Displaying publications 21 - 40 of 49 in total

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  1. Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review
    Aziz ZAA, Ahmad A, Setapar SHM, Karakucuk A, Azim MM, Lokhat D, et al.
    Curr Drug Metab, 2018;19(13):1100-1110.
    PMID: 30039757 DOI: 10.2174/1389200219666180723144850
    BACKGROUND: Essential oils are liquid extracts from aromatic plants, which have numerous applications in multiple industries. There are a variety of methods used for the extraction of essential oils, with each method exhibiting certain advantages and determining the biological and physicochemical properties of the extracted oils. Essential oils from different plant species contain more than 200 constituents which are comprised of volatile and non-volatile components. The application of essential oils as antimicrobial, anticancer, anti-inflammatory and anti-viral agents is due to their effective and efficient properties, inter alia.

    METHOD: Several advanced (supercritical fluid extraction, subcritical extraction liquid, solvent-free microwave extraction) and conventional (hydrodistillation, steam distillation, hydrodiffusion, solvent extraction) methods have been discussed for the extraction of essential oils. Advanced methods are considered as the most promising extraction techniques due to less extraction time, low energy consumption, low solvent used and less carbon dioxide emission.

    CONCLUSION: This manuscript reviewed the major research studies in the field and discussed several research findings on the chemical composition of essential oils, methods of oil extraction, and application of these oils in pharmaceutical and therapeutic fields. These essential oils can be used as anticancer, antimicrobial, antiviral, and as skin permeation enhancer agents.

  2. Fulltext Enrichment of Eucalyptus oil nanoemulsion by micellar nanotechnology: transdermal analgesic activity using hot plate test in rats' assay
    Aziz ZAA, Nasir HM, Ahmad A, Setapar SHM, Ahmad H, Noor MHM, et al.
    Sci Rep, 2019 Sep 23;9(1):13678.
    PMID: 31548590 DOI: 10.1038/s41598-019-50134-y
    Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vivo analgesic activity assay in rats. The nanoemulsion system containing Eucalyptus-micelles was optimized at different surfactant types (Tween 40, 60 and 80) and concentrations (3.0, 6.0, 9.0, 12.0, 15.0, and 18.0 wt. %). These formulations were characterized by thermodynamically stability, viscosity, micelles particle size, pH, and morphology structure. The spontaneous emulsification technique offered a greener micelles formation in nanoemulsion system by slowly titrated of organic phase, containing Eucalyptus globulus (active compound), grape seed oil (carrier oil) and hydrophilic surfactant into aqueous phase, and continuously stirred for 30 min to form a homogeneity solution. The characterizations evaluation revealed an optimized formulation with Tween 40 surfactant type at 9.0 wt. % of surfactant concentration promoted the most thermodynamic stability, smaller micelles particle size (d = 17.13 ± 0.035 nm) formed with spherical shape morphological structure, and suitable in viscosity (≈2.3 cP) and pH value (6.57) for transdermal purpose. The in vivo analgesic activity assay of optimized emulsion showed that the transdermal administration of micellar nanoparticle of Eucalyptus globulus on fore and hind limb of rats, possessed the central and peripheral analgesic effects by prolonged the rats pain responses towards the heat stimulus after being put on top of hot plate (55 °C), with longest time responses, 40.75 s at 60 min after treatment administration. Thus, this study demonstrated that micellar nanoparticle of Eucalyptus globulus formed in nanoemulsion system could be promising as an efficient transdermal nanocarrier for the analgesic therapy alternative.
  3. Elimination of reactive blue 4 from aqueous solutions using 3-aminopropyl triethoxysilane modified chitosan beads
    Vakili M, Rafatullah M, Salamatinia B, Ibrahim MH, Abdullah AZ
    Carbohydr Polym, 2015 Nov 05;132:89-96.
