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  1. Pseudaspidimerus palatus, a new species of the genus Pseudaspidimerus Kapur, 1948 from the Malay Peninsula (Coleoptera, Coccinellidae)
    Huo L, Li W, Wang X
    Zookeys, 2017.
    PMID: 29118623 DOI: 10.3897/zookeys.706.18081
    A new species of the genus Pseudaspidimerus Kapur, 1948 (Coleoptera: Coccinellidae), Pseudaspidimerus palatus Huo & Wang, sp. n. from the Malay Peninsula is described with illustrations and a distribution map. The genus Pseudaspidimerus is recorded for the first time from Malaysia and Singapore.
    Matched MeSH terms: Malaysia
  2. The Mosses of Crocker Range Park, Malaysian Borneo
    Suleiman M, Masundang DP, Akiyama H
    PhytoKeys, 2017.
    PMID: 29118647 DOI: 10.3897/phytokeys.88.14674
    This paper reports the mosses from Crocker Range Park (CRP) in Sabah, Malaysian Borneo. In total, 293 species, three subspecies and eight varieties belonging to 118 genera and 36 families are reported. This represents about 40% and 47% of the species and infra-specific taxa reported from Borneo and Sabah, respectively. Out of these, six species are new records for Borneo, namely Barbella horridula, Chaetomitrium lancifolium, Distichophyllum leiopogon, Rhaphidostichum luzonense, Rosulabryum capillare and Taxiphyllum taxirameum and 12 species and one variety are new to Sabah. With these additions, the current number of mosses in Sabah and Borneo are 651 and 766, respectively. The largest family of mosses is Calymperaceae with 35 species and one subspecies, followed by Sematophyllaceae with 32 species and two varieties and Pylaisiadelphaceae with 21 species and one variety. In conclusion, CRP has a very high species richness of mosses which is the second highest in Borneo, after Mount Kinabalu.
    Matched MeSH terms: Malaysia
  3. Fulltext Transcriptome data of Epinephelus fuscoguttatus infected by Vibrio vulnificus
    Jazamuddin FM, Aizat WM, Goh HH, Low CF, Baharum SN
    Data Brief, 2018 Feb;16:466-469.
    PMID: 29255779 DOI: 10.1016/j.dib.2017.11.024
    Vibriosis disease by Vibrio spp. greatly reduced productivity of aquaculture, such as brown-marbled grouper (Epinephelus fuscoguttatus), which is an economically important fish species in Malaysia. Preventive measures and immediate treatment are critical to reduce the mortality of E. fuscoguttatus from vibriosis. To investigate the molecular mechanisms associated with immune response and host-bacteria interaction, a transcriptomic analysis was performed to compare between healthy and Vibrio-infected groupers. This permits the discovery of immune-related genes, specifically the resistance genes upon infection. Herein, we provide the raw transcriptome data from Illumina HiSeq. 4000 that have been deposited into NCBI SRA database with the BioProject accession number PRJNA396437. A total of 493,403,076 raw sequences of 74.5 Gb were obtained. Trimming of the raw data produced 437,186,232 clean reads of ~58 Gb. These datasets will be useful to elucidate the defence mechanisms of E. fuscoguttatus against Vibrio vulnificus infection for future development of effective prevention and treatment of vibriosis.
    Matched MeSH terms: Malaysia
  4. Labisia pumila prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model
    Madzuki IN, Lau SF, Che Ahmad Tantowi NA, Mohd Ishak NI, Mohamed S
    Inflammopharmacology, 2018 Oct;26(5):1207-1217.
