MyMedR

First report on sensitization to allergens of a house dust mite, Suidasia pontifica (Acari: Saproglyphidae)

Mariana A, Ho TM, Gendeh BS, Iskandar H, Zainuldin-Taib M

Southeast Asian J Trop Med Public Health, 2000 Dec;31(4):722-3.

A species of house dust mite, Suidasia pontifica, was recently shown to produce allergens affecting man. The species may be as important as other allergen producing mite in sensitization and causing allergic symptoms in Malaysians. Surveys conducted demonstrated that 80% of the houses surveyed were positive for this mite with densities ranged from 2 to 50 mites per gram of dust. Colonies of the species has been successfully established and materials from those colonies have been used to produce extracts for studies on sensitization to the mites. A total of 85 suspected allergic rhinitis patients were tested and 74.1% demonstrated positive reactions. Extract of this mite should be considered for routine diagnostic testing and possible immunotherapy.

Matched MeSH terms: Hypersensitivity/immunology*

Cord IgE and ECP levels of Malay neonates

Yadav A, Naidu R

Allergol Immunopathol (Madr), 2013 Nov-Dec;41(6):364-8.

PMID: 23276420 DOI: 10.1016/j.aller.2012.08.007

Cord IgE and ECP levels are major atopic markers implicated in early childhood allergy development. Most epidemiological studies to date have not utilised current technology to establish baseline cord IgE levels, further aggravated by lack of data in this region. This study also attempts to identify a relationship between cord IgE and ECP levels as a mean to improve sensitivity for early prediction of atopy.

Matched MeSH terms: Hypersensitivity/diagnosis*; Hypersensitivity/immunology; Hypersensitivity/epidemiology

Prevalence of allergic fungal sinusitis in refractory chronic rhinosinusitis in adult Malaysians

Goh BS, Gendeh BS, Rose IM, Pit S, Samad SA

Otolaryngol Head Neck Surg, 2005 Jul;133(1):27-31.

PMID: 16025048

To determine the prevalence of allergic fungal sinusitis (AFS) in refractory chronic rhinosinusitis (CRS) in adult Malaysians.

Matched MeSH terms: Respiratory Hypersensitivity/microbiology*; Respiratory Hypersensitivity/epidemiology*; Respiratory Hypersensitivity/pathology

Fulltext Food Allergy and Helicobacter pylori Infection: A Systematic Review

Ma ZF, Majid NA, Yamaoka Y, Lee YY

Front Microbiol, 2016;7:368.

PMID: 27047479 DOI: 10.3389/fmicb.2016.00368

Based on the hygiene hypothesis, a low prevalence of Helicobacter pylori (H. pylori) infection may explain the recent high prevalence of allergic diseases including food allergy. However, there are very few studies that investigate the relationship between H. pylori and food allergy.

Matched MeSH terms: Food Hypersensitivity

Asthma, allergy, and atopy in three south-east Asian populations

Leung R, Ho P

Thorax, 1994 Dec;49(12):1205-10.

PMID: 7878553

Whilst many recent reports have suggested a rise in the prevalence of asthma and allergic disease in Western countries, little is known about the epidemiology of these common conditions in south-east Asia. This study compared the prevalence of asthma and allergic disease amongst secondary school students in three south-east Asian populations--Hong Kong, Kota Kinabalu in Malaysia, and San Bu in China--and investigated the associations with atopy and family history.

Matched MeSH terms: Hypersensitivity/epidemiology*; Hypersensitivity, Immediate/epidemiology

Fulltext Incidental pharmacogenetics findings in an HLA-related research: Considerations for primary prevention

Bakhtiar MF, Too CL, Tang MM, Sulaiman S, Tan LK, Ahmad-Fauzi NA, et al.

Clin Exp Allergy, 2019 04;49(4):537-540.

PMID: 30693574 DOI: 10.1111/cea.13347

Matched MeSH terms: Drug Hypersensitivity/genetics; Drug Hypersensitivity/immunology; Drug Hypersensitivity/epidemiology

Fulltext A Systematic Review of the Prevalence of Atopic Diseases in Children on the Arabian Peninsula

Al-Herz W

Med Princ Pract, 2018;27(5):436-442.