    PMID: 26256328 DOI: 10.1016/j.carbpol.2015.05.080
    The adsorption behavior of chitosan (CS) beads modified with 3-aminopropyl triethoxysilane (APTES) for the removal of reactive blue 4 (RB4) in batch studies has been investigated. The effects of modification conditions, such as the APTES concentration, temperature and reaction time on RB4 removal, were studied. The adsorbent prepared at a concentration of 2 wt% APTES for 8h at 50 °C was the most effective one for RB4 adsorption. The adsorption capacity of modified CS beads (433.77 mg/g) was 1.37 times higher than that of unmodified CS beads (317.23 mg/g). The isotherm data are adequately described by a Freundlich model, and the kinetic study revealed that the pseudo-second-order rate model was in better agreement with the experimental data. The negative values of the thermodynamic parameters, including ΔG° (-2.28 and -4.70 kJ/mol at 30 ± 2 °C), ΔH° (-172.18 and -43.82 kJ/mol) and ΔS° (-560.71 and -129.08 J/mol K) for CS beads and APTES modified beads, respectively, suggest that RB4 adsorption is a spontaneous and exothermic process.
  4. Fulltext Electrodeposited Hybrid Biocathode-Based CO2 Reduction via Microbial Electro-Catalysis to Biofuels
    Anwer AH, Khan N, Umar MF, Rafatullah M, Khan MZ
    Membranes (Basel), 2021 Mar 22;11(3).
    PMID: 33810075 DOI: 10.3390/membranes11030223
    Microbial electrosynthesis is a new approach to converting C1 carbon (CO2) to more complex carbon-based products. In the present study, CO2, a potential greenhouse gas, was used as a sole carbon source and reduced to value-added chemicals (acetate, ethanol) with the help of bioelectrochemical reduction in microbial electrosynthesis systems (MES). The performance of MES was studied with varying electrode materials (carbon felt, stainless steel, and cobalt electrodeposited carbon felt). The MES performance was assessed in terms of acetic acid and ethanol production with the help of gas chromatography (GC). The electrochemical characterization of the system was analyzed with chronoamperometry and cyclic voltammetry. The study revealed that the MES operated with hybrid cobalt electrodeposited carbon felt electrode yielded the highest acetic acid (4.4 g/L) concentration followed by carbon felt/stainless steel (3.7 g/L), plain carbon felt (2.2 g/L), and stainless steel (1.87 g/L). The alcohol concentration was also observed to be highest for the hybrid electrode (carbon felt/stainless steel/cobalt oxide is 0.352 g/L) as compared to the bare electrodes (carbon felt is 0.22 g/L) tested, which was found to be in correspondence with the pH changes in the system. Electrochemical analysis revealed improved electrotrophy in the hybrid electrode, as confirmed by the increased redox current for the hybrid electrode as compared to plain electrodes. Cyclic voltammetry analysis also confirmed the role of the biocatalyst developed on the electrode in CO2 sequestration.
  5. Fulltext Editorial: Potential of the plant rhizomicrobiome for bioremediation of contaminants in agroecosystems
    Bhandari G, Gangola S, Bhatt P, Rafatullah M
    Front Plant Sci, 2024;15:1397360.
    PMID: 38711602 DOI: 10.3389/fpls.2024.1397360
  6. Fulltext Eco-Friendly CuO/Fe3O4 Nanocomposite synthesis, characterization, and cytotoxicity study
    Dwivedi P, Malik A, Fatima Hussain HZ, Jatrana I, Imtiyaz K, Rizvi MMA, et al.
    Heliyon, 2024 Mar 30;10(6):e27787.
    PMID: 38496878 DOI: 10.1016/j.heliyon.2024.e27787
    The current study report a convenient, simple, and low cost approach for the biogenic synthesis of CuO/Fe3O4 nanocomposites (NCs) from pumpkin seeds extract and their vitro cytotoxicity. The characterization of finally obtained CuO/Fe3O4 nanocomposites (NCs) performed using UV-Visible, FT-IR, XRD, XPS, GC-MS, SEM-EDX and TEM analysis. The formation and elemental analysis were determined using the energy-dispersive X-ray (EDX) microanalysis technique. The formation of rod-like monoclinic and spherical, having size range 5 nm-20 nm confirmed by scanning electron microscope (SEM) and transmission electron microscopy (TEM) respectively. Finally, the MTT assay of the synthesized composites was evaluated for toxicity against cancerous cell lines HCT-116 (Colon cancer cell) and A549 (human lung adenocarcinoma cell). The synthesized composite material showed moderate (IC50 = 199 μg/mL) to low (IC50 = 445 μg/mL) activity against HCT-116 and A549 cell lines, respectively.