    PMID: 29460078 DOI: 10.1007/s10787-018-0452-6
    The tropical herb Labisia pumila is traditionally used in facilitating childbirth and post-partum care. The effects of L. pumila leaf extract (LP) in explant cartilage culture and on postmenopausal osteoarthritis (OA) rat model were assessed. The LP (10, 25 and 50 µg/ml) or diclofenac (10 µg/ml) was added to the cartilage explants containing bovine IL-1β (20 ng/ml), to evaluate their direct effects on cartilage degradation. In the preclinical study, rats were grouped (n = 8) into: non-treated OA; OA + diclofenac (5 mg/kg); OA + LP extract (150 and 300 mg/kg); and healthy control. To induce OA, monosodium iodoacetate was injected into the ovariectomised female rats' intra-articular knee joints and evaluated for OA severity after 8 weeks via physical (radiological, macroscopic and histological observations), biochemical, ELISA and mRNA expression analysis (for inflammation and cartilage degradation biomarkers). The LP reduced the nitric oxide and proteoglycan release from the cartilage explants under IL-1β induction. The radiological, macroscopic, microscopic and histological images showed the OA rats treated with LP and diclofenac had significantly reduced osteophytes and cartilage erosions compared to non-treated OA rats. The extract significantly up-regulated the anti-inflammatory interleukin-10, collagen type II and down-regulated pro-inflammatory PTGS2 (prostaglandin-endoperoxide synthase 2) mRNA expressions compared to non-treated control. The LP treatment significantly reduced serum collagenases (MMP-1 and MMP-3) and collagen type II degradation biomarker (CTX-II) levels in OA rats. The LP containing myricetin and gallic acid suppressed inflammation, collagenases and cartilage degradation, and helped cartilage matrix synthesis, to prevent OA at the dose equivalent to 30-60 mg/kg daily for humans.
    Matched MeSH terms: Malaysia
  5. Fulltext Beyond the joints in rheumatoid arthritis: Effects of adalimumab on hematologic and lipid indices
    Sakthiswary R, Syahrul Sazliyana S, Mohd Shahrir MS, Shahril NS, Hussein H
    EXCLI J, 2012;11:142-9.
    PMID: 27385955
    Tumor necrosis factor alpha (TNFα) is a multifunctional cytokine which plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA). Apart from its well recognized proinflammatory properties, it is known to interfere with lipid metabolism and erythropoiesis. We evaluated the effects of adalimumab on hematologic, lipid and inflammatory parameters using data from patients on adalimumab 40 mg fortnightly from 2 centers in Malaysia. Mean changes in laboratory values from baseline to Weeks 4, 12 and 24 were compared using paired T test and Wilcoxon signed-rank test. We studied 18 patients with RA who were on adalimumab 40 mg fortnightly. The inflammatory markers i.e. erythrocyte sedimentation rate and C reactive protein showed significant changes as early as at week 4 compared to baseline with p values of 0.003 and 0.005, respectively. From a baseline of high disease activity with a mean Disease Activity Score using 28 joint counts (DAS 28) of 5.3, there was a steady improvement in the disease activity and remission was achieved at week 24 with a DAS 28 of 2.4. The hemoglobin level improved at week 12 (p=0.013) and this was sustained till week 24. As opposed to previous studies, the LDL level significantly decreased at week 12 (p=0.015) and this change persisted till week 24 (p=0.001). The total cholesterol showed a similar pattern as the LDL. The pharmacodynamics of adalimumab therapy in rheumatoid arthritis extend beyond the joints with favorable effects on haemoglobin and lipid profile.

    Study site: Putrajaya Hospital and Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
    Matched MeSH terms: Malaysia
  6. Seven new species of the earthworm genus Metaphire Sims & Easton, 1972 from Thailand (Clitellata: Megascolecidae)
    Bantaowong U, Chanabun R, James SW, Panha S
    Zootaxa, 2016;4117(1):63-84.
