-Harada disease and treated with systemic corticosteroids. Both patients developed secondary cataracts and glaucoma that necessitated surgical intervention. Persistent chronic inflammation led to the formation of a thick fibrin membrane anterior to the intraocular lens (IOL) after phacoemulsification surgery with IOL implantation. This membrane was removed surgically, and intracameral injection of rtPA (25 μg) was carried out. The persistent inflammation had resolved and visual acuity had significantly improved within 1 week of intracameral rtPA injection. There were no reported ocular or systemic side effects. Intracameral rtPA is beneficial in patients with recalcitrant anterior uveitis who have undergone intraocular surgery. In most cases, surgical intervention improves the patients' vision. Intracameral rtPA should be considered in cases of persistent inflammation of varying etiology.
    Matched MeSH terms: Vision, Low
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