  7. Fulltext Development of Ultra-Performance Liquid Chromatography-Mass Spectrometry Method for Simultaneous Determination of Three Cationic Dyes in Environmental Samples
    Hakami AAH, Wabaidur SM, Ali Khan M, Abdullah Alothman Z, Rafatullah M, Siddiqui MR
    Molecules, 2020 Oct 06;25(19).
    PMID: 33036289 DOI: 10.3390/molecules25194564
    Lower dye concentrations and the presence of several dyes along with other matrices in environmental samples restrict their determination. Herein, a highly sensitive and rapid ultra-performance tandem mass spectrometric method was developed for simultaneous determination of cationic dyes, namely methylene blue (MB), rhodamine B (RB) and crystal violet (CV), in environmental samples. To preconcentrate environmental samples, solid-phase extraction cartridges were developed by using hydrogen peroxide modified pistachio shell biomass (MPSB). The surface morphological and chemical functionalities of MPSB were well characterized. The developed method was validated considering different validation parameters. In terms of accuracy and precision, the %RSD for all three dyes at all four concentration points was found to be between 1.26 and 2.76, while the accuracy reported in terms of the recovery was found to be 98.02%-101.70%. The recovery was found to be in the range of 98.11% to 99.55%. The real sample analysis shows that MB, RB, and CV were found in the ranges of 0.39-5.56, 0.32-1.92 and 0.27-4.36 μg/mL, respectively.
  8. Chitosan hydrogel beads impregnated with hexadecylamine for improved reactive blue 4 adsorption
    Vakili M, Rafatullah M, Ibrahim MH, Abdullah AZ, Salamatinia B, Gholami Z
    Carbohydr Polym, 2016 Feb 10;137:139-146.
    PMID: 26686114 DOI: 10.1016/j.carbpol.2015.09.017
    Adsorption performance of chitosan (CS) hydrogel beads was investigated after impregnation of CS with hexadecylamine (HDA) as a cationic surfactant, for the elimination of reactive blue 4 (RB4) from wastewater. The CS/HDA beads formed with 3.8% HDA were the most effective adsorbent. The adsorption capacity was increased by 1.43 times from 317 mg/g (CS) to 454 mg/g (CS/HDA). The RB4 removal increased with decrease in the pH of dye solution from 4 to 9. The isotherm data obtained from RB4 adsorption on CS and CS/HDA are adequately described by Freundlich model (R(2)=0.946 and 0.934, χ(2)=22.414 and 64.761). The kinetic study revealed that the pseudo-second-order rate model (R(2)=0.996 and 0.997) was in better agreement with the experimental data. The negative values of ΔG° (-2.28 and -6.30 kJ/mol) and ΔH° (-172.18 and -101.62 kJ/mol) for CS beads and HDA modified CS beads, respectively; suggested a spontaneous and exothermic process for RB4 adsorption.
  9. Catalytic thermolysis in treating Cibacron Blue in aqueous solution: Kinetics and degradation pathway
    Su CX, Teng TT, Wong YS, Morad N, Rafatullah M
    Chemosphere, 2016 Mar;146:503-10.
    PMID: 26741557 DOI: 10.1016/j.chemosphere.2015.12.048
    A thermal degradation pathway of the decolourisation of Reactive Cibacron Blue F3GA (RCB) in aqueous solution through catalytic thermolysis is established. Catalytic thermolysis is suitable for the removal of dyes from wastewater as it breaks down the complex dye molecules instead of only transferring them into another phase. RCB is a reactive dye that consists of three main groups, namely anthraquinone, benzene and triazine groups. Through catalytic thermolysis, the bonds that hold the three groups together were effectively broken and at the same time, the complex molecules degraded to form simple molecules of lower molecular weight. The degradation pathway and products were characterized and determined through UV-Vis, FT-IR and GCMS analysis. RCB dye molecule was successfully broken down into simpler molecules, namely, benzene derivatives, amines and triazine. The addition of copper sulphate, CuSO4, as a catalyst, hastens the thermal degradation of RCB by aiding in the breakdown of large, complex molecules. At pH 2 and catalyst mass loading of 5 g/L, an optimum colour removal of 66.14% was observed. The degradation rate of RCB is well explained by first order kinetics model.
  10. Fulltext Carbon Based Polymeric Nanocomposites for Dye Adsorption: Synthesis, Characterization, and Application
    Ali Khan M, Govindasamy R, Ahmad A, Siddiqui MR, Alshareef SA, Hakami AAH, et al.