PMID: 30149382 DOI: 10.1159/000493267

OBJECTIVES: To study the available data on the prevalence of atopic diseases and food allergy in children living on the Arabian Peninsula.

METHODS: A PubMed search for relevant published articles was conducted using the following search terms singly or in combination: "atopy," "atopic disease," "atopic disorder," "International Study of Asthma and Allergies in Childhood," "ISAAC," "asthma," "allergic rhinitis," "eczema," and "food allergy" in combination with the names of countries of the Arabian Peninsula (Kuwait, United Arab Emirates, Bahrain, Qatar, Oman, Kingdom of Saudi Arabia, and Yemen). The search captured studies published up to December 2017.

RESULTS: A total of 8 publications reporting prevalence rates of any type of atopic disease in children in 7 countries of the Arabian Peninsula were retrieved. The prevalence of all atopic disorders was comparable between countries of the Arabian Peninsula. The overall prevalence of asthma ranged from 8 to 23%, while the reported prevalence of eczema ranged from 7.5 to 22.5%. There was great variation in the prevalence rates of rhinoconjunctivitis, which ranged from 6.3 to 30.5%. The prevalence of food allergy (8.1%) was reported for 1 country only, the United Arab Emirates.

CONCLUSIONS: The reported overall rates of atopic disease in countries of the Arabian Peninsula are comparable to those reported in other industrialized countries. This is probably related to the good economic status in the region, which is reflected in the living standards and lifestyle. Further, genetic factors, such as factors related to gene polymorphism, and the high rate of consanguinity in the region may contribute to the higher prevalence of atopic diseases.

Matched MeSH terms: Food Hypersensitivity/epidemiology*; Hypersensitivity/epidemiology

Fulltext The effects of light and height of building in attracting Paederus fuscipes curtis to disperse towards human residential areas

Sufian Maryam, Nik Fadzly, Wan Fatma Zuharah

Trop Life Sci Res, 2016;27(11):95-101.

MyJurnal

Paederus fuscipes Curtis is a nocturnal insect. The attractiveness of artificial
light sources from residential premises eventually causes the risk of severe dermatitis
effect, once Paederus is in contact with human skin. The objective of this study is to
investigate whether the light and height factors of residential buildings and its’ association
to rice cultivation phases are primary reasons for P. fuscipes’s mass dispersal into human
residential areas. The study site was located in residential premises that were built
adjacent to rice field areas (≈ 32–60 m and 164 m) north of the rice field located in Teluk
Air Tawar, mainland of Pulau Pinang. Overall, both light sources and rice cultivation
phases caused a significant effect for P. fuscipes beetles dispersal flight to invade human
settlements. More P. fuscipes were captured near the bright light source with the highest
number of beetles found during harvesting stage. Whereas, significantly higher number of
P. fuscipes were captured at level 2 and 3 compared to ground and level 1 of the
apartment building and P. fuscipes was also found significantly affected by the rice
cultivation phases at different elevation levels. This indicates that bright light sources and
higher elevation levels are the main factors in attracting P. fuscipes beetles to disperse
and causes infestations in residential areas. This finding could create awareness among
the public on P. fuscipes dispersal pattern.

Matched MeSH terms: Food Hypersensitivity

Middle turbinate edema as a diagnostic marker of inhalant allergy

Hamizan AW, Christensen JM, Ebenzer J, Oakley G, Tattersall J, Sacks R, et al.

Int Forum Allergy Rhinol, 2017 01;7(1):37-42.

PMID: 27530103 DOI: 10.1002/alr.21835

BACKGROUND: Middle turbinate edema could be a characteristic feature of aeroallergen sensitization. In this study we sought to determine the diagnostic characteristics of middle turbinate edema as a marker of inhalant allergy.

METHODS: A cross-sectional diagnostic study was performed on patients who had undergone nasal endoscopy and allergy testing. Allergy status was determined by positive serology or epicutaneous testing. Endoscopy was reviewed by blinded assessors for middle turbinate head edema. Appearance was graded as either normal, focal, multifocal, diffuse, or polypoid edema. Receiver-operator (ROC) analysis, likelihood ratio (LR), sensitivity, specificity, and positive predictive value (PPV) were determined.