    PMID: 27395158 DOI: 10.11646/zootaxa.4117.1.3
    Earthworm specimens collected from various parts of Thailand were found to contain seven new species of the genus Metaphire Sims & Easton, 1972. These are M. songkhlaensis sp. n. in the octothecal pulauensis species group,                        M. trangensis sp. n. in the octothecal ignobilis species group, M. khaoluangensis sp. n. and M. khaochamao sp. n. in the sexthecal houlleti species group, M. doiphamon sp. n. in the sexthecal peguana species group, M. saxicalcis sp. n. in the quadrithecal planata species group, and the bithecal M. surinensis sp. n. Type material of some established species from Thailand or northern Malaysia was reinvestigated and illustrated to confirm the status of the new species and to facilitate species comparisons: M. pulauensis (Beddard, 1900), M. baruana (Stephenson, 1932), both with newly designated         lectotypes, and M. planata (Gates, 1936), illustrated and redescribed.
    Matched MeSH terms: Malaysia
  7. Fulltext Popliteal artery to tibial plateau distance at the knee level: a radiological study to assess injury risks in osteoarthritic knees using dual source dual energy CT scan
    Ezamin, A.R., Hasyma, A.H., Suppiah, S., Suraini, M.S., Arifaizad, A., Paisal, Hussin, et al.
    Pertanika Journal of Science & Technology, 2017;25(1):371-378.
    MyJurnal
    Popliteal artery injury is the most disastrous intraoperative complication during total knee replacement. This study aims to determine the mean distance between the popliteal artery (PA) and the tibial plateau in normal and osteoarthritic patients who underwent Dual Energy CT Angiography (CTA) of the lower limb.
    Materials and Methods: All CTA lower limb examinations from January 2013 to October 2014 were retrospectively reviewed. The distance between the PA the tibial plateau distance and the thickness of popliteus muscle were electronically measured. We used modified Kellgren and Lawrence’s Classification to grade the osteoarthritis in patients who underwent CT examinations regardless of symptoms.
    Results: There were a total of 126 patients who underwent CTA (93 males and 33 females). 54 of them were Malays, 47 Indians, and 24 Chinese. The mean age of patients was 58 years (range 16 to 92). The mean PA-totibial plateau distance was 9.9 mm for the right lower limb (range 2.5 mm to 17.2 mm) and 10.24 mm for the left (range 5.5 mm to 15.4 mm). There were no significant correlations between PA-to-tibial plateau distance with osteoarthritis grade, age, gender, and racial origin (P > 0.05); however, there was a positive
    correlation between PA-to-tibial plateau distances with popliteus muscle thickness (P = 0.000).
    Conclusion: Osteoarthritic condition in the knee does not reduce the popliteal artery to the tibial plateau distance. Hence, a higher osteoarthritic grade does not impose additional risks with regards to popliteal artery to tibial plateau distance, with relatively similar arterial injury risks compared to normal knees.
    Matched MeSH terms: Malaysia
  8. Fulltext Neuroimaging findings are sensitive and specific in diagnosis of tuberculous meningitis
    Mei-Ling Sharon TAI, Hazman MOHD NOR, Kartini Rahmat, Shanthi Viswanathan, Khairul Azmi Abdul Kadir, Norlisah Ramli, et al.
    Neurology Asia, 2017;22(1):15-23.
    MyJurnal
    Objective: The primary objective of this study was to describe the neuroimaging changes of tuberculous meningitis (TBM), and to determine the role of neuroimaging in the diagnosis of TBM.
    Methods: Between January 2009 and July 2015, we prospectively recruited TBM patients in two hospitals in Malaysia. Neuroimaging was performed and findings were recorded. The control consists of other types of meningo-encephalitis seen over the same period.