    Polymers (Basel), 2021 Jan 28;13(3).
    PMID: 33525497 DOI: 10.3390/polym13030419
    Agglomeration and restacking can reduce graphene oxide (GO) activity in a wide range of applications. Herein, GO was synthesized by a modified Hummer's method. To minimize restacking and agglomeration, in situ chemical oxidation polymerization was carried out to embed polyaniline (PANI) chains at the edges of GO sheets, to obtain GO-PANI nanocomposite. The GO-PANI was tested for the adsorptive removal of brilliant green (BG) from an aqueous solution through batch mode studies. Infrared (FT-IR) analysis revealed the dominance of hydroxyl and carboxylic functionalities over the GO-PANI surface. Solution pH-dependent BG uptake was observed, with maximum adsorption at pH 7, and attaining equilibrium in 30 min. The adsorption of BG onto GO-PANI was fit to the Langmuir isotherm, and pseudo-second-order kinetic models, with a maximum monolayer adsorption capacity (qm) of 142.8 mg/g. An endothermic adsorption process was observed. Mechanistically, π-π stacking interaction and electrostatic interaction played a critical role during BG adsorption on GO-PANI.
  11. Fulltext Bioremediation and Electricity Generation by Using Open and Closed Sediment Microbial Fuel Cells
    Abbas SZ, Rafatullah M, Khan MA, Siddiqui MR
    Front Microbiol, 2018;9:3348.
    PMID: 30692985 DOI: 10.3389/fmicb.2018.03348
    The industrial contamination of marine sediments with mercury, silver, and zinc in Penang, Malaysia was studied with bio-remediation coupled with power generation using membrane less open (aerated) and closed (non-aerated) sediment microbial fuel cells (SMFCs). The prototype for this SMFC is very similar to a natural aquatic environment because it is not stimulated externally and an oxygen sparger is inserted in the cathode chamber to create the aerobic environment in the open SMFC and no oxygen supplied in the closed SMFC. The open and closed SMFCs were showed the maximum voltage generation 300.5 mV (77.75 mW/m2) and 202.7 mV (45.04 (mW/m2), respectively. The cyclic voltammetry showed the oxidation peak in open SMFCs at +1.9 μA and reduction peak at -0.3 μA but in closed SMFCs oxidation and reduction peaks were noted at +1.5 μA and -1.0 μA, respectively. The overall impedance (anode, cathode and solution) of closed SMFCs was higher than open SMFCs. The charge transfer impedance showed that the rates of substrate oxidation and reduction were very low in the closed SMFCs than open SMFCs. The Nyquist arc indicated that O2 act as electron acceptor in the open SMFCs and CO2 in the closed SMFCs. The highest remediation efficiency of toxic metals [Hg (II) ions, Zn (II) ions, and Ag (I) ions] in the open SMFCs were 95.03%, 86.69%, and 83.65% in closed SMFCs were 69.53%, 66.57%, and 65.33%, respectively, observed during 60-80 days. The scanning electron microscope and 16S rRNA analysis showed diverse exoelectrogenic community in the open SMFCs and closed SMFCs. The results demonstrated that open SMFCs could be employed for the power generation and bioremediation of pollutants.
  12. Bioremediation and Detoxification of the Textile Wastewater with Membrane Bioreactor Using the White-rot Fungus and Reuse of Wastewater
    Hossain K, Quaik S, Ismail N, Rafatullah M, Avasan M, Shaik R
    Iran J Biotechnol, 2016 Sep;14(3):154-162.
    PMID: 28959331 DOI: 10.15171/ijb.1216
    BACKGROUND: Application of membrane technology to wastewater treatment has expanded over the last decades due to increasingly stringent legislation, greater opportunities for water reuse/recycling processes and continuing advancement in membrane technology.

    OBJECTIVES: In the present study, a bench-scale submerged microfiltration membrane bioreactor (MBR) was used to assess the treatment of textile wastewater.

    MATERIALS AND METHODS: The decolorization capacity of white-rot fungus coriolus versicolor was confirmed through agar plate and liquid batch studies. The temperature and pH of the reactor were controlled at 29±1°C and 4.5±2, respectively. The bioreactor was operated with an average flux of 0.05 m.d(-1) (HRT=15hrs) for a month.