RESULTS: One hundred eighty-seven patients representing 304 nasal cavities were assessed (42% female, age 39.74 ± 14.7 years, 57% allergic). Diffuse edema (PPV 91.7%/LR = 8) and polypoid edema (PPV 88.9%/LR = 6.2) demonstrated the strongest association with inhalant allergy. Multifocal edema was used as a cut-off to represent inhalant allergy from ROC analysis, which demonstrated 94.7% specificity and 23.4% sensitivity. The PPV for multifocal was 85.1% and LR = 4.4.

CONCLUSION: Middle turbinate edema is a useful nasal endoscopic feature to predict presence of inhalant allergy and, although not sensitive, has excellent PPV.

Matched MeSH terms: Hypersensitivity/diagnosis*; Hypersensitivity/immunology; Hypersensitivity/pathology

Fulltext Kajian kesihatan respiratori berkaitan pencemaran udara akibat lalu lintas dalam kalangan kanak-kanak sekolah rendah dengan rujukan kepada Sekolah Kebangsaan Langgar dan Sekolah Kebangsaan Demit, Kota Bharu, Kelantan

Haliza Abdul Rahman, Noraini Mansor, Noor Aini Hussain

Jurnal Sains Kesihatan Malaysia, 2011;9(1):13-21.

MyJurnal

Perkembangan industri permotoran telah menyebabkan pencemaran udara yang menjadi faktor kepada peningkatan simptom masalah respiratori dalam kalangan kanak-kanak sekolah rendah. Kajian ini mengkaji perkaitan antara peningkatan simptom masalah kesihatan respiratori dalam kalangan kanak-kanak sekolah rendah dengan pendedahan terhadap pencemaran udara akibat lalu lintas. Kajian school-based jenis keratan lintang telah dilakukan di dua buah sekolah di daerah Kota Bharu, Kelantan iaitu Sekolah Kebangsaan Langgar dan Sekolah Kebangsaan Demit dengan melibatkan pelajar berumur 10, 11 dan 12 tahun. Saiz sampel seramai 124 orang (n = 124) dipilih menggunakan corak persampelan kebarangkalian iaitu persampelan rawak mudah. Responden disoal menggunakan instrumen yang telah disahihkan dan diadaptasi dari International Study of Asthma and Allergies in Childhood (ISAAC). Analisis data dilakukan dengan menggunakan Statistical Package For Social Sciences (SPSS). Hasil kajian menunjukkan peningkatan simptom masalah respiratori yang dihadapi oleh pelajar di dua buah sekolah rendah di Kota Bharu adalah berkait rapat dengan pencemaran udara yang berpunca dari lalu lintas dengan p < 0.05. Kajian mendapati pendedahan kepada bahan pencemar udara yang berpunca dari lalu lintas telah meningkatkan simptom masalah respiratori dalam kalangan kanak-kanak sekolah di rendah lokasi kajian.

Matched MeSH terms: Hypersensitivity

Fulltext Diacritical digital Quran authentication model

Saqib Iqbal Hakak, Amirrudin Kamsin, Mohd. Yamani Idna Idris, Abdullah Gani, Saber Zerdoumi

Pertanika Journal of Science & Technology, 2017;25(106):133-142.

MyJurnal

There has been an increase of content related to Quran and Hadith on the internet over the past few years. Diacritical Digital Quran is very sensitive to tampering. Diacritics are the symbols used beneath/above Quranic verses for reading purposes of the Quran. Minor change in diacritics can alter the meaning of a particular Quranic verse. Hence, there is a need for an authentication system to differentiate between fake and original verses. In this work, a model is proposed related to automatic authentication of Digital Quran. Authentication model is divided into two phases: tokenisation and authentication. For tokenisation, regular expressions are used to split input Quranic verse into single characters. In case of authentication, existing and standard exact matching algorithm i.e. Quick search (QS) is used. On testing the proposed model by comparing popular search engines and other related existing works, our approach is 100 % accurate in terms of full verse detection.