    Results: Fifty four TBM patients were recruited. Leptomeningeal enhancement was seen in 39 (72.2%) patients, commonly at prepontine cistern and interpeduncular fossa. Hydrocephalus was observed in 38 (70.4%) patients, 25 (46.3%) patients had moderate and severe hydrocephalus. Thirty four patients (63.0%) had cerebral infarction. Tuberculoma were seen in 29 (53.7%) patients; 27 (50.0%) patients had classical tuberculoma, 2 (3.7%) patients
    had “other” type of tuberculoma, 18 (33.3%) patients had ≥5 tuberculoma, and 11 (20.4%) patients had < 5 tuberculoma. Fifteen (37.2%) patients had vasculitis, 6 (11.1%) patients had vasospasm. Close to nine tenth (88.9%) of the patients had ≥1 classical neuroimaging features, 77.8% had ≥ 2 classical imaging features of TBM (basal enhancement, hydrocephalus, basal ganglia / thalamic infarct, classical tuberculoma, and vasculitis/vasospasm). Only 4% with other types of meningitis/encephalitis had ≥1 feature, and 1% had two or more classical TBM neuroimaging features. The sensitivity of the imaging features of the imaging features for diagnosis of TBM was 88.9% and the specificity was 95.6%.
    Conclusion: The classic imaging features of basal enhancement, hydrocephalus, basal ganglia/thalamic infarct, classic tuberculoma, and vasculitis are sensitive and specific to diagnosis of TBM.
    Matched MeSH terms: Malaysia
  9. Fulltext Cardiovascular endurance fitness performance among Kedah Rugby Agong Cup’s players based on 20-meter multistage shuttle run pacer test
    Syed Ahmad Ezahar Syed Ambon, Mohd. Foazi Md Nor, Syed Idrus Syed Mudayah, Junaidy Mohamad Hashim
    Jurnal Sains Sukan & Pendidikan Jasmani, 2017;6(2):55-64.
    MyJurnal
    The study was conducted to determine the level of cardiovascular performance for Kedah team rugby players who will participate in the national Agong Cup's rugby championship. The test instrument used was the 20-meter multistage shuttle run pacer test. The total sample of the study was 40 (n = 40) consisted of players between the ages of 19 and 39. Assessment of cardiovascular endurance levels can be performed with measurements of VO2max (ml • kg-1 • min-1) as the most accurate score can be obtained to measure the fitness level of individual cardiovascular endurance. Therefore min VO2max (ml • kg-1 • min-1) obtained from the 20- meter multistage shuttle run pacer test shows that the VO2max (ml • kg-1 • min-1) level of the study sample is good and is at high level.
    Matched MeSH terms: Malaysia
  10. Fulltext Relative risk estimation for dengue disease mapping in Malaysia based on Besag, York and Mollié model
    Samat, N.A., Pei Zhen, W.
    Pertanika Journal of Science & Technology, 2017;25(3):759-766.
    MyJurnal
    In the study of disease mapping, relative risk estimation is the focus of analysis. Many methods have
    been introduced to estimate relative risk. In this paper, one of the common spatial models known as
    Besag, York and Mollié (BYM) model is discussed, and its application to dengue data for epidemiology
    weeks 1 to 52 of the year 2013 for 16 states in Malaysia is studied. Findings show that Selangor has the highest relative risk of dengue in comparison with other states. Data on the estimated relative risks are presented in the form of risk maps which can be used as a tool for the prevention and control of dengue.
    Matched MeSH terms: Malaysia
  11. Fulltext Integration of Naqli and Aqli in Microbiology teaching: Sharing the experience
    Nurul Azmawati Mohamed, Anuar Sani, Wan Shahida, Zarini Ismail, Ilina Isahak, Norazman Alias
    International Medical Journal Malaysia, 2017;16(1):143-146.
    MyJurnal
    In line with Universiti Sains Islam Malaysia’s (USIM) tagline ‘Exploring Islamic Science, Spearheading Knowledge’, we embarked on a new paradigm of teaching by integrating naqli components into the microbiology and immunology curriculum. The main objective of this integration was to enhance students’ appreciation towards Islam and Science, so that they would become good Muslim doctors. The naqli components were delivered through various teaching and learning techniques such as lectures, seminars, and online assignments
    Matched MeSH terms: Malaysia
  12. Fulltext Acinetobacter spp. infections in Malaysia: a review of antimicrobial resistance trends, mechanisms and epidemiology
    Mohd Rani F, A Rahman NI, Ismail S, Alattraqchi AG, Cleary DW, Clarke SC, et al.