    RESULTS: Extensive growth of fungi and their attachment to the membrane led to its fouling and associated increase of the transmembrane pressure requiring a periodic withdrawal of sludge and membrane cleaning. However, stable decoloration activity (approx. 98%), BOD (40-50%), COD (50-67%) and total organic carbon (TOC) removal (>95%) was achieved using the entire system (fungi + membrane), while the contribution of the fungi culture alone for TOC removal, as indicated by the quality of the reactor supernatant, was 35-50% and 70%, respectively.

    CONCLUSIONS: The treated wastewater quality satisfied the requirement of water quality for dyeing and finishing process excluding light coloration. Therefore, textile wastewater reclamation and reuse is a promising alternative, which can both conserve or supplement the available water resource and reduce or eliminate the environmental pollution.

  13. Fulltext Bioflocculants Produced by Bacterial Strains Isolated from Palm Oil Mill Effluent for Application in the Removal of Eriochrome Black T Dye from Water
    Abbas SZ, Yong YC, Ali Khan M, Siddiqui MR, Hakami AAH, Alshareef SA, et al.
    Polymers (Basel), 2020 Jul 13;12(7).
    PMID: 32668712 DOI: 10.3390/polym12071545
    Four strains of bioflocculant-producing bacteria were isolated from a palm oil mill effluent (POME). The four bacterial strains were identified as Pseudomonas alcaliphila (B1), Pseudomonas oleovorans (B2), Pseudomonas chengduensis (B3), and Bacillus nitratireducens (B4) by molecular identification. Among the four bacterial strains, Bacillus nitratireducens (B4) achieved the highest flocculating activity (49.15%) towards kaolin clay suspension after eight hours of cultivation time and was selected for further studies. The optimum conditions for Eriochrome Black T (EBT) flocculation regarding initial pH, type of cation, and B4 dosage were determined to be pH 2, Ca2⁺ cations, and a dosage of 250 mL/L of nutrient broth containing B4. Under these conditions, above 90% of EBT dye removal was attained. Fourier transform infrared spectroscopic (FT-IR) analysis of the bioflocculant revealed the presence of hydroxyl, alkyl, carboxyl, and amino groups. This bioflocculant was demonstrated to possess a good flocculating activity, being a promissory, low-cost, harmless, and environmentally friendly alternative for the treatment of effluents contaminated with dyes.
  14. Bioelectricity production and xylene biodegradation through double chamber benthic microbial fuel cells fed with sugarcane waste as a substrate
    Umar MF, Rafatullah M, Abbas SZ, Ibrahim MNM, Ismail N
    J Hazard Mater, 2021 10 05;419:126469.
    PMID: 34192640 DOI: 10.1016/j.jhazmat.2021.126469
    Xylene, a recalcitrant compound present in wastewater from activities of petrochemical and chemical industries causes chronic problems for living organisms and the environment. Xylene contaminated wastewater may be biodegraded through a benthic microbial fuel cell (BMFC) as seen in this study. Xylene was oxidized into intermediate 3-methyl benzoic acid and entirely converted into non-toxic carbon dioxide. The highest voltage of the BMFC reactor was generated at 410 mV between 23 and 90 days when cell potential was 1 kΩ. The reactor achieved a maximum power density of about 63 mW/m2, and a current of 0.4 mA which was optimized from variable resistance (20 Ω - 1 kΩ). However, the maximum biodegradation efficiency of the BMFC was at 87.8%. The cyclic voltammetry curve helped to determine that the specific capacitance was 0.124 F/g after 30 days of the BMFC operation. Furthermore, the fitting equivalent circuit was observed with the help of Nyquist plot for calculating overall internal resistance of 65.82 Ω on 30th day and 124.5 Ω on 80th day. Staphylococcus edaphicus and Staphylococcus sparophiticus were identified by 16S rRNA sequencing as the dominant species in the control and BMFC electrode, presumably associated with xylene biodegradation.
  15. Fulltext Bio-Mediated Synthesis of Reduced Graphene Oxide Nanoparticles from Chenopodium album: Their Antimicrobial and Anticancer Activities
    Umar MF, Ahmad F, Saeed H, Usmani SA, Owais M, Rafatullah M
    Nanomaterials (Basel), 2020 Jun 01;10(6).
