MyMedR

An overview of the history, applications, advantages, disadvantages and prospects of gene therapy

Jafarlou M, Baradaran B, Saedi TA, Jafarlou V, Shanehbandi D, Maralani M, et al.

J Biol Regul Homeost Agents, 2016 Apr-Jun;30(2):315-21.

Gene therapy has become a significant issue in science-related news. The principal concept of gene therapy is an experimental technique that uses genes to treat or prevent disease. Although gene therapy was originally conceived as a way to treat life-threatening disorders (inborn defects, cancers) refractory to conventional treatment, it is now considered for many nonlife-threatening conditions, such as those adversely impacting a patients quality of life. An extensive range of efficacious vectors, delivery techniques, and approaches for developing gene-based interventions for diseases have evolved in the last decade. The lack of suitable treatment has become a rational basis for extending the scope of gene therapy. The aim of this review is to investigate the general methods by which genes are transferred and to give an overview to clinical applications. Maximizing the potential benefits of gene therapy requires efficient and sustained therapeutic gene expression in target cells, low toxicity, and a high safety profile. Gene therapy has made substantial progress albeit much slower than was initially predicted. This review also describes the basic science associated with many gene therapy vectors and the present progress of gene therapy carried out for various surface disorders and diseases. The conclusion is that, with increased pathobiological understanding and biotechnological improvements, gene therapy will become a standard part of clinical practice.

Matched MeSH terms: Humans

A Review Of Oculoplastic Photography: A Guide For Clinician Photographers

Ong CT, Yap JF, Wai YZ, Ng QX

Cureus, 2016;8(8):e733.

PMID: 27630805 DOI: 10.7759/cureus.733

Clinical photography in the field of oculoplastic surgery has many applications. It is possible for clinicians to obtain standardized clinical photographs without a studio. A clinician photographer has the advantage of knowing exactly what to photograph as well as having immediate access to the images. In order to maintain standardization in the photographs, the photographic settings should remain constant. This article covers essential photographic equipment, camera settings, patient pose, and digital asset management.

Matched MeSH terms: Humans

Fulltext The impact of a patient education package on outcomes of pain management following orthopaedic surgery in a tertiary hospital in Malaysia

Ho, S.E., Wan Ahmad, L., Tan, Z.Y., Ho, Christopher Ck, Nursharifah, M.S., Choy, Y.C., et al.

Medicine & Health, 2015;10(1):58-65.

MyJurnal

Patient’s belief towards pain management may affect pain management outcomes and quality of life. The main aim of the present study was to determine the impact of a pre-operative pain education package towards pain belief among patients undergoing orthopaedic surgery in a tertiary hospital. A one-group pre-test post-test design study was conducted on orthopaedic surgery patients. Thirty respondents were recruited and pre-operative pain education was administered individually before surgery. Pre-operative and post-operative pain belief, management scores and side effects were measured using the Barrier Questionnaire (BQ-13). The results reported significant differences between pre-test scores (Mean = 41.87, Standard Deviation = 11.467) and post-test scores (Mean=34.80, Standard Deviation=13.026) of pain belief (t = 2.84, p = 0.004). There were also significant differences between pre-test scores (Mean = 37.10, Standard Deviation = 10.610) and post-test scores (Mean=30.80, Standard Deviation = 11.424) of pain management (t = 3.856, p = 0.0005). Respondent’s gender (t = -2.403, p = 0.023) and ethnicity (F = 5.038, p=0.014) reported significant differences with p value < 0.05, respectively. However, there were no significant differences between educational level, ethnicity, prior surgical history with pain belief (p> 0.05). There was positive impact of the pain education package towards pain belief and painmanagement among respondents who underwent orthopaedics surgery in a tertiary hospital. Reinforcement of pain educational program is pivotal in order to achieve optimal post-operative pain management.
Keywords: pain, education, orthopaedics, patient, surgery

Matched MeSH terms: Humans

Fulltext Dimensional accuracy of the skull models produced by rapid prototyping technology using stereolithography apparatus

Nizam, A., Gopal, R.N., Naing, L., Hakim, A.B., Samsudin, A.R.