Matched MeSH terms: Hypersensitivity

Fulltext Scanning electron microscope study on selected species of genus Desmos loureiro FL. (annonaceae) in the Malaysia

Normalawati, S., Suhaniza, R., Hing, H.L.

Malaysian Journal of Microscopy, 2016;12(1):6-11.

MyJurnal

Ultrastructural study was carried out 2 groups of pollen with numerous, arranged and spirals on convex. Five species was studied; Desmos chinensis Lour. Fl., Desmos cochinchinensis Lour Fl. , Desmos dumonsus (Roxb.) Safford. , Desmos dunalii (Hk. F. et Th.) Safford. and Desmos dasymaschalus (Bl.) Safford. Pollen was collected from UKM Herbarium specimens and fresh specimen was collected at difference area in the Malaysia. They were acetolysis and dried by CPD method. Parameter studied via scanning electron microscope are mounted pollen, were stamen material; shape, P/E, size, surface structure and calpus ornamentation. Results obtained showed that pollen was inaperturate with needle structure and solitary globus. The morphology of pollen grains of all the species is presented and an identification key base on scanning electron microscope observations is tested.

Matched MeSH terms: Drug Hypersensitivity

A palynological investigation of Vatica L. (Dipterocarpaceae) in Peninsular Malaysia

Houssein M.A. El-Taguri, Latiff A

Sains Malaysiana, 2014;43:1283-1293.

Pollen morphology of 24 species of Vatica L. had been investigated using light and scanning electron microscopes. Vatica is a stenopalynous genus, the pollens are radially symmetrical, isopolar, subprolate to suboblate sometimes prolate rarely oblate, all tricolpate. Exine ornamentation varies from thin to medium reticulate. On the basis of pollen shape two groups of Vatica have been recognized. Within the genus pollen diversity is valuable for identification and delimiting species.

Matched MeSH terms: Drug Hypersensitivity

Common allergy problems in infancy and childhood

Smith G

Family Practitioner, 1978;3:10-12.

Matched MeSH terms: Hypersensitivity

Fulltext Simple and sensitive method for the analysis of ketorolac in human plasma using high-performance liquid chromatography

Muralidharan S, Jayaraja Kumar K, Parasuraman S

J Young Pharm, 2013 Sep;5(3):98-101.

PMID: 24396250 DOI: 10.1016/j.jyp.2013.06.007

To develop a simple and sensitive method of ketorolac in drug free human plasma using high-performance liquid chromatographic (HPLC).

Matched MeSH terms: Hypersensitivity

Fulltext Mucosal enterokinase activity in cow's milk protein sensitive enteropathy

Iyngkaran N, Yadav M, Boey CG

Singapore Med J, 1995 Aug;36(4):393-6.

PMID: 8919154

Enterokinase has a critical role in initiating proteolytic digestion by hydrolysing the conversion of pancreatic trypsinogen into trypsin. The enzyme is synthesised by enterocytes of the proximal small intestine and initially incorporated into the brush border from where it is released into the intestinal lumen by the action of pancreatic secretions. The aim of the study was to analyse enterokinase activity in the duodenal mucosa of infants with diarrhoeal disease including cow's milk protein-sensitive enteropathy. Our observations show that the mean depletion of enterokinase was only 17% compared to 60-80% for other brush border enzymes like disaccharidases, peptidases and alkaline phosphatases in infants with diarrhoea. This suggests that enterokinase activity in the small bowel enteropathies may be dependent not only on the degree of mucosal damage specifically but also on the extent of damage to the goblet cell population where the enzyme is synthesised. Thus the enterokinase activity was reduced in acute and chronic diarrhoea with marked mucosal damage where significant reduction of goblet cell population was evident but the enzyme was relatively little affected when the mucosa was damaged mildly.

Matched MeSH terms: Milk Hypersensitivity/diagnosis*; Milk Hypersensitivity/enzymology; Milk Hypersensitivity/pathology

Severity and extent of upper small bowel mucosal damage in cow's milk protein-sensitive enteropathy

Iyngkaran N, Yadav M, Boey CG, Lam KL

J Pediatr Gastroenterol Nutr, 1988 Sep-Oct;7(5):667-74.