    PMID: 32492878 DOI: 10.3390/nano10061096
    A novel method of preparing reduced graphene oxide (RGOX) from graphene oxide (GOX) was developed employing vegetable extract, Chenopodium album, as a reducing and stabilizing agent. Chenopodium album is a green leafy vegetable with a low shelf life, fresh leaves of this vegetable are encouraged to be used due to high water content. The previously modified 'Hummers method' has been in practice for the preparation of GOX by using precursor graphite powder. In this study, green synthesis of RGOX was functionally verified by employing FTIR and UV-visible spectroscopy, along with SEM and TEM. Our results demonstrated typical morphology of RGOX stacked in layers that appeared as silky, transparent, and rippled. The antibacterial activity was shown by analyzing minimal inhibitory concentration values, agar diffusion assay, fluorescence techniques. It showed enhanced antibacterial activity against Gram-positive and Gram-negative bacteria in comparison to GOX. It has also been shown that the synthesized compound exhibited enhanced antibiofilm activity as compared to its parent compound. The efficacy of RGOX and GOX has been demonstrated on a human breast cancer cell line, which suggested RGOX as a potential anticancer agent.
  16. Fulltext Bacterial Diversity and Community Structure of a Municipal Solid Waste Landfill: A Source of Lignocellulolytic Potential
    Chukwuma OB, Rafatullah M, Tajarudin HA, Ismail N
    Life (Basel), 2021 May 28;11(6).
    PMID: 34071172 DOI: 10.3390/life11060493
    Omics have given rise to research on sparsely studied microbial communities such as the landfill, lignocellulolytic microorganisms and enzymes. The bacterial diversity of Municipal Solid Waste sediments was determined using the illumina MiSeq system after DNA extraction and Polymerase chain reactions. Data analysis was used to determine the community's richness, diversity, and correlation with environmental factors. Physicochemical studies revealed sites with mesophilic and thermophilic temperature ranges and a mixture of acidic and alkaline pH values. Temperature and moisture content showed the highest correlation with the bacteria community. The bacterial analysis of the community DNA revealed 357,030 effective sequences and 1891 operational taxonomic units (OTUs) assigned. Forty phyla were found, with the dominant phyla Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidota, while Aerococcus, Stenotrophomonas, and Sporosarcina were the dominant species. PICRUSt provided insight on community's metabolic function, which was narrowed down to search for lignocellulolytic enzymes' function. Cellulase, xylanase, esterase, and peroxidase were gene functions inferred from the data. This article reports on the first phylogenetic analysis of the Pulau Burung landfill bacterial community. These results will help to improve the understanding of organisms dominant in the landfill and the corresponding enzymes that contribute to lignocellulose breakdown.
  17. Application of chitosan and its derivatives as adsorbents for dye removal from water and wastewater: a review
    Vakili M, Rafatullah M, Salamatinia B, Abdullah AZ, Ibrahim MH, Tan KB, et al.
    Carbohydr Polym, 2014 Nov 26;113:115-30.
    PMID: 25256466 DOI: 10.1016/j.carbpol.2014.07.007
    Chitosan based adsorbents have received a lot of attention for adsorption of dyes. Various modifications of this polysaccharide have been investigated to improve the adsorption properties as well as mechanical and physical characteristics of chitosan. This review paper discusses major research topics related to chitosan and its derivatives for application in the removal of dyes from water. Modification of chitosan changes the original properties of this material so that it can be more suitable for adsorption of different types of dye. Many chitosan derivatives have been obtained through chemical and physical modifications of raw chitosan that include cross-linking, grafting and impregnation of the chitosan backbone. Better understanding of these varieties and their affinity toward different types of dye can help future research to be properly oriented to address knowledge gaps in this area. This review provides better opportunity for researchers to better explore the potential of chitosan-derived adsorbents for removal of a great variety of dyes.
  18. An insight into the role of experimental parameters in advanced oxidation process applied for pharmaceutical degradation
    Qutob M, Alshehri S, Shakeel F, Alam P, Rafatullah M
    Environ Sci Pollut Res Int, 2024 Apr;31(18):26452-26479.