Archives of Orofacial Sciences, 2006;1(1):60-66.

MyJurnal

The purpose of this study was to determine the dimensional accuracy of the skull models produced by Rapid prototyping technology using stereolithography apparatus. Computed tomography images were captured from four dry normal adult human skulls. The resultant 2-D images were stored in Digital Imaging and Communications in Medicine (DICOM) format. The segmentation of the images was prepared in MIMICS software. The slice files were then exported to a stereolithography apparatus (SLA) to produce the replica of each skull. Eight linear measurements were repeatedly made between identified landmarks on each of the original skull and its replica model using an electronic digital calliper. Each of the linear measurements was repeated 5 times and the average was taken to determine the absolute difference and percent difference between the original skull and its replica model. The overall absolute difference between the four human adult skulls and its replica models was 0.23 mm with a standard deviation of 1.37 mm. The percent difference was 0.08% with a standard deviation of 1.25%. The degree of error established by this system seems affordable in clinical applications when these models are used in the field of dental surgery for surgical treatment planning.

Matched MeSH terms: Humans

Fulltext Submasseteric abscess: an unusual head and neck condition

Sayuti, R., Baharudin, A., Amran, M.

Archives of Orofacial Sciences, 2007;2(1):59-60.

MyJurnal

Submasseteric abscess is unusual in the head and neck region. Patients with this condition may be misdiagnosed as a parotid abscess due to the similarities in their presentation. Awareness and due recognition should be given to this unusual problem.

Matched MeSH terms: Humans

Fulltext Applications of lasers in dentistry: a review

Husein, A.

Archives of Orofacial Sciences, 2006;1(1):1-4.

MyJurnal

Lasers were introduced into the field of clinical dentistry with the hope of overcoming some of the drawbacks posed by the conventional methods of dental procedures. Since its first experiment for dental application in the 1960s, the use of laser has increased rapidly in the last couple of decades. At present, wide varieties of procedures are carried out using lasers. The aim of this review is to describe the application of lasers in dental hard tissue procedures. Lasers are found to be effective in cavity preparation, caries removal, restoration removal, etching, and treatment of dentinal sensitivity, caries prevention and bleaching. Based on development in adhesive dentistry and the propagation of minimum intervention principles, lasers may revolutionize cavity design and preparation.

Matched MeSH terms: Humans

Fulltext Transcervical thyroidectomy for huge posterior mediastinal goitre: a challenging case

Khandasamy, Y., Nani Harlina, M.L., Saladina, J.J., Rohaizak, M.

Journal of Surgical Academia, 2015;5(1):82-84.

MyJurnal

The decision for median sternotomy for retrosternal goiter is complex and proper consensus are lacking. Generally, it is based on clinical, radiological and intraoperative assessment. Among the few known features include primary mediastinal goiter, posterior mediastinal goiter and recurrent retrosternal goiter. We present a patient with posterior mediastinal, secondary goiter that extended until the tracheal bifurcation. The goiter was removed successfully via a low cervical incision and this was achieved by dissecting along the anatomical plane close to the thyroid capsule using blunt dissection with fingers. It is possible for these kinds of high risk retrosternal goitres to be safely removed without the need for thoracotomy when the surgery was performed along the proper plane.

Matched MeSH terms: Humans

Fulltext Role of parents in motorcycle riding practices among teenagers. [Peranan ibu bapa dalam amalan remaja menunggang motosikal]

Norliza Ahmad, Hanafiah Mohd Salleh

Malaysian Journal of Public Health Medicine, 2002;2(2):47-51.