    Front Microbiol, 2017;8:2479.
    PMID: 29312188 DOI: 10.3389/fmicb.2017.02479
    Acinetobacter spp. are important nosocomial pathogens, in particular the Acinetobacter baumannii-calcoaceticus complex, which have become a global public health threat due to increasing resistance to carbapenems and almost all other antimicrobial compounds. High rates of resistance have been reported among countries in Southeast Asia, including Malaysia. In this review, we examine the antimicrobial resistance profiles of Acinetobacter spp. hospital isolates from Malaysia over a period of nearly three decades (1987-2016) with data obtained from various peer-reviewed publications as well as the Malaysian National Surveillance on Antibiotic Resistance (NSAR). NSAR data indicated that for most antimicrobial compounds, including carbapenems, the peak resistance rates were reached around 2008-2009 and thereafter, rates have remained fairly constant (e.g., 50-60% for carbapenems). Individual reports from various hospitals in Peninsular Malaysia do not always reflect the nationwide resistance rates and often showed higher rates of resistance. We also reviewed the epidemiology and mechanisms of resistance that have been investigated in Malaysian Acinetobacter spp. isolates, particularly carbapenem resistance and found that blaOXA-23 is the most prevalent acquired carbapenemase-encoding gene. From the very few published reports and whole genome sequences that are available, most of the Acinetobacter spp. isolates from Malaysia belonged to the Global Clone 2 (GC2) CC92 group with ST195 being the predominant sequence type. The quality of data and analysis in the national surveillance reports could be improved and more molecular epidemiology and genomics studies need to be carried out for further in-depth understanding of Malaysian Acinetobacter spp. isolates.
    Matched MeSH terms: Malaysia
  13. Fulltext First Draft Genome Sequences of Malaysian Clinical Isolates of Corynebacterium diphtheriae
    Ahmad N, Hii SY, Mohd Khalid MK, Abd Wahab MA, Hashim R, Tang SN, et al.
    Genome Announc, 2017 Mar 02;5(9).
    PMID: 28254972 DOI: 10.1128/genomeA.01670-16
    Corynebacterium diphtheriae has caused multiple isolated diphtheria cases in Malaysia over the years. Here, we report the first draft genome sequences of 15 Malaysia C. diphtheriae clinical isolates collected from the years 1981 to 2016.
    Matched MeSH terms: Malaysia
  14. Paediatric middle aortic syndrome with endovascular treatment in East Malaysia
    Hong Ong G, Benjamin Leong DK
    Med J Malaysia, 2018 02;73(1):57-59.
    PMID: 29531207 MyJurnal
    Middle-aortic syndrome is a surgically curable cause of childhood hypertension. Open surgery is traditionally offered but with the advance of medical technology, endovascular approached is available in many country. Failure to control BP in open surgery is as low as 4.1% compares to 13% in endovascular approaches. However, mortality is 4% in open surgery almost 2 times higher than 2.3% in endovascular approach. This article presents a case of 10 years old child treated successfully without complication with endovascular balloon dilatation, as a first case of such disease in East Malaysia.
    Matched MeSH terms: Malaysia
  15. Acquired lung cysts in post primary tuberculosis: An uncommon radiological finding in a common disease
    Tan LS, Tan S
    Med J Malaysia, 2018 02;73(1):54-56.
    PMID: 29531206 MyJurnal
    Tuberculosis (TB) is still an endemic disease in Malaysia. Cystic lung disease in post primary tuberculosis is not common. It can occur before, during or after completion of anti-TB treatment. Clinical history and review of serial chest radiograph is paramount to make the diagnosis. This case report highlights an interesting case of a young female patient who developed extensive cystic lung disease during the course of anti-TB treatment and the importance of recognizing this unusual manifestation.