    PMID: 38546921 DOI: 10.1007/s11356-024-33040-3
    The advanced oxidation process (AOP) is an efficient method to treat recalcitrance pollutants such as pharmaceutical compounds. The essential physicochemical factors in AOP experiments significantly influence the efficiency, speed, cost, and safety of byproducts of the treatment process. In this review, we collected recent articles that investigated the elimination of pharmaceutical compounds by various AOP systems in a water medium, and then we provide an overview of AOP systems, the formation mechanisms of active radicals or reactive oxygen species (ROS), and their detection methods. Then, we discussed the role of the main physicochemical parameters (pH, chemical interference, temperature, catalyst, pollutant concentration, and oxidant concentration) in a critical way. We gained insight into the most frequent scenarios for the proper and improper physicochemical parameters for the degradation of pharmaceutical compounds. Also, we mentioned the main factors that restrict the application of AOP systems in a commercial way. We demonstrated that a proper adjustment of AOP experimental parameters resulted in promoting the treatment performance, decreasing the treatment cost and the treatment operation time, increasing the safeness of the system products, and improving the reaction stoichiometric efficiency. The outcomes of this review will be beneficial for future AOP applicants to improve the pharmaceutical compound treatment by providing a deeper understanding of the role of the parameters. In addition, the proper application of physicochemical parameters in AOP systems acts to track the sustainable development goals (SDGs).
  19. Fulltext Advancement in Benthic Microbial Fuel Cells toward Sustainable Bioremediation and Renewable Energy Production
    Umar MF, Rafatullah M, Abbas SZ, Mohamad Ibrahim MN, Ismail N
    Int J Environ Res Public Health, 2021 Apr 06;18(7).
    PMID: 33917378 DOI: 10.3390/ijerph18073811
    Anthropogenic activities are largely responsible for the vast amounts of pollutants such as polycyclic aromatic hydrocarbons, cyanides, phenols, metal derivatives, sulphides, and other chemicals in wastewater. The excess benzene, toluene and xylene (BTX) can cause severe toxicity to living organisms in wastewater. A novel approach to mitigate this problem is the benthic microbial fuel cell (BMFC) setup to produce renewable energy and bio-remediate wastewater aromatic hydrocarbons. Several mechanisms of electrogens have been utilized for the bioremediation of BTX through BMFCs. In the future, BMFCs may be significant for chemical and petrochemical industry wastewater treatment. The distinct factors are considered to evaluate the performance of BMFCs, such as pollutant removal efficiency, power density, and current density, which are discussed by using operating parameters such as, pH, temperature and internal resistance. To further upgrade the BMFC technology, this review summarizes prototype electrode materials, the bioremediation of BTX, and their applications.
  20. Advanced oxidation of polycyclic aromatic hydrocarbons in tropical soil: Self-catalytic utilization of natural iron contents in an oxygenation reactor supported with persulfate
    Qutob M, Rafatullah M, Muhammad SA, Siddiqui MR, Alam M
    Sci Total Environ, 2024 May 20;926:171843.
    PMID: 38521259 DOI: 10.1016/j.scitotenv.2024.171843
    The catalysts derived from natural iron minerals in the advanced oxidation process offer several advantages. However, their utilization in soil remediation is restricted due to the presence of soil impurities, which can inhibit the catalytic activity of these minerals. The soils in tropical regions exhibit lower organic matter content, limited cation exchange capacity, and are non-saline, this enhances the efficiency of utilizing natural iron minerals from tropical soil as a catalyst. In this regard, the catalytic potential of naturally iron-bearing tropical soil was investigated to eliminate phenanthrene (PHE), pyrene (PYR), and benzo[α]pyrene (B[α]P) using an oxygenated reactor supported with persulfate (PS). The system showed an efficient performance, and the removal efficiencies under the optimum conditions were 81 %, 73 %, and 86 % for PHE, PYR, and B[α]P, respectively. This indicated that the catalytic activity of iron was working efficiently. However, there were changes in the soil characteristics after the remediation process such as a significant reduction in iron and aluminum contents. The scavenging experiments demonstrated that HO• had a minor role in the oxidation process, SO4•- and O2•- emerged as the primary reactive species responsible for the effective degradation of the PAHs. Moreover, the by-products were monitored after soil remediation to evaluate their toxicity and to propose degradation pathways. The Mutagenicity test showed that two by-products from each PHE and B[α]P had positive results, while only one by-product of PYR showed positive. The toxicity tests of oral rat LD50 and developmental toxicity tests revealed that certain PAHs by-products could be more toxic from the parent pollutant itself. This study represents a notable progression in soil remediation by providing a step forward in the application of the advanced oxidation process (AOP) without requiring additional catalysts to activate oxidants and degrade pollutant PAHs from the soil.
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