MyJurnal

This study was designed to examine the role of parents and family in motorcycle riding practices among teenagers and motorcycle accident in FELDA Trolak Utara, Perak. This was a cross sectional study using universal sampling that involved 309 teenage riders aging from 11 to 19 years old. Only 6.1% respondents that rode motorcycle had a valid driving licenses. Mean age of starting to ride was 11.46 ± 1.75 years old. Mean years of riding motorcycle was 3.66 ± 1.95 years. The major buyer of motorcycles for the teenagers were father (78.3%) and other family members (13.7%). About 42.7% of teenagers learnt riding by themselves and in 51.8%, family members taught teenagers to ride motorcycle. The main purpose for riding motorcycle were to go to shop (37.2%), to school (32.7%) and for recreation (25.2%). From the perception of teenagers, about 82.2% parents encouraged them to ride. Mean usual riding speed (n = 296) was 58.72 ± 23.97 km/h. The mean maximum riding speed (n = 290) was 89.81 ± 30.70 km/h. There were positive correlation between years of motorcycle riding and usual motorcycle riding speed (r = 0.292, p < 0.05) and maximum motorcycle riding speed (r = 0.371, p < 0.05). The usual motorcycle riding speed was predictor factor for motorcycle accident. Parents, families and communities should play their role to make sure that their teenage children do not ride at a very young age and ride without a valid license. Reducing years of motorcycle riding among teenagers may reduce usual riding speed and consecutively reducing teenagers’ involvement in motorcycle accidents.
Key words : role of parents, teenagers’ riding practice, motorcycle

Matched MeSH terms: Humans

Fulltext Role of community counsellors in dealing with social problems in the community: the Selayang experience

Khalil, A.L., Hanafiah, M.S., Idris, M.N., Khadijah, S., Suraiyah, H., Siti Sapor, B., et al.

Malaysian Journal of Public Health Medicine, 2002;2(2):27-31.

MyJurnal

This is an intervention study utilising Community Counsellors ( CC) for social change. Each CC is allocated to problematic families and is asked to do Outreach Family Intervention (OFI) in the form of family diagnosis, counselling and therapy for a period of six utonths. The findings revealed that the outreach activities are moderately successful. With only minimal efforts; 33.3% ofthe total Family»Counsellors Contacts (FCC) and 56.6% ofthe total Duration of Visits (DV), CCs are capable of bringing almost 40% ofthe expected. change, understanding 57% ofthe family problems and taking action on 44% ofthe problems. This study has proven that OFI utilising CCs is quite a useful tool to bring change in the society.

Matched MeSH terms: Humans

Fulltext Problems of stress and health effect among the office computer users at Terengganu health office. [Tenaga kerja dan masalah kesihatan di kalangan pengguna-pengguna komputer di Jabatan Kesihatan Negeri Terengganu]

Azmi, H., Mohd Kamil, H., W Fadillah, W.H.

Malaysian Journal of Public Health Medicine, 2002;2(1):13-20.

MyJurnal

The aim of this study was to identify the problems of stress and health effect among the office computer users. A total of 41 office workers whose job required the use of computers. A set of constructed questionnaire were use to measure the work stress and health problems among workers. The data was analyzed by using of descriptive and inference statistic. The result showed that subjects who use computer for more than 2 hours would experienced work stress such as fatigue 29(70.7%), eye and visual symptoms such as blurring of vision 27(65.9%) and musculoskeletal pain at neck 32( 78.6%). However most of symptoms were moderate. There were a significant relationship between the time spent of using computer with problem of stress (r= 0.440, p<0.05) and eyes and visual problem (r=0.319, p<0.05). However there was no significant relationship between the work station design with stress, musculoskeletal, eye and visual problems. Therefore the longer time spent using computer will lead to health problems. Using the safety operating procedure will reduce the work stress problems.
Keys word: Work stress, health problems, computer users

Matched MeSH terms: Humans

Fulltext Are patients satisfied with hospital food?

Teng, Sang-Chong, Esah Bahaman, Tang, Wen-Yen

Malaysian Journal of Public Health Medicine, 2003;3(1):52-56.