    Matched MeSH terms: Malaysia
  16. A new species of Marsipococcus Cockerell & Bueker (Hemiptera: Coccomorpha: Coccidae) from Malaysia
    Łagowska B, Martin JH, Hodgson CJ
    Zootaxa, 2017 Nov 29;4358(2):295-310.
    PMID: 29245470 DOI: 10.11646/zootaxa.4358.2.4
    The adult female, first-instar nymph, second-instar male, third-instar female, pupa and adult male of a new species of Marsipococcus Cockerell & Bueker (Hemiptera: Coccomorpha: Coccidae) from Malaysia, M. ulubendulensis Łagowska & Martin sp. n., are described and illustrated, while the second-instar female is only described. Marsipococcus is rediagnosed and a key to the adult females of the four species now placed in this genus is included.
    Matched MeSH terms: Malaysia
  17. Dietary protein interacts with polygenic risk scores and modulates serum concentrations of C-reactive protein in overweight and obese Malaysian adults
    Tan PY, Amini F, Mitra SR
    Nutr Res, 2022 Nov;107:75-85.
    PMID: 36206635 DOI: 10.1016/j.nutres.2022.09.002
    Dietary intake may interact with gene variants and modulate inflammatory status. This study aimed to investigate the combined effect of fat mass and obesity-associated rs9930501, rs9930506, and rs9932754 and beta-2 adrenergic receptor rs1042713 on C-reactive protein (CRP) concentrations using polygenic risk scores (PRS), and modulatory effect of dietary nutrients on these associations. We hypothesized that higher protein intake is associated with lower inflammatory status in individuals genetically predisposed to obesity. PRS was computed as the weighted sum of the risk alleles possessed and stratified into first (0-0.64), second (0.65-3.59), and third (3.60-8.18) tertiles. A total of 128 overweight and obese Malaysian adults were dichotomized into groups of low and elevated inflammatory status (CRP concentrations ≤3 and >3 mg/L, respectively). One-half of the study participants (51%) were found to have elevated inflammatory status. Second- and third-tertile PRS were significantly associated with increased odds of elevated inflammatory status, 7.56 (95% confidence interval [CI], 1.98-28.80; adjusted P = .003) and 3.87 (95% CI, 1.10-13.60; adjusted P = .035), respectively. Individuals in the third-tertile PRS had significantly lower CRP concentrations (4.61 ± 1.3 mg/L vs 9.60 ± 2.6 mg/L, P = .019) when consuming ≥14% energy from protein (with an average of 18.0% ± 2.4%, 43.0% ± 7.7%, and 39.0% ± 8.0% energy from protein, carbohydrate, and fat per day). In conclusion, third-tertile PRS was significantly associated with increased odds of elevated CRP; higher protein intake may alleviate inflammatory status and reduce CRP concentrations systemically in those individuals.
    Matched MeSH terms: Malaysia
  18. Distribution of faecal indicator bacteria in tropical waters of Peninsular Malaysia and their decay rates in tropical seawater
    Wong YY, Lee CW, Chai SCY, Lim JH, Bong CW, Sim EUH, et al.
    Mar Pollut Bull, 2022 Dec;185(Pt A):114297.
    PMID: 36327936 DOI: 10.1016/j.marpolbul.2022.114297
    We investigated the appropriateness of faecal indicator bacteria in tropical waters. We compared total coliform (undetectable to 7.2 × 105 cfu 100 mL-1), faecal coliform (undetectable to 6.1 × 105 cfu 100 mL-1) and enterococci (undetectable to 3.1 × 104 cfu 100 mL-1) distribution in Peninsular Malaysia. Faecal indicator bacteria was highest in freshwater, and lowest in seawater (q > 4.18, p 
    Matched MeSH terms: Malaysia
  19. Between the devil and the deep blue sea: Trends, drivers, and impacts of coastal reclamation in Malaysia and way forward
    Chee SY, Tan ML, Tew YL, Sim YK, Yee JC, Chong AKM
    Sci Total Environ, 2023 Feb 01;858(Pt 2):159889.