PMID: 3183870

A series of 31 infants, 28 with cow's milk protein sensitive enteropathy (CMPSE) and 3 controls, was studied for severity and extent of mucosal damage of the upper small bowel in relation to the development of clinical symptoms. Following challenge with the offending cow's milk, 18 infants (Group 1) developed severe mucosal changes at both the proximal and distal small bowel mucosa and all of these infants presented with clinical symptoms. The other 10 infants (Group 2) who did not develop clinical symptoms following the challenge had less severe damage to the distal small bowel mucosa as compared to the proximal region. The histological score of both the proximal and distal postchallenge biopsies were significantly lower in Group 2 as compared to Group 1 infants. The mucosal disaccharidase and alkaline phosphatase levels were depleted in both the proximal and distal biopsies following challenge but the depletion was greater in the proximal than the distal biopsies. It is suggested that the extent and severity of mucosal damage to the proximal duodenum and jejunum have a critical bearing on the development of clinical symptoms.

Matched MeSH terms: Food Hypersensitivity/complications; Food Hypersensitivity/enzymology; Food Hypersensitivity/etiology; Food Hypersensitivity/pathology*

Fulltext Dapsone syndrome--first Malaysian paediatric case report

Zurina Z, Elizawaty O, Thevarajah S, Norlijah O

Med J Malaysia, 2012 Feb;67(1):105-7.

PMID: 22582558

Dapsone syndrome is a potentially fatal hypersensitivity reaction to sulphone. We report a 12-year-old girl who developed high grade fever associated with intense jaundice, exfoliative skin rash and hepatomegaly after five weeks of starting the multidrug regimen for the treatment of Hansen's disease. Laboratory investigations revealed presence of leucocytosis with eosinophilia, deranged liver enzymes and an abnormal coagulation profile. Immediate cessation of the offending drug and administration of steroid proved successful. A high level of clinical awareness is fundamental for early diagnosis of dapsone syndrome as initiation of a prompt treatment may lead to rapid recovery.

Matched MeSH terms: Drug Hypersensitivity/diagnosis*

Fulltext Atopic sensitization of children with rhinitis in Malaysia

Gendeh BS, Mujahid SH, Murad S, Rizal M

Med J Malaysia, 2004 Oct;59(4):522-9.

PMID: 15779586 MyJurnal

Atopy is defined as the genetic propensity to develop immunoglobulin E antibodies in response to exposure to allergens and assessed by skin prick test (SPT) responses to common allergens, which may contribute to the development of the clinical disorders (phenotype). Although it is generally agreed that atopy is an important risk factor for allergic diseases such as asthma, rhinitis, and eczema, the extent to which atopy accounts for these diseases is controversial. One hundred forty one children (up to 12 years) were skin prick tested to evaluate 16 foods common to the Malaysian diet and 4 common aeroallergens. Eighty-five percent of patients had positive SPT reactivity. The most commonly implicated aeroallergen and food allergen was house dust mite (HDM) and Prawn. Seventy percent had positive SPT reactivity results to HDM and 24.8% to prawns. Fifty five percent were positive to more than one allergen and 17.7% positive to single aeroallergen. The prevalence of atopy in children with history of eczema was 90%. The incidence of HDM and food allergy especially crabs and prawns, is significantly greater in Malaysian Children with rhinitis symptoms.

Matched MeSH terms: Food Hypersensitivity/immunology

Assessment of knowledge, attitude and practice of food allergies among food handlers in the state of Penang, Malaysia

Shafie AA, Azman AW

Public Health, 2015 Sep;129(9):1278-84.

PMID: 25931434 DOI: 10.1016/j.puhe.2015.03.016

Food handler's knowledge, attitude and practice regarding food allergies are important to prevent debilitating and sometimes fatal reactions. This study aimed to assess their food allergy knowledge, attitude and practice, which could help to maintain the safety and hygiene of food consumed by the public.

Matched MeSH terms: Food Hypersensitivity*

Displaying publications 21 - 40 of 274 in total