MyJurnal

Although only 6.3% of the 221 respondents in this crass-sectional study stated outright that the hospital food served to them was not good, a high proportion of respondents ( 62.0%) supplemented ltaspimlfoad with outside food. When the reasons for supplementation were considered, it is likely that 53.8% ( $5.5%; 95% CI ) of the patients in this study were dissatisfied with hospimlfoudfar some reasons or when particularly with regards t0 variety, attractiveness and sewing lime. The pl‘0]701’l‘i011 of respondents wha were dissatisfied with hospital faud was significantly higher (p

Matched MeSH terms: Humans

Fulltext Disaster Medicine-Is it time we embrace it?

Amjad, N.M.

International Medical Journal Malaysia, 2011;10(1):1-2.

MyJurnal

Education and training in disaster medicine is an ongoing process to all categories of personnel involved.
In addition to the collaborative inter-professional table top exercises, regularly conducted field exercise drills offers the best form of training. Currently in most countries there is no standardized curriculum
for the training of disaster management from the medical perspective. It is imperative that the concept of disaster medicine and its principles should be a component in the undergraduate and postgraduate
curriculum of Medical and Allied health related programmes.

Matched MeSH terms: Humans

Fulltext Use of Radiographic Densitometry to Predict the BoneHealing Index in Distraction Osteogenesis

Saw, A., Manimaran, S., Faizal S., Bulgiba, A.M.

Malays Orthop J, 2008;2(1):44-48.

MyJurnal

Bone lengthening with distraction osteogenesis involves prolonged application of an external fixator frame. Qualitative and quantitative evaluation of callus has been described using various imaging modalities but there is no simple reliable and readily available method. This study aims to investigate the use of a densitometer to analyze plain radiographic images and correlate them with the rate of new bone formation as represented by the bone healing index. A total of 34 bone lengthening procedures in 29 patients were retrospectively reviewed. We used an X-Rite 301 densitometer to measure densities of new callus on plain radiographs taken at 4 and 8 weeks after surgery. Patients aged below 16y had significantly lower BHIs indicating faster bone healing and shorter duration of treatment. The ratio of radiographic densities between centre and edge of the new bone measured from plain radiographs taken at 8 weeks correlated positively with the eventual BHI of the patient. This method provides a simple and easy way to predict the rate of bone healing at an early stage of treatment and may also allow remedial action to be taken for those with poor progress in bone formation.

Matched MeSH terms: Humans

Fulltext Nasopharyngeal hairy polyp as a rare cause of neonatal respiratory distress: a case report

Hasme Zam, H., Hazama, M., Suzina, S.A.H., Nik Fariza Husna, N.H., Irfan, M.

Malaysian Journal of Medicine and Health Sciences, 2013;9(2):81-84.

MyJurnal

Hairy polyps are rare developmental malformations. They are benign lesions presented as a pedunculated mass that may arise from the naso-oropharyngeal region. Larger mass can cause upper respiratory obstruction causing respiratory distress or feeding difficulty, while smaller mass will present as intermittent respiratory distress due to a ball-valve type of obstruction. They are commonly seen in female, with ratio of 6:1 and majority of the cases occur in the infantile period. We are reporting a case of hairy polyp in a female infant that causing intermittent respiratory distress.

Matched MeSH terms: Humans

Fulltext Medical relief to 2008 Sichuan earthquake, China

Chew BH

Malays Fam Physician, 2008;3(3):170-172.

MyJurnal

The massive 2008 Sichuan earthquake brought unprecedented international humanitarian aid to China. The monstrous damages and casualties aroused all human's sympathy. I took the opportunity to join a Malaysian voluntary medical relief team to Sichuan in June 2008. This essay recounts the immediate events post-earthquake and reports on my experience during the mission.

Matched MeSH terms: Humans

Fulltext Stress at workplace and its effect on workers’ health and safety. [Stres di tempat kerja dan kesannya terhadap keselamatan dan kesihatan pekerjaan.]

Zafir, M.M., Fazilah, M.H.

Malaysian Journal of Community Health, 2006;12(1):37-64.