    PMID: 36328260 DOI: 10.1016/j.scitotenv.2022.159889
    Cities all over the world are edging further into the ocean. Coastal reclamation is a global conservation issue with implications for ocean life, ecosystems, and human well-being. Using Malaysia as a case study, the coastal reclamation trends over three decades (1991-2021) were mapped using Landsat images and Normalized Difference Water Index (NDWI) via the Google Earth Engine platform. The changes in drivers and impacts of these coastal expansions throughout the decades were also reviewed. Twelve out of the 14 states in Malaysia had planned, active, or completed reclamations on their shorelines. Between 1991 and 2021, an absolute area of 82.64 km2 has been or will be reclaimed should all the projects be completed. The most reported driver for coastal expansion in Malaysia is for development and modernization (41 %), followed by rise in human population (20 %), monetary gains from the development of prime land (15 %), and agriculture and aquaculture activities (9 %). Drivers such as reduction of construction costs, financial advantage of prime land, oil and gas, advancement of technology, and tourism (Malaysia My Second Home (MM2H)) had only started occurring within the last decade, while others have been documented since the 1990's. Pollution is the most reported impact (24 %) followed by disruption of livelihoods, sources of income and human well-being (21 %), destruction of natural habitats (17 %), decrease in biodiversity (11 %), changes in landscapes (10 %), erosion / accretion (8 %), threat to tourism industry (6 %), and exposure to wave surges (3 %). Of these, changes in landscape, shoreline alignment, seabed contour, and coastal groundwater, as well as wave surges had only started to surface as impacts in the last two decades. Efforts to protect existing natural coastal and marine ecosystems, restore degraded ones, and fund endeavours that emphasize nature is needed to support sustainable development goals for the benefit of future generations.
    Matched MeSH terms: Malaysia
  20. Fulltext Cultural adaptation and validation of the Malay Chronic Kidney Disease Self-management instrument (MCKD-SM)
    Al Sawad AA, Lim SK, Tang LY, Rashid AA, Chew BH
    BMC Nephrol, 2022 Dec 01;23(1):384.
    PMID: 36457069 DOI: 10.1186/s12882-022-03016-x
    BACKGROUND: There is growing evidence that self-management behaviour can improve outcomes for patients with chronic kidney disease (CKD). However, no measures are available in Malay to effectively assess the self-management of CKD. The aim of this study was to translate, culturally adapt and validate the Malay Chronic Kidney Disease Self-Management (MCKD-SM) instrument for Malay-speaking health professionals and patients.

    METHODS: This study was carried out in two phases: the translation and cultural adaptation phase and the validation phase. The instrument was translated from English to Malay and then adapted and validated in a sample of 337 patients with CKD stages 3-4 attending a nephrology clinic in a tertiary hospital in Malaysia. Structural validity was evaluated by exploratory factor analysis. The instrument's reliability was assessed by internal consistency and test-retest reliability. The correlations between the MCKD-SM and kidney disease knowledge and the MCKD-SM and self-efficacy were hypothesised a priori and investigated.

    RESULTS: The MCKD-SM instrument has 29 items grouped into three factors: 'Understanding and Managing My CKD', 'Seeking Support' and 'Adherence to Recommended Regimen'. The three factors accounted for 56.3% of the total variance. Each factor showed acceptable internal reliability, with Cronbach's α from 0.885 to 0.960. The two-week intra-rater test-retest reliability intraclass correlation coefficient values for all items ranged between 0.938 and 1.000. The MCKD-SM scores significantly correlated with kidney disease knowledge (r = 0.366, p 

    Matched MeSH terms: Malaysia
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