MyJurnal

Stres di tempat kerja terjadi apabila keperluan kerja tidak sepadan dengan kebolehan, sumber, dan kehendak pekerja. Ia boleh memberi kesan ke atas psikologi dan fisiologi manusia. Seseorang individu yang berasa tertekan dengan kerja yang dilakukan akan menunjukkan kemurungan yang berpanjangan. Apabila rasa tertekan, psikologi akan terganggu dan pekerja gagal membuat keputusan dengan baik. Situasi ini boleh menjejaskan prestasi kerja mereka dan menggugat produktiviti organisasi. Masalah paling dibimbangi adalah stres di tempat kerja boleh menyebabkan penyakit berbahaya seperti tekanan darah tinggi, sakit jantung dan melemahkan sistem pertahanan badan terhadap penyakit. Stres di tempat kerja juga boleh menyebabkan kemalangan di tempat kerja, peningkatan kos keselamatan dan kesihatan pekerjaan, gangguan trauma kumulatif, menjejaskan prestasi kerja serta mengganggu kehidupan sosial individu. Masalah keselamatan dan kesihatan pekerjaan akibat stres di tempat kerja seharusnya tidak diabaikan oleh organisasi kerana ia boleh menyebabkan sumber manusia sesebuah negara kehilangan daya saingnya. Sumber manusia yang berasa terancam akibat masalah keselamatan dan kesihatan akan gagal menggunakan sepenuhnya kreativiti mereka dan melakukan tugas pada tahap minimum. Fenomena ini seharusnya dibimbangi dalam persekitaran perniagaan masa kini yang sangat kompetitif. Di Malaysia, kajian yang berkaitan dengan stres seharusnya dipertingkatkan kerana kajian lepas terhadap stres di tempat kerja adalah tidak menyeluruh. Perkembangan ini sejajar dengan perubahan yang berlaku di persekitaran kerja seperti teknologi, sosial, ekonomi, undang-undang buruh dan seumpamanya. Kajian stres di tempat kerja perlu dijalankan kerana sumbangannya amat bernilai dalam menghasilkan sumber manusia yang lebih produktif dan berdaya saing.

Matched MeSH terms: Humans

Prisoners, prisons, and HIV: time for reform

Beyrer C, Kamarulzaman A, McKee M, Lancet HIV in Prisoners Group

Lancet, 2016 Sep 10;388(10049):1033-1035.

PMID: 27427447 DOI: 10.1016/S0140-6736(16)30829-7

Matched MeSH terms: Humans

Quality of life in patients with erythema nodosum leprosum in Kuala Lumpur, Malaysia

Yap FB, Kiung ST, Yap JB

Indian Dermatol Online J, 2016 Jul-Aug;7(4):255-8.

PMID: 27559497 DOI: 10.4103/2229-5178.185495

There is a paucity of data on quality of life issues in patients with leprosy suffering from erythema nodosum leprosum (ENL). Thus, we aim to study the effect of ENL on quality of life.

Matched MeSH terms: Humans

Metastatic follicular thyroid carcinoma: a case report

Sathasivam H, Loh YM, Saw CL, Khalid N

Gerodontology, 2017 Jun;34(2):276-279.

PMID: 27384017 DOI: 10.1111/ger.12240

OBJECTIVE: A case of oral metastatic follicular thyroid carcinoma is presented.

BACKGROUND: Metastatic tumours are more frequent in older individuals and can be the only sign/symptom of an undiagnosed primary malignancy.

CASE REPORT: A 69-year-old lady presented with an enlarging mandibular swelling. Incisional biopsy and imaging studies were suggestive of metastatic follicular thyroid carcinoma.

CONCLUSION: Metastatic tumours should be considered in the differential diagnosis of mandibular swellings especially in older individuals.

Matched MeSH terms: Humans

Fulltext Responsible use of fixed-dose combination antibiotics in India

Shankar PR, Hassali MA, Shahwani NA, Iqbal Q, Anwar M, Saleem F

Lancet Glob Health, 2016 10;4(10):e689.

PMID: 27633429 DOI: 10.1016/S2214-109X(16)30214-5

Matched MeSH terms: Humans

Displaying publications 2841 - 2860 of 55